-
1
-
-
65249116958
-
Thyrotropin and homologous glycoprotein hormone receptors: Structural and functional aspects of extracellular signaling mechanisms
-
10.1210/er.2008-0044. 19176466
-
Thyrotropin and homologous glycoprotein hormone receptors: structural and functional aspects of extracellular signaling mechanisms. G Kleinau G Krause, Endocr Rev 2009 30 2 133 51 10.1210/er.2008-0044 19176466
-
(2009)
Endocr Rev
, vol.30
, Issue.2
, pp. 133-51
-
-
Kleinau, G.1
Krause, G.2
-
2
-
-
79251644004
-
Principles and determinants of G-protein coupling by the rhodopsin-like thyrotropin receptor
-
10.1371/journal.pone.0009745. 20305779
-
Principles and determinants of G-protein coupling by the rhodopsin-like thyrotropin receptor. G Kleinau,, et al. PLoS One 2010 5 3 9745 10.1371/journal.pone.0009745 20305779
-
(2010)
PLoS One
, vol.5
, Issue.3
, pp. 59745
-
-
Kleinau, G.1
-
3
-
-
0025052465
-
Thyrotropin activates both the cyclic AMP and the PIP2 cascades in CHO cells expressing the human cDNA of TSH receptor
-
10.1016/0303-7207(90)90209-Q. 2178105
-
Thyrotropin activates both the cyclic AMP and the PIP2 cascades in CHO cells expressing the human cDNA of TSH receptor. J Van Sande,, et al. Mol Cell Endocrinol 1990 74 1 1 6 10.1016/0303-7207(90)90209-Q 2178105
-
(1990)
Mol Cell Endocrinol
, vol.74
, Issue.1
, pp. 181-6
-
-
Van Sande, J.1
-
4
-
-
0028224772
-
The human thyrotropin receptor activates G-proteins Gs and Gq/11
-
8188646
-
The human thyrotropin receptor activates G-proteins Gs and Gq/11. A Allgeier,, et al. J Biol Chem 1994 269 19 13733 5 8188646
-
(1994)
J Biol Chem
, vol.269
, Issue.19
, pp. 13733-5
-
-
Allgeier, A.1
-
5
-
-
0026743033
-
The thyrotropin receptor and the regulation of thyrocyte function and growth
-
1425489
-
The thyrotropin receptor and the regulation of thyrocyte function and growth. G Vassart JE Dumont, Endocr Rev 1992 13 3 596 611 1425489
-
(1992)
Endocr Rev
, vol.13
, Issue.3
, pp. 596-611
-
-
Vassart, G.1
Dumont, J.E.2
-
6
-
-
34848892423
-
11 deficiency impairs thyroid function and prevents goiter development
-
DOI 10.1172/JCI30380
-
Thyrocyte-specific Gq/G11 deficiency impairs thyroid function and prevents goiter development. J Kero,, et al. J Clin Invest 2007 117 9 2399 407 10.1172/JCI30380 17694176 (Pubitemid 47494342)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.9
, pp. 2399-2407
-
-
Kero, J.1
Ahmed, K.2
Wettschureck, N.3
Tunaru, S.4
Wintermantel, T.5
Greiner, E.6
Schutz, G.7
Offermanns, S.8
-
7
-
-
77956626717
-
Genetic defects, thyroid growth and malfunctions of the TSHR in pediatric patients
-
10.2741/3654. 20515734
-
Genetic defects, thyroid growth and malfunctions of the TSHR in pediatric patients. H Biebermann F Winkler G Kleinau, Front Biosci 2010 15 913 933 10.2741/3654 20515734
-
(2010)
Front Biosci
, vol.15
, pp. 913-933
-
-
Biebermann, H.1
Winkler, F.2
Kleinau, G.3
-
8
-
-
0028891649
-
Brief report: Congenital hyperthyroidism caused by a mutation in the thyrotropin-receptor gene
-
10.1056/NEJM199501193320304. 7800007
-
Brief report: congenital hyperthyroidism caused by a mutation in the thyrotropin-receptor gene. P Kopp,, et al. N Engl J Med 1995 332 3 150 4 10.1056/NEJM199501193320304 7800007
-
(1995)
N Engl J Med
, vol.332
, Issue.3
, pp. 150-4
-
-
Kopp, P.1
-
9
-
-
65349158284
-
Activating TSH-receptor mutation (Met453Thr) as a cause of adenomatous non-autoimmune hyperthyroidism in a 3-year-old boy
-
10.1515/JPEM.2009.22.3.269. 19492584
-
