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Volumn 11, Issue 10, 2011, Pages 857-880

Immunoadjuvant and anti-inflammatory plant saponins: Characteristics and biotechnological approaches towards sustainable production

Author keywords

Anti inflammatory; Cell culture; Immunoadjuvant; Metabolic engineering; Plant; Production; Saponin

Indexed keywords

2'' O ACETYL POLYGALACIN D; ALPHA HEDERIN; ANTIINFLAMMATORY AGENT; ARJUNGENIN; ARJUNGLUCOSIDE I; BALANIN B1; BALANIN B2; BIDESMOSIDE DERIVATIVE; COMBREGENIN; COMBREGLUCOSIDE; CORTICOSTERONE; DEXAMETHASONE; ESCIN; FLORIBUNDASAPONIN A; GINSENOSIDE RG 3; GINSENOSIDE RH 2; HEDERACOLCHISIDE E; HEDERACOLCHISIDE F; HEDERASAPONIN C; IMMUNOLOGICAL ADJUVANT; MANNIOSIDE A; PLATYCODIN; SAIKOSAPONIN A; SAIKOSAPONIN D; SAPONIN; SOYASAPONIN I; SPIROCONAZOLE A; UNCLASSIFIED DRUG; UNINDEXED DRUG; VERBASCOSAPONIN; VERBASCOSAPONIN A;

EID: 79961005165     PISSN: 13895575     EISSN: 18755607     Source Type: Journal    
DOI: 10.2174/138955711796575470     Document Type: Article
Times cited : (38)

References (207)
  • 2
    • 77955428907 scopus 로고    scopus 로고
    • Production of plant bioactive triterpenoid saponins: Elicitation strategies and target genes to improve yields
    • Yendo, A.C.A.; Costa, F.; Gosmann, G.; Fett-Neto, A.G. Production of plant bioactive triterpenoid saponins: elicitation strategies and target genes to improve yields. Mol. Biotechnol., 2010, 46, 94-104.
    • (2010) Mol. Biotechnol , vol.46 , pp. 94-104
    • Yendo, A.C.A.1    Costa, F.2    Gosmann, G.3    Fett-Neto, A.G.4
  • 5
    • 72049112027 scopus 로고    scopus 로고
    • The need for new vaccines
    • Taylor, K.; Nguyen, A.; Stéphenne, J. The need for new vaccines. Vaccine, 2009, 27 S6, G3-G8.
    • (2009) Vaccine , vol.27 , Issue.6 , pp. 3-8
    • Taylor, K.1    Nguyen, A.2    Stéphenne, J.3
  • 6
    • 77952547186 scopus 로고    scopus 로고
    • Molecular mechanism of endothelial nitric-oxide synthase activation by Platycodon grandiflorum root-derived saponins
    • Kim, H.G.; Hien, T.T.; Han, E.H.; Chung, Y.C.; Jeong, H.G. Molecular mechanism of endothelial nitric-oxide synthase activation by Platycodon grandiflorum root-derived saponins. Toxicol. Lett., 2010, 195, 106-113.
    • (2010) Toxicol. Lett , vol.195 , pp. 106-113
    • Kim, H.G.1    Hien, T.T.2    Han, E.H.3    Chung, Y.C.4    Jeong, H.G.5
  • 7
    • 79951722038 scopus 로고    scopus 로고
    • Escin exerts synergistic anti-inflammatory effects with low doses of glucocorticoids in vivo and in vitro
    • Xin, W.; Zhang, L.; Sun, F.; Jiang, N.; Fan, H.; Wang, T.; Li, Z.; He, J.; Fu, F. Escin exerts synergistic anti-inflammatory effects with low doses of glucocorticoids in vivo and in vitro. Phytomedicine, 2011, 18, 272-277.
    • (2011) Phytomedicine , vol.18 , pp. 272-277
    • Xin, W.1    Zhang, L.2    Sun, F.3    Jiang, N.4    Fan, H.5    Wang, T.6    Li, Z.7    He, J.8    Fu, F.9
  • 8
    • 77950914748 scopus 로고    scopus 로고
    • Red ginseng saponin extract attenuates murine collagen-induced arthritis by reducing pro-inflammatory responses and matrix metalloproteinase-3 expression
    • Kim, K.R.; Chung, T.Y.; Shin, H.; Son, S.H.; Park, K.K.; Choi, J.H.; Chung, W.Y. Red ginseng saponin extract attenuates murine collagen-induced arthritis by reducing pro-inflammatory responses and matrix metalloproteinase-3 expression. Biol. Pharm. Bull., 2010, 33, 604-610.
    • (2010) Biol. Pharm. Bull , vol.33 , pp. 604-610
    • Kim, K.R.1    Chung, T.Y.2    Shin, H.3    Son, S.H.4    Park, K.K.5    Choi, J.H.6    Chung, W.Y.7
  • 9
    • 33846257261 scopus 로고    scopus 로고
    • Chronic inflammation: Importance of NOD2 and NALP3 in interleukin- 1β generation
    • Ferrero-Miliani, L.; Nielsen, O.H.; Andersen, P.S.; Girardin, S.E. Chronic inflammation: importance of NOD2 and NALP3 in interleukin- 1β generation. Clin. Exp. Immunol., 2007, 47, 227-235.
    • (2007) Clin. Exp. Immunol , vol.47 , pp. 227-235
    • Ferrero-Miliani, L.1    Nielsen, O.H.2    Andersen, P.S.3    Girardin, S.E.4
  • 10
    • 0033620677 scopus 로고    scopus 로고
    • Role and regulation of cyclooxygenase-2 during inflammation
    • Simon, L.S. Role and regulation of cyclooxygenase-2 during inflammation. Am. J. Med., 1999, 106 (5), 37S-42S.
    • (1999) Am. J. Med , vol.106 , Issue.5
    • Simon, L.S.1
  • 11
    • 0030871687 scopus 로고    scopus 로고
    • COX-1 and COX-2 tissue expression: Implications and predictions
    • Crofford, L.J. COX-1 and COX-2 tissue expression: implications and predictions. J. Rheumatol. Suppl., 1997, 49, 15-19.
    • (1997) J. Rheumatol. Suppl , vol.49 , pp. 15-19
    • Crofford, L.J.1
  • 13
    • 33847142871 scopus 로고    scopus 로고
    • Steroidal saponins from Smilax china and their anti-inflammatory activities
    • Shao, B.; Guo, H.; Cui, Y.; Ye, M.; Han, J.; Guo, D. Steroidal saponins from Smilax china and their anti-inflammatory activities. Phytochemistry, 2007, 68, 623-630.
    • (2007) Phytochemistry , vol.68 , pp. 623-630
    • Shao, B.1    Guo, H.2    Cui, Y.3    Ye, M.4    Han, J.5    Guo, D.6
  • 14
    • 77649098135 scopus 로고    scopus 로고
    • Triterpene glycosides with in vitro anti-inflammatory activity from Cyclamen repandum tubers
    • Dall'acqua, S.; Castagliuolo, I.; Brun, P.; Ditadi, F.; Palu, G.; Innocenti, G. Triterpene glycosides with in vitro anti-inflammatory activity from Cyclamen repandum tubers. Carbohydr. Res., 2010, 345, 709-714.
    • (2010) Carbohydr. Res , vol.345 , pp. 709-714
    • Dall'acqua, S.1    Castagliuolo, I.2    Brun, P.3    Ditadi, F.4    Palu, G.5    Innocenti, G.6
  • 16
    • 41949104170 scopus 로고    scopus 로고
    • Anti-inflammatory activities of triterpenoid saponins from Polygala japonica
    • Wang, H.; Gao, J.; Kou, J.; Zhu, D.; Yu, B. Anti-inflammatory activities of triterpenoid saponins from Polygala japonica. Phytomedicine, 2008, 15, 321-326.
    • (2008) Phytomedicine , vol.15 , pp. 321-326
    • Wang, H.1    Gao, J.2    Kou, J.3    Zhu, D.4    Yu, B.5
  • 17
    • 77954948762 scopus 로고    scopus 로고
    • Triterpene Saponins from Clematis chinensis and Their Potential Anti-inflammatory Activity
    • Fu, Q.; Zan, K.; Zhao, M.; Zhou, S.; Shi, S.; Jiang, Y.; Tu, P. Triterpene Saponins from Clematis chinensis and Their Potential Anti-inflammatory Activity. J. Nat. Prod., 2010, 73, 1234-1239.
