Role of tetrahydrobiopterin in resistance to myocardial ischemia in Brown Norway and Dahl S rats

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 297, Issue 5, 2009, Pages

  An, Jianzhong ^a   Du, Jianhai ^a   Wei, Na ^a,b   Xu, Hao ^a   Pritchard Jr , Kirkwood A ^a   Shi, Yang ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b SHANDONG UNIVERSITY   (China)

Author keywords

Cardioprotection; Guanosine 5 triphosphate cyclohydrolase I; Nitric oxide

Indexed keywords

2,4 DIAMINO 6 HYDROXYPYRIMIDINE; DIHYDROBIOPTERIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; HEAT SHOCK PROTEIN 90; PYRIMIDINE DERIVATIVE; SEPIAPTERIN; SUPEROXIDE; TETRAHYDROBIOPTERIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOSYNTHESIS; BROWN NORWAY RAT; CONTROLLED STUDY; CONVALESCENCE; DAHL SALT SENSITIVE RAT; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART VENTRICLE PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; REPERFUSION INJURY;

ANIMALS; BIOPTERIN; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GTP CYCLOHYDROLASE; HSP90 HEAT-SHOCK PROTEINS; HYPOXANTHINES; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PTERINS; RATS; RATS, INBRED BN; RATS, INBRED DAHL; RNA, MESSENGER; SPECIES SPECIFICITY; SUPEROXIDES; VENTRICULAR FUNCTION, LEFT; VENTRICULAR PRESSURE;

EID: 70350464515     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00364.2009     Document Type: Article

References (33)