Activating TSH-receptor mutation (Met453Thr) as a cause of adenomatous non-autoimmune hyperthyroidism in a 3-year-old boy. S Kraemer,, et al. J Pediatr Endocrinol Metab 2009 22 3 269 74 10.1515/JPEM.2009.22.3.269 19492584
-
(2009)
J Pediatr Endocrinol Metab
, vol.22
, Issue.3
, pp. 269-74
-
-
Kraemer, S.1
-
10
-
-
67649203613
-
A heterozygous mutation in the third transmembrane domain causes a dominant-negative effect on signaling capability of the MC4R
-
10.1159/000138251. 20054175
-
A heterozygous mutation in the third transmembrane domain causes a dominant-negative effect on signaling capability of the MC4R. P Tarnow,, et al. Obes Facts 2008 1 3 155 162 10.1159/000138251 20054175
-
(2008)
Obes Facts
, vol.1
, Issue.3
, pp. 155-162
-
-
Tarnow, P.1
-
11
-
-
34748892295
-
Evolutionary aspects in evaluating mutations in the melanocortin 4 receptor
-
DOI 10.1210/en.2007-0138
-
Evolutionary aspects in evaluating mutations in the melanocortin 4 receptor. C Staubert,, et al. Endocrinology 2007 148 10 4642 8 10.1210/en.2007-0138 17628007 (Pubitemid 47481513)
-
(2007)
Endocrinology
, vol.148
, Issue.10
, pp. 4642-4648
-
-
Staubert, C.1
Tarnow, P.2
Brumm, H.3
Pitra, C.4
Gudermann, T.5
Gruters, A.6
Schoneberg, T.7
Biebermann, H.8
Rompler, H.9
-
12
-
-
10944228424
-
Identification of a Novel Epitope in the Thyroid-stimulating Hormone Receptor Ectodomain Acting as Intramolecular Signaling Interface
-
DOI 10.1074/jbc.M404748200
-
Identification of a novel epitope in the thyroid-stimulating hormone receptor ectodomain acting as intramolecular signaling interface. G Kleinau,, et al. J Biol Chem 2004 279 49 51590 600 10.1074/jbc.M404748200 15345720 (Pubitemid 40017910)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.49
, pp. 51590-51600
-
-
Kleinau, G.1
Jasclike, H.2
Neumann, S.3
Lattig, J.4
Paschke, R.5
Krause, G.6
-
13
-
-
54449086544
-
Asp330 and Tyr331 in the C-terminal cysteine-rich region of the luteinizing hormone receptor are key residues in hormone-induced receptor activation
-
10.1074/jbc.M804395200. 18641392
-
Asp330 and Tyr331 in the C-terminal cysteine-rich region of the luteinizing hormone receptor are key residues in hormone-induced receptor activation. M Bruysters M Verhoef-Post AP Themmen, J Biol Chem 2008 283 38 25821 8 10.1074/jbc.M804395200 18641392
-
(2008)
J Biol Chem
, vol.283
, Issue.38
, pp. 25821-8
-
-
Bruysters, M.1
Verhoef-Post, M.2
Themmen, A.P.3
-
14
-
-
0036214718
-
Activation of the cAMP pathway by the TSH receptor involves switching of the ectodomain from a tethered inverse agonist to an agonist
-
DOI 10.1210/me.16.4.736
-
Activation of the cAMP pathway by the TSH receptor involves switching of the ectodomain from a tethered inverse agonist to an agonist. V Vlaeminck-Guillem,, et al. Mol Endocrinol 2002 16 4 736 46 10.1210/me.16.4.736 11923470 (Pubitemid 34297743)
-
(2002)
Molecular Endocrinology
, vol.16
, Issue.4
, pp. 736-746
-
-
Vlaeminck-Guillem, V.1
Ho, S.-C.2
Rodien, P.3
Vassart, G.4
Costagliola, S.5
-
15
-
-
43049109876
-
The thyrotropin receptor hinge region is not simply a scaffold for the leucine-rich domain but contributes to ligand binding and signal transduction
-
DOI 10.1210/me.2007-0407
-
The thyrotropin receptor hinge region is not simply a scaffold for the leucine-rich domain but contributes to ligand binding and signal transduction. Y Mizutori,, et al. Mol Endocrinol 2008 22 5 1171 82 10.1210/me.2007-0407 18218728 (Pubitemid 351629617)
-
(2008)
Molecular Endocrinology
, vol.22
, Issue.5
, pp. 1171-1182
-
-
Mizutori, Y.1
