메뉴 건너뛰기




Volumn 51, Issue 7, 2011, Pages 1411-1427

Modeling of biopterin-dependent pathways of eNOS for nitric oxide and superoxide production

Author keywords

Biopterin ratio; eNOS uncoupling; Free radicals; Kinetic analysis; Mathematical model; NOS biochemical pathway

Indexed keywords

BIOPTERIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUTATHIONE; NITRIC OXIDE; PEROXYNITRITE; SUPEROXIDE; TETRAHYDROBIOPTERIN;

EID: 80052268768     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.06.009     Document Type: Article
Times cited : (35)

References (85)
  • 1
    • 0035425503 scopus 로고    scopus 로고
    • Nitric oxide synthases: Structure, function and inhibition
    • DOI 10.1042/0264-6021:3570593
    • W.K. Alderton, C.E. Cooper, and R.G. Knowles Nitric oxide synthases: structure, function and inhibition Biochem. J. 357 2001 593 615 (Pubitemid 32735142)
    • (2001) Biochemical Journal , vol.357 , Issue.3 , pp. 593-615
    • Alderton, W.K.1    Cooper, C.E.2    Knowles, R.G.3
  • 2
    • 0028349156 scopus 로고
    • Nitric oxide synthases in mammals
    • R.G. Knowles, and S. Moncada Nitric oxide synthases in mammals Biochem. J. 298 1994 249 258 (Pubitemid 24072462)
    • (1994) Biochemical Journal , vol.298 , Issue.2 , pp. 249-258
    • Knowles, R.G.1    Moncada, S.2
  • 3
    • 33645780634 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase in vascular disease: From marvel to menace
    • U. Forstermann, and T. Munzel Endothelial nitric oxide synthase in vascular disease: from marvel to menace Circulation 113 2006 1708 1714
    • (2006) Circulation , vol.113 , pp. 1708-1714
    • Forstermann, U.1    Munzel, T.2
  • 4
    • 0037086565 scopus 로고    scopus 로고
    • The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: An EPR spin trapping study
    • DOI 10.1042/0264-6021:3620733
    • J. Vasquez-Vivar, P. Martasek, J. Whitsett, J. Joseph, and B. Kalyanaraman The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study Biochem. J. 362 2002 733 739 (Pubitemid 34242326)
    • (2002) Biochemical Journal , vol.362 , Issue.3 , pp. 733-739
    • Vasquez-Vivar, J.1    Martasek, P.2    Whitsett, J.3    Joseph, J.4    Kalyanaraman, B.5
  • 5
    • 0025883342 scopus 로고
    • Nitric oxide: Physiology, pathophysiology, and pharmacology
    • S. Moncada, R.M. Palmer, and E.A. Higgs Nitric oxide: physiology, pathophysiology, and pharmacology Pharmacol. Rev. 43 1991 109 142
    • (1991) Pharmacol. Rev. , vol.43 , pp. 109-142
    • Moncada, S.1    Palmer, R.M.2    Higgs, E.A.3
  • 8
    • 0037073486 scopus 로고    scopus 로고
    • Nonendothelial source of nitric oxide in arterioles but not in venules: Alternative source revealed in vivo by diaminofluorescein microfluorography
    • S. Kashiwagi, M. Kajimura, Y. Yoshimura, and M. Suematsu Nonendothelial source of nitric oxide in arterioles but not in venules: alternative source revealed in vivo by diaminofluorescein microfluorography Circ. Res. 91 2002 e55 e64
    • (2002) Circ. Res. , vol.91
    • Kashiwagi, S.1    Kajimura, M.2    Yoshimura, Y.3    Suematsu, M.4
  • 9
    • 0033573058 scopus 로고    scopus 로고
    • + through the walls of single perfused mesenteric venules in anaesthetised rats
    • + through the walls of single perfused mesenteric venules in anaesthetised rats J. Physiol. 521 1999 665 677 (Pubitemid 30042780)
    • (1999) Journal of Physiology , vol.521 , Issue.3 , pp. 665-677
    • Kajimura, M.1    Michel, C.C.2
  • 10
    • 76149138872 scopus 로고    scopus 로고
    • Technique for real-time measurements of endothelial permeability in a microfluidic membrane chip using laser-induced fluorescence detection
    • E.W. Young, M.W. Watson, S. Srigunapalan, A.R. Wheeler, and C.A. Simmons Technique for real-time measurements of endothelial permeability in a microfluidic membrane chip using laser-induced fluorescence detection Anal. Chem. 82 2010 808 816
    • (2010) Anal. Chem. , vol.82 , pp. 808-816
    • Young, E.W.1    Watson, M.W.2    Srigunapalan, S.3    Wheeler, A.R.4    Simmons, C.A.5
  • 11
    • 33644839612 scopus 로고    scopus 로고
    • Signaling mechanisms regulating endothelial permeability
    • D. Mehta, and A.B. Malik Signaling mechanisms regulating endothelial permeability Physiol. Rev. 86 2006 279 367
    • (2006) Physiol. Rev. , vol.86 , pp. 279-367
    • Mehta, D.1    Malik, A.B.2
  • 12
    • 13444262357 scopus 로고    scopus 로고
    • Tetrahydrobiopterin: Regulator of endothelial nitric oxide synthase in vascular disease
    • DOI 10.1016/j.tcm.2004.10.003, PII S1050173804001549
    • K.M. Channon Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease Trends Cardiovasc. Med. 14 2004 323 327 (Pubitemid 41110612)
