Discovering benzamide derivatives as glycogen phosphorylase inhibitors and their binding site at the enzyme

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 21, 2007, Pages 6763-6774

  Chen, Ling ^a   Li, Honglin ^a,b   Liu, Jun ^c   Zhang, Luyong ^c   Liu, Hong ^a   Jiang, Hualiang ^a,d  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b DALIAN UNIVERSITY OF TECHNOLOGY   (China)

^c CHINA PHARMACEUTICAL UNIVERSITY   (China)

^d EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Binding site; Glycogen phosphorylase (GP) inhibitors; Molecular docking; Structure based pharmacophore

Indexed keywords

2 AMINO 4 FLUORO 5 (1 METHYL 1H IMIDAZOL 2 YLTHIO) N 4 TOLYLBENZAMIDE; 2 AMINO 4 FLUORO 5 (1 METHYL 1H IMIDAZOL 2 YLTHIO) N [3 (TRIFLUOROMETHYL)PHENYL]BENZAMIDE; 2 AMINO 4 FLUORO 5 (1 METHYL 1H IMIDAZOL 2 YLTHIO) N PHENYLBENZAMIDE; 2 AMINO 4 FLUORO N (2 METHOXYPHENYL) 5 (1 METHYL 1H IMIDAZOL 2 YLTHIO)BENZAMIDE; 2 AMINO 4 FLUORO N (3 FLUOROPHENYL) 5 (1 METHYL 1H IMIDAZOL 2 YLTHIO)BENZAMIDE; 2 AMINO 4 FLUORO N (3 METHOXYPHENYL) 5 (1 METHYL 1H IMIDAZOL 2 YLTHIO)BENZAMIDE; 2 AMINO 4 FLUORO N (4 METHOXYPHENYL) 5 (1 METHYL 1H IMIDAZOL 2 YLTHIO)BENZAMIDE; 2 AMINO N (2 AMINOPHENYL) 4 FLUORO 5 (1 METHYL 1H IMIDAZOL 2 YLTHIO)BENZAMIDE; 2 AMINO N (2 CYANOPHENYL) 4 FLUORO 5 (1 METHYL 1H IMIDAZOL 2 YLTHIO)BENZAMIDE; 2 AMINO N (2,6 DIFLUOROPHENYL) 4 FLUORO 5 (1 METHYL 1H IMIDAZOL 2 YLTHIO)BENZAMIDE; 2 AMINO N (3 AMINOPHENYL) 4 FLUORO 5 (1 METHYL 1H IMIDAZOL 2 YLTHIO)BENZAMIDE; 2 AMINO N (3 CYANOPHENYL) 4 FLUORO 5 (1 METHYL 1H IMIDAZOL 2 YLTHIO)BENZAMIDE; 2 AMINO N (4 AMINOPHENYL) 4 FLUORO 5 (1 METHYL 1H IMIDAZOL 2 YLTHIO)BENZAMIDE; 2 AMINO N (4 CYANOPHENYL) 4 FLUORO 5 (1 METHYL 1H IMIDAZOL 2 YLTHIO)BENZAMIDE; 2 AMINO N BENZYL 4 FLUORO 5 (1 METHYL 1H IMIDAZOL 2 YLTHIO)BENZAMIDE; BENZAMIDE DERIVATIVE; GLUCOSE 1 PHOSPHATE; GLYCOGEN PHOSPHORYLASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME BINDING; GLYCOGEN SYNTHESIS; MOLECULAR DOCKING; NONHUMAN; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZAMIDES; BINDING SITES; DRUG DESIGN; ENZYME INHIBITORS; GLYCOGEN PHOSPHORYLASE; IMIDAZOLES; INHIBITORY CONCENTRATION 50; MUSCLE, SKELETAL; PROTEIN CONFORMATION; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

ORYCTOLAGUS CUNICULUS;

EID: 34548575720     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.08.003     Document Type: Article

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