Investigation of anti-leukemia molecular mechanism of ITR-284, a carboxamide analog, in leukemia cells and its effects in WEHI-3 leukemia mice

Biochemical Pharmacology

Volumn 79, Issue 3, 2010, Pages 389-398

  Wen, Yen Fang ^a   Yang, Jai Sing ^b   Kuo, Sheng Chu ^b   Hwang, Chrong Shiong ^a   Chung, Jing Gung ^b   Wu, Hsi Chin ^c   Huang, Wen Wen ^b   Jhan, Jia Hua ^b   Lin, Chung Ming ^d   Chen, Hui Jye ^b  

^a INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d MING CHUAN UNIVERSITY   (Taiwan)

Author keywords

Anti leukemia activity; Apoptosis; Caspase; ITR 284; Orthotopic mice model of leukemia

Indexed keywords

AMIDE; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; FAS ANTIGEN; ITR 284; N (2 DIMETHYLAMINOETHYL) 4,8 DIHYDROBENZO[1,2 B,4,5 B']DITHIOPHENE 2 CARBOXAMIDE PHOSPHORIC ACID; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; RETINOIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER SURVIVAL; CELL STRAIN HL 60; CELL VIABILITY; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG POTENTIATION; ENZYME ACTIVITY; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA; LEUKEMIA CELL LINE; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MONOTHERAPY; MOUSE; MYELOBLAST; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SPLENOMEGALY; SURVIVAL RATE; WEIGHT REDUCTION;

AMIDES; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; GROWTH INHIBITORS; HL-60 CELLS; HUMANS; LEUKEMIA, EXPERIMENTAL; MICE; MICE, INBRED BALB C; THIOPHENES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 70449627030     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2009.09.011     Document Type: Article

References (42)

