Cellular accumulation of tetrahydrobiopterin following its administration is mediated by two different processes; Direct uptake and indirect uptake mediated by a methotrexate-sensitive process

Molecular Genetics and Metabolism

Volumn 86, Issue SUPPL., 2005, Pages 133-138

  Sawabe, Keiko ^a   Suetake, Yasuko ^a   Nakanishi, Nobuo ^b   Wakasugi, Kazunori O ^c   Hasegawa, Hiroyuki ^a  

^a TEIKYO UNIVERSITY OF SCIENCE   (Japan)

^b MEIKAI UNIVERSITY SCHOOL OF DENTISTRY   (Japan)

^c TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

BH4 supplementation; Caco 2 cell; Dihydrobiopterin; Dihydrofolate reductase; Hepatocyte; Intestinal epithelium; Methotrexate; Tetrahydrobiopterin

Indexed keywords

DIHYDROFOLATE REDUCTASE; METHOTREXATE; TETRAHYDROBIOPTERIN;

ANIMAL CELL; ARTICLE; CELL ISOLATION; CELL STRAIN CACO 2; CELL TYPE; DIASTEREOISOMER; DRUG ACCUMULATION; DRUG RESPONSE; DRUG UPTAKE; HUMAN; HUMAN CELL; IN VITRO STUDY; INHIBITION KINETICS; INTESTINE EPITHELIUM CELL; INTESTINE MUCOSA; LIVER; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 28844466386     PISSN: 10967192     EISSN: 10967206     Source Type: Journal    
DOI: 10.1016/j.ymgme.2005.06.020     Document Type: Article

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