Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid

Biochemistry

Volumn 48, Issue 26, 2009, Pages 6259-6267

  Wecksler, Aaron T ^a   Jacquot, Cyril ^b   Van Der Donk, Wilfred A ^b   Holman, Theodore R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

15-LIPOXYGENASE; ALLOSTERIC EFFECTORS; ARACHIDONIC ACIDS; C-H BOND; CANCEROUS TISSUES; CATALYTIC MECHANISMS; HYDROGEN ATOM ABSTRACTION; LINOLEIC ACID; LIPOXYGENASE; LIPOXYGENASES; OXYGEN CONCENTRATIONS; RATE LIMITING; RATE-LIMITING STEPS; REACTION MECHANISM; RELATIVE ACTIVITIES; SOLVENT ISOTOPE EFFECTS; SUBSTRATE SPECIFICITY; TUNNELING MECHANISM; VARIABLE TEMPERATURE;

ABSTRACTING; ACIDS; BLOOD SUBSTITUTES; CARRIER MOBILITY; FATTY ACIDS; HYDROGEN; ISOTOPES; OXYGEN; REACTION KINETICS; SOLVENTS;

SUBSTRATES;

12 HYDROXYICOSATETRAENOIC ACID; ARACHIDONIC ACID; HYDROGEN; LINOLEIC ACID; LIPOXYGENASE; OXYGEN; PLATELET 12 LIPOXYGENASE; RETICULOCYTE 15 LIPOXYGENASE 1; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; CONCENTRATION (PARAMETERS); ENZYME KINETICS; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION; SOLVENT EFFECT; STEADY STATE; TEMPERATURE DEPENDENCE;

12-HYDROXY-5,8,10,14-EICOSATETRAENOIC ACID; ALLOSTERIC REGULATION; ARACHIDONATE 12-LIPOXYGENASE; ARACHIDONATE 15-LIPOXYGENASE; ARACHIDONIC ACID; BIOCATALYSIS; BLOOD PLATELETS; CARBON ISOTOPES; HUMANS; KINETICS; LEUKOTRIENES; LINOLEIC ACID; LINOLEIC ACIDS; LIPID PEROXIDES; MODELS, CHEMICAL; OXYGEN; RECOMBINANT PROTEINS; RETICULOCYTES; SOLVENTS; TEMPERATURE;

EID: 67650094037     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi802332j     Document Type: Article

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