Neuroactive steroids and anxiety disorders

Journal of Psychiatry and Neuroscience

Volumn 27, Issue 3, 2002, Pages 161-165

  Le Mellédo, Jean Michel ^a   Baker, Glen B ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; ANXIOLYTIC AGENT; ELTANOLONE; NEUROSTEROID; PRASTERONE; PROGESTERONE DERIVATIVE; SEROTONIN UPTAKE INHIBITOR; TETRAHYDRODEOXYCORTICOSTERONE;

ANXIETY; ANXIETY NEUROSIS; BLOOD LEVEL; CEREBROSPINAL FLUID LEVEL; GABAERGIC SYSTEM; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; NONHUMAN; NOTE; PSYCHOPHARMACOLOGY;

ANIMALS; ANXIETY DISORDERS; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; NERVOUS SYSTEM; PITUITARY-ADRENAL SYSTEM; STEROIDS;

EID: 0036295429     PISSN: 11804882     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Note

References (33)

1. Neuroactive steroids
2. Neuroactive steroids: Mechanism of action and neuropsychopharmacological perspectives
3. Neurosteroids: Beginning of the story
4. Neurosteroid biosynthesis: Genes for adrenal steroidogenic enzymes are expressed in the brain
5. Potentiation of GABAergic neurotransmission by steroids
6. Neurosteroids. Behavioral studies
7. Anxiolytic effect of progesterone is mediated by the neurosteroid allopregnanolone at brain GABAA receptors
8. Pregnenolone and pregnenolone sulfate, alone and with ethanol, in mice on the plus-maze
9. Neurosteroids: Endogenous bimodal modulators of the GABAA receptor. Mechanism of action and physiological significance
10. Excitatory amino acid receptor antagonists block the cardiovascular and anxiety responses elicited by gamma-aminobutyric acid A receptor blockade in the basolateral amygdala of rats
11. Differential anxiolytic effects of neurosteroids in the mirrored chamber behavior test in mice
12. Dehydroepiandrosterone is an anxiolytic in mice on the plus maze
13. Effects of antidepressant treatment on neuroactive steroids in major depression
14. Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine
15. Fluoxetine-elicited changes in brain neurosteroid content measured by negative ion mass fragmentography
16. Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes
17. Neuroactive steroid plasma levels in patients with generalized anxiety disorder
18. Decreased serum levels of pregnenolone sulfate in patients with generalized social phobia
19. GABAA receptor-modulating neuroactive steroid composition in patients with panic disorder before and during paroxetine treatment
20. Pregnenolone sulfate: A positive allosteric modulator at the NMDA receptor
21. Elevated circulatory levels of GABA antagonistic neurosteroids in patients with combat-related post-traumatic stress disorder
22. Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain
23. Time-dependent changes in rat brain neuroactive steroid concentrations and GABA-A receptor function after acute stress
24. Neuroactive steroid response to pentagastrin in patients with panic disorder and healthy volunteers
25. A receptors and modulated by endogenous steroids
26. The neurosteroid tetrahydroprogesterone counteracts corticotropin-releasing hormone-induced anxiety and alters the release and gene expression of corticotropin-releasing hormone in the rat hypothalamus
27. The neurosteroid tetrahydroprogesterone attenuates the endocrine response to stress and exerts glucocorticoid-like effects on vasopressin gene transcription in the rat hypothalamus
28. Neonatal treatment of rats with the neuroactive steroid tetrahydrodeoxycorticosterone (THDOC) abolishes the behavioral and neuroendocrine consequences of adverse early life events
29. Neurotransmitter modulation of corticotropin-releasing factor secretion into the hypophysial portal circulation
30. Behavioral, biochemical and blood pressure responses to alprazolam in healthy subjects: Interactions with yohimbine
31. Adrenocorticotropin-releasing hormone: Changes in panic disorder and effects of alprazolam treatment
32. Protective and damaging effects of mediators of stress: Elaborating and testing the concepts of allostasis and allostatic load
33. Concentration of 3 alpha-reduced neuroactive steroids and their precursors in plasma of patients with major depression and after clinical recovery