A water-mediated and substrate-assisted catalytic mechanism for Sulfolobus solfataricus DNA polymerase IV

Journal of the American Chemical Society

Volumn 129, Issue 15, 2007, Pages 4731-4737

  Wang, Lihua ^a   Yu, Xinyun ^a   Hu, Po ^a   Broyde, Suse ^a   Zhang, Yingkai ^a  

^a NEW YORK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLATES; DNA POLYMERASES; PHOSPHORANES; RATE-LIMITING STEPS;

DISEASES; DNA; LIGANDS; PROTON TRANSFER; QUANTUM THEORY; STABILIZATION; SUBSTRATES; SYNTHESIS (CHEMICAL); TUMORS;

ENZYMES;

DNA POLYMERASE; DNA POLYMERASE IV; MAGNESIUM ION; PHOSPHORANE DERIVATIVE; PROTEIN DPO4; PYROPHOSPHATE; SOLVENT; UNCLASSIFIED DRUG;

ARTICLE; BASE MISPAIRING; DNA SYNTHESIS; ENZYME MECHANISM; MOLECULAR MECHANICS; MOLECULAR MODEL; NONHUMAN; NUCLEOTIDE METABOLISM; PROTON TRANSPORT; QUANTUM MECHANICS; SULFOLOBUS SOLFATARICUS;

BINDING SITES; CATALYSIS; DNA POLYMERASE BETA; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY; SULFOLOBUS SOLFATARICUS; WATER;

EID: 34247549227     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja068821c     Document Type: Article

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