Assessment of rat liver slices as a suitable model system for studying the simultaneous sulphation and glucuronidation of phenolic xenobiotics

Xenobiotica

Volumn 27, Issue 4, 1997, Pages 369-378

  Oddy, E A ^a,b   Manchee, G R ^b   Coughtrie, M W H ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 NAPHTHOL; PHENOL DERIVATIVE; XENOBIOTIC AGENT;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GLUCURONIDATION; KINETICS; LIVER CYTOSOL; LIVER SLICE; MALE; METABOLITE; MODEL; NONHUMAN; RAT; SULFATION; XENOBIOTIC METABOLISM;

ANIMALIA; MAMMALIA;

EID: 0030904118     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/004982597240523     Document Type: Article

References (26)

1. BAYLISS, M. K., 1991, Comparative evaluation of the drug metabolising activity of rat, dog and human hepatocytes using two model substrates and loxtidine. PhD thesis University of Hertfordshire.
2. BRAY, H. G., HUMPHRIS, B. G., THORPE, W. V., WHITE, K. and WOOD, P. B., 1952, Kinetic studies of the metabolism of foreign organic compounds. The conjugation of phenols with sulphuric acid. Biochemical Journal, 52, 419.
3. BURCHELL, B. and COUGHTRIE, M. W. H., 1989, UDP-glucuronosyltransferases. Pharmacology and Therapeutics, 43, 261-289.
4. 14C] phenol in various species. Xenobiotica, 2, 25-34.
5. CAPEL, I. D., MILLBURN, P. and WILLIAMS, R. T., 1974, The conjugation of 1- and 2-naphthols and other phenols in the cat and pig. Xenobiotica, 4, 601-615.
6. CONWAY, J. G., KAUFFMAM, F. C., JI, S. and THURMAN, R. G., 1982a, Rates of sulfation and glucuronidation of 7-hydroxycoumarin in periportal and pericentral regions of the liver lobule. Molecular Pharmacology, 22, 509-516.
7. CONWAY, J. G., KAUFFMAN, F. C., TSUKAD, T. and THURMAN, R. G., 1982b, Glucuronidation of 7-hydroxycoumarin in periportal and pericentral regions of the liver lobule. Molecular Pharmacology, 25, 487-493.
8. COUGHTRIE, M. W. H., 1996, Sulphation catalysed by the human cytosolic sulphotransferases - chemical defence or molecular terrorism? Human and Experimental Toxicology, 15, 547-555.
9. COUGHTRIE, M. W. H. and SHARP, S., 1990, Purification and immunochemical characterization of a rat liver sulfotransferase conjugating paracetamol. Biochemical Pharmacology, 40, 2305-2313.
10. HIRSHEY, S. J. and FALANY, C. N., 1990, Purification and characterization of rat liver minoxidil sulphotransferase. Biochemical Journal, 270, 721-728.
11. JAKOBY, W. B., SEKURA, R. D., LYON, E. S., MARCUS, C. J. and WANG, J.-L., 1980, Sulfotransferases. In Enzymatic Basis of Detoxification, edited by W. B. Jakoby (New York: Academic), pp. 199-228.
12. KAUFFMAN, F. C., WHITTAKER, M., ANUNDI, I. and THURMAN, R. G., 1991, Futile cycling of a sulfate conjugate by isolated hepatocytes. Molecular Pharmacology, 39, 414-420.
13. KOSTER, H., HALSEMA, I., SCHOLTENS, E., KNIPPERS, M. and MULDER, G. J., 1981, Dose-dependent shifts in the sulfation and glucuronidation of phenolic compounds in the rat in vivo and in isolated hepatocytes. Biochemical Pharmacology, 30, 2569-2575.
14. KRUMDIECK, C. L., DOS SANTOS, J. E. and HO, K. J., 1980, A new instrument for the rapid preparation of tissue slices. Analytical Biochemistry, 104, 118-123.
15. LOWRY, O. H., ROSEBROUGH, N. J., FARR, A. L. and RANDALL, R. J., 1951, Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry, 193, 265-275.
16. MEERMAN, J. H. N., NIJLAND, C. and MULDER, G. J., 1987, Sex differences in sulfation and glucuronidation of phenol, 4-nitrophenol and N-hydroxy-2-acetylaminofluorene in the rat in vivo. Biochemical Pharmacology, 36, 2605-2608.
17. MEHTA, R., HIROM, P. C. and MILLBURN, P., 1978, The influence of dose on the pattern of conjugation of phenol and 1-naphthol in non-human primates. Xenobiotica, 8, 445-452.
18. MULDER, G. J. and JAKOBY, W. B., 1990, Sulfation. In Conjugation Reactions in Drug Metabolism, edited by G. J. Mulder (London: Taylor & Francis), pp. 107-161.
19. NAGATA, K., OZAWA, S., MIYATA, M., SHIMADA, M., GONG, D.-W., YAMAZOE, Y. and KATO, R., 1993, Isolation and expression of a cDNA encoding a male-specific rat sulfotransferase that catalyzes activation of N-hydroxy-2-acetylaminofluorene. Journal of Biological Chemistry, 268, 24720-24725.
20. PANG, K. S., KOSTER, H., HALSEMA, I. C. M., SCHOLTENS, E., MULDER, G. J. and STILLWELL, R. N., 1981, Normal and retrograde perfusion to probe the zonal distribution of sulfation and glucuronidation activities of harmol in the perfused rat liver preparation. Journal of Pharmacology and Experimental Therapeutics, 224, 647-653.
21. RAPPAPORT, A. M., BOROWY, Z. J., LOUGHEED, W. M. and LOTTO, W. N., 1954, Subdivision of hexagonal liver lobules into a structural and functional unit. Role in hepatic physiology and pathology. Anatomical Research, 119, 11-27.
22. SCHWENK, M. and LOCHER, M., 1985, 1-naphthol conjugation in isolated cells from liver, jejunum, colon and kidney of the guinea pig. Biochemical Pharmacology, 34, 697-701.
23. SMITH, P. F., KRACK, G., MCKEE, R. L., JOHNSON, D. G., GANDOLFI, A. J., HRUBY, V. J., KRUMDIECK, C. L. and BRENDEL, K., 1986, Maintenance of adult rat liver slices in dynamic organ culture. In vitro Cell and Developmental Biology, 22, 706-712.
24. TOSH, D., BORTHWICK, E. B., SHARP, S., BURCHELL, A., BURCHELL, B. and COUGHTRIE, M. W. H., 1996, Heterogeneous expression of sulfotransferases in periportal and perivenous hepatocytes prepared from male and female rat liver. Biochemical Pharmacology, 51, 369-374.
25. WEINSHILBOUM, R. and OTTERNESS, D., 1994, Sulfotransferase enzymes. In Conjugation-Deconjugation Reactions in Drug Metabolism and Toxicity, edited by F. C. Kauffman (Berlin: Springer), pp. 45-78.
26. WEITERING, J. G., KRIJGSHELD, K. R. and MULDER, G. J., 1979, The availability of inorganic sulphate as a rate limiting factor in the sulphate conjugation of xenobiotics in the rat? Biochemical Pharmacology, 28, 757-762.