    • (2010) J. Nat. Prod , vol.73 , pp. 1234-1239
    • Fu, Q.1    Zan, K.2    Zhao, M.3    Zhou, S.4    Shi, S.5    Jiang, Y.6    Tu, P.7
  • 18
    • 19944367912 scopus 로고    scopus 로고
    • Acute anti-inflammatory activity of four saponins isolated from ivy: Alpha- hederin, hederasaponin-C, hederacolchiside-E and hederacolchiside- F in carrageenan-induced rat paw edema
    • Gepdiremen, A.; Mshvildadze, V.; Suleyman, H.; Elias, R. Acute anti-inflammatory activity of four saponins isolated from ivy: alpha- hederin, hederasaponin-C, hederacolchiside-E and hederacolchiside- F in carrageenan-induced rat paw edema. Phytomedicine, 2005, 12, 440-444.
    • (2005) Phytomedicine , vol.12 , pp. 440-444
    • Gepdiremen, A.1    Mshvildadze, V.2    Suleyman, H.3    Elias, R.4
  • 19
    • 33646153527 scopus 로고    scopus 로고
    • Inhibitory effect of the saponins derived from roots of Platycodon grandiflorum on carrageenan-induced inflammation
    • Kim, J.Y.; Hwang, Y.P.; Kim, D.H.; Han, E.H.; Chung, Y.C.; Roh, S.H.; Jeong, H.G. Inhibitory effect of the saponins derived from roots of Platycodon grandiflorum on carrageenan-induced inflammation. Biosci. Biotechnol. Biochem., 2006, 70, 858-864.
    • (2006) Biosci. Biotechnol. Biochem , vol.70 , pp. 858-864
    • Kim, J.Y.1    Hwang, Y.P.2    Kim, D.H.3    Han, E.H.4    Chung, Y.C.5    Roh, S.H.6    Jeong, H.G.7
  • 20
    • 29044450102 scopus 로고    scopus 로고
    • Inhibition of tumor necrosis factor-alpha-induced expression of adhesion molecules in human endothelial cells by the saponins derived from roots of Platycodon grandiflorum
    • Kim, J.Y.; Kim, D.H.; Kim, H.G.; Song, G.Y.; Chung, Y.C.; Roh, S.H.; Jeong, H.G. Inhibition of tumor necrosis factor-alpha-induced expression of adhesion molecules in human endothelial cells by the saponins derived from roots of Platycodon grandiflorum. Toxicol. Appl. Pharmacol., 2006, 210, 150-156.
    • (2006) Toxicol. Appl. Pharmacol , vol.210 , pp. 150-156
    • Kim, J.Y.1    Kim, D.H.2    Kim, H.G.3    Song, G.Y.4    Chung, Y.C.5    Roh, S.H.6    Jeong, H.G.7
  • 21
    • 27744529165 scopus 로고    scopus 로고
    • Soybean saponins suppress the release of proinflammatory mediators by LPS-stimulated peritoneal macrophages
    • Kang, J.H.; Sung, M.K.; Kawada, T.; Yoo, H.; Kim, Y.K.; Kim, J.S.; Yu, R. Soybean saponins suppress the release of proinflammatory mediators by LPS-stimulated peritoneal macrophages. Cancer Lett., 2005, 230, 219-227.
    • (2005) Cancer Lett , vol.230 , pp. 219-227
    • Kang, J.H.1    Sung, M.K.2    Kawada, T.3    Yoo, H.4    Kim, Y.K.5    Kim, J.S.6    Yu, R.7
  • 23
    • 70349182370 scopus 로고    scopus 로고
    • Anti-inflammatory effects of ginsenosides from Panax ginseng and their structural analogs
    • Park, J.; Cho, J.Y. Anti-inflammatory effects of ginsenosides from Panax ginseng and their structural analogs. Afr. J. Biotechnol., 2009, 8, 3682-3690.
    • (2009) Afr. J. Biotechnol , vol.8 , pp. 3682-3690
    • Park, J.1    Cho, J.Y.2
  • 24
    • 77953307436 scopus 로고    scopus 로고
    • Pharmacology of ginsenosides: A literature review
    • Leung, K.W.; Wong, A.ST. Pharmacology of ginsenosides: a literature review. Chin. Med., 2010, 5, 20-27.
    • (2010) Chin. Med , vol.5 , pp. 20-27
    • Leung, K.W.1    Wong, A.S.T.2
  • 26
    • 14644424029 scopus 로고    scopus 로고
    • Inhibition of inducible nitric oxide synthase and cyclooxygenase II by Platycodon grandiflorum saponins via suppression of nuclear factor-kappaB activation in RAW 264.7 cells
    • Ahn, K.S.; Noh, E.J.; Zhao, H.L.; Jung, S.H.; Kang, S.S.; Kim, Y.S. Inhibition of inducible nitric oxide synthase and cyclooxygenase II by Platycodon grandiflorum saponins via suppression of nuclear factor-kappaB activation in RAW 264.7 cells. Life Sci., 2005, 76, 2315-2318.
    • (2005) Life Sci , vol.76 , pp. 2315-2318
    • Ahn, K.S.1    Noh, E.J.2    Zhao, H.L.3    Jung, S.H.4    Kang, S.S.5    Kim, Y.S.6
  • 27
    • 58249095044 scopus 로고    scopus 로고
    • Compositional analysis of major saponins and anti-inflammatory activity of steam-processed Platycodi Radix under pressure
    • Ha, I.J.; Chung, J.W.; Ha, Y.W.; Shin, E.M.; Kim, Y.S. Compositional analysis of major saponins and anti-inflammatory activity of steam-processed Platycodi Radix under pressure. Nat. Prod. Sci., 2008, 14, 274-280.
    • (2008) Nat. Prod. Sci , vol.14 , pp. 274-280
    • Ha, I.J.1    Chung, J.W.2    Ha, Y.W.3    Shin, E.M.4    Kim, Y.S.5
  • 28
    • 70549111637 scopus 로고    scopus 로고
    • Effects of escin on acute inflammation and the immune system in mice
    • Wang, T.; Fu, F.; Zhang, L.; Han, B.; Zhu, M.; Zhang, X. Effects of escin on acute inflammation and the immune system in mice. Pharmacol. Rep., 2009, 61, 697-704.
    • (2009) Pharmacol. Rep , vol.61 , pp. 697-704
    • Wang, T.1    Fu, F.2    Zhang, L.3    Han, B.4    Zhu, M.5    Zhang, X.6
  • 29
    • 33846804159 scopus 로고    scopus 로고
    • Inhibitory effects of saikosaponin-d on CCl4-induced hepatic fibrogenesis in rats
    • Dang, S.S.; Wang, B.F.; Cheng, Y.A.; Song, P.; Liu, Z.G.; Li, Z.F. Inhibitory effects of saikosaponin-d on CCl4-induced hepatic fibrogenesis in rats. World J. Gastroenterol., 2007, 13, 557-563.
    • (2007) World J. Gastroenterol , vol.13 , pp. 557-563
    • Dang, S.S.1    Wang, B.F.2    Cheng, Y.A.3    Song, P.4    Liu, Z.G.5    Li, Z.F.6
  • 30
    • 77951219887 scopus 로고    scopus 로고
    • Curcumin and saikosaponin a inhibit chemical-induced liver inflammation and fibrosis in rats
    • Wu, S.J.; Tam, K.W.; Tsai, Y.H.; Chang, C.C.; Chao, J.C. Curcumin and saikosaponin a inhibit chemical-induced liver inflammation and fibrosis in rats. Am. J. Chin. Med., 2010, 38, 99-111.
    • (2010) Am. J. Chin. Med , vol.38 , pp. 99-111
    • Wu, S.J.1    Tam, K.W.2    Tsai, Y.H.3    Chang, C.C.4    Chao, J.C.5
  • 31
    • 41649108407 scopus 로고    scopus 로고
    • Antiinflammatory and analgesic activities of flavonoid and saponin fractions from Zizyphus lotus (L.) Lam
    • Borgi, W.; Recio, M.C.; Rios, J.L.; Chouchane, N. Antiinflammatory and analgesic activities of flavonoid and saponin fractions from Zizyphus lotus (L.) Lam. S. Afr. J. Bot., 2008, 74, 320-324.