    • (2004) Trends in Cardiovascular Medicine , vol.14 , Issue.8 , pp. 323-327
    • Channon, K.M.1
  • 13
    • 0032571411 scopus 로고    scopus 로고
    • Structure of nitric oxide synthase oxygenase dimer with pterin and substrate
    • DOI 10.1126/science.279.5359.2121
    • B.R. Crane, A.S. Arvai, D.K. Ghosh, C. Wu, E.D. Getzoff, D.J. Stuehr, and J.A. Tainer Structure of nitric oxide synthase oxygenase dimer with pterin and substrate Science 279 1998 2121 2126 (Pubitemid 28196359)
    • (1998) Science , vol.279 , Issue.5359 , pp. 2121-2126
    • Crane, B.R.1    Arvai, A.S.2    Ghosh, D.K.3    Wu, C.4    Getzoff, E.D.5    Stuehr, D.J.6    Tainer, J.A.7
  • 14
    • 0027975453 scopus 로고
    • Nitric oxide: A physiologic messenger molecule
    • D.S. Bredt, and S.H. Snyder Nitric oxide: a physiologic messenger molecule Annu. Rev. Biochem. 63 1994 175 195
    • (1994) Annu. Rev. Biochem. , vol.63 , pp. 175-195
    • Bredt, D.S.1    Snyder, S.H.2
  • 15
    • 0037898947 scopus 로고    scopus 로고
    • Tetrahydrobiopterin radical enzymology
    • C.C. Wei, B.R. Crane, and D.J. Stuehr Tetrahydrobiopterin radical enzymology Chem. Rev. 103 2003 2365 2383
    • (2003) Chem. Rev. , vol.103 , pp. 2365-2383
    • Wei, C.C.1    Crane, B.R.2    Stuehr, D.J.3
  • 16
    • 0037465508 scopus 로고    scopus 로고
    • Structure of tetrahydrobiopterin tunes its electron transfer to the heme-dioxy intermediate in nitric oxide synthase
    • DOI 10.1021/bi026898h
    • C.C. Wei, Z.Q. Wang, A.S. Arvai, C. Hemann, R. Hille, E.D. Getzoff, and D.J. Stuehr Structure of tetrahydrobiopterin tunes its electron transfer to the heme-dioxy intermediate in nitric oxide synthase Biochemistry 42 2003 1969 1977 (Pubitemid 36258669)
    • (2003) Biochemistry , vol.42 , Issue.7 , pp. 1969-1977
    • Wei, C.-C.1    Wang, Z.-Q.2    Arvai, A.S.3    Hemann, C.4    Hille, R.5    Getzoff, E.D.6    Stuehr, D.J.7
  • 17
    • 0242416195 scopus 로고    scopus 로고
    • Ability of Tetrahydrobiopterin Analogues to Support Catalysis by Inducible Nitric Oxide Synthase: Formation of a Pterin Radical is Required for Enzyme Activity
    • DOI 10.1021/bi035491p
    • A.R. Hurshman, C. Krebs, D.E. Edmondson, and M.A. Marletta Ability of tetrahydrobiopterin analogues to support catalysis by inducible nitric oxide synthase: formation of a pterin radical is required for enzyme activity Biochemistry 42 2003 13287 13303 (Pubitemid 37420682)
    • (2003) Biochemistry , vol.42 , Issue.45 , pp. 13287-13303
    • Hurshman, A.R.1    Krebs, C.2    Edmondson, D.E.3    Marletta, M.A.4
  • 18
    • 1542283780 scopus 로고    scopus 로고
    • Regulation of Endothelial Nitric Oxide Synthase by Tetrahydrobiopterin in Vascular Disease
    • DOI 10.1161/01.ATV.0000110785.96039.f6
    • N.J. Alp, and K.M. Channon Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease Arterioscler. Thromb. Vasc. Biol. 24 2004 413 420 (Pubitemid 38326132)
    • (2004) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.24 , Issue.3 , pp. 413-420
    • Alp, N.J.1    Channon, K.M.2
  • 19
    • 59449086328 scopus 로고    scopus 로고
    • Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: Insights from cells with tet-regulated GTP cyclohydrolase i expression
    • M.J. Crabtree, A.L. Tatham, Y. Al-Wakeel, N. Warrick, A.B. Hale, S. Cai, K.M. Channon, and N.J. Alp Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression J. Biol. Chem. 284 2009 1136 1144
    • (2009) J. Biol. Chem. , vol.284 , pp. 1136-1144
    • Crabtree, M.J.1    Tatham, A.L.2    Al-Wakeel, Y.3    Warrick, N.4    Hale, A.B.5    Cai, S.6    Channon, K.M.7    Alp, N.J.8
  • 20
    • 70249093891 scopus 로고    scopus 로고
    • Tetrahydrobiopterin, superoxide, and vascular dysfunction
    • J. Vasquez-Vivar Tetrahydrobiopterin, superoxide, and vascular dysfunction Free Radic. Biol. Med. 47 2009 1108 1119
    • (2009) Free Radic. Biol. Med. , vol.47 , pp. 1108-1119
    • Vasquez-Vivar, J.1
  • 21
    • 0035808315 scopus 로고    scopus 로고
    • Rapid kinetic studies link tetrahydrobiopterin radical formation to heme-dioxy reduction and arginine hydroxylation in inducible nitric-oxide synthase
    • DOI 10.1074/jbc.M008441200
    • C.C. Wei, Z.Q. Wang, Q. Wang, A.L. Meade, C. Hemann, R. Hille, and D.J. Stuehr Rapid kinetic studies link tetrahydrobiopterin radical formation to heme-dioxy reduction and arginine hydroxylation in inducible nitric-oxide synthase J. Biol. Chem. 276 2001 315 319 (Pubitemid 32050321)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.1 , pp. 315-319
    • Wei, C.-C.1    Wang, Z.-Q.2    Wang, Q.3    Meade, A.L.4    Hemann, C.5    Hille, R.6    Stuehr, D.J.7
  • 22
    • 0037305699 scopus 로고    scopus 로고