Chen, C.-R.2
McLachlan, S.M.3
Rapoport, B.4
-
16
-
-
77952875267
-
Genetics and phenomics of hypothyroidism due to TSH resistance
-
10.1016/j.mce.2010.01.008. 20083154
-
Genetics and phenomics of hypothyroidism due to TSH resistance. L Persani,, et al. Mol Cell Endocrinol 2010 322 1-2 72 82 10.1016/j.mce.2010.01. 008 20083154
-
(2010)
Mol Cell Endocrinol
, vol.322
, Issue.1-2
, pp. 72-82
-
-
Persani, L.1
-
17
-
-
23644456322
-
Thyrotropin receptor-associated diseases: From adenomata to Graves disease
-
DOI 10.1172/JCI26031
-
Thyrotropin receptor-associated diseases: from adenomata to Graves disease. TF Davies,, et al. J Clin Invest 2005 115 8 1972 83 10.1172/JCI26031 16075037 (Pubitemid 41134132)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.8
, pp. 1972-1983
-
-
Davies, T.F.1
Ando, T.2
Lin, R.-Y.3
Tomer, Y.4
Latif, R.5
-
18
-
-
10344230404
-
Molecular genetic defects in congenital hypothyroidism
-
15554885
-
Molecular genetic defects in congenital hypothyroidism. A Gruters H Krude H Biebermann, Eur J Endocrinol 2004 151 Suppl 3 39 44 15554885
-
(2004)
Eur J Endocrinol
, vol.151
, Issue.SUPPL. 3
, pp. 2139-44
-
-
Gruters, A.1
Krude, H.2
Biebermann, H.3
-
19
-
-
78751555174
-
Genetic hyperthyroidism: Hyperthyroidism due to activating TSHR mutations
-
10.1530/EJE-10-0775. 20926595
-
Genetic hyperthyroidism: hyperthyroidism due to activating TSHR mutations. A Hebrant,, et al. Eur J Endocrinol 2011 164 1 1 9 10.1530/EJE-10-0775 20926595
-
(2011)
Eur J Endocrinol
, vol.164
, Issue.1
, pp. 1-9
-
-
Hebrant, A.1
-
20
-
-
0029044073
-
Somatic mutations causing constitutive activity of the thyrotropin receptor are the major cause of hyperfunctioning thyroid adenomas: Identification of additional mutations activating both the cyclic adenosine 3',5'-monophosphate and inositol phosphate-Ca2+ cascades
-
10.1210/me.9.6.725. 8592518
-
Somatic mutations causing constitutive activity of the thyrotropin receptor are the major cause of hyperfunctioning thyroid adenomas: identification of additional mutations activating both the cyclic adenosine 3',5'-monophosphate and inositol phosphate-Ca2+ cascades. J Parma,, et al. Mol Endocrinol 1995 9 6 725 33 10.1210/me.9.6.725 8592518
-
(1995)
Mol Endocrinol
, vol.9
, Issue.6
, pp. 725-33
-
-
Parma, J.1
-
21
-
-
33750251520
-
Similar prevalence of somatic TSH receptor and Gsalpha mutations in toxic thyroid nodules in geographical regions with different iodine supply in Turkey
-
10.1530/eje.1.02253. 16990652
-
Similar prevalence of somatic TSH receptor and Gsalpha mutations in toxic thyroid nodules in geographical regions with different iodine supply in Turkey. HI Gozu,, et al. Eur J Endocrinol 2006 155 4 535 45 10.1530/eje.1.02253 16990652
-
(2006)
Eur J Endocrinol
, vol.155
, Issue.4
, pp. 535-45
-
-
Gozu, H.I.1
-
22
-
-
51849084353
-
A family with a novel TSH receptor activating germline mutation (p.Ala485Val)
-
10.1007/s00431-007-0659-9. 18175146
-
A family with a novel TSH receptor activating germline mutation (p.Ala485Val). S Akcurin,, et al. Eur J Pediatr 2008 167 11 1231 7 10.1007/s00431-007-0659-9 18175146
-
(2008)
Eur J Pediatr
, vol.167
, Issue.11
, pp. 1231-7
-
-
Akcurin, S.1
-
23
-
-
77955375893
-
A new phenotype of nongoitrous and nonautoimmune hyperthyroidism caused by a heterozygous thyrotropin receptor mutation in transmembrane helix 6
-
10.1210/jc.2010-0112. 20501679
-
A new phenotype of nongoitrous and nonautoimmune hyperthyroidism caused by a heterozygous thyrotropin receptor mutation in transmembrane helix 6. F Winkler,, et al. J Clin Endocrinol Metab 2010 95 8 3605 10 10.1210/jc.2010-0112 20501679