    • (2008) S. Afr. J. Bot , vol.74 , pp. 320-324
    • Borgi, W.1    Recio, M.C.2    Rios, J.L.3    Chouchane, N.4
  • 32
    • 50649083057 scopus 로고    scopus 로고
    • Panax notoginseng saponins attenuate atherosclerosis in rats by regulating the blood lipid profile and an anti-inflammatory action
    • Zhang, Y.G.; Zhang, H.G.; Zhang, G.Y.; Fan, J.S.; Li, X.H.; Liu, Y.H.; Li, S.H.; Lian, X.M.; Tang, Z. Panax notoginseng saponins attenuate atherosclerosis in rats by regulating the blood lipid profile and an anti-inflammatory action. Clin. Exp. Pharmacol. Physiol., 2008, 35, 1238-1244.
    • (2008) Clin. Exp. Pharmacol. Physiol , vol.35 , pp. 1238-1244
    • Zhang, Y.G.1    Zhang, H.G.2    Zhang, G.Y.3    Fan, J.S.4    Li, X.H.5    Liu, Y.H.6    Li, S.H.7    Lian, X.M.8    Tang, Z.9
  • 33
    • 0035051648 scopus 로고    scopus 로고
    • In vitro inhibitory effect of protopanaxadiol ginsenosides on tumor necrosis factor (TNF)-alpha production and its modulation by known TNFalpha antagonists
    • Cho, J.Y.; Yoo, E.S.; Baik, K.U.; Park, M.H.; Han, B.H. In vitro inhibitory effect of protopanaxadiol ginsenosides on tumor necrosis factor (TNF)-alpha production and its modulation by known TNFalpha antagonists. Planta Med., 2001, 67, 213-218.
    • (2001) Planta Med , vol.67 , pp. 213-218
    • Cho, J.Y.1    Yoo, E.S.2    Baik, K.U.3    Park, M.H.4    Han, B.H.5
  • 34
    • 0037293063 scopus 로고    scopus 로고
    • Inhibitory effects of the ginsenoside Rg3 on phorbol ester-induced cyclooxygenase-2 expression, NF-kappaB activation and tumor promotion
    • Keum, Y.S.; Han, S.S.; Chun, K.S.; Park, K.K.; Park, J.H.; Lee, S.K.; Surh, Y.J. Inhibitory effects of the ginsenoside Rg3 on phorbol ester-induced cyclooxygenase-2 expression, NF-kappaB activation and tumor promotion. Mutat. Res., 2003, 523-524, 75-85.
    • (2003) Mutat. Res
    • Keum, Y.S.1    Han, S.S.2    Chun, K.S.3    Park, K.K.4    Park, J.H.5    Lee, S.K.6    Surh, Y.J.7
  • 36
    • 33745683962 scopus 로고    scopus 로고
    • Ginsenosides Rg3 and Rh2 inhibit the activation of AP-1 and protein kinase A pathway in lipopolysaccharide/interferon-gammastimulated BV-2 microglial cells
    • Bae, E.A.; Kim, E.J.; Park, J.S.; Kim, H.S.; Ryu, J.H.; Kim, D.H. Ginsenosides Rg3 and Rh2 inhibit the activation of AP-1 and protein kinase A pathway in lipopolysaccharide/interferon-gammastimulated BV-2 microglial cells. Planta Med., 2006, 72, 627-633.
    • (2006) Planta Med , vol.72 , pp. 627-633
    • Bae, E.A.1    Kim, E.J.2    Park, J.S.3    Kim, H.S.4    Ryu, J.H.5    Kim, D.H.6
  • 39
    • 67349235535 scopus 로고    scopus 로고
    • Anti-inflammatory effect of anemarsaponin B isolated from the rhizomes of Anemarrhena asphodeloides in LPS-induced RAW 264.7 macrophages is mediated by negative regulation of the nuclear factor-kappaB and p38 pathways
    • Kim, J.Y.; Shin, J.S.; Ryu, J.H.; Kim, S.Y.; Cho, Y.W.; Choi, J.H.; Lee, K.T. Anti-inflammatory effect of anemarsaponin B isolated from the rhizomes of Anemarrhena asphodeloides in LPS-induced RAW 264.7 macrophages is mediated by negative regulation of the nuclear factor-kappaB and p38 pathways. Food. Chem. Toxicol., 2009, 47, 1610-1617.
    • (2009) Food. Chem. Toxicol , vol.47 , pp. 1610-1617
    • Kim, J.Y.1    Shin, J.S.2    Ryu, J.H.3    Kim, S.Y.4    Cho, Y.W.5    Choi, J.H.6    Lee, K.T.7
  • 42
    • 78449269782 scopus 로고    scopus 로고
    • 28-noroleanane- type triterpene saponins from Camellia japonica and their inhibitory activity on LPS-induced NO production in macrophage RAW264.7 cells
    • Thao, N.T.; Hung, T.M.; Cuong, T.D.; Kim, J.C.; Kim, E.H.; Jin, S.E.; Na, M.; Lee, Y.M.; Kim, Y.H.; Choi, J.S.; Min, B.S. 28-noroleanane- type triterpene saponins from Camellia japonica and their inhibitory activity on LPS-induced NO production in macrophage RAW264.7 cells. Bioorg. Med. Chem. Lett., 2010, 20, 7435-7439.
    • (2010) Bioorg. Med. Chem. Lett , vol.20 , pp. 7435-7439
    • Thao, N.T.1    Hung, T.M.2    Cuong, T.D.3    Kim, J.C.4    Kim, E.H.5    Jin, S.E.6    Na, M.7    Lee, Y.M.8    Kim, Y.H.9    Choi, J.S.10    Min, B.S.11
  • 44
    • 0036634940 scopus 로고    scopus 로고
    • Activity- guided isolation of saponins from Kalopanax pictus with antiinflammatory activity
    • Li, D.W.; Lee, E.B.; Kang, S.S.; Hyun, J.E.; Whang, W.K. Activity- guided isolation of saponins from Kalopanax pictus with antiinflammatory activity. Chem. Pharm. Bull., 2002, 50, 900-903.
    • (2002) Chem. Pharm. Bull , vol.50 , pp. 900-903
    • Li, D.W.1    Lee, E.B.2    Kang, S.S.3    Hyun, J.E.4    Whang, W.K.5
  • 45
    • 24944459772 scopus 로고    scopus 로고
    • Isolation of saponins with the inhibitory effect on nitric oxide, prostaglandin E2 and tumor necrosis factor-alpha production from Pleurospermum kamtschaticum
    • Jung, H.J.; Kim, S.G.; Nam, J.H.; Park, K.K.; Chung, W.Y.; Kim, W.B.; Lee, K.T.; Won, J.H.; Choi, J.W.; Park, H.J. Isolation of saponins with the inhibitory effect on nitric oxide, prostaglandin E2 and tumor necrosis factor-alpha production from Pleurospermum kamtschaticum. Biol. Pharm. Bull., 2005, 28, 1668-1671.
    • (2005) Biol. Pharm. Bull , vol.28 , pp. 1668-1671
    • Jung, H.J.1    Kim, S.G.2    Nam, J.H.3    Park, K.K.4    Chung, W.Y.5    Kim, W.B.6    Lee, K.T.7    Won, J.H.8    Choi, J.W.9    Park, H.J.10
  • 46
    • 77957846291 scopus 로고    scopus 로고
    • Triterpenoidal saponins of Pulsatilla koreana roots
    • Yang, H.; Cho, Y.W.; Kim, S.H.; Kim, Y.C.; Sung, S.H. Triterpenoidal saponins of Pulsatilla koreana roots. Phytochemistry, 2010, 71, 1892-1899.
