PH dependence of catalysis by pseudomonas aeruginosa isochorismate - Pyruvate lyase: Implications for transition state stabilization and the role of lysine 42

Biochemistry

Volumn 50, Issue 33, 2011, Pages 7198-7207

  Olucha, Jose ^a   Ouellette, Andrew N ^a   Luo, Qianyi ^a   Lamb, Audrey L ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ACTIVE SITE ARCHITECTURE; CATALYTIC EFFICIENCIES; CATALYTIC POWER; CHORISMATE MUTASE; ELECTROSTATIC PROPERTIES; ENZYME ACTIVE SITES; HIGH PH; LYASE ACTIVITY; MUTASE ACTIVITY; PERICYCLIC REACTION; PH DEPENDENCE; POSITIVE CHARGES; PSEUDOMONAS AERUGINOSA; PYRUVATES; REACTION CONDITIONS; REACTION PATHS; REACTIVE CONFORMATION; SIDE-CHAINS; STRUCTURAL DATA; TRANSITION STATE STABILIZATION; TRANSITION-STATE;

AMINO ACIDS; BACTERIA; ELECTROSTATICS; ENZYME ACTIVITY; STABILIZATION;

CATALYSIS;

CHORISMATE MUTASE; CHORISMIC ACID; HISTIDINE; LYASE; LYSINE; PYRUVATE LYASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BACTERIAL MUTATION; CATALYSIS; CHEMICAL REACTION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTON TRANSPORT; PSEUDOMONAS AERUGINOSA;

CATALYSIS; CATALYTIC DOMAIN; CHORISMATE MUTASE; CHORISMIC ACID; CRYSTALLOGRAPHY, X-RAY; HYDROGEN-ION CONCENTRATION; LYSINE; MODELS, MOLECULAR; MUTATION; PROTEIN CONFORMATION; PSEUDOMONAS AERUGINOSA; PYRUVIC ACID;

PSEUDOMONAS; PSEUDOMONAS AERUGINOSA;

EID: 80051712349     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200599j     Document Type: Article

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