Glycogen phosphorylase as a molecular target for type 2 diabetes therapy

Current Protein and Peptide Science

Volumn 3, Issue 6, 2002, Pages 561-586

  Oikonomakos, Nikos G ^a  

^a INSTITUTE OF BIOLOGY   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIHYDROPYRIDINE 2,3 DICARBOXYLATE; ALPHA ANHYDROGLUCOHEPTONIC ACID; ANTIDIABETIC AGENT; BETA AMINOETHYL 1 DEOXYGLUCOSE; BETA AMINOMETHYL 1 DEOXYGLUCOSE; BETA ANHYDROGLUCOHEPTONIC ACID; BETA AZIDOMETHYL 1 DEOXYGLUCOSE; BETA MESYLATE; BETA METHYLCYANO 1 DEOXYGLUCOSE; BETA THIO 1 DEOXYGLUCOSE; CAFFEINE; CARBOHYDRATE DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; FLAVOPIRIDOL; GENTIOBIOSE; GLUCOHEPTONIC ACID; GLUCOSE; GLUCOSE DERIVATIVE; GLYCEROL DERIVATIVE; GLYCOGEN; GLYCOGEN PHOSPHORYLASE; GLYCOGEN PHOSPHORYLASE INHIBITOR; GLYCOSYLTRANSFERASE INHIBITOR; HYDANTOCIDIN; HYDROXYETHYL BETA GLUCOSIDE; IMINOSUGAR DERIVATIVE; ISOPROTEIN; L 86 825; N ACETYL BETA GLUCOPYRANOSYLAMINE; THIOGLUCOSE; UNCLASSIFIED DRUG; UNINDEXED DRUG; W 1807;

ALLOSTERISM; ANIMAL CELL; BINDING AFFINITY; BINDING SITE; BLOOD GLUCOSE MONITORING; BRAIN; CATALYSIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRYSTALLOGRAPHY; DRUG BINDING SITE; DRUG DESIGN; DRUG SPECIFICITY; DRUG TARGETING; GLYCOGEN METABOLISM; GLYCOGENOLYSIS; HUMAN; LIGAND BINDING; LIVER; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; MUSCLE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; RAT; REVIEW; STRUCTURE ACTIVITY RELATION;

ALLOSTERIC SITE; ANIMALS; DIABETES MELLITUS, TYPE 2; DRUG DESIGN; ENZYME INHIBITORS; GLUCOSE; GLYCOGEN PHOSPHORYLASE; HUMANS;

ANIMALIA;

EID: 0036889606     PISSN: 13892037     EISSN: None     Source Type: Journal    
DOI: 10.2174/1389203023380422     Document Type: Review

References (106)