-
(2010)
J Clin Endocrinol Metab
, vol.95
, Issue.8
, pp. 3605-10
-
-
Winkler, F.1
-
24
-
-
26944450868
-
Novel thyrotropin receptor germline mutation (Ile568Val) in a Saxonian family with hereditary nonautoimmune hyperthyroidism
-
DOI 10.1089/thy.2005.15.1089
-
Novel thyrotropin receptor germline mutation (Ile568Val) in a Saxonian family with hereditary nonautoimmune hyperthyroidism. M Claus,, et al. Thyroid 2005 15 9 1089 94 10.1089/thy.2005.15.1089 16187920 (Pubitemid 41475722)
-
(2005)
Thyroid
, vol.15
, Issue.9
, pp. 1089-1094
-
-
Claus, M.1
Maier, J.2
Paschke, R.3
Kujat, C.4
Stumvoll, M.5
Fuhrer, D.6
-
25
-
-
9044240477
-
Functional characteristics of three new germline mutations of the thyrotropin receptor gene causing autosomal dominant toxic thyroid hyperplasia
-
DOI 10.1210/jc.81.2.547
-
Functional characteristics of three new germline mutations of the thyrotropin receptor gene causing autosomal dominant toxic thyroid hyperplasia. M Tonacchera,, et al. J Clin Endocrinol Metab 1996 81 2 547 54 10.1210/jc.81.2.547 8636266 (Pubitemid 26055662)
-
(1996)
Journal of Clinical Endocrinology and Metabolism
, vol.81
, Issue.2
, pp. 547-554
-
-
Tonacchera, M.1
Van Sande, J.2
Cetani, F.3
Swillens, S.4
Schvartz, C.5
Winiszewski, P.6
Portmann, L.7
Dumont, J.E.8
Vassart, G.9
Parma, J.10
-
26
-
-
0030710212
-
Somatic mutations in the thyrotropin receptor gene and not in the G(s)α protein gene in 31 toxic thyroid nodules
-
Somatic mutations in the thyrotropin receptor gene and not in the Gs alpha protein gene in 31 toxic thyroid nodules. D Fuhrer,, et al. J Clin Endocrinol Metab 1997 82 11 3885 91 10.1210/jc.82.11.3885 9360556 (Pubitemid 27509388)
-
(1997)
Journal of Clinical Endocrinology and Metabolism
, vol.82
, Issue.11
, pp. 3885-3891
-
-
Fuhrer, D.1
Holzapfel, H.-P.2
Wonerow, P.3
Scherbaum, W.A.4
Paschke, R.5
-
27
-
-
23244440500
-
Thyrotropin receptor gene mutations and TSH resistance: Variable expressivity in the heterozygotes
-
DOI 10.1111/j.1365-2265.2005.02314.x
-
Thyrotropin receptor gene mutations and TSH resistance: variable expressivity in the heterozygotes. M Camilot,, et al. Clin Endocrinol (Oxf) 2005 63 2 146 151 10.1111/j.1365-2265.2005.02314.x (Pubitemid 41097982)
-
(2005)
Clinical Endocrinology
, vol.63
, Issue.2
, pp. 146-151
-
-
Camilot, M.1
Teofoli, F.2
Gandini, A.3
Franceschi, R.4
Rapa, A.5
Corriasi, A.6
Bona, G.7
Radetti, G.8
Tato, L.9
-
28
-
-
59649103480
-
An inactivating mutation within the first extracellular loop of the thyrotropin receptor impedes normal posttranslational maturation of the extracellular domain
-
18927215
-
An inactivating mutation within the first extracellular loop of the thyrotropin receptor impedes normal posttranslational maturation of the extracellular domain. S Sura-Trueba,, et al. Endocrinology 2009 150 2 1043 50 18927215
-
(2009)
Endocrinology
, vol.150
, Issue.2
, pp. 1043-50
-
-
Sura-Trueba, S.1
-
29
-
-
34447134181
-
2+ cascade mediates TSH action on thyroid hormone synthesis
-
DOI 10.1210/jc.2007-0366
-
A familial thyrotropin (TSH) receptor mutation provides in vivo evidence that the inositol phosphates/Ca2+ cascade mediates TSH action on thyroid hormone synthesis. H Grasberger,, et al. J Clin Endocrinol Metab 2007 92 7 2816 20 10.1210/jc.2007-0366 17456567 (Pubitemid 47037394)
-
(2007)
Journal of Clinical Endocrinology and Metabolism
, vol.92
, Issue.7
, pp. 2816-2820