    • The role of tetrahydrobiopterin in superoxide generation from eNOS: Enzymology and physiological implications
    • DOI 10.1080/1071576021000040655
    • J. Vasquez-Vivar, B. Kalyanaraman, and P. Martasek The role of tetrahydrobiopterin in superoxide generation from eNOS: enzymology and physiological implications Free. Radic. Res. 37 2003 121 127 (Pubitemid 36124338)
    • (2003) Free Radical Research , vol.37 , Issue.2 , pp. 121-127
    • Vsquez-Vivar, J.1    Kalyanaraman, B.2    Martasek, P.3
  • 23
    • 41849144894 scopus 로고    scopus 로고
    • Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS
    • DOI 10.1152/ajpheart.00823.2007
    • M.J. Crabtree, C.L. Smith, G. Lam, M.S. Goligorsky, and S.S. Gross Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS Am. J. Physiol. Heart Circ. Physiol. 294 2008 H1530 H1540 (Pubitemid 351492501)
    • (2008) American Journal of Physiology - Heart and Circulatory Physiology , vol.294 , Issue.4
    • Crabtree, M.J.1    Smith, C.L.2    Lam, G.3    Goligorsky, M.S.4    Gross, S.S.5
  • 24
    • 1542344000 scopus 로고    scopus 로고
    • Increased Endothelial Tetrahydrobiopterin Synthesis by Targeted Transgenic GTP-Cyclohydrolase I Overexpression Reduces Endothelial Dysfunction and Atheroscleroses in ApoE-Knockout Mice
    • DOI 10.1161/01.ATV.0000115637.48689.77
    • N.J. Alp, M.A. McAteer, J. Khoo, R.P. Choudhury, and K.M. Channon Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice Arterioscler. Thromb. Vasc. Biol. 24 2004 445 450 (Pubitemid 38326136)
    • (2004) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.24 , Issue.3 , pp. 445-450
    • Alp, N.J.1    McAteer, M.A.2    Khoo, J.3    Choudhury, R.P.4    Channon, K.M.5
  • 25
    • 85047690420 scopus 로고    scopus 로고
    • Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression
    • DOI 10.1172/JCI200317786
    • N.J. Alp, S. Mussa, J. Khoo, S. Cai, T. Guzik, A. Jefferson, N. Goh, K.A. Rockett, and K.M. Channon Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression J. Clin. Invest. 112 2003 725 735 (Pubitemid 38057713)
    • (2003) Journal of Clinical Investigation , vol.112 , Issue.5 , pp. 725-735
    • Alp, N.J.1    Mussa, S.2    Khoo, J.3    Cai, S.4    Guzik, T.5    Jefferson, A.6    Goh, N.7    Rockett, K.A.8    Channon, K.M.9
  • 26
    • 79959746256 scopus 로고    scopus 로고
    • Tetrahydrobiopterin deficiency and nitric oxide synthase uncoupling contribute to atherosclerosis induced by disturbed flow
    • L. Li, W. Chen, A. Rezvan, H. Jo, and D.G. Harrison Tetrahydrobiopterin deficiency and nitric oxide synthase uncoupling contribute to atherosclerosis induced by disturbed flow Arterioscler. Thromb. Vasc. Biol. 31 2011 1547 1554
    • (2011) Arterioscler. Thromb. Vasc. Biol. , vol.31 , pp. 1547-1554
    • Li, L.1    Chen, W.2    Rezvan, A.3    Jo, H.4    Harrison, D.G.5
  • 27
    • 0030035889 scopus 로고    scopus 로고
    • Effect of tetrahydrobiopterin on endothelial function in canine middle cerebral arteries
    • M. Tsutsui, S. Milstien, and Z.S. Katusic Effect of tetrahydrobiopterin on endothelial function in canine middle cerebral arteries Circ. Res. 79 1996 336 342 (Pubitemid 26255888)
    • (1996) Circulation Research , vol.79 , Issue.2 , pp. 336-342
    • Tsutsui, M.1    Milstien, S.2    Katusic, Z.S.3
  • 28
    • 34247220499 scopus 로고    scopus 로고
    • Oral administration of tetrahydrobiopterin slows the progression of atherosclerosis in apolipoprotein E-knockout mice
    • DOI 10.1161/01.ATV.0000258946.55438.0e
    • Y. Hattori, S. Hattori, X. Wang, H. Satoh, N. Nakanishi, and K. Kasai Oral administration of tetrahydrobiopterin slows the progression of atherosclerosis in apolipoprotein E-knockout mice Arterioscler. Thromb. Vasc. Biol. 27 2007 865 870 (Pubitemid 46606718)
    • (2007) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.27 , Issue.4 , pp. 865-870
    • Hattori, Y.1    Hattori, S.2    Wang, X.3    Satoh, H.4    Nakanishi, N.5    Kasai, K.6
  • 29
    • 28844466386 scopus 로고    scopus 로고
    • Cellular accumulation of tetrahydrobiopterin following its administration is mediated by two different processes; Direct uptake and indirect uptake mediated by a methotrexate-sensitive process
    • DOI 10.1016/j.ymgme.2005.06.020, PII S1096719205002453
    • K. Sawabe, Y. Suetake, N. Nakanishi, K.O. Wakasugi, and H. Hasegawa Cellular accumulation of tetrahydrobiopterin following its administration is mediated by two different processes; direct uptake and indirect uptake mediated by a methotrexate-sensitive process Mol. Genet. Metab. 86 Suppl. 1 2005 S133 S138 (Pubitemid 41771122)
    • (2005) Molecular Genetics and Metabolism , vol.86 , Issue.SUPPL.