1. Zimmet, P., Albert, K.G.M.M. and Shaw, J. (2001) Nature 414, 782-787
2. DeFronzo, R.A. (1999) Ann. Intern. Med. 37, 667-687.
3. Zhang, B.B. and Moller, D.E. (2000) Curr. Opin. Chem. Biol. 4, 461-467.
4. Moller, D.E. (2001) Nature 414, 821-827.
5. Newgard, C.B., Hwang, P.K. and Fletterick, R.J. (1989) Crit. Rev. Biochem. Mol. Biol. 24,69-99.
6. Alemany S. and Cohen P. (1986) FEBS Lett. 198, 194-202.
7. Bollen, M. and Stalmans, W. (1992) Crit. Rev. Biochem. Mol. Biol. 27, 227-281.
8. Monod, J., Changeux, J.-P., Jacob, F. (1965) J. Mol. Biol. 12, 88-118.
9. Sprang, S.R., Acharya, K.R., Goldsmith, E.J., Stuart, D.I., Varvill, K., Fletterick, R.J., Madsen, N.B. and Johnson, L.N. (1988) Nature 336, 215-221.
10. Barford, D. and Johnson, L.N. (1989) Nature 340, 609-616.
11. Barford, D., Hu, S.H. and Johnson, L.N. (1991) J. Mol. Biol. 218, 233-260.
12. Sprang, S.R., Withers, S.G., Goldsmith, E.J., Fletterick, R.J. and Madsen, N.B. (1991) Science 254, 1367-1371.
13. Johnson, L.N., Hajdu, J., Acharya, K.R., Stuart, D.I., McLaughfin, P.J., Oikonomakos, N.G. and Barford, D. (1989) In Allosteric Enzymes (Herve, G., Ed.), pp. 81-127, CRC Press, Boca Raton, FL.
14. Johnson, L.N. (1992) FASEB J. 6, 2274-2282.
15. Oikonomakos, N.G., Acharya, K.R., Johnson, L.N. (1992) In Post-translational modification of proteins (Harding, J.J. and Crabbe, M.J.C., Eds.), pp, 81-151, CRC Press, Boca Raton, FL.
16. Oikonomakos, N.G., Skamnaki, V.T., Tsitsanou, K.E., Gavalas, N.G. and Johnson, L.N. (2000) Structure 8, 575-584.
17. Oikonomakos, N.G., Zographos, S.E., Skamnaki, V.T., Tsitsanou, K.E. and Johnson, L.N. (2000) J. Biol. Chem. 275, 34566-34573.
18. Rath, V.L., Ammirati, M., Danley, D.E., Ekstrom, J.L., Gibbs, E.M., Hynes, T.R., Mathiowetz, A.M., McPherson, R.K., Olson, T.V., Treadway, J.L. and Hoover, D.J. (2000) Chem. Biol. 7, 677-682.
19. Ainston, S., Hampson, L., Gomez-Foix, A.M., Guinovart, J.J. and Agius, L. (2001) J. Biol. Chem. 276, 23858-23866.
20. Somsćak, L., Kovács, L., Tóth, M., Ösz, E., Szilágyi, L., Györgydeák, Z., Dinya, Z., Docsa, T., Tóth, B. and Gergely, P. (2001) J. Med. Chem. 44, 2843-2848.
21. Treadway, J. L., Mendys, P. and Hoover, D.J. (2001) Exp. Opin. Invest. Drugs 10, 439-454.
22. Martin, J.L., Johnson, L.N. and Withers, S.G. (1990) Biochemistry 29, 10745-10757
23. Martin, J.L., Veluraja, K., Johnson, L.N., Fleet, G.W.J., Ramsden, N.G., Bruce, I., Oikonomakos, N.G., Papageorgiou, A.C., Leonidas, D.D. and Tsitoura, H.S. (1991) Biochemistry 30, 10101-10116.
24. Sprang, S.R., Goldsmith, E.J., Fletterick, R.J., Withers, S.G. and Madsen, N.B. (1982) Biochemistry 21, 5364-5371.
25. Vyas, N.K., Vyas, M.N. and Quiocho, F.A. (1988) Science 2429 1290-1295.
26. Quiochio, F.A. (1989) Pure Appl. Chem. 61, 1293-1306.
27. Barford, D., Schwabe, J.W.R., Oikonomakos, N.G., Acharya, K.R., Hajdu, J., Papageorgiou, A.C., Martin, J.L., Knott, J.C.A., Vasella, A. and Johnson, L.N. (1988) Biochemistry 27, 6733-6741.
28. Papageorgiou, A.C., Oikonomakos, N.G., Leonidas, D.D., Bernet, B., Beer, D. and Vasella, A. (1991) Biochem. J 274, 329-338.
29. Oikonomakos, N.G., Kontou, M., Zographos, S.E., Tsitoura, H.S., Johnson, L.N., Watson, K.A., Mitchell, E.P., Fleet, G.W.J., Son, J.C., Bichard, C.U., Leonidas, D.D. and Acharya, K.R. (1994) Eur. J. Drug. Metab. Pharmacokinet 19, 185-192.
