1,1-Bis(3′-indolyl)-1-(p-substitutedphenyl)methanes are peroxisome proliferator-activated receptor γ agonists but decrease HCT-116 colon cancer cell survival through receptor-independent activation of early growth response-1 and nonsteroidal anti-inflammatory drug-activated gene-1

Molecular Pharmacology

Volumn 68, Issue 6, 2005, Pages 1782-1792

  Chintharlapalli, Sudhakar ^a   Papineni, Sabitha ^b   Seung, Joon Baek ^c   Liu, Shengxi ^d   Safe, Stephen ^b,d  

^a TEXAS A AND M UNIVERSITY   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

^c UNIVERSITY OF TENNESSEE   (United States)

^d TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,1 BIS(3' INDOLYL) 1 (4 BIPHENYL)METHANE; 1,1 BIS(3' INDOLYL) 1 (4 TERT BUTYLPHENYL)METHANE; 1,1 BIS(3' INDOLYL) 1 (4 TRIFLUOROMETHYLPHENYL)METHANE; CAVEOLIN 1; CELL CYCLE PROTEIN; EARLY GROWTH RESPONSE FACTOR 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PHOSPHATIDYLINOSITOL 3 KINASE; ROSIGLITAZONE; TRANSFORMING GROWTH FACTOR BETA; TROGLITAZONE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL SURVIVAL; COLON CANCER; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; ENZYME INHIBITION; GENE ACTIVATION; GENE DELETION; GENE INDUCTION; HUMAN; HUMAN CELL; MALE; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN INDUCTION; SUBSTITUTION REACTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; COLONIC NEOPLASMS; CYTOKINES; EARLY GROWTH RESPONSE PROTEIN 1; GENE EXPRESSION REGULATION; HUMANS; INDOLES; PPAR GAMMA; PROMOTER REGIONS (GENETICS);

EID: 27844442222     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.105.017046     Document Type: Article

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