Chemopreventive effects of synthetic C-substituted diindolylmethanes originating from cruciferous vegetables in human oral cancer cells

European Journal of Cancer Prevention

Volumn 20, Issue 5, 2011, Pages 417-425

  Shin, Ji Ae ^a   Shim, Jung Hyun ^a   Choi, Eun Sun ^a   Leem, Dae Ho ^a   Kwon, Ki Han ^b   Lee, Syng Ook ^c   Safe, Stephen ^c   Cho, Nam Pyo ^a   Cho, Sung Dae ^a  

^a Chonbuk National University   (South Korea)

^b Kwangju University   (South Korea)

^c TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

apoptosis; C substituted diindolylmethane; death receptor 5; endoplasmic reticulum stress; human oral cancer cell; mitochondrial membrane potential

Indexed keywords

ANTINEOPLASTIC AGENT; C SUBSTITUTED DIINDOLYLMETHANE DERIVATIVE; CASPASE 8; DEATH RECEPTOR 5; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; ISOTHIOCYANIC ACID DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL COUNT; CELL MEMBRANE DEPOLARIZATION; CELL STRAIN KB; CELL VIABILITY; CHEMOPROPHYLAXIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SCREENING; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; HEP 2 CELL; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUTH CANCER; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION;

ANTICARCINOGENIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CASPASE 8; CELL PROLIFERATION; CINNAMATES; ENDOPLASMIC RETICULUM; HUMANS; INDOLES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MOUTH NEOPLASMS; POLY(ADP-RIBOSE) POLYMERASES; PPAR GAMMA; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; THIOUREA; TRANSCRIPTION FACTOR CHOP; TUMOR CELLS, CULTURED; VEGETABLES;

EID: 80051787222     PISSN: 09598278     EISSN: 14735709     Source Type: Journal    
DOI: 10.1097/CEJ.0b013e32834473c3     Document Type: Article

References (35)