30. Goodford, P.J. (1985) J. Med. Chem. 28, 849-857.
31. Rohrer, D.C., Sarko, A., Bluhm, T.L. and Lee, Y.N. (1980) Acta Crystallogr. B36, 650-654.
32. Watson, K.A., Mitchell, E.P., Johnson, L.N., Son, J.C., Bichard, C.J.F., Fleet, G.W.J., Ford, P., Watkin, D.J. and Oikonomakos, N.G. (1993) J. Chem. Soc. Chem. Commun., 654-656.
33. Johnson, L.N., Watson, K.A., Mitchell, E.P., Fleet, G.W.J., Son, J.C., Bichard, C.J.F., Oikonomakos, N.G., Papageorgiou, A.C. and Leonidas, D.D. (1994) In complex carbohydrates in drug research, Alfred Benzon Symposium 36, pp. 214-226, Editors: Klaus Bock, Henrik Clausen, Munksgaard, Copenhagen.
34. Dunitz, J.D. (1995) Chem. Biol. 2, 709-712.
35. Watson, KA., Mitchell, E.P., Johnson, L.N., Son, J.C., Bichard, C.J.F., Orchard, M.G., Fleet, G.W.J., Oikonomakos, N.G., Leonidas, D.D., Kontou, M. and Papageorgiou, A.C. (1994) Biochemistry 33, 5745-5758.
36. Oikonomakos, N.G., Kontou, M., Zographos, S.E., Watson, K.A., Johnson, L.N., Bichard, C.J.F., Fleet, G.W.J. and Acharya, K.R. (1995) Protein Sci. 4, 2469-2477.
37. Watson, K.A., Mitchell, E.P., Johnson, L.N., Cruciani, G, Son, J.C., Bichard, C.J.F., Fleet, G.W.J., Oikonomakos, N.G., Kontou, M. and Zographos, S.E. (1995) Acta Crystallogr. D51, 458-472.
38. Board, M., Hadwen, M. and Johnson, L.N. (1995) Eur. J. Biochem. 228, 753-761.
39. Board, M., Bollen, M., Stalmans, W., Kim, Y., Fleet, G.W.J. and Johnson, L.N. (1995) Biochem J. 311, 845-852.
40. Board, M. and Johnson, L.N. (1995) Diabetes Research 28, 95-109.
41. Board, M. (1997) Biochem. J. 3289 695-700.
42. Bleriot, Y., Smelt, K.H., Cadefau, J., Bollen, M., Stalmans, W., Biggadike, K., Johnson, L.N., Oikonomakos, N.G., Lane, A.L., Crook, S., Watkin, D.J. and Fleet, G.W.J. (1996) Tetrahedron Lett. 37, 7155-7158.
43. Mitchell, E.P., Watson, K.A., Bichard, C.J.F., Fleet, G.W.J., Zographos, S.E., Oikonomakos, N.G., Board, M. and Johnson, L.N. (1995) In Making the Most of your Model (Proceedings of the CCP4 Study Weekend, 6-7 January 1995 (Combiled by Hunter, W.N., Thornton, J.M. and Bailey, S.), CCL Daresbury Laboratory, pp. 111-119.
44. Fonne-Pfister, R., Chemla, P., Ward, E., Giradet, M., Kreuz, K.E., Honzatko, R.B., Fromm, H.J., Schar, H.-P., Grutter, M.G. and Cowan-Jacob, S.W. (1996) Proc. Natl. Acad. Sci. USA 93, 9431-9436.
45. Bichard, C.J.F., Mitchell, E.P., Wormald, M.R., Watson, K.A., Johnson, L.N., Zographos, S.E., Koutra, D.D., Oikonomakos, N.G. and Fleet, G.W.J. (1995) Tetrahedron Lett. 36, 2145-2148.
46. Krulle, T.M., Fuente, C., Watson, K.A., Gregoriou, M., Johnson, L.N., Tsitsanou, K.E., Zographos, S.E., Oikonomakos, N.G. and Fleet, G.W.J. (1997) Synlett. 1997, 211-213.
47. Gregoriou, M., Noble, M.E.M., Watson, K.A., Garman, E.F., Krulle, T.M., Fuente, C., Fleet, G.W.J., Oikonomakos, N.G. and Johnson, L.N. (1998) Protein Sci. 7, 915-927.
48. Fuente, C., Krulle, T.M., Watson, K.A., Gregoriou, M., Johnson, L.N., Tsitsanou, K.E., Zographos, S.E Oikonomakos, N.G. and Fleet, G.W.J. (1997) Synlett. 1997, 485-487.
49. Brandstetter, T.W., Fuente, C., Kim, Y.-H., Coope:, R.I., Watkin, D.J., Oikonomakos, N.G., Johnson, L.N. and Fleet, G.W.J. (1996) Tetrahedron 52, 10711-10720.
50. Brandstetter, T.W., Fuente, C., Kim, Y.-H, Johnson, L.N., Crook, S., Q. Lilley, P.M., Watkin, D.J., Tsitsanou, K.E., Zographos, S.E., Chrysina, E.D., Oikonomakos, N.G. and Fleet, G.W.J. (1996) Tetrahedron 52, 10721-10736.