    • Sawabe, K.1    Suetake, Y.2    Nakanishi, N.3    Wakasugi, K.O.4    Hasegawa, H.5
  • 30
  • 31
    • 0036100972 scopus 로고    scopus 로고
    • Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertensive individuals
    • DOI 10.1016/S0895-7061(01)02317-2, PII S0895706101023172
    • Y. Higashi, S. Sasaki, K. Nakagawa, Y. Fukuda, H. Matsuura, T. Oshima, and K. Chayama Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertensive individuals Am. J. Hypertens. 15 2002 326 332 (Pubitemid 34408972)
    • (2002) American Journal of Hypertension , vol.15 , Issue.4 , pp. 326-332
    • Higashi, Y.1    Sasaki, S.2    Nakagawa, K.3    Fukuda, Y.4    Matsuura, H.5    Oshima, T.6    Chayama, K.7
  • 32
    • 0036183645 scopus 로고    scopus 로고
    • Tetrahydrobiopterin improves impaired endothelium-dependent forearm vasodilation in patients with heart failure
    • DOI 10.1097/00005344-200203000-00007
    • S. Setoguchi, Y. Hirooka, K. Eshima, H. Shimokawa, and A. Takeshita Tetrahydrobiopterin improves impaired endothelium-dependent forearm vasodilation in patients with heart failure J. Cardiovasc. Pharmacol. 39 2002 363 368 (Pubitemid 34175061)
    • (2002) Journal of Cardiovascular Pharmacology , vol.39 , Issue.3 , pp. 363-368
    • Setoguchi, S.1    Hirooka, Y.2    Eshima, K.3    Shimokawa, H.4    Takeshita, A.5
  • 34
    • 0033752910 scopus 로고    scopus 로고
    • Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus
    • T. Heitzer, K. Krohn, S. Albers, and T. Meinertz Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus Diabetologia 43 2000 1435 1438
    • (2000) Diabetologia , vol.43 , pp. 1435-1438
    • Heitzer, T.1    Krohn, K.2    Albers, S.3    Meinertz, T.4
  • 36
    • 0036182797 scopus 로고    scopus 로고
    • Tetrahydrobiopterin restores endothelial function of coronary arteries in patients with hypercholesterolaemia
    • Y. Fukuda, H. Teragawa, K. Matsuda, T. Yamagata, H. Matsuura, and K. Chayama Tetrahydrobiopterin restores endothelial function of coronary arteries in patients with hypercholesterolaemia Heart 87 2002 264 269 (Pubitemid 34177685)
    • (2002) Heart , vol.87 , Issue.3 , pp. 264-269
    • Fukuda, Y.1    Teragawa, H.2    Matsuda, K.3    Yamagata, T.4    Matsuura, H.5    Chayama, K.6
  • 37
    • 33750688578 scopus 로고    scopus 로고
    • Exogenous tetrahydrobiopterin causes endothelium-dependent contractions in isolated canine basilar artery
    • H. Kinoshita, and Z.S. Katusic Exogenous tetrahydrobiopterin causes endothelium-dependent contractions in isolated canine basilar artery Am. J. Physiol. 271 1996 H738 H743
    • (1996) Am. J. Physiol. , vol.271
    • Kinoshita, H.1    Katusic, Z.S.2
  • 38
    • 0035814951 scopus 로고    scopus 로고
    • Endothelial regulation of vasomotion in ApoE-deficient mice: Implications for interactions between peroxynitrite and tetrahydrobiopterin
    • J.B. Laursen, M. Somers, S. Kurz, L. McCann, A. Warnholtz, B.A. Freeman, M. Tarpey, T. Fukai, and D.G. Harrison Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin Circulation 103 2001 1282 1288 (Pubitemid 32221353)
    • (2001) Circulation , vol.103 , Issue.9 , pp. 1282-1288
    • Laursen, J.B.1    Somers, M.2    Kurz, S.3    McCann, L.4    Warnholtz, A.5    Freeman, B.A.6    Tarpey, M.7    Fukai, T.8    Harrison, D.G.9
  • 39
    • 0034739459 scopus 로고    scopus 로고
    • Endothelial dysfunction of coronary resistance arteries is improved by tetrahydrobiopterin in atherosclerosis
    • C.P. Tiefenbacher, T. Bleeke, C. Vahl, K. Amann, A. Vogt, and W. Kubler Endothelial dysfunction of coronary resistance arteries is improved by tetrahydrobiopterin in atherosclerosis Circulation 102 2000 2172 2179
    • (2000) Circulation , vol.102 , pp. 2172-2179
    • Tiefenbacher, C.P.1    Bleeke, T.2    Vahl, C.3    Amann, K.4    Vogt, A.5    Kubler, W.6
  • 40
    • 0036790604 scopus 로고    scopus 로고
    • Altered tetrahydrobiopterin metabolism in atherosclerosis: Implications for use of oxidized tetrahydrobiopterin analogues and thiol antioxidants
    • J. Vasquez-Vivar, D. Duquaine, J. Whitsett, B. Kalyanaraman, and S. Rajagopalan Altered tetrahydrobiopterin metabolism in atherosclerosis: implications for use of oxidized tetrahydrobiopterin analogues and thiol antioxidants Arterioscler. Thromb. Vasc. Biol. 22 2002 1655 1661
    • (2002) Arterioscler. Thromb. Vasc. Biol. , vol.22 , pp. 1655-1661
    • Vasquez-Vivar, J.1    Duquaine, D.2    Whitsett, J.3    Kalyanaraman, B.4    Rajagopalan, S.5
  • 41
    • 33746313420 scopus 로고    scopus 로고