1. Krueger H., McLean D., Williams D., and Leukemias. Progress in Experimental Tumor Research Fortschritte der Experimentellen Tumorforschung 40 (2008) 45-50
2. Batsi C., Markopoulou S., Kontargiris E., Charalambous C., Thomas C., Christoforidis S., et al. Bcl-2 blocks 2-methoxyestradiol induced leukemia cell apoptosis by a p27(Kip1)-dependent G1/S cell cycle arrest in conjunction with NF-kappaB activation. Biochemical Pharmacology 78 (2009) 33-44
3. Nau K.C., and Lewis W.D. Multiple myeloma: diagnosis and treatment. American Family Physician 78 (2008) 853-859
4. Fotoohi A.K., Assaraf Y.G., Moshfegh A., Hashemi J., Jansen G., Peters G.J., et al. Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that preserve intracellular levels of folate and nucleotide biosynthesis. Biochemical Pharmacology 77 (2009) 1410-1417
5. Kim S.H., Yoo J.C., and Kim T.S. Nargenicin enhances 1,25-dihydroxyvitamin D(3)- and all-trans retinoic acid-induced leukemia cell differentiation via PKCbetaI/MAPK pathways. Biochemical Pharmacology 77 (2009) 1694-1701
6. Tallman M.S. Differentiating therapy in acute myeloid leukemia. Leukemia 10 Suppl. 2 (1996) s33-s38
7. Schimmer A.D. Novel therapies targeting the apoptosis pathway for the treatment of acute myeloid leukemia. Current Treatment Options in Oncology 8 (2007) 277-286
8. Lee M.O., Han S.Y., Jiang S., Park J.H., and Kim S.J. Differential effects of retinoic acid on growth and apoptosis in human colon cancer cell lines associated with the induction of retinoic acid receptor beta. Biochemical Pharmacology 59 (2000) 485-496
9. Floryk D., and Thompson T.C. Perifosine induces differentiation and cell death in prostate cancer cells. Cancer Letters 266 (2008) 216-226
10. Kang M.R., Kang J.S., Han S.B., Kim J.H., Kim D.M., Lee K., et al. A novel delta-lactam-based histone deacetylase inhibitor, KBH-A42, induces cell cycle arrest and apoptosis in colon cancer cells. Biochemical Pharmacology 78 (2009) 486-494
11. Khan N., and Mukhtar H. Multitargeted therapy of cancer by green tea polyphenols. Cancer Letters 269 (2008) 269-280
12. Ma E., Wang X., Li Y., Sun X., Tai W., Li T., et al. Induction of apoptosis by furanodiene in HL60 leukemia cells through activation of TNFR1 signaling pathway. Cancer Letters 271 (2008) 158-166
13. Trincavelli M.L., Falleni A., Chelli B., Tuscano D., Costa B., Gremigni V., et al. A(2A) adenosine receptor ligands and proinflammatory cytokines induce PC 12 cell death through apoptosis. Biochemical Pharmacology 66 (2003) 1953-1962
14. Rustin P., and Kroemer G. Mitochondria and cancer. Ernst Schering Foundation Symposium Proceedings (2007) 1-21
15. Saitoh M., Nagai K., Nakagawa K., Yamamura T., Yamamoto S., and Nishizaki T. Adenosine induces apoptosis in the human gastric cancer cells via an intrinsic pathway relevant to activation of AMP-activated protein kinase. Biochemical Pharmacology 67 (2004) 2005-2011
16. Ashkenazi A. Targeting the extrinsic apoptosis pathway in cancer. Cytokine & Growth Factor Reviews 19 (2008) 325-331
17. Ow Y.P., Green D.R., Hao Z., and Mak T.W. Cytochrome c: functions beyond respiration. Nature Reviews Molecular Cell Biology 9 (2008) 532-542
18. Marzo I., and Naval J. Bcl-2 family members as molecular targets in cancer therapy. Biochemical Pharmacology 76 (2008) 939-946
19. Wen Y.F., Lee K.H., Huang P.T., Chen M.H., Shin W.C., Huang L.J., et al. Cell differentiation enhancement by hydrophilic derivatives of 4,8-dihydrobenzo[1,2-b:5,4-b′]dithiophene-4,8-diones in HL-60 leukemia cells. Bioorganic & Medicinal Chemistry Letters 17 (2007) 2908-2912
20. Kemeny-Beke A., Aradi J., Damjanovich J., Beck Z., Facsko A., Berta A., et al. Apoptotic response of uveal melanoma cells upon treatment with chelidonine, sanguinarine and chelerythrine. Cancer Letters 237 (2006) 67-75
21. Kuo T.C., Yang J.S., Lin M.W., Hsu S.C., Lin J.J., Lin H.J., et al. Emodin has cytotoxic and protective effects in rat C6 glioma cells: roles of Mdr1a and nuclear factor kappaB in cell survival. The Journal of Pharmacology and Experimental Therapeutics 330 (2009) 736-744
22. Park W.H., Han Y.W., Kim S.W., Kim S.H., Cho K.W., and Kim S.Z. Antimycin A induces apoptosis in As4.1 juxtaglomerular cells. Cancer Letters 251 (2007) 68-77
23. Liu B., Wang T., Qian X., Liu G., Yu L., and Ding Y. Anticancer effect of tetrandrine on primary cancer cells isolated from ascites and pleural fluids. Cancer Letters 268 (2008) 166-175
24. Lin S.S., Huang H.P., Yang J.S., Wu J.Y., Hsia T.C., Lin C.C., et al. DNA damage and endoplasmic reticulum stress mediated curcumin-induced cell cycle arrest and apoptosis in human lung carcinoma A-549 cells through the activation caspases cascade- and mitochondrial-dependent pathway. Cancer Letters 272 (2008) 77-90
25. Chung J.G., Yang J.S., Huang L.J., Lee F.Y., Teng C.M., Tsai S.C., et al. Proteomic approach to studying the cytotoxicity of YC-1 on U937 leukemia cells and antileukemia activity in orthotopic model of leukemia mice. Proteomics 7 (2007) 3305-3317
26. Lin J.P., Yang J.S., Lu C.C., Chiang J.H., Wu C.L., Lin J.J., et al. Rutin inhibits the proliferation of murine leukemia WEHI-3 cells in vivo and promotes immune response in vivo. Leukemia Research 33 (2009) 823-828
27. Dawson M.I., Elstner E., Kizaki M., Chen D.L., Pakkala S., Kerner B., et al. Myeloid differentiation mediated through retinoic acid receptor/retinoic X receptor (RXR) not RXR/RXR pathway. Blood 84 (1994) 446-452
28. Lukka P.B., Kestell P., Paxton J.W., and Baguley B.C. Development and validation of a liquid chromatography-mass spectrometry (LC-MS) assay for the determination of the anti-cancer agent N-[2-(dimethylamino)ethyl]-2,6-dimethyl-1-oxo-1,2-dihydrobenzo[b]-1,6-naph thyridine-4-carboxamide (SN 28049). Journal of Chromatography B 875 (2008) 368-372
29. Feng W., Satyanarayana M., Tsai Y.C., Liu A.A., Liu L.F., and LaVoie E.J. 11-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridine derivatives as novel topoisomerase I-targeting agents. Bioorganic & Medicinal Chemistry 16 (2008) 8598-8606
30. Creighton-Gutteridge M., Cardellina II J.H., Stephen A.G., Rapisarda A., Uranchimeg B., Hite K., et al. Cell type-specific, topoisomerase II-dependent inhibition of hypoxia-inducible factor-1alpha protein accumulation by NSC 644221. Clinical Cancer Research 13 (2007) 1010-1018
31. Dhanasekaran D.N., and Reddy E.P. JNK signaling in apoptosis. Oncogene 27 (2008) 6245-6251
32. Wojtczak L., and Zablocki K. Mitochondria in cell life, death and disease. Postepy Biochemii 54 (2008) 129-141
33. Higuchi Y. Chromosomal DNA fragmentation in apoptosis and necrosis induced by oxidative stress. Biochemical Pharmacology 66 (2003) 1527-1535
34. Srivastava R.K. TRAIL/Apo-2L: mechanisms and clinical applications in cancer. Neoplasia (New York, NY) 3 (2001) 535-546
35. Barnhart B.C., Alappat E.C., and Peter M.E. The CD95 type I/type II model. Seminars in Immunology 15 (2003) 185-193
36. Clarke P., and Tyler K.L. Reovirus-induced apoptosis: a minireview. Apoptosis 8 (2003) 141-150
37. Evens A.M., Tallman M.S., and Gartenhaus R.B. The potential of arsenic trioxide in the treatment of malignant disease: past, present, and future. Leukemia Research 28 (2004) 891-900
38. He L.Z., Merghoub T., and Pandolfi P.P. In vivo analysis of the molecular pathogenesis of acute promyelocytic leukemia in the mouse and its therapeutic implications. Oncogene 18 (1999) 5278-5292
39. Wang Z.Y., and Chen Z. Acute promyelocytic leukemia: from highly fatal to highly curable. Blood 111 (2008) 2505-2515
40. Patatanian E., and Thompson D.F. Retinoic acid syndrome: a review. Journal of Clinical Pharmacy and Therapeutics 33 (2008) 331-338
41. Liu B., Pan S., Dong X., Qiao H., Jiang H., Krissansen G.W., et al. Opposing effects of arsenic trioxide on hepatocellular carcinomas in mice. Cancer Science 97 (2006) 675-681
42. Soucy N.V., Ihnat M.A., Kamat C.D., Hess L., Post M.J., Klei L.R., et al. Arsenic stimulates angiogenesis and tumorigenesis in vivo. Toxicological Sciences 76 (2003) 271-279