51. Krulle, T.M., Watson, K.A., Gregoriou, M., Johnson, L.N., Crook, S., Watkin, D.J., Griffiths, R.C., Nasj, R.J., Tsitsanou, A.E., Zographos, S.E., Oikonomakos, N.G. and Fleet, G.W.J. (1995) Tetrahedron Lett. 36, 8291-8294.
52. Oikonomakos, N.G., Skamnaki, V.T., Ösz, E., Szilágyi, L., Somsák L., Docsa, T., Tóth, B. and Gergely, P. (2002) Bioorg. Med Chem. 10, 261-268.
53. Ösz, E., Somsák, L., Szilágyi, L., Kovács, L., Docsa, T., Tóth, B. and Gergely, P. (1999) Bioorg. Med. Chem. Lett. 9, 1383-1390.
54. Somsák, L. and Nagy, V. (2000) Tetrahedron Asymmetry 11, 1719-1729.
55. Somsák L., Nagy, V., Docsa, T., Tóth, B. and Gergely, P. (2000) Tetrahedron Asymmetry 11, 409-412.
56. Krulle, T.M., Fuente, C., Pickering, L., Aplin, R.T., Tsitsanou, K.E., Zographos, S.E., Oikonomakos, N.G., Nash, R.J., Griffiths, R.C. and Fleet, G.W.J. (1997) Tetrahedron Asymmetry. 8, 3807-3820.
57. Tsitsanou, K.E, Oikonomakos, N.G., Zographos, S.E., Skamnaki, V.T., Gregoriou, M., Watson, K.A., Johnson, L.N. and Fleet, G.W.J. (1999) Protein Sci. 8, 741-749.
58. Mitchell, E.P., Withers, S.G., Emert, P., Vasella, A.T., Garman, E.F., Oikonomakos, N.G. and Johnson, L.N. (1996) Biochemistry 35, 7341-7355.
59. Andersen, B., Rassov, A., Westergaard, N. and Lundgren, K. (1999) Biochem. J. 342, 545-550.
60. Fosgerau, K., Westergaard, N., Quistorff, B., Grunnet, N., Kristiansen, M. and Lungren, K. (2000) Arch. Biochem. Biophys. 15, 274-284.
61. Jacobsen, P., Lundbeck, J.M., Kristiansen, M., Breiholt, J., Demuth, H., Pawlas, J., Torres Candela, M.P. andersen, B., Westergaard, N., Lundgren, K. and Asano, N. (2001) Bioorg. Med. Chem. 9, 733-744.
62. Lillelund, V.H., Jensen, H.H., Liang, X. and Bols, M. (2002) Chem. Rev., in press.
63. Liu, H., Liang, X., Sohoel, H., Bullow, A. and Bols. M. (2001) J. Am. Chem. Soc. 123, 5116-5117.
64. Goldmann, S., Ahr, H.-J., Puls, W., Bischoff, H., Petzinna, D., Schlossmann, K. and Bender, J. (1988) US Patent 4, 786, 641 Bayer AG (Levrkusen, Germany), (1988).
65. Bergans, N., Stalmans, W., Goldmann, S. and Vanstapel, F. (2000) Diabetes 49, 1419-1426.
66. Zographos, S.E., Oikonomakos, N.G., Tsitsanou, K.E., Leonidas, D.D., Chrysina, E.D., Skamnaki, V.T., Bischoff, H., Goldman, S., Schram, M., Watson, K.A. and Johnson, L.N. (1997) Structure 5, 1413-1425.
67. Oikonomakos, N.G., Tsitsanou, K.E., Zographos, S.E., Skamnaki, V.T., Goldmann, S. and Bischoff, H. (1999) Protein Sci. 8, 1930-1945.
68. Tsitsanou, K.E., Skamnaki, V.T. and Oikonomakos, N.G. (2000) Arch. Biochem. Biophys. 384, 245-254.
69. Burley, S.K. and Petsko, G.A. (1988) Adv. Protein. Chem. 39, 125-189.
70. Battersby, M.K. and Radda, G.K. (1976) Biochemistry 18, 3774-3780.
71. Wang, J.H., Tu, J.I. and Lo, F.M. (1970) J. Biol. Chem. 245, 3115-3121.
72. Leonidas, D.D., Oikonomakos, N.G., Papageorgiou, A.C., Xenakis, A., Cazianis, C.T. and Bern, F. (1990) FEBS Lett. 261, 23-27.
73. Oikonomakos, N.G., Zographos, S.E., Johnson, L.N., Papageorgiou, A.C. and Acharya, K.R. (1995) J. Mol. Biol. 254, 900-917.
74. Melpidou, A.E. and Oikonomakos, N.G. (1983) FEBS Lett. 154, 105-110.
75. Johnson, L.N., Martin, L., Acharya, K.R., Barford, D. and Oikonomakos, N.G. (1993) J. Mol. Biol. 232, 253-267.