    • Theoretical analysis of biochemical pathways of nitric oxide release from vascular endothelial cells
    • DOI 10.1016/j.freeradbiomed.2006.05.009, PII S0891584906003200
    • K. Chen, and A.S. Popel Theoretical analysis of biochemical pathways of nitric oxide release from vascular endothelial cells Free Radic. Biol. Med. 41 2006 668 680 (Pubitemid 44102718)
    • (2006) Free Radical Biology and Medicine , vol.41 , Issue.4 , pp. 668-680
    • Chen, K.1    Popel, A.S.2
  • 42
    • 0035966114 scopus 로고    scopus 로고
    • Differences in three kinetic parameters underpin the unique catalytic profiles of nitric-oxide synthases I, II, and III
    • J. Santolini, A.L. Meade, and D.J. Stuehr Differences in three kinetic parameters underpin the unique catalytic profiles of nitric-oxide synthases I, II, and III J. Biol. Chem. 276 2001 48887 48898
    • (2001) J. Biol. Chem. , vol.276 , pp. 48887-48898
    • Santolini, J.1    Meade, A.L.2    Stuehr, D.J.3
  • 43
    • 5444247065 scopus 로고    scopus 로고
    • Redox function of tetrahydrobiopterin and effect of L-arginine on oxygen binding in endothelial nitric oxide synthase
    • DOI 10.1021/bi049026j
    • V. Berka, H.C. Yeh, D. Gao, F. Kiran, and A.L. Tsai Redox function of tetrahydrobiopterin and effect of l-arginine on oxygen binding in endothelial nitric oxide synthase Biochemistry 43 2004 13137 13148 (Pubitemid 39362782)
    • (2004) Biochemistry , vol.43 , Issue.41 , pp. 13137-13148
    • Berka, V.1    Yeh, H.-C.2    Gao, D.3    Kiran, F.4    Tsai, A.-L.5
  • 44
    • 0034622567 scopus 로고    scopus 로고
    • Characterization of interactions among the heme center, tetrahydrobiopterin, and L-arginine binding sites of ferric eNOS using imidazole, cyanide, and nitric oxide as probes
    • DOI 10.1021/bi992769y
    • V. Berka, and A.L. Tsai Characterization of interactions among the heme center, tetrahydrobiopterin, and l-arginine binding sites of ferric eNOS using imidazole, cyanide, and nitric oxide as probes Biochemistry 39 2000 9373 9383 (Pubitemid 30626329)
    • (2000) Biochemistry , vol.39 , Issue.31 , pp. 9373-9383
    • Berka, V.1    Tsai, A.-L.2
  • 45
    • 0029805172 scopus 로고    scopus 로고
    • Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and ugly
    • J.S. Beckman, and W.H. Koppenol Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly Am. J. Physiol. 271 1996 C1424 C1437
    • (1996) Am. J. Physiol. , vol.271
    • Beckman, J.S.1    Koppenol, W.H.2
  • 49
    • 0033527413 scopus 로고    scopus 로고
    • Oxidation of tetrahydrobiopterin by peroxynitrite: Implications for vascular endothelial function
    • DOI 10.1006/bbrc.1999.1422
    • S. Milstien, and Z. Katusic Oxidation of tetrahydrobiopterin by peroxynitrite: implications for vascular endothelial function Biochem. Biophys. Res. Commun. 263 1999 681 684 (Pubitemid 29490686)
    • (1999) Biochemical and Biophysical Research Communications , vol.263 , Issue.3 , pp. 681-684
    • Milstien, S.1    Katusic, Z.2
  • 50
    • 0032488596 scopus 로고    scopus 로고
    • Comparative functioning of dihydro- and tetrahydropterins in supporting electron transfer, catalysis, and subunit dimerization in inducible nitric oxide synthase
    • DOI 10.1021/bi971944c
    • A. Presta, U. Siddhanta, C. Wu, N. Sennequier, L. Huang, H.M. Abu-Soud, S. Erzurum, and D.J. Stuehr Comparative functioning of dihydro- and tetrahydropterins in supporting electron transfer, catalysis, and subunit dimerization in inducible nitric oxide synthase Biochemistry 37 1998 298 310 (Pubitemid 28049133)
    • (1998) Biochemistry , vol.37 , Issue.1 , pp. 298-310
    • Presta, A.1    Siddhanta, U.2    Wu, C.3    Sennequier, N.4    Huang, L.5    Abu-Soud, H.M.6    Erzurum, S.7    Stuehr, D.J.8
  • 51
    • 0032533159 scopus 로고    scopus 로고
    • Arginine metabolism: Nitric oxide and beyond
    • G. Wu, and S.M. Morris Jr. Arginine metabolism: nitric oxide and beyond Biochem. J. 336 1998 1 17 (Pubitemid 28532555)
    • (1998) Biochemical Journal , vol.336 , Issue.1 , pp. 1-17
    • Wu, G.1    Morris Jr., S.M.2
  • 52
    • 0024368187 scopus 로고
    • Theory of oxygen transport to tissue
    • A.S. Popel Theory of oxygen transport to tissue Crit. Rev. Biomed. Eng. 17 1989 257 321
    • (1989) Crit. Rev. Biomed. Eng. , vol.17 , pp. 257-321
    • Popel, A.S.1
  • 53
    • 0030249458 scopus 로고    scopus 로고
    • Peroxynitrite reaction with carbon dioxide/bicarbonate: Kinetics and influence on peroxynitrite-mediated oxidations
    • DOI 10.1006/abbi.1996.0363