1. Abdelrahim M, Newman K, Vanderlaag K, Samudio I, Safe S (2006). 3, 30-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5. Carcinogenesis 27:717-728.
2. Aggarwal BB, Ichikawa H (2005). Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. Cell Cycle 4:1201-1215. (Pubitemid 41365390)
3. Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, et al. (2005). A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science 307:935-939. (Pubitemid 40229232)
4. Broadbent TA, Broadbent HS (1998). 1. The chemistry and pharmacology of indole-3-carbinol (indole-3-methanol) and 3-(methoxymethyl) indole. [Part II]. Curr Med Chem 5:469-491. (Pubitemid 28549926)
5. Chintharlapalli S, Smith R III, Samudio I, Zhang W, Safe S (2004). 1, 1-Bis (30-indolyl)-1-(p-substitutedphenyl) methanes induce peroxisome proliferatoractivated receptor gamma-mediated growth inhibition, transactivation, and differentiation markers in colon cancer cells. Cancer Res 64:5994-6001. (Pubitemid 39129396)
6. Chintharlapalli S, Papineni S, Baek SJ, Liu S, Safe S (2005). 1, 1-Bis (30-indolyl)-1-(p-substitutedphenyl) methanes are peroxisome proliferator-activated receptor gamma agonists but decrease HCT-116 colon cancer cell survival through receptor-independent activation of early growth response-1 and nonsteroidal anti-inflammatory drug-activated gene-1. Mol Pharmacol 68:1782-1792. (Pubitemid 41654361)
7. Chintharlapalli S, Papineni S, Safe S (2006). 1, 1-Bis (30-indolyl)-1-(p-substituted phenyl) methanes inhibit colon cancer cell and tumor growth through PPARgamma-dependent and PPARgamma-independent pathways. Mol Cancer Ther 5:1362-1370. (Pubitemid 43881330)
8. Faitova J, Krekac D, Hrstka R, Vojtesek B (2006). Endoplasmic reticulum stress and apoptosis. Cell Mol Biol Lett 11:488-505. (Pubitemid 46708877)
9. Fowke JH (2007). Head and neck cancer: a case for inhibition by isothiocyanates and indoles from cruciferous vegetables. Eur J Cancer Prev 16:348-356. (Pubitemid 47165301)
10. Friedlander R, Jarosch E, Urban J, Volkwein C, Sommer T (2000). A regulatory link between ER-associated protein degradation and the unfolded-protein response. Nat Cell Biol 2:379-384.
11. Hong J, Samudio I, Liu S, Abdelrahim M, Safe S (2004). Peroxisome proliferatoractivated receptor gamma-dependent activation of p21 in Panc-28 pancreatic cancer cells involves Sp1 and Sp4 proteins. Endocrinology 145:5774-5785. (Pubitemid 39564619)
12. Hong J, Samudio I, Chintharlapalli S, Safe S (2008). 1, 1-bis (30-indolyl)-1-(psubstituted phenyl) methanes decrease mitochondrial membrane potential and induce apoptosis in endometrial and other cancer cell lines. Mol Carcinog 47:492-507. (Pubitemid 351898580)
13. Jo EH, Kim SH, Ahn NS, Park JS, Hwang JW, Lee YS, Kang KS (2007). Efficacy of sulforaphane is mediated by p38 MAP kinase and caspase-7 activations in ER-positive and COX-2-expressed human breast cancer cells. Eur J Cancer Prev 16:505-510.
14. Kassouf W, Chintharlapalli S, Abdelrahim M, Nelkin G, Safe S, Kamat AM (2006). Inhibition of bladder tumor growth by 1, 1-bis (30-indolyl)-1-(p- substituted phenyl) methanes: a new class of peroxisome proliferator-activated receptor gamma agonists. Cancer Res 66:412-418. (Pubitemid 43166049)
15. Kaufman RJ (1999). Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev 13:1211-1233. (Pubitemid 29250189)
16. Larsson SC, Hakansson N, Naslund I, Bergkvist L, Wolk A (2006). Fruit and vegetable consumption in relation to pancreatic cancer risk: a prospective study. Cancer Epidemiol Biomarkers Prev 15:301-305. (Pubitemid 43342178)
17. Lee AS (2001). The glucose-regulated proteins: stress induction and clinical applications. Trends Biochem Sci 26:504-510. (Pubitemid 32735452)
18. Lei P, Abdelrahim M, Safe S (2006). 1, 1-Bis (30-indolyl)-1-(p- substituted phenyl) methanes inhibit ovarian cancer cell growth through peroxisome proliferatoractivated receptor-dependent and independent pathways. Mol Cancer Ther 5:2324-2336. (Pubitemid 44530470)
19. Lei P, Abdelrahim M, Cho SD, Liu S, Chintharlapalli S, Safe S (2008). 1, 1-Bis (30-indolyl)-1-(p-substituted phenyl) methanes inhibit colon cancer cell and tumor growth through activation of c-jun N-terminal kinase. Carcinogenesis 29:1139-1147. (Pubitemid 351958692)
20. Michaud DS, Spiegelman D, Clinton SK, Rimm EB, Willett WC, Giovannucci EL (1999). Fruit and vegetable intake and incidence of bladder cancer in a male prospective cohort. J Natl Cancer Inst 91:605-613. (Pubitemid 29194046)
21. Pahl HL (1999). Signal transduction from the endoplasmic reticulum to the cell nucleus. Physiol Rev 79:683-701. (Pubitemid 29330171)
22. Patil C, Walter P (2001). Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals. Curr Opin Cell Biol 13:349-355.
23. Poh TW, Huang S, Hirpara JL, Pervaiz S (2007). LY303511 amplifies TRAIL-induced apoptosis in tumor cells by enhancing DR5 oligomerization, DISC assembly, and mitochondrial permeabilization. Cell Death Differ 14:1813-1825. (Pubitemid 47423648)
24. Preobrazhenskaya MN, Bukhman VM, Korolev AM, Efimov SA (1993). Ascorbigen and other indole-derived compounds from brassica vegetables and their analogs as anticarcinogenic and immunomodulating agents. Pharmacol Ther 60:301-313. (Pubitemid 24117381)
25. Qin C, Morrow D, Stewart J, Spencer K, Porter W, Smith R III, et al. (2004). A new class of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists that inhibit growth of breast cancer cells: 1, 1-Bis (3'-indolyl)-1-(psubstituted phenyl) methanes. Mol Cancer Ther 3:247-260.
26. Rashidkhani B, Lindblad P, Wolk A (2005). Fruits, vegetables and risk of renal cell carcinoma: a prospective study of Swedish women. Int J Cancer 113:451-455. (Pubitemid 40038714)
27. Schroder M, Kaufman RJ (2005). The mammalian unfolded protein response. Annu Rev Biochem 74:739-789. (Pubitemid 40995523)
28. Terry P, Giovannucci E, Michels KB, Bergkvist L, Hansen H, Holmberg L, Wolk A (2001). Fruit, vegetables, dietary fiber, and risk of colorectal cancer. J Natl Cancer Inst 93:525-533. (Pubitemid 32318431)
29. Verhoeven DT, Verhagen H, Goldbohm RA, Van den Brandt PA, Van Poppel G (1997). A review of mechanisms underlying anticarcinogenicity by brassica vegetables. Chem Biol Interact 103:79-129. (Pubitemid 27081513)
30. Wang Y, Cheung YH, Yang Z, Chiu JF, Che CM, He QY (2006). Proteomic approach to study the cytotoxicity of dioscin (saponin). Proteomics 6:2422-2432.
31. Zeegers MP, Goldbohm RA, Van den Brandt PA (2001). Consumption of vegetables and fruits and urothelial cancer incidence: a prospective study. Cancer Epidemiol Biomarkers Prev 10:1121-1128. (Pubitemid 33064299)
32. Zhang K, Kaufman RJ (2006). The unfolded protein response: a stress signaling pathway critical for health and disease. Neurology 66:S102-S109. (Pubitemid 43739994)
33. Zhang SM, Hunter DJ, Rosner BA, Giovannucci EL, Colditz GA, Speizer FE, Willett WC (2000). Intakes of fruits, vegetables, and related nutrients and the risk of non-Hodgkin's lymphoma among women. Cancer Epidemiol Biomarkers Prev 9:477-485. (Pubitemid 30313890)
34. Zinszner H, Kuroda M, Wang X, Batchvarova N, Lightfoot RT, Remotti H, et al. (1998). CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev 12:982-995. (Pubitemid 28204605)
35. Zou W, Yue P, Khuri FR, Sun SY (2008). Coupling of endoplasmic reticulum stress to CDDO-Me-induced up-regulation of death receptor 5 via a CHOP-dependent mechanism involving JNK activation. Cancer Res 68:7484-7492.