Molecular evidence of anti-leukemia activity of gypenosides on human myeloid leukemia HL-60 cells in vitro and in vivo using a HL-60 cells murine xenograft model

Phytomedicine

Volumn 18, Issue 12, 2011, Pages 1075-1085

  Lin, Jen Jyh ^a,b   Hsu, Hui Ying ^a   Yang, Jai Sing ^a   Lu, Kung Wen ^a   Wu, Rick Sai Chuen ^b   Wu, King Chuen ^c   Lai, Tung Yuan ^a,b   Chen, Po Yuan ^a   Ma, Chia Yu ^d   Wood, W Gibson ^e   Chung, Jing Gung ^a,f  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c I SHOU UNIVERSITY   (Taiwan)

^d TECHNOLOGY AND SCIENCE INSTITUTE OF NORTHERN TAIWAN   (Taiwan)

^e UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^f ASIA UNIVERSITY   (Taiwan)

Author keywords

Anti leukemia; Apoptosis; Gynostemma pentaphyllum; Gypenosides; HL 60 cells; In vitro; In vivo

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTOR 6; ANTILEUKEMIC AGENT; CASPASE 3; CASPASE 8; GYPENOSIDE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA FRAGMENTATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LASER MICROSCOPY; LEUKEMIA CELL; MOUSE; MYELOID LEUKEMIA; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; TUMOR VOLUME; XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CALCIUM; CASPASES; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL SURVIVAL; DNA DAMAGE; DNA FRAGMENTATION; GYNOSTEMMA; HUMANS; LEUKEMIA, EXPERIMENTAL; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; PHYTOTHERAPY; PLANT EXTRACTS; REACTIVE OXYGEN SPECIES; TRANSCRIPTION FACTOR CHOP; TRANSCRIPTION FACTORS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

GYNOSTEMMA PENTAPHYLLUM; MURINAE; MUS;

EID: 80052454266     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2011.03.009     Document Type: Article

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