In vitro inhibition of cytochrome P450 enzymes in human liver microsomes by a potent CYP2A6 inhibitor, trans-2-phenylcyclopropylamine (tranylcypromine), and its nonamine analog, cyclopropylbenzene

Drug Metabolism and Disposition

Volumn 29, Issue 3, 2001, Pages 217-222

  Taavitsainen, P ^a   Juvonen, R ^a   Pelkonen, O ^a  

^a UNIVERSITY OF OULU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPROPYLBENZENE; MONOAMINE DERIVATIVE; TRANYLCYPROMINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CATALYSIS; DRUG EFFECT; DRUG POTENCY; ENZYME INHIBITION; ENZYME METABOLISM; ENZYME SPECIFICITY; HUMAN; HUMAN TISSUE; HYDROXYLATION; LIVER MICROSOME; PRIORITY JOURNAL; RECEPTOR BINDING; STRUCTURE ANALYSIS;

ARYL HYDROCARBON HYDROXYLASES; BENZENE DERIVATIVES; BINDING SITES; CHLORZOXAZONE; COUMARINS; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; INHIBITORY CONCENTRATION 50; ISOENZYMES; KINETICS; METHOXSALEN; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; MOLECULAR STRUCTURE; MONOTERPENES; SPECTROPHOTOMETRY; TERPENES; TRANYLCYPROMINE;

EID: 0035119491     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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