    • A. Denicola, B.A. Freeman, M. Trujillo, and R. Radi Peroxynitrite reaction with carbon dioxide/bicarbonate: kinetics and influence on peroxynitrite-mediated oxidations Arch. Biochem. Biophys. 333 1996 49 58 (Pubitemid 26276973)
    • (1996) Archives of Biochemistry and Biophysics , vol.333 , Issue.1 , pp. 49-58
    • Denicola, A.1    Freeman, B.A.2    Trujillo, M.3    Radi, R.4
  • 54
    • 0034235409 scopus 로고    scopus 로고
    • Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiency
    • DOI 10.1042/0264-6021:3490353
    • C.J. Meininger, R.S. Marinos, K. Hatakeyama, R. Martinez-Zaguilan, J.D. Rojas, K.A. Kelly, and G. Wu Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiency Biochem. J. 349 2000 353 356 (Pubitemid 30440201)
    • (2000) Biochemical Journal , vol.349 , Issue.1 , pp. 353-356
    • Meininger, C.J.1    Marinos, R.S.2    Hatakeyama, K.3    Martinez-Zaguilan, R.4    Rojas, J.D.5    Kelly, K.A.6    Wu, G.7
  • 55
    • 0029847608 scopus 로고    scopus 로고
    • Palmitoylation of endothelial nitric oxide synthase is necessary for optimal stimulated release of nitric oxide: Implications for caveolae localization
    • DOI 10.1021/bi961720e
    • J. Liu, G. Garcia-Cardena, and W.C. Sessa Palmitoylation of endothelial nitric oxide synthase is necessary for optimal stimulated release of nitric oxide: implications for caveolae localization Biochemistry 35 1996 13277 13281 (Pubitemid 26349419)
    • (1996) Biochemistry , vol.35 , Issue.41 , pp. 13277-13281
    • Liu, J.1    Garcia-Cardena, G.2    Sessa, W.C.3
  • 56
    • 0036138931 scopus 로고    scopus 로고
    • Calmodulin is a limiting factor in the cell
    • DOI 10.1016/S1050-1738(01)00144-X, PII S105017380100144X
    • A. Persechini, and P.M. Stemmer Calmodulin is a limiting factor in the cell Trends Cardiovasc. Med. 12 2002 32 37 (Pubitemid 34048708)
    • (2002) Trends in Cardiovascular Medicine , vol.12 , Issue.1 , pp. 32-37
    • Persechini, A.1    Stemmer, P.M.2
  • 57
    • 0023813127 scopus 로고
    • Measurement of intracellular calcium concentration in intact monolayers of human endothelial cells
    • N.W. Wickham, G.M. Vercellotti, C.F. Moldow, M.R. Visser, and H.S. Jacob Measurement of intracellular calcium concentration in intact monolayers of human endothelial cells J. Lab. Clin. Med. 112 1988 157 167
    • (1988) J. Lab. Clin. Med. , vol.112 , pp. 157-167
    • Wickham, N.W.1    Vercellotti, G.M.2    Moldow, C.F.3    Visser, M.R.4    Jacob, H.S.5
  • 58
    • 0038604446 scopus 로고    scopus 로고
    • Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: Implications for uncoupling endothelial nitric-oxide synthase
    • DOI 10.1074/jbc.M302227200
    • N. Kuzkaya, N. Weissmann, D.G. Harrison, and S. Dikalov Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase J. Biol. Chem. 278 2003 22546 22554 (Pubitemid 36830310)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.25 , pp. 22546-22554
    • Kuzkaya, N.1    Weissmann, N.2    Harrison, D.G.3    Dikalov, S.4
  • 59
    • 33746927625 scopus 로고    scopus 로고
    • Kinetic modeling of nitric-oxide-associated reaction network
    • DOI 10.1007/s11095-006-9031-4
    • T.M. Hu, W.L. Hayton, and S.R. Mallery Kinetic modeling of nitric-oxide-associated reaction network Pharm. Res. 23 2006 1702 1711 (Pubitemid 44200532)
    • (2006) Pharmaceutical Research , vol.23 , Issue.8 , pp. 1702-1711
    • Hu, T.-M.1    Hayton, W.L.2    Mallery, S.R.3
  • 60
    • 33749005136 scopus 로고    scopus 로고
    • Nitroxidative, nitrosative, and nitrative stress: Kinetic predictions of reactive nitrogen species chemistry under biological conditions
    • DOI 10.1021/tx060061w
    • J.R. Lancaster Jr. Nitroxidative, nitrosative, and nitrative stress: kinetic predictions of reactive nitrogen species chemistry under biological conditions Chem. Res. Toxicol. 19 2006 1160 1174 (Pubitemid 44454032)
    • (2006) Chemical Research in Toxicology , vol.19 , Issue.9 , pp. 1160-1174
    • Lancaster Jr., J.R.1
  • 63
    • 0031943236 scopus 로고    scopus 로고
    • VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells
    • J.D. Hood, C.J. Meininger, M. Ziche, and H.J. Granger VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells Am. J. Physiol. 274 1998 H1054 H1058
    • (1998) Am. J. Physiol. , vol.274
    • Hood, J.D.1    Meininger, C.J.2    Ziche, M.3    Granger, H.J.4
  • 64
    • 0028095848 scopus 로고
    • Role of calcium and calmodulin in flow-induced nitric oxide production in endothelial cells