-
-
Grasberger, H.1
Van Sande, J.2
Mahameed, A.H.-D.3
Tenenbaum-Rakover, Y.4
Refetoff, S.5
-
30
-
-
48749099119
-
Evidence for cooperative signal triggering at the extracellular loops of the TSH receptor
-
10.1096/fj.07-104711. 18381815
-
Evidence for cooperative signal triggering at the extracellular loops of the TSH receptor. G Kleinau,, et al. FASEB J 2008 22 8 2798 808 10.1096/fj.07-104711 18381815
-
(2008)
FASEB J
, vol.22
, Issue.8
, pp. 2798-808
-
-
Kleinau, G.1
-
31
-
-
79551650974
-
GPCR structure and activation: An essential role for the first extracellular loop in activating the adenosine A2B receptor
-
10.1096/fj.10-164319. 21030693
-
GPCR structure and activation: an essential role for the first extracellular loop in activating the adenosine A2B receptor. MC Peeters,, et al. FASEB J 2011 25 632 643 10.1096/fj.10-164319 21030693
-
(2011)
FASEB J
, vol.25
, pp. 632-643
-
-
Peeters, M.C.1
-
32
-
-
78650919353
-
Importance of the extracellular loops in G protein-coupled receptors for ligand recognition and receptor activation
-
10.1016/j.tips.2010.10.001. 21075459
-
Importance of the extracellular loops in G protein-coupled receptors for ligand recognition and receptor activation. MC Peeters,, et al. Trends Pharmacol Sci 2011 32 35 42 10.1016/j.tips.2010.10.001 21075459
-
(2011)
Trends Pharmacol Sci
, vol.32
, pp. 35-42
-
-
Peeters, M.C.1
-
33
-
-
77955375893
-
A New Phenotype of Nongoitrous and Nonautoimmune Hyperthyroidism Caused by a Heterozygous Thyrotropin Receptor Mutation in Transmembrane Helix 6
-
10.1210/jc.2010-0112. 20501679
-
A New Phenotype of Nongoitrous and Nonautoimmune Hyperthyroidism Caused by a Heterozygous Thyrotropin Receptor Mutation in Transmembrane Helix 6. F Winkler,, et al. J Clin Endocrinol Metab 2010 95 3605 3610 10.1210/jc.2010-0112 20501679
-
(2010)
J Clin Endocrinol Metab
, vol.95
, pp. 3605-3610
-
-
Winkler, F.1
-
34
-
-
0028240982
-
Germline mutations in the thyrotropin receptor gene cause non-autoimmune autosomal dominant hyperthyroidism
-
DOI 10.1038/ng0794-396
-
Germline mutations in the thyrotropin receptor gene cause non-autoimmune autosomal dominant hyperthyroidism. L Duprez,, et al. Nat Genet 1994 7 3 396 401 10.1038/ng0794-396 7920658 (Pubitemid 24204416)
-
(1994)
Nature Genetics
, vol.7
, Issue.3
, pp. 396-401
-
-
Duprez, L.1
Parma, J.2
Van Sande, J.3
Allgeier, A.4
Leclere, J.5
Schvartz, C.6
Delisle, M.-J.7
Decoulx, M.8
Orgiazzi, J.9
Dumont, J.10
Vassart, G.11
-
35
-
-
77950961448
-
Signal transduction in the human thyrocyte and its perversion in thyroid tumors
-
10.1016/j.mce.2009.11.015. 19962425
-
Signal transduction in the human thyrocyte and its perversion in thyroid tumors. PP Roger,, et al. Mol Cell Endocrinol 2010 321 1 3 19 10.1016/j.mce.2009.11.015 19962425
-
(2010)
Mol Cell Endocrinol
, vol.321
, Issue.1
, pp. 3-19
-
-
Roger, P.P.1
-
36
-
-
78649234225
-
Lack of in vitro constitutive activity for four previously reported TSH receptor mutations identified in patients with nonautoimmune hyperthyroidism and hot thyroid carcinomas
-
10.1111/j.1365-2265.2010.03872.x
-
Lack of in vitro constitutive activity for four previously reported TSH receptor mutations identified in patients with nonautoimmune hyperthyroidism and hot thyroid carcinomas. H Jaeschke S Mueller M Eszlinger R Paschke, Clin Endocrinol (Oxf) 2010 73 815 820 10.1111/j.1365-2265.2010.03872.x
-
(2010)
Clin Endocrinol (Oxf)
, vol.73
, pp. 815-820
-
-
Jaeschke, H.1
Mueller, S.2
Eszlinger, M.3
Paschke, R.4
|