Structure-based site of metabolism prediction for cytochrome P450 2D6

Journal of Medicinal Chemistry

Volumn 54, Issue 17, 2011, Pages 6098-6105

  Moors, Samuel L C ^a   Vos, Ann M ^b   Cummings, Maxwell D ^c   Van Vlijmen, Herman ^b   Ceulemans, Arnout ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b TIBOTEC BVBA   (Belgium)

^c JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2D6; HEME; IRON;

AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME METABOLISM; MOLECULAR DOCKING; PROTEIN STRUCTURE; VALIDATION PROCESS;

BINDING SITES; CATALYTIC DOMAIN; CYTOCHROME P-450 CYP2D6; HEME; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

EID: 80052380142     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2006468     Document Type: Article

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