76. Sprang, S.R., Goldsmith, E. and Fletterick, R. (1987) Science 237, 1012-1019.
77. Sprang, S.R., Fletterick, R.J., Stern, M.J., Yang, D., Madsen, N.B. and Sturtevant, J.S. (1982) Biochemistry 21, 2036-2048.
78. Chebotareva, N., Klinov, S.V. and Kurganov, B.I. (2001) Biotechnology and Genetic Engineering Reviews 18, 265-297.
79. Kasvinsky, P.J., Shechosky, S. and Fletterick, R.J. (1978) J. Biol. Chem. 253, 9102-9106.
80. Kasvinsky, P.J., Fletterick, R.J. and Madsen, N.B. (1981) Can. J. Biochem. 59, 387-395.
81. Ercan-Fang, N. and Nuttall, F.Q. (1997) J. Pharmacol. Exp. Ther. 280, 1312-1318.
82. Soman, G. and Philip, G. (1975) Biochem. J. 147, 369-371.
83. Senderowicz, A. (1999) New Drugs 17, 313-320.
84. Chao, S.H., Fujinaga, K., Marion, J.E., Taube, R., Sausville, EA, Senderowicz, A.M., Peterlin, B.M. and Price, D.H. (2000) J. Biol. Chem. 275, 28345-28348.
85. Kaizer, A., Nishi, K, Gorin, F.A., Walsh, DA, Bradbury, E.M. and Schnier, J.B. (2001) Arch. Biochem. Biophys. 386, 179-187.
86. Lommerse, J.P.M., Stone, A.J., Taylor, R. and Allen, F.H. (1996) J. Am. Chem. Soc. 118, 3108-3116.
87. Hoover, D.J., Lefkowitz-Snow, S., Burgess-Henry, J.L., Martin, W.H., Armento, S.J., Stock, I.A., McPherson, R.K., Genereux, P.E., Gibbs, E.M. and Treadway, J.L. (1998) J. Med. Chem. 41, 2934-2938.
88. Martin, W.H., Hoover, D.J., Armento, S.J., Stock, I.A., McPherson, R.K., Danley, D.E., Stevenson, R.W., Barrett, E.J., Treadway, J.L. (1998) Proc. Mad. Acad. Sci. USA 95, 1776-1781.
89. Oikonomakos, N.G., Zographos, S.E., Skamnaki, V.T. and Archontis, G. (2002) Bioorg. Med. Chem. 10, 1313-1319.
90. Weiss, M.S., Brandl, M., Suhnel, J., Pal, D., Hilgenfeld, R. (2001) Trends Biochem. Sci. 26, 521-523.
91. Nishio, M., Umezawa, Y., Hirota, M. and Takeuchi, Y. (1995) Tetrahedron 51, 8665-8701.
92. Abraham, D.J., Wieko, F.C., Randad, R.S., Poyart, C., Kister, J., Bohn, B., Liard, J.-F., Kunert, M.P. (1992) Biochemistry 31, 9141-9149.
93. Perutz, M.F. (1997) Science is not a quiet life. Unravelling the Atomic Mechanism of Haemoglobin. Edited by Perutz MF, Imperial College Press, published by World Scientific Publishing Co. Pte. Ltd, Singapore, pp. 473-500.
94. Rath, V.L., Ammirati, M., LeMotte, P.K., Fennell, K.F., Mansour, M.N., Danley, D.E., Hynes, T.R., Schulte, G.K., Wasilko, D.J. and Pandit, J. (2000) Mol. Cell 6, 139-148.
95. Hudson, J.W., Golding, G.B. and Crerar, M.M. (1993) J. Mol. Biol. 234, 700-721.
96. Gruciani, G. and Watson, K.A. (1994) J. Med. Chem. 37, 2589-2601.
97. Pastor, M., Cruciani, G. and Watson, K.A. (1997) J. Med. Chem. 40, 4089-4102.
98. So, S.S. and Karplus, M. (1999) J. Comput. Aided Mol. Des. 13, 243-258.
99. Venkatarangan, P. and Hopfinger, A.J. (1999) J. Med. Chem. 42, 2169-2179.
100. So, S.S. and Karplus, M. (2001) J. Comput. Aided Mol. Des. 15, 613-647.
101. Nienaber, V.L., Richardson, P.L., Klighofer, V., Bouska, J.J., Giranda, V.L., Greer, J. (2000) Nature Biotechnology 18, 1105-1108.
102. Abagyan, R. and Totrov, M. (2001) Current Opinion in Chemical Biology 5, 375-382.
103. Weiss, M.S., Sicker, T. and Hilgenfeld, R. (2001) Structure 9, 771-777.
104. Rodrigues, A.D. and Lin, J.H. (2001) Current Opinion in Chemical Biology 5, 396-401.
105. Kafatos, F.C. (2001) Mol. Aspects Med. 22, 101-111.
106. Bailey, D. and Brown, D. (2001) Drug. Discov. Today 6, 57-59.