Elaborate ligand-based pharmacophore exploration and QSAR analysis guide the synthesis of novel pyridinium-based potent β-secretase inhibitory leads

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 9, 2010, Pages 3088-3115

  Al Nadaf, Afaf ^a   Sheikha, Ghassan Abu ^b   Taha, Mutasem O ^c  

^a APPLIED SCIENCE PRIVATE UNIVERSITY   (Jordan)

^b AL ZAYTOONAH UNIVERSITY OF JORDAN   (Jordan)

^c Applied Science Private Univsity   (Jordan)

Author keywords

Secretase inhibitors; Ligand efficiency; Pharmacophore modeling; Pyridinium; Quantitative structure activity relationship; Receiver operating characteristic curve

Indexed keywords

1 [(3 BENZOYLAMINO PHENYLCARBAMOYL)METHYL]PYRIDINIUM; 1 [[3 (4 METHOXYPHENYLSULFAMOYL)PHENYLCARBAMOYL]METHYL]PYRIDINIUM; 1 [[3 (4 METHYLBENZOYLAMINO)PHENYLCARBAMOYL]METHYL]PYRIDINIUM; 2 CHLORO N [3 (TOLUENE 4 SULFONYLAMINO)PHENYL]ACETAMIDE; 3 (2 CHLOROACETYLAMINO) N (4 CHLOROPHENYL)BENZAMIDE; 3 (2 CHLOROACETYLAMINO) N (4 METHOXYPHENYL)BENZAMIDE; 3 (2 CHLOROACETYLAMINO) N 3 TOLYLBENZAMIDE; 3 (2 CHLOROACETYLAMINO) N 4 TOLYLBENZAMIDE; 3 AMINO N (4 CHLOROPHENYL)BENZAMIDE; 3 AMINO N (4 METHOXYPHENYL)BENZAMIDE; 3 AMINO N (4 METHOXYPHENYL)BENZENESULFONAMIDE; 3 AMINO N 3 TOLYLBENZAMIDE; 3 AMINO N 4 TOLYLBENZAMIDE; 3 NITRO N 3 TOLYLBENZAMIDE; 3 NITRO N 4 TOLYLBENZAMIDE; 4 METHYL N (3 NITROPHENYL)BENZAMIDE; 4 METHYL N (3 NITROPHENYL)BENZENESULFONAMIDE; BETA SECRETASE; BETA SECRETASE INHIBITOR; N (3 AMINO PHENYL) 4 METHYLBENZAMIDE; N (3 AMINO PHENYL) 4 METHYLBENZENESULFONAMIDE; N (3 AMINO PHENYL)BENZAMIDE; N (3 NITROPHENYL)BENZAMIDE; N (4 CHLOROPHENYL) 3 NITROBENZAMIDE; N (4 METHOXYPHENYL) 3 NITROBENZAMIDE; N (4 METHOXYPHENYL) 3 NITROBENZENESULFONAMIDE; N [3 (2 CHLOROACETYLAMINO)PHENYL] 4 METHYLBENZAMIDE; N [3 (2 CHLOROACETYLAMINO)PHENYL]BENZAMIDE; PYRIDINIUM DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; MOLECULAR MODEL; PHARMACOPHORE; PHYSICAL CHEMISTRY; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

AMYLOID PRECURSOR PROTEIN SECRETASES; ENZYME INHIBITORS; FLUORESCENCE RESONANCE ENERGY TRANSFER; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRIDINIUM COMPOUNDS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; ROC CURVE;

EID: 77951208774     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.03.043     Document Type: Article

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