    • (2010) Phytochemistry , vol.71 , pp. 1892-1899
    • Yang, H.1    Cho, Y.W.2    Kim, S.H.3    Kim, Y.C.4    Sung, S.H.5
  • 48
    • 79955863438 scopus 로고    scopus 로고
    • Anti- Inflammatory and Anti-Melanogenic Steroidal Saponin Glycosides from Fenugreek (Trigonella foenum-graecum L.) Seeds
    • Available from: 10.1055/s-0030-1250477
    • Kawabata, T.; Cui, M.; Hasegawa, T.; Takano, F.; Ohta, T. Anti- Inflammatory and Anti-Melanogenic Steroidal Saponin Glycosides from Fenugreek (Trigonella foenum-graecum L.) Seeds. Planta Med., 2011, Available from: 10.1055/s-0030-1250477.
    • (2011) Planta Med
    • Kawabata, T.1    Cui, M.2    Hasegawa, T.3    Takano, F.4    Ohta, T.5
  • 49
    • 34247169514 scopus 로고    scopus 로고
    • Vaccine adjuvants revisited
    • Aguilar, J.C.; Rodríguez, E.G. Vaccine adjuvants revisited. Vaccine, 2007, 25, 3752-3762.
    • (2007) Vaccine , vol.25 , pp. 3752-3762
    • Aguilar, J.C.1    Rodríguez, E.G.2
  • 50
    • 0028171987 scopus 로고
    • Trial of immunological adjuvant QS-21 with a GM2 ganglioside-keyhole limpet haemocyanin conjugate vaccine in patients with malignant melanoma
    • Livingston, P.O.; Adluri, S.; Helling, F.; Yao, T.J.; Kensil, C.R.; Newman, M.J.; Marciani, D. Phase I trial of immunological adjuvant QS-21 with a GM2 ganglioside-keyhole limpet haemocyanin conjugate vaccine in patients with malignant melanoma. Vaccine, 1994, 12(14), 1275-1280.
    • (1994) Vaccine , vol.12 , Issue.14 , pp. 1275-1280
    • Livingston, P.O.1    Adluri, S.2    Helling, F.3    Yao, T.J.4    Kensil, C.R.5    Newman, M.J.6    Marciani, D.7    Phase, I.8
  • 51
    • 36048962961 scopus 로고    scopus 로고
    • How do adjuvants work? Important considerations for a new generation adjuvants
    • McKee, A.S.; Munks, M.W.; Marrack, P. How do adjuvants work? Important considerations for a new generation adjuvants. Immunity, 2007, 27, 687-690.
    • (2007) Immunity , vol.27 , pp. 687-690
    • McKee, A.S.1    Munks, M.W.2    Marrack, P.3
  • 52
    • 0030963614 scopus 로고    scopus 로고
    • Induction of Th1 and Th2 CD4+ T cell responses: The alternative approaches
    • Constant, S.L.; Bottomly, K. Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches. Annu. Rev. Immunol., 1997, 15, 297-322.
    • (1997) Annu. Rev. Immunol , vol.15 , pp. 297-322
    • Constant, S.L.1    Bottomly, K.2
  • 53
    • 33748795114 scopus 로고    scopus 로고
    • Saponin-adjuvanted particulate vaccines for clinical use
    • Skene, C.D.; Sutton, P. Saponin-adjuvanted particulate vaccines for clinical use. Methods, 2006, 40, 53-59.
    • (2006) Methods , vol.40 , pp. 53-59
    • Skene, C.D.1    Sutton, P.2
  • 55
    • 61349084783 scopus 로고    scopus 로고
    • Advances in saponins-based adjuvants
    • Sun, H-X.; Xie, Y.; Ye, Y-P. Advances in saponins-based adjuvants. Vaccine, 2009, 27, 1787-1796.
    • (2009) Vaccine , vol.27 , pp. 1787-1796
    • Sun, H.-X.1    Xie, Y.2    Ye, Y.-P.3
  • 56
    • 0034017617 scopus 로고    scopus 로고
    • Induction of antibodies against GM2 ganglioside by immunizing melanoma patients using GM2-keyhole limpet hemocyanin+QS-21 vaccine: A dose-response study
    • Chapman, P.B.; Morrissey, D.M.; Panageas, K.S.; Hamilton, W.B.; Zhan, C.; Destro, A.N.; Williams, L.; Israel, R.J.; Livingston, P.O. Induction of antibodies against GM2 ganglioside by immunizing melanoma patients using GM2-keyhole limpet hemocyanin+QS-21 vaccine: a dose-response study. Clin. Cancer Res., 2000, 6(3), 874-879.
    • (2000) Clin. Cancer Res , vol.6 , Issue.3 , pp. 874-879
    • Chapman, P.B.1    Morrissey, D.M.2    Panageas, K.S.3    Hamilton, W.B.4    Zhan, C.5    Destro, A.N.6    Williams, L.7    Israel, R.J.8    Livingston, P.O.9
  • 58
    • 0141532308 scopus 로고    scopus 로고
    • Immunization with an adjuvant hepatitis B vaccine after liver transplantation for hepatitis B-related disease
    • Bienzle, U.; Günther, M.; Neuhaus, R.; Vandepapeliere, P.; Vollmar, J.; Lun, A.; Neuhaus, P. Immunization with an adjuvant hepatitis B vaccine after liver transplantation for hepatitis B-related disease. Hepatology, 2003, 38(4), 811-819.
    • (2003) Hepatology , vol.38 , Issue.4 , pp. 811-819
    • Bienzle, U.1    Günther, M.2    Neuhaus, R.3    Vandepapeliere, P.4    Vollmar, J.5    Lun, A.6    Neuhaus, P.7
  • 59
    • 3242695961 scopus 로고    scopus 로고
    • Sequential immunization of melanoma patients with GD3 ganglioside vaccine and antiidiotypic monoclonal antibody that mimics GD3 ganglioside
    • Chapman, P.B.; Wu, D.; Ragupathi, G.; Lu, S.; Williams, L.; Hwu, W-J.; Johnson, D.; Livingston, P.O. Sequential immunization of melanoma patients with GD3 ganglioside vaccine and antiidiotypic monoclonal antibody that mimics GD3 ganglioside. Clin. Cancer Res., 2004, 10, 4717-4723.
    • (2004) Clin. Cancer Res , vol.10 , pp. 4717-4723
    • Chapman, P.B.1    Wu, D.2    Ragupathi, G.3    Lu, S.4    Williams, L.5    Hwu, W.-J.6    Johnson, D.7    Livingston, P.O.8
  • 60
    • 34247611891 scopus 로고    scopus 로고
    • Synthetic vaccine update: Applying lessons learned from recent SPf66 malarial vaccine physicochemical, structural and immunological characterization
    • Bermúdez, A.; Reyes, C.; Guzmán, F.; Vanegas, M.; Rosas, J.; Amador, R.; Rodríguez, R.; Patarroyo, M.A.; Patarroyo, M.E. Synthetic vaccine update: Applying lessons learned from recent SPf66 malarial vaccine physicochemical, structural and immunological characterization. Vaccine, 2007, 25, 4487-4501.
    • (2007) Vaccine , vol.25 , pp. 4487-4501
    • Bermúdez, A.1    Reyes, C.2    Guzmán, F.3    Vanegas, M.4    Rosas, J.5    Amador, R.6    Rodríguez, R.7    Patarroyo, M.A.8    Patarroyo, M.E.9
  • 63
    • 34249323320 scopus 로고    scopus 로고
    • Improvement of a commercial footand- mouth disease vaccine by supplement of Quil A
    • Xiao, C.; Rajput, Z.I.; Hu, S. Improvement of a commercial footand- mouth disease vaccine by supplement of Quil A. Vaccine, 2007, 25, 4795-4800.
    • (2007) Vaccine , vol.25 , pp. 4795-4800
    • Xiao, C.1    Rajput, Z.I.2    Hu, S.3
  • 65
    • 78650818539 scopus 로고    scopus 로고
    • Antibody responses in mice after immunization with inactivated bovine respiratory syncytial virus using different adjuvants
    • Spilki, F.R.; Almeida, R.S.; Arns, C.W. Antibody responses in mice after immunization with inactivated bovine respiratory syncytial virus using different adjuvants. Cien. Rural, 2010, 40(11), 2332-2337.
    • (2010) Cien. Rural , vol.40 , Issue.11 , pp. 2332-2337
    • Spilki, F.R.1    Almeida, R.S.2    Arns, C.W.3
  • 66
    • 0026033441 scopus 로고
    • Separation and characterization of saponins with adjuvant activity from Quillaja saponaria Molina cortex
    • Kensil, C.R.; Patel, U.; Lennick, M.; Marciani, D. Separation and characterization of saponins with adjuvant activity from Quillaja saponaria Molina cortex. J. Immunol., 1991, 146(2), 431-437.
    • (1991) J. Immunol , vol.146 , Issue.2 , pp. 431-437
    • Kensil, C.R.1    Patel, U.2    Lennick, M.3    Marciani, D.4
  • 68
    • 33645242521 scopus 로고    scopus 로고
    • Adjuvant effect of Achyranthes bidentata saponins on specific antibody and cellular response to ovalbumin in mice
    • Sun, H-X. Adjuvant effect of Achyranthes bidentata saponins on specific antibody and cellular response to ovalbumin in mice. Vaccine, 2006, 24, 3432-3439.
    • (2006) Vaccine , vol.24 , pp. 3432-3439
    • Sun, H.-X.1
  • 69
    • 0343114291 scopus 로고    scopus 로고
    • Adjuvant and haemolytic activities of 47 saponins derived from medicinal and food plants
    • Oda, K., Matsuda, H.; Murakami, T.; Katayama, S.; Ohgitani, T.; Yoshikawa, M. Adjuvant and haemolytic activities of 47 saponins derived from medicinal and food plants. Biol. Chem., 2000, 381, 67-74.
    • (2000) Biol. Chem , vol.381 , pp. 67-74
    • Oda, K.1    Matsuda, H.2    Murakami, T.3    Katayama, S.4    Ohgitani, T.5    Yoshikawa, M.6
  • 70
    • 50949130754 scopus 로고    scopus 로고
    • Haemolytic activities and adjuvant effect of Anemone raddeana saponins (ARS) on the immune responses to ovalbumin in mice
    • Sun, Y.; Li, M.; Liu, J. Haemolytic activities and adjuvant effect of Anemone raddeana saponins (ARS) on the immune responses to ovalbumin in mice. Int. Immunopharmacol., 2008, 8, 1095-1102.
    • (2008) Int. Immunopharmacol , vol.8 , pp. 1095-1102
    • Sun, Y.1    Li, M.2    Liu, J.3
  • 71
    • 2342445213 scopus 로고    scopus 로고
    • Immunoadjuvant potential of Asparagus racemosus aqueous extract in experimental system
    • Gautam, M.; Diwanay, S.; Gairola, S.; Shinde, Y.; Patki, P.; Patwardhan, B. Immunoadjuvant potential of Asparagus racemosus aqueous extract in experimental system. J. Ethnopharmacol., 2004, 91, 251-255.
    • (2004) J. Ethnopharmacol , vol.91 , pp. 251-255
    • Gautam, M.1    Diwanay, S.2    Gairola, S.3    Shinde, Y.4    Patki, P.5    Patwardhan, B.6
  • 73
    • 25144454868 scopus 로고    scopus 로고
    • Haemolytic activities and adjuvant effect of Astragalus membranaceus saponins (AMS) on the immune responses to ovalbumin in mice
    • Yang, Z-G.; Sun, H-X.; Fang, W-H. Haemolytic activities and adjuvant effect of Astragalus membranaceus saponins (AMS) on the immune responses to ovalbumin in mice. Vaccine, 2005, 23, 5196-5203.
    • (2005) Vaccine , vol.23 , pp. 5196-5203
    • Yang, Z.-G.1    Sun, H.-X.2    Fang, W.-H.3
  • 74
    • 32344449646 scopus 로고    scopus 로고
    • Haemolytic activities and adjuvant effect of Bupleurum chinense saponins on the immune responses to ovalbumin in mice
    • Sun, H-X. Haemolytic activities and adjuvant effect of Bupleurum chinense saponins on the immune responses to ovalbumin in mice. Vaccine, 2006, 24, 1324-1331.
    • (2006) Vaccine , vol.24 , pp. 1324-1331
    • Sun, H.-X.1
  • 75
    • 11144258881 scopus 로고    scopus 로고
    • Pulcherrimasaponin, from leaves of Calliandra pulcherrima, as adjuvant for immunization in the murine model of visceral leishmaniasis
    • Pereira da Silva, B.; Soares, J.B.R.C.; de Souza, E.P.; Palatnik, M.; Palatnik de Sousa, C.B.; Parente, J.P. Pulcherrimasaponin, from leaves of Calliandra pulcherrima, as adjuvant for immunization in the murine model of visceral leishmaniasis. Vaccine, 2005, 23, 1061-1071.
    • (2005) Vaccine , vol.23 , pp. 1061-1071
    • da Silva, P.B.1    Soares, J.B.R.C.2    de Souza, E.P.3    Palatnik, M.4    de Sousa, P.C.B.5    Parente, J.P.6
  • 76
    • 33845222410 scopus 로고    scopus 로고
    • Assessment of the monoterpene, glycidic and triterpene- moieties contributions to the adjuvant function of the CP05saponin of Calliandra pulcherrina Benth during vaccination against experimental visceral leishmaniasis
    • Nico, D.; Santos, F.N.; Borja-Cabrera, G.P.; Palatnik, M.; Palatnik de Sousa, C.B. Assessment of the monoterpene, glycidic and triterpene- moieties contributions to the adjuvant function of the CP05saponin of Calliandra pulcherrina Benth during vaccination against experimental visceral leishmaniasis. Vaccine, 2007, 25, 649-658.
    • (2007) Vaccine , vol.25 , pp. 649-658
    • Nico, D.1    Santos, F.N.2    Borja-Cabrera, G.P.3    Palatnik, M.4    de Sousa, P.C.B.5
  • 77
    • 79960988813 scopus 로고    scopus 로고
    • Tandem mass spectrometric analysis of a complex triterpene saponins mixture of Chenopodium quinoa
    • Madl, T.; Sterk, H.; Mittelbach, M.; Rechberger, G.N. Tandem mass spectrometric analysis of a complex triterpene saponins mixture of Chenopodium quinoa. J. Am. Soc. Mass Spectrom., 2006, 96(1-2), 71-77.
    • (2006) J. Am. Soc. Mass Spectrom , vol.96 , Issue.1-2 , pp. 71-77
    • Madl, T.1    Sterk, H.2    Mittelbach, M.3    Rechberger, G.N.4
  • 78
    • 0037449105 scopus 로고    scopus 로고
    • Relationship between adjuvant activity and amphipathic structure of soyasaponins
    • Oda, K., Matsuda, H.; Murakami, T.; Katayama, S.; Ohgitani, T.; Yoshikawa, M. Relationship between adjuvant activity and amphipathic structure of soyasaponins. Vaccine, 2003, 21, 2145-2151.
    • (2003) Vaccine , vol.21 , pp. 2145-2151
    • Oda, K.1    Matsuda, H.2    Murakami, T.3    Katayama, S.4    Ohgitani, T.5    Yoshikawa, M.6
  • 79
    • 32544439349 scopus 로고    scopus 로고
    • Immunological adjuvant effect of Glycyrrhiza uralensis saponins on the immune responses to ovalbumin in mice
    • Sun, H-X.; Pan, H-J. Immunological adjuvant effect of Glycyrrhiza uralensis saponins on the immune responses to ovalbumin in mice. Vaccine, 2006, 24, 1914-1920.
    • (2006) Vaccine , vol.24 , pp. 1914-1920
    • Sun, H.-X.1    Pan, H.-J.2
  • 80
    • 27944495709 scopus 로고    scopus 로고
    • Haemolytic activities and adjuvant effect of Gynostemma pentaphyllum saponins on the immune responses to ovalbumin in mice
    • Sun, H.; Zheng, Q. Haemolytic activities and adjuvant effect of Gynostemma pentaphyllum saponins on the immune responses to ovalbumin in mice. Phytother. Res., 2005, 19(10), 895-900.
    • (2005) Phytother. Res , vol.19 , Issue.10 , pp. 895-900
    • Sun, H.1    Zheng, Q.2
  • 82
    • 0031171173 scopus 로고    scopus 로고
    • Haemolytic activities of plant saponins and adjuvants. Effect of Periandra mediterranea saponins on the humoral response to the FML antigen of Leishmania donovani
    • Santos, W.R.; Bernardo, R.R.; Peçanha, L.M.T.; Palatnik, M.; Parente, J.P.; Palatnik de Souza, C.B. Haemolytic activities of plant saponins and adjuvants. Effect of Periandra mediterranea saponins on the humoral response to the FML antigen of Leishmania donovani. Vaccine, 1997, 15(9), 1024-1029.
    • (1997) Vaccine , vol.15 , Issue.9 , pp. 1024-1029
    • Santos, W.R.1    Bernardo, R.R.2    Peçanha, L.M.T.3    Palatnik, M.4    Parente, J.P.5    de Souza, P.C.B.6
  • 83
    • 0033979115 scopus 로고    scopus 로고
    • Isolation and evaluation of immunological adjuvant activities of saponins from Polygala senega L
    • Estrada, A.; Katselis, G.S.; Laarveld, B.; Barl, B. Isolation and evaluation of immunological adjuvant activities of saponins from Polygala senega L. Comp. Immunol. Microbiol. Infect. Dis., 2000, 23, 27-43.
    • (2000) Comp. Immunol. Microbiol. Infect. Dis , vol.23 , pp. 27-43
    • Estrada, A.1    Katselis, G.S.2    Laarveld, B.3    Barl, B.4
  • 84
    • 0035860609 scopus 로고    scopus 로고
    • Onjisaponins, from the root of Polygala tenuifolia Willdenow, as effective adjuvants for nasal influenza and diphtheria-pertussistetanus vaccines
    • Nagai, T.; Suzuki, Y.; Kiyohara, H.; Susa, E.; Kato, T.; Nagamine, T.; Hagiwara, Y.; Tamura, S.I.; Yabe, T.; Aizawa, C.; Yamada, H. Onjisaponins, from the root of Polygala tenuifolia Willdenow, as effective adjuvants for nasal influenza and diphtheria-pertussistetanus vaccines. Vaccine, 2001, 19, 4824-4834.
    • (2001) Vaccine , vol.19 , pp. 4824-4834
    • Nagai, T.1    Suzuki, Y.2    Kiyohara, H.3    Susa, E.4    Kato, T.5    Nagamine, T.6    Hagiwara, Y.7    Tamura, S.I.8    Yabe, T.9    Aizawa, C.10    Yamada, H.11
  • 85
    • 77950517051 scopus 로고    scopus 로고
    • Isolation and evaluation of immunological adjuvant activities os saponins from the roots of Pulsatilla chinensis with less adverse reactions
    • Sun, Y.; Liu, J.; Yu, H.; Gong, C. Isolation and evaluation of immunological adjuvant activities os saponins from the roots of Pulsatilla chinensis with less adverse reactions. Int. Immunopharmacol., 2010, 10, 584-590.
    • (2010) Int. Immunopharmacol , vol.10 , pp. 584-590
    • Sun, Y.1    Liu, J.2    Yu, H.3    Gong, C.4
  • 87
    • 0034727709 scopus 로고    scopus 로고
    • Structural studies of triterpenoid saponins with new acyl components from Quillaja saponaria Molina
    • Guo, S.; Kenne, L. Structural studies of triterpenoid saponins with new acyl components from Quillaja saponaria Molina. Phytochemistry, 2000, 55, 419-428.
    • (2000) Phytochemistry , vol.55 , pp. 419-428
    • Guo, S.1    Kenne, L.2
  • 88
    • 0035914559 scopus 로고    scopus 로고
    • Multivariate analysis of 1H NMR spectra for saponins from Quillaja saponaria Molina
    • Nord, L.I.; Kenne, L.; Jacobsson, S.P. Multivariate analysis of 1H NMR spectra for saponins from Quillaja saponaria Molina. Anal. Chim. Acta, 2001, 446, 199-209.
    • (2001) Anal. Chim. Acta , vol.446 , pp. 199-209
    • Nord, L.I.1    Kenne, L.2    Jacobsson, S.P.3
  • 90
    • 0032823606 scopus 로고    scopus 로고
    • Separation and structural analysis of saponins in a bark extract from Quillaja saponaria Molina
    • Nord, L.I.; Kenne, L. Separation and structural analysis of saponins in a bark extract from Quillaja saponaria Molina. Carbohydr. Res., 1999, 320, 70-81.
    • (1999) Carbohydr. Res , vol.320 , pp. 70-81
    • Nord, L.I.1    Kenne, L.2
  • 91
    • 0034622536 scopus 로고    scopus 로고
    • Characterization of some O-acetylated saponins from Quillaja saponaria Molina
    • Guo, S.; Kenne, L. Characterization of some O-acetylated saponins from Quillaja saponaria Molina. Phytochemistry, 2000, 54, 615-623.
    • (2000) Phytochemistry , vol.54 , pp. 615-623
    • Guo, S.1    Kenne, L.2
  • 92
    • 0033394043 scopus 로고    scopus 로고
    • Separation and structural analysis of some saponins from Quillaja saponaria Molina
    • Nyberg, N.T.; Kenne, L; Rönnberg, B.; Sundquist, B.G. Separation and structural analysis of some saponins from Quillaja saponaria Molina. Carbohydr. Res., 2000, 323, 87-97.
    • (2000) Carbohydr. Res , vol.323 , pp. 87-97
    • Nyberg, N.T.1    Kenne, L.2    Rönnberg, B.3    Sundquist, B.G.4
  • 93
    • 0033793089 scopus 로고    scopus 로고
    • Quality control of commercial Quillaja (Quillaja saponaria Molina) extracts by reverse phase HPLC
    • San Martin, R.; Briones, R. Quality control of commercial Quillaja (Quillaja saponaria Molina) extracts by reverse phase HPLC. J. Sci. Food Agric., 2000, 80, 2063-2068.
    • (2000) J. Sci. Food Agric , vol.80 , pp. 2063-2068
    • San, M.R.1    Briones, R.2
  • 94
    • 0346665664 scopus 로고    scopus 로고
    • Solid-phase extraction NMR studies of chromatographic fractions of saponins from Quillaja saponaria
    • Nyberg, N.T.; Baumann, H.; Kenn, L. Solid-phase extraction NMR studies of chromatographic fractions of saponins from Quillaja saponaria. Anal. Chem., 2003, 75(2), 268-274.
    • (2003) Anal. Chem , vol.75 , Issue.2 , pp. 268-274
    • Nyberg, N.T.1    Baumann, H.2    Kenn, L.3
  • 95
    • 38149108206 scopus 로고    scopus 로고
    • Structural classification of Quillaja saponins by electrospray ionization ion trap multiple-stage mass spectrometry in combination with multivariate analysis, proof of concept
    • Bankefors, J.; Nord, L.I.; Kenne, L. Structural classification of Quillaja saponins by electrospray ionization ion trap multiple-stage mass spectrometry in combination with multivariate analysis, proof of concept. Chemom. Intell. Lab. Syst., 2008, 90, 178-187.
    • (2008) Chemom. Intell. Lab. Syst , vol.90 , pp. 178-187
    • Bankefors, J.1    Nord, L.I.2    Kenne, L.3
  • 96
    • 38649091974 scopus 로고    scopus 로고
    • Development of a comprehensive twodimensional hydrophilic interaction chromatography/quadrupole time-of-flight mass spectrometry system and its application in separation and identification of saponins from Quillaja saponaria
    • Wang, Y.; Lu, X.; Xu, G. Development of a comprehensive twodimensional hydrophilic interaction chromatography/quadrupole time-of-flight mass spectrometry system and its application in separation and identification of saponins from Quillaja saponaria. J. Chromatogr., A, 2008, 1181, 51-59.
    • (2008) J. Chromatogr., A , vol.1181 , pp. 51-59
    • Wang, Y.1    Lu, X.2    Xu, G.3
  • 97
    • 0030064618 scopus 로고    scopus 로고
    • Structure of the saponin adjuvant QS-21 and its base-catalyzed isomerization product by 1H and natural abundance 13C NMR spectroscopy
    • Jacobsen, N.E.; Fairbrother, W.J.; Kensil, C.R.; Lim, A.; Wheeler, D.A.; Powell, M.F. Structure of the saponin adjuvant QS-21 and its base-catalyzed isomerization product by 1H and natural abundance 13C NMR spectroscopy. Carbohydr. Res., 1996, 280, 1-14.
    • (1996) Carbohydr. Res , vol.280 , pp. 1-14
    • Jacobsen, N.E.1    Fairbrother, W.J.2    Kensil, C.R.3    Lim, A.4    Wheeler, D.A.5    Powell, M.F.6
  • 98
    • 0034531378 scopus 로고    scopus 로고
    • Novel acetylated triterpenoid saponins in a chromatographic fraction from Quillaja saponaria Molina
    • Nord, L.I.; Kenne, L. Novel acetylated triterpenoid saponins in a chromatographic fraction from Quillaja saponaria Molina. Carbohydr. Res., 2000, 329, 817-829.
    • (2000) Carbohydr. Res , vol.329 , pp. 817-829
    • Nord, L.I.1    Kenne, L.2
  • 99
    • 33846208386 scopus 로고    scopus 로고
    • Adjuvant activity of Quillaja brasiliensis saponins on the immune responses to bovine herpesvirus type 1 in mice
    • Fleck, J.D.; Kauffmann, C.; Spilki, F.; Lencina, C.L.; Roehe, P. M.; Gosmann, G. Adjuvant activity of Quillaja brasiliensis saponins on the immune responses to bovine herpesvirus type 1 in mice. Vaccine, 2006, 24(49-50), 7129-7134.
    • (2006) Vaccine , vol.24 , Issue.49-50 , pp. 7129-7134
    • Fleck, J.D.1    Kauffmann, C.2    Spilki, F.3    Lencina, C.L.4    Roehe, P.M.5    Gosmann, G.6
  • 101
    • 0037104630 scopus 로고    scopus 로고
    • Can ginsenosides protect human erythrocytes against free-radical-induced hemolysis?
    • Liu, Z.; Luo, X.; Sun, Y.; Chen, Y.; Wang, Z. Can ginsenosides protect human erythrocytes against free-radical-induced hemolysis? Biochim. Biophys. Acta, Gen. Subj., 2002, 1572, 58-66.
    • (2002) Biochim. Biophys. Acta, Gen. Subj , vol.1572 , pp. 58-66
    • Liu, Z.1    Luo, X.2    Sun, Y.3    Chen, Y.4    Wang, Z.5
  • 103
    • 50349101675 scopus 로고    scopus 로고
    • Chapter 1 Ginsenosides Chemistry, Biosynthesis, Analysis, and Potential Health Effects
    • Christensen, L.P. Chapter 1 Ginsenosides Chemistry, Biosynthesis, Analysis, and Potential Health Effects. Adv. Food. Nutr. Res., 2009, 55, 1-99.
    • (2009) Adv. Food. Nutr. Res , vol.55 , pp. 1-99
    • Christensen, L.P.1
  • 104
    • 0034495024 scopus 로고    scopus 로고
    • Improvement of ginsenoside production by jasmonic acid and some other elicitors in hairy root culture of ginseng (Panax ginseng C.A. Meyer)
    • Yu, K.W.; Gao, W.Y.; Son, S.H.; Paek, K.Y. Improvement of ginsenoside production by jasmonic acid and some other elicitors in hairy root culture of ginseng (Panax ginseng C.A. Meyer). In Vitro Cell Dev. Biol. Plant, 2000, 36, 424-428.
    • (2000) In Vitro Cell Dev. Biol. Plant , vol.36 , pp. 424-428
    • Yu, K.W.1    Gao, W.Y.2    Son, S.H.3    Paek, K.Y.4
  • 105
    • 28444457369 scopus 로고    scopus 로고
    • Structure and biological activity of protopanaxatriol- type saponins from the roots of Panax notoginseng
    • Sun, H.; Yang, Z.; Ye, Y. Structure and biological activity of protopanaxatriol- type saponins from the roots of Panax notoginseng. Int. Immunopharmacol., 2006, 6, 14-25.
    • (2006) Int. Immunopharmacol , vol.6 , pp. 14-25
    • Sun, H.1    Yang, Z.2    Ye, Y.3
  • 106
    • 33750375026 scopus 로고    scopus 로고
    • Qualitative and quantitative determination of ten major saponins in Platycodi Radix by high performance liquid chromatography with evaporative light scattering detection and mass spectrometry
    • Ha, Y.W.; Na, Y-C.; Seo, J-J.; Kim, S-N.; Linhardt, R.J.; Kim, Y.S. Qualitative and quantitative determination of ten major saponins in Platycodi Radix by high performance liquid chromatography with evaporative light scattering detection and mass spectrometry. J. Chromatogr., A, 2006, 1135, 27-35.
    • (2006) J. Chromatogr., A , vol.1135 , pp. 27-35
    • Ha, Y.W.1    Na, Y.-C.2    Seo, J.-J.3    Kim, S.-N.4    Linhardt, R.J.5    Kim, Y.S.6
  • 107
    • 13444302476 scopus 로고    scopus 로고
    • New triterpenoid saponins from the roots of Platycodon grandiflorum
    • He, Z.D.; Qiao, C.F.; Han, Q.B.; Wang, Y.; Ye, W.C.; Xu, H.X. New triterpenoid saponins from the roots of Platycodon grandiflorum. Tetrahedron, 2005, 61, 2211-2215.
    • (2005) Tetrahedron , vol.61 , pp. 2211-2215
    • He, Z.D.1    Qiao, C.F.2    Han, Q.B.3    Wang, Y.4    Ye, W.C.5    Xu, H.X.6
  • 108
    • 33645539655 scopus 로고    scopus 로고
    • Studies on the chemical constituents from the roots of Platycodon grandiflorum
    • Fu, WW.; Dou, DQ.; Shimizu, N.; Takeda, T.; Pei, YH.; Chen, YJ. Studies on the chemical constituents from the roots of Platycodon grandiflorum. J. Nat. Med., 2006, 60, 68-72.
    • (2006) J. Nat. Med , vol.60 , pp. 68-72
    • Fu, W.W.1    Dou, D.Q.2    Shimizu, N.3    Takeda, T.4    Pei, Y.H.5    Chen, Y.J.6
  • 110
    • 33748460082 scopus 로고    scopus 로고
    • New A-ring lactone triterpenoid saponins from the roots of Platycodon grandiflorum
    • Fu, W-W.; Shimizu, N.; Takeda, T.; Dou, DQ.; Chen, B.; Pei, YH.; Chen, YJ. New A-ring lactone triterpenoid saponins from the roots of Platycodon grandiflorum. Chem. Pharm. Bull., 2006, 54, 1285-1287.
    • (2006) Chem. Pharm. Bull , vol.54 , pp. 1285-1287
    • Fu, W.-W.1    Shimizu, N.2    Takeda, T.3    Dou, D.Q.4    Chen, B.5    Pei, Y.H.6    Chen, Y.J.7
  • 111
    • 34247251926 scopus 로고    scopus 로고
    • A new triterpenoid saponins from the roots of Platycodon grandiflorum
    • Li, W.; Xiang, L.; Zhang, J.; Zheng, Y.N.; Han, L.K.; Saito, M. A new triterpenoid saponins from the roots of Platycodon grandiflorum. Chin. Chem. Lett., 2007, 18, 306-308.
    • (2007) Chin. Chem. Lett , vol.18 , pp. 306-308
    • Li, W.1    Xiang, L.2    Zhang, J.3    Zheng, Y.N.4    Han, L.K.5    Saito, M.6
  • 112
    • 46149092981 scopus 로고    scopus 로고
    • A promising balanced Th1 and Th2 directing immunological adjuvant, saponins from the root of Platycodon grandiflorum
    • Xie, Y.; Pan, H.; Sun, H.; Li, D. A promising balanced Th1 and Th2 directing immunological adjuvant, saponins from the root of Platycodon grandiflorum. Vaccine, 2008, 26, 3937-3945.
    • (2008) Vaccine , vol.26 , pp. 3937-3945
    • Xie, Y.1    Pan, H.2    Sun, H.3    Li, D.4
  • 113
    • 50949087401 scopus 로고    scopus 로고
    • Platycodin D2 is a potential less hemolytic saponin adjuvant eliciting Th1 and Th2 immune responses
    • Xie, Y.; Deng, W.; Sun, H.; Li, D. Platycodin D2 is a potential less hemolytic saponin adjuvant eliciting Th1 and Th2 immune responses. Int. Immunopharmacol., 2008, 8, 1143-1150.
    • (2008) Int. Immunopharmacol , vol.8 , pp. 1143-1150
    • Xie, Y.1    Deng, W.2    Sun, H.3    Li, D.4
  • 114
    • 44749094127 scopus 로고    scopus 로고
    • Contribution of the glycidic moieties to the haemolytic and adjuvant activity of platycodigenintype saponins from the root of Platycodon grandiflorum
    • Xie, Y.; Ye, Y-P.; Sun, H.; Li, D. Contribution of the glycidic moieties to the haemolytic and adjuvant activity of platycodigenintype saponins from the root of Platycodon grandiflorum. Vaccine, 2008, 26, 3452-3460.
    • (2008) Vaccine , vol.26 , pp. 3452-3460
    • Xie, Y.1    Ye, Y.-P.2    Sun, H.3    Li, D.4
  • 116
    • 2942513672 scopus 로고    scopus 로고
    • Current status and potential application of ISCOMs in veterinary medicine
    • Morein, B.; Hu, K.F.; Abusugra, I. Current status and potential application of ISCOMs in veterinary medicine. Adv. Drug Delivery Rev., 2004, 56, 1367-1382.
    • (2004) Adv. Drug Delivery Rev , vol.56 , pp. 1367-1382
    • Morein, B.1    Hu, K.F.2    Abusugra, I.3
  • 117
    • 46149088682 scopus 로고    scopus 로고
    • Evaluation of ISCOMATRIX™ and ISCOM™ vaccines for immunization against
    • Skene, C.D.; Doidge, C.; Sutton, P. Evaluation of ISCOMATRIX™ and ISCOM™ vaccines for immunization against Helicobacter pylori. Vaccine, 2008, 26, 3880-3884.
    • (2008) Helicobacter Pylori. Vaccine , vol.26 , pp. 3880-3884
    • Skene, C.D.1    Doidge, C.2    Sutton, P.3
  • 118
    • 0031171898 scopus 로고    scopus 로고
    • Induction of crossreactive cytotoxic T-lymphocyte responses specific for HIV-1 gp120 using saponins adjuvant (QS-21) supplemented subunit vaccine formulations
    • Newman, M.J.; Wu, J.Y.; Gardner, B.H.; Anderson, C.A.; Kensil, C.R.; Recchia, J.; Coughlin, R.T.; Powell, M.F. Induction of crossreactive cytotoxic T-lymphocyte responses specific for HIV-1 gp120 using saponins adjuvant (QS-21) supplemented subunit vaccine formulations. Vaccine, 1997, 15(9), 1001-1007.
    • (1997) Vaccine , vol.15 , Issue.9 , pp. 1001-1007
    • Newman, M.J.1    Wu, J.Y.2    Gardner, B.H.3    Anderson, C.A.4    Kensil, C.R.5    Recchia, J.6    Coughlin, R.T.7    Powell, M.F.8
  • 119
    • 33748487165 scopus 로고    scopus 로고
    • Synthetic studies of complex immunostimulants from Quillaja saponaria: Synthesis of the potent clinical immunoadjuvant QS-21Aapi
    • Kim, Y.J.; Wang, P.; Navarro-Villalobos M.; Rohde, B.D.; Derryberry, J.; Gin, D.Y. Synthetic studies of complex immunostimulants from Quillaja saponaria: synthesis of the potent clinical immunoadjuvant QS-21Aapi. J. Am. Chem. Soc., 2006, 128(36), 11906-11915.
    • (2006) J. Am. Chem. Soc , vol.128 , Issue.36 , pp. 11906-11915
    • Kim, Y.J.1    Wang, P.2    Navarro-Villalobos, M.3    Rohde, B.D.4    Derryberry, J.5    Gin, D.Y.6
  • 122
    • 0037073568 scopus 로고    scopus 로고
    • Longevity of neutralizing antibody levels in macaques vaccinated with Quil A-adjuvanted measles vaccine candidates
    • Stittelaar, K.J.; Vos, H.W.; Van Amerongen, G.; Kersten, G.F.A.; Osterhaus, A.D.M.E.; De Swart, R.L. Longevity of neutralizing antibody levels in macaques vaccinated with Quil A-adjuvanted measles vaccine candidates. Vaccine, 2002, 21, 155-157.
    • (2002) Vaccine , vol.21 , pp. 155-157
    • Stittelaar, K.J.1    Vos, H.W.2    van Amerongen, G.3    Kersten, G.F.A.4    Osterhaus, A.D.M.E.5    de Swart, R.L.6
  • 123
    • 0033522821 scopus 로고    scopus 로고
    • Immunogenicity of various presentation forms of PorA outer membrane protein of Neisseria meningitidis in mice
    • Peeters, C.C.A.M.; Claassen, I.J.T.M.; Schuller, M.; Kersten, G.F.A.; Voort, E.M.R.V.D.; Poolman, J.T. Immunogenicity of various presentation forms of PorA outer membrane protein of Neisseria meningitidis in mice. Vaccine, 1999, 17, 2702-2712.
    • (1999) Vaccine , vol.17 , pp. 2702-2712
    • Peeters, C.C.A.M.1    Claassen, I.J.T.M.2    Schuller, M.3    Kersten, G.F.A.4    Voort, E.M.R.V.D.5    Poolman, J.T.6
  • 124
    • 0034663498 scopus 로고    scopus 로고
    • Induction of antibody and T-cell responses by immunization with ISCOMS containing the 38-kilodalton protein of Mycobacterium tuberculosis
    • Fonseca, D.P.A.J.; Frerichs, J.; Singh, M.; Snippe, H.; Verheul, A.F.M. Induction of antibody and T-cell responses by immunization with ISCOMS containing the 38-kilodalton protein of Mycobacterium tuberculosis. Vaccine, 2001, 19, 122-131.
    • (2001) Vaccine , vol.19 , pp. 122-131
    • Fonseca, D.P.A.J.1    Frerichs, J.2    Singh, M.3    Snippe, H.4    Verheul, A.F.M.5
  • 125
    • 0029828632 scopus 로고    scopus 로고
    • Host protective fragments and antibody binding epitopes of the Taenia ovis 45W recombinant antigen
    • Lightowlers, M.N.; Waterkeyn, J.G.; Rothel, J.S.; Gaucci, C.G.; Harrison, G.B. Host protective fragments and antibody binding epitopes of the Taenia ovis 45W recombinant antigen. Parasite Immunol., 1996, 18(10), 507-513.
    • (1996) Parasite Immunol , vol.18 , Issue.10 , pp. 507-513
    • Lightowlers, M.N.1    Waterkeyn, J.G.2    Rothel, J.S.3    Gaucci, C.G.4    Harrison, G.B.5
  • 126
    • 33846842379 scopus 로고    scopus 로고
    • Cestode vaccines: Origins, current status and future prospects
    • Lightowlers, M.N. Cestode vaccines: origins, current status and future prospects. Parasitology, 2006, 133, S27-S42.
    • (2006) Parasitology , vol.133 , pp. 27-42
    • Lightowlers, M.N.1
  • 128
    • 56949083591 scopus 로고    scopus 로고
    • The effect of Quill A adjuvant on the course of experimental Fasciola hepatica infection in sheep
    • Haçaiz, O.; Sayers, G.; McCullough, M.; Garret, M.; O'Donovan, J.; Mulcahy, G. The effect of Quill A adjuvant on the course of experimental Fasciola hepatica infection in sheep. Vaccine, 2009, 27, 45-50.
    • (2009) Vaccine , vol.27 , pp. 45-50
    • Haçaiz, O.1    Sayers, G.2    McCullough, M.3    Garret, M.4    O'Donovan, J.5    Mulcahy, G.6
  • 129
    • 77955597687 scopus 로고    scopus 로고
    • Unmet needs in modern vaccinology adjuvants to improve the immune response
    • