The role of cytochrome-P450 inhibitors in the prevention of hepatotoxicity after paracetamol overdose in rats

Human and Experimental Toxicology

Volumn 23, Issue 1, 2004, Pages 49-54

  Walubo, A ^a   Barr, S ^a   Abraham, A M ^a   Coetsee, C ^a  

^a UNIVERSITY OF THE FREE STATE   (South Africa)

Author keywords

CYP1A; CYP2E1; CYP3A; Enzyme inhibitors; Hepatotoxicity; KIC solution; Paracetamol

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CAFFEINE; CYTOCHROME P450 1A2; CYTOCHROME P450 2A1; CYTOCHROME P450 3A; CYTOCHROME P450 INHIBITOR; ENZYME INHIBITOR; ISONIAZID; KETOCONAZOLE; PARACETAMOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG OVERDOSE; DRUG RESEARCH; DRUG SAFETY; FLUORESCENCE POLARIZATION IMMUNOASSAY; HISTOPATHOLOGY; LIVER FUNCTION TEST; LIVER TOXICITY; MALE; NECROSIS; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; HEPATITIS, TOXIC; ISONIAZID; KETOCONAZOLE; MALE; OVERDOSE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 1342284954     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1191/0960327104ht415oa     Document Type: Article

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