Ligand-based modelling followed by synthetic exploration unveil novel glycogen phosphorylase inhibitory leads

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 16, 2011, Pages 4746-4771

  Habash, Maha ^a   Taha, Mutasem O ^b  

^a APPLIED SCIENCE PRIVATE UNIVERSITY   (Jordan)

^b UNIVERSITY OF JORDAN   (Jordan)

Author keywords

Glycogen phosphorylase; In silico screening; In vitro validation; Pharmacophore; QSAR; Synthetic exploration

Indexed keywords

AMIDE; ENZYME INHIBITOR; GLYCOGEN PHOSPHORYLASE; N (5 CHLORO 2 METHYL PHENYL) N' NAPHTHALEN 1 YL OXALAMIDE; N 2 AMINOPYRIDINE SUCCINAMIC ACID; N 2 CHLOROANILINE SUCCINAMIC ACID; N 2 TOLYLSUCCINAMIC ACID; N 3 TOLYLSUCCINAMIC ACID; N 4 ANISIDINE SUCCINAMIC ACID; N 4 METHYL ORTHO ANISIDINE SUCCINAMIC ACID; N 5 CHLORO 2 METHYLANILINE SUCCINAMIC ACID; N NAPHTHALEN 1 YL N' ORTHO TOLYL OXALAMIDE; N NAPHTHYLAMINE SUCCINAMIC ACID; N,N' BIS(2 METHOXY 4 METHYL PHENYL)OXALAMIDE; N,N' DI 2 TOLYL OXALAMIDE; N,N' DI 3 TOLYL OXALAMIDE; N1 (NAPHTHALEN 1 YL) N3 (NAPHTHALEN 1 YL)MALONAMIDE; N1,N3 BIS(2 DICHLOROPHENYL)MALONAMIDE; N1,N3 BIS(2 METHOXY 4 METHYLPHENYL)MALONAMIDE; N1,N3 BIS(2 METHOXY PHENYL)MALONAMIDE; N1,N3 BIS(3,4 DICHLOROPHENYL)MALONAMIDE; N1,N3 BIS(4 DICHLOROPHENYL)MALONAMIDE; N1,N3 BIS(4 METHOXY PHENYL)MALONAMIDE; N1,N3 BIS(5 CHLORO 2 METHYLPHENYL)MALONAMIDE; N1,N3 DI 2 TOLYLMALONAMIDE; N1,N3 DI 3 TOLYLMALONAMIDE; N1,N3 DI 4 TOLYLMALONAMIDE; N1,N3 DIBENZYL MALONAMIDE; PSN 357; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CHEMICAL MODEL; CHEMICAL REACTION; CHEMICAL STRUCTURE; COMPUTER MODEL; COMPUTER PROGRAM; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CORRELATION COEFFICIENT; CRYSTAL STRUCTURE; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME INHIBITION; IC 50; IN VITRO STUDY; MOLECULAR MODEL; NON INSULIN DEPENDENT DIABETES MELLITUS; PHARMACOPHORE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RECEIVER OPERATING CHARACTERISTIC;

AMIDES; ANIMALS; COMPUTER SIMULATION; DATA MINING; DRUG DESIGN; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; GLYCOGEN PHOSPHORYLASE; HUMANS; HYPOGLYCEMIC AGENTS; LIGANDS; MODELS, MOLECULAR; MOLECULAR TARGETED THERAPY; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RABBITS; SOFTWARE; SUCCINIC ACIDS;

EID: 79961169717     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.06.086     Document Type: Article

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