LY303511 amplifies TRAIL-induced apoptosis in tumor cells by enhancing DR5 oligomerization, DISC assembly, and mitochondrial permeabilization

Cell Death and Differentiation

Volumn 14, Issue 10, 2007, Pages 1813-1825

  Poh, T W ^a   Huang, S ^a   Hirpara, J L ^a   Pervaiz, S ^a,b,c  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

BH3 PROTEIN; CASPASE 2; CASPASE 3; CASPASE 8; CASPASE 9; DEATH RECEPTOR 5; DNA FRAGMENT; LY 303511; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; VINCRISTINE; X LINKED INHIBITOR OF APOPTOSIS;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; COLONY FORMATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME SUBSTRATE; HELA CELL; HUMAN; HUMAN CELL; INCUBATION TIME; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL PERMEABILITY; MOLECULAR MECHANICS; MOLECULE; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION;

APOPTOSIS; CASPASE 8; CELL LINE, TUMOR; CHROMONES; CYTOCHROMES C; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; HELA CELLS; HT29 CELLS; HUMANS; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; MORPHOLINES; PIPERAZINES; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

EID: 34548713016     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/sj.cdd.4402177     Document Type: Article

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