    • M.J. Kuchan, and J.A. Frangos Role of calcium and calmodulin in flow-induced nitric oxide production in endothelial cells Am. J. Physiol. 266 1994 C628 C636
    • (1994) Am. J. Physiol. , vol.266
    • Kuchan, M.J.1    Frangos, J.A.2
  • 65
    • 68349135431 scopus 로고    scopus 로고
    • NO/peroxynitrite dynamics of high glucose-exposed HUVECs: Chemiluminescent measurement and computational model
    • S. Potdar, and M. Kavdia NO/peroxynitrite dynamics of high glucose-exposed HUVECs: chemiluminescent measurement and computational model Microvasc. Res. 78 2009 191 198
    • (2009) Microvasc. Res. , vol.78 , pp. 191-198
    • Potdar, S.1    Kavdia, M.2
  • 66
    • 10644235479 scopus 로고    scopus 로고
    • Nitric oxide is significantly reduced in ex vivo porcine arteries during reverse flow because of increased superoxide production
    • DOI 10.1113/jphysiol.2004.075218
    • X. Lu, and G.S. Kassab Nitric oxide is significantly reduced in ex vivo porcine arteries during reverse flow because of increased superoxide production J. Physiol. 561 2004 575 582 (Pubitemid 39646544)
    • (2004) Journal of Physiology , vol.561 , Issue.2 , pp. 575-582
    • Lu, X.1    Kassab, G.S.2
  • 67
    • 0031859924 scopus 로고    scopus 로고
    • Estimation of nitric oxide production and reaction rates in tissue by use of a mathematical model
    • M.W. Vaughn, L. Kuo, and J.C. Liao Estimation of nitric oxide production and reaction rates in tissue by use of a mathematical model Am. J. Physiol. 274 1998 H2163 H2176
    • (1998) Am. J. Physiol. , vol.274
    • Vaughn, M.W.1    Kuo, L.2    Liao, J.C.3
  • 69
    • 0035846988 scopus 로고    scopus 로고
    • A kinetic simulation model that describes catalysis and regulation in nitric-oxide synthase
    • DOI 10.1074/jbc.M006858200
    • J. Santolini, S. Adak, C.M. Curran, and D.J. Stuehr A kinetic simulation model that describes catalysis and regulation in nitric-oxide synthase J. Biol. Chem. 276 2001 1233 1243 (Pubitemid 32096551)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.2 , pp. 1233-1243
    • Santolini, J.1    Adak, S.2    Curran, C.M.L.3    Stuehr, D.J.4
  • 71
    • 0034625348 scopus 로고    scopus 로고
    • Electron transfer, oxygen binding, and nitric oxide feedback inhibition in endothelial nitric-oxide synthase
    • DOI 10.1074/jbc.M000050200
    • H.M. Abu-Soud, K. Ichimori, A. Presta, and D.J. Stuehr Electron transfer, oxygen binding, and nitric oxide feedback inhibition in endothelial nitric-oxide synthase J. Biol. Chem. 275 2000 17349 17357 (Pubitemid 30430770)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.23 , pp. 17349-17357
    • Abu-Soud, H.M.1    Ichimori, K.2    Presta, A.3    Stuehr, D.J.4
  • 72
  • 73
  • 74
    • 0345306661 scopus 로고    scopus 로고
    • ω-Hydroxyarginine Oxidation by Nitric-oxide Synthase
    • DOI 10.1074/jbc.M307682200
    • C.C. Wei, Z.Q. Wang, C. Hemann, R. Hille, and D.J. Stuehr A tetrahydrobiopterin radical forms and then becomes reduced during Nomega-hydroxyarginine oxidation by nitric-oxide synthase J. Biol. Chem. 278 2003 46668 46673 (Pubitemid 37452244)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.47 , pp. 46668-46673
    • Wei, C.-C.1    Wang, Z.-Q.2    Hemann, C.3    Hille, R.4    Stuehr, D.J.5
  • 75
    • 0028302095 scopus 로고
    • The pteridine binding site of brain nitric oxide synthase: Tetrahydrobiopterin binding kinetics, specificity, and allosteric interaction with the substrate domain
    • P. Klatt, M. Schmid, E. Leopold, K. Schmidt, E.R. Werner, and B. Mayer The pteridine binding site of brain nitric oxide synthase: tetrahydrobiopterin binding kinetics, specificity, and allosteric interaction with the substrate domain J. Biol. Chem. 269 1994 13861 13866
    • (1994) J. Biol. Chem. , vol.269 , pp. 13861-13866
    • Klatt, P.1    Schmid, M.2    Leopold, E.3    Schmidt, K.4    Werner, E.R.5    Mayer, B.6
  • 76
    • 0041461886 scopus 로고    scopus 로고
    • Analysis of cellular exposure to peroxynitrite in suspension cultures
    • N. Nalwaya, and W.M. Deen Analysis of cellular exposure to peroxynitrite in suspension cultures Chem. Res. Toxicol. 16 2003 920 932 (Pubitemid 36899007)
    • (2003) Chemical Research in Toxicology , vol.16 , Issue.7 , pp. 920-932
    • Nalwaya, N.1    Deen, W.M.2
  • 77
    • 0033621724 scopus 로고    scopus 로고
    • Nitric oxide, superoxide, and peroxynitrite effects on the insulin secretion and viability of βTC3 cells
    • DOI 10.1114/1.258
