Experimental and computational investigations of oxygen reactivity in a heme and tyrosyl radical-containing fatty acid α-(Di)oxygenase

Biochemistry

Volumn 50, Issue 34, 2011, Pages 7375-7389

  Huff, Gregory S ^a   Doncheva, Irina S ^a   Brinkley, David W ^a   Angeles Boza, Alfredo M ^a   Mukherjee, Arnab ^a   Cramer, Christopher J ^b   Roth, Justine P ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b University of Minnesota   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON RADICALS; COMPUTATIONAL INVESTIGATION; CONCENTRATION RANGES; DENSITY-FUNCTIONAL LEVEL; DEUTERIUM KINETIC ISOTOPE EFFECT; ELECTRON TRANSFER; HYDROGEN ATOM ABSTRACTION; KINETIC ISOTOPE EFFECTS; NATURAL ABUNDANCE; OXYGEN REACTIVITY; OXYGEN-18; OXYGENASES; PEROXYL RADICAL; POLARIZED TRANSITION STATE; PROTON-COUPLED ELECTRON TRANSFER; STEREOSPECIFIC; TYROSYL RADICALS;

CARRIER MOBILITY; CATALYTIC OXIDATION; DENSITY FUNCTIONAL THEORY; DEUTERIUM; ELECTRON TRANSITIONS; FREE RADICAL REACTIONS; KINETICS; OXYGEN; PORPHYRINS; PROTONS;

FATTY ACIDS;

DEUTERIUM; DIOXYGENASE; FATTY ACID; HEME; HYDROGEN; OXYGEN; OXYGEN 18; PEROXY RADICAL; RADICAL;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; DENSITY FUNCTIONAL THEORY; ELECTRON TRANSPORT; KINETICS; OXIDATION; PRIORITY JOURNAL; PROTON TRANSPORT; REDUCTION; STEREOSPECIFICITY;

BINDING, COMPETITIVE; DIFFUSION; DIOXYGENASES; ELECTRON TRANSPORT; FATTY ACIDS; FREE RADICALS; HEME; KINETICS; MODELS, MOLECULAR; ORYZA SATIVA; OXYGEN; OXYGEN ISOTOPES; PROTEIN BINDING; PROTEIN CONFORMATION; QUANTUM THEORY; SOLVENTS; STEREOISOMERISM; SUBSTRATE SPECIFICITY; TYROSINE; VISCOSITY;

EID: 80052007912     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi201016h     Document Type: Article

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