Rates of metabolism of chlorzoxazone, dextromethorphan, 7-ethoxycoumarin, imipramine, quinidine, testosterone and verapamil by fresh and cryopreserved rat liver slices, and some comparisons with microsomes

Toxicology in Vitro

Volumn 17, Issue 4, 2003, Pages 481-488

  Axelsson, H ^a   Granhall, C ^a   Floby, E ^a   Jaksch, Y ^a   Svedling, M ^a   Sohlenius Sternbeck, A K ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

Cryopreservation; Cytochrome P450; Drug metabolising activities; Intrinsic clearance; Liver slices; Metabolic stability; Microsomes; Rat

Indexed keywords

7 ETHOXYCOUMARIN; CHLORZOXAZONE; CYTOCHROME P450 ISOENZYME; DEXTROMETHORPHAN; IMIPRAMINE; ISOFLURANE; QUINIDINE; TESTOSTERONE; VERAPAMIL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CRYOPRESERVATION; DOSE TIME EFFECT RELATION; DRUG ACTIVITY; DRUG CLEARANCE; DRUG METABOLISM; ENZYME SUBSTRATE; LIVER MICROSOME; LIVER SLICE; MALE; NONHUMAN; RAT;

EID: 0038094384     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-2333(03)00049-3     Document Type: Article

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