    • M. Kavdia, J.L. Stanfield, and R.S. Lewis Nitric oxide, superoxide, and peroxynitrite effects on the insulin secretion and viability of betaTC3 cells Ann. Biomed. Eng. 28 2000 102 109 (Pubitemid 30563024)
    • (2000) Annals of Biomedical Engineering , vol.28 , Issue.1 , pp. 102-109
    • Kavdia, M.1    Stanfield, J.L.2    Lewis, R.S.3
  • 78
    • 0031023654 scopus 로고    scopus 로고
    • Metabolic fate of peroxynitrite in aqueous solution: Reaction with nitric oxide and pH-dependent decomposition to nitrite and oxygen in a 2:1 stoichiometry
    • S. Pfeiffer, A.C. Gorren, K. Schmidt, E.R. Werner, B. Hansert, D.S. Bohle, and B. Mayer Metabolic fate of peroxynitrite in aqueous solution: reaction with nitric oxide and pH-dependent decomposition to nitrite and oxygen in a 2:1 stoichiometry J. Biol. Chem. 272 1997 3465 3470
    • (1997) J. Biol. Chem. , vol.272 , pp. 3465-3470
    • Pfeiffer, S.1    Gorren, A.C.2    Schmidt, K.3    Werner, E.R.4    Hansert, B.5    Bohle, D.S.6    Mayer, B.7
  • 79
    • 0041589260 scopus 로고    scopus 로고
    • The autoxidation of tetrahydrobiopterin revisited: Proof of superoxide formation from reaction of tetrahydrobiopterin with molecular oxygen
    • DOI 10.1074/jbc.M211779200
    • M. Kirsch, H.G. Korth, V. Stenert, R. Sustmann, and H. de Groot The autoxidation of tetrahydrobiopterin revisited: proof of superoxide formation from reaction of tetrahydrobiopterin with molecular oxygen J. Biol. Chem. 278 2003 24481 24490 (Pubitemid 37548600)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.27 , pp. 24481-24490
    • Kirsch, M.1    Korth, H.-G.2    Stenert, V.3    Sustmann, R.4    De Groot, H.5
  • 80
    • 0035887885 scopus 로고    scopus 로고
    • Reaction of tetrahydrobiopterin with superoxide: EPR-kinetic analysis and characterization of the pteridine radical
    • DOI 10.1016/S0891-5849(01)00680-3, PII S0891584901006803
    • J. Vasquez-Vivar, J. Whitsett, P. Martasek, N. Hogg, and B. Kalyanaraman Reaction of tetrahydrobiopterin with superoxide: EPR-kinetic analysis and characterization of the pteridine radical Free Radic. Biol. Med. 31 2001 975 985 (Pubitemid 32939393)
    • (2001) Free Radical Biology and Medicine , vol.31 , Issue.8 , pp. 975-985
    • Vasquez-Vivar, J.1    Whitsett, J.2    Martasek, P.3    Hogg, N.4    Kalyanaraman, B.5
  • 81
    • 0036468241 scopus 로고    scopus 로고
    • Oxidation of tetrahydrobiopterin by biological radicals and scavenging of the trihydrobiopterin radical by ascorbate
    • DOI 10.1016/S0891-5849(01)00777-8, PII S0891584901007778
    • K.B. Patel, M.R. Stratford, P. Wardman, and S.A. Everett Oxidation of tetrahydrobiopterin by biological radicals and scavenging of the trihydrobiopterin radical by ascorbate Free Radic. Biol. Med. 32 2002 203 211 (Pubitemid 34119398)
    • (2002) Free Radical Biology and Medicine , vol.32 , Issue.3 , pp. 203-211
    • Patel, K.B.1    Stratford, M.R.L.2    Wardman, P.3    Everett, S.A.4
  • 83
    • 0029664647 scopus 로고    scopus 로고
    • Determination of Km for oxygen of nitric oxide synthase isoforms
    • A. Rengasamy, and R.A. Johns Determination of Km for oxygen of nitric oxide synthase isoforms J. Pharmacol. Exp. Ther. 276 1996 30 33
    • (1996) J. Pharmacol. Exp. Ther. , vol.276 , pp. 30-33
    • Rengasamy, A.1    Johns, R.A.2
  • 84
    • 0030447944 scopus 로고    scopus 로고
    • Spatial relationship between L-arginine and heme binding sites of endothelial nitric-oxide synthase
    • DOI 10.1074/jbc.271.52.33293
    • V. Berka, P.F. Chen, and A.L. Tsai Spatial relationship between l-arginine and heme binding sites of endothelial nitric-oxide synthase J. Biol. Chem. 271 1996 33293 33300 (Pubitemid 27010138)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.52 , pp. 33293-33300
    • Berka, V.1    Chen, P.-F.2    Tsai, A.-L.3
  • 85
    • 15744396356 scopus 로고    scopus 로고
    • The three nitric-oxide synthases differ in their kinetics of tetrahydrobiopterin radical formation, heme-dioxy reduction, and arginine hydroxylation
    • DOI 10.1074/jbc.M409737200
    • C.C. Wei, Z.Q. Wang, D. Durra, C. Hemann, R. Hille, E.D. Garcin, E.D. Getzoff, and D.J. Stuehr The three nitric-oxide synthases differ in their kinetics of tetrahydrobiopterin radical formation, heme-dioxy reduction, and arginine hydroxylation J. Biol. Chem. 280 2005 8929 8935 (Pubitemid 40409584)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.10 , pp. 8929-8935
    • Wei, C.-C.1    Wang, Z.-Q.2    Durra, D.3    Hemann, C.4    Hille, R.5    Garcin, E.D.6    Getzoff, E.D.7    Stuehr, D.J.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.