1. Baker JE, Konorev EA, Gross GJ, Chilian WM, Jacob HJ. Resistance to myocardial ischemia in five rat strains: is there a genetic component of cardioprotection? Am J Physiol Heart Circ Physiol 278: H1395-H1400, 2000.
2. Bolli R. Cardioprotective function of inducible nitric oxide synthase and role of nitric oxide in myocardial ischemia and preconditioning: an overview of a decade of research. J Mol Cell Cardiol 33: 1897-1918, 2001.
3. Bredt DS, Snyder SH. Nitric oxide: a physiologic messenger molecule. Annu Rev Biochem 63: 175-195, 1994. (Pubitemid 2109107)
4. Chatterjee A, Catravas JD. Endothelial nitric oxide (NO) and its pathophysiologic regulation. Vascul Pharmacol 49: 134-140, 2008.
5. Cohen MV, Yang XM, Downey JM. Nitric oxide is a preconditioning mimetic and cardioprotectant and is the basis of many available infarct-sparing strategies. Cardiovasc Res 70: 231-239, 2006.
6. 4 biosynthesis in macrophages. Am J Physiol Cell Physiol 297: H742-H749, 2009.
7. 4. Proc Natl Acad Sci USA 104: 15081-15086, 2007.
8. Gorren AC, List BM, Schrammel A, Pitters E, Hemmens B, Werner ER, Schmidt K, Mayer B. Tetrahydrobiopterin-free neuronal nitric oxide synthase: evidence for two identical highly anticooperative pteridine binding sites. Biochemistry 35: 16735-16745, 1996. (Pubitemid 27020518)
9. Gross SS, Levi R. Tetrahydrobiopterin synthesis: an absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle. J Biol Chem 267: 25722-25729, 1992. (Pubitemid 23013967)
10. Hemmens B, Mayer B. Enzymology of nitric oxide synthases. Methods Mol Biol 100: 1-32, 1998.
11. 4 production via de novo and salvage pathways regulates NO responses to cytokines in adult cardiac myocytes. Am J Physiol Heart Circ Physiol 295: H2178-H2187, 2008.
12. Kasai K, Hattori Y, Banba N, Hattori S, Motohashi S, Shimoda S, Nakanishi N, Gross SS. Induction of tetrahydrobiopterin synthesis in rat cardiac myocytes: impact on cytokine-induced NO generation. Am J Physiol Heart Circ Physiol 273: H665-H672, 1997. (Pubitemid 27392220)
13. Kawahara K, Takase M, Yamauchi Y. Increased vulnerability to ischemia/reperfusion-induced ventricular tachyarrhythmias by pre-ischemic inhibition of nitric oxide synthase in isolated rat hearts. Cardiovasc Pathol 12: 49-56, 2003. (Pubitemid 36206512)
14. Mitra R, Morad M. A uniform enzymatic method for dissociation of myocytes from hearts and stomachs of vertebrates. Am J Physiol Heart Circ Physiol 249: H1056-H1060, 1985. (Pubitemid 16197350)
15. Moens AL, Kass DA. Tetrahydrobiopterin and cardiovascular disease. Arterioscler Thromb Vasc Biol 26: 2439-2444, 2006.
16. Sawabe K, Yamamoto K, Harada Y, Ohashi A, Sugawara Y, Matsuoka H, Hasegawa H. Cellular uptake of sepiapterin and push-pull accumulation of tetrahydrobiopterin. Mol Genet Metab 94: 410-416, 2008.
17. Schmidt K, Werner ER, Mayer B, Wachter H, Kukovetz WR. Tetra-hydrobiopterin- dependent formation of endothelium-derived relaxing factor (nitric oxide) in aortic endothelial cells. Biochem J 281: 297-300, 1992.
18. Schulz R, Kelm M, Heusch G. Nitric oxide in myocardial ischemia/ reperfusion injury. Cardiovasc Res 61: 402-413, 2004. (Pubitemid 38210147)
19. Shi Y, Baker JE, Zhang C, Tweddell JS, Su J, Pritchard KA Jr. Chronic hypoxia increases endothelial nitric oxide synthase generation of nitric oxide by increasing heat shock protein 90 association and serine phosphorylation. Circ Res 91: 300-306, 2002. (Pubitemid 34976995)
20. Shi Y, Hutchins W, Ogawa H, Chang CC, Pritchard KA Jr, Zhang C, Khampang P, Lazar J, Jacob HJ, Rafiee P, Baker JE. Increased resistance to myocardial ischemia in the Brown Norway vs. Dahl S rat: role of nitric oxide synthase and Hsp90. J Mol Cell Cardiol 38: 625-635, 2005. (Pubitemid 40461826)
21. Shinozaki K, Nishio Y, Yoshida Y, Koya D, Ayajiki K, Masada M, Kashiwagi A, Okamura T. Supplement of tetrahydrobiopterin by a gene transfer of GTP cyclohydrolase I cDNA improves vascular dysfunction in insulin-resistant rats. J Cardiovasc Pharmacol 46: 505-512, 2005. (Pubitemid 41407581)
22. Thomas SR, Chen K, Keaney JF Jr. Oxidative stress and endothelial nitric oxide bioactivity. Antioxid Redox Signal 5: 181-194, 2003. (Pubitemid 36457594)
23. Thomas SR, Witting PK, Drummond GR. Redox control of endothelial function and dysfunction: molecular mechanisms and therapeutic opportunities. Antioxid Redox Signal 10: 1713-1765, 2008.
24. Tiefenbacher CP, Chilian WM, Mitchell M, DeFily DV. Restoration of endothelium-dependent vasodilation after reperfusion injury by tetrahydrobiopterin. Circulation 94: 1423-1429, 1996. (Pubitemid 26307275)
25. Tiefenbacher CP, Lee CH, Kapitza J, Dietz V, Niroomand F. Sepiapterin reduces postischemic injury in the rat heart. Pflügers Arch 447: 1-7, 2003. (Pubitemid 38177650)
26. Trochu JN, Bouhour JB, Kaley G, Hintze TH. Role of endothelium-derived nitric oxide in the regulation of cardiac oxygen metabolism: implications in health and disease. Circ Res 87: 1108-1117, 2000.
27. Vasquez-Vivar J, Kalyanaraman B, Martasek P. The role of tetrahydrobiopterin in superoxide generation from eNOS: enzymology and physiological implications. Free Radic Res 37: 121-127, 2003. (Pubitemid 36124338)
28. Vasquez-Vivar J, Kalyanaraman B, Martasek P, Hogg N, Masters BS, Karoui H, Tordo P, Pritchard KA Jr. Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors. Proc Natl Acad Sci USA 95: 9220-9225, 1998. (Pubitemid 28506212)
29. Werner-Felmayer G, Golderer G, Werner ER. Tetrahydrobiopterin biosynthesis, utilization and pharmacological effects. Curr Drug Metab 3: 159-173, 2002. (Pubitemid 34326528)
30. Xie L, Smith JA, Gross SS. GTP cyclohydrolase I inhibition by the prototypic inhibitor 2,4-diamino-6-hydroxypyrimidine. Mechanisms and unanticipated role of GTP cyclohydrolase I feedback regulatory protein. J Biol Chem 273: 21091-21098, 1998. (Pubitemid 28385395)
31. Yamashiro S, Noguchi K, Kuniyoshi Y, Koja K, Sakanashi M. Role of tetrahydrobiopterin on ischemia-reperfusion injury in isolated perfused rat hearts. J Cardiovasc Surg (Torino) 44: 37-49, 2003. (Pubitemid 36527367)
32. Yamashiro S, Noguchi K, Matsuzaki T, Miyagi K, Nakasone J, Sakanashi M, Koja K. Beneficial effect of tetrahydrobiopterin on ischemia-reperfusion injury in isolated perfused rat hearts. J Thorac Cardiovasc Surg 124: 775-784, 2002. (Pubitemid 36025356)
33. Ziolo MT, Kohr MJ, Wang H. Nitric oxide signaling and the regulation of myocardial function. J Mol Cell Cardiol 45: 625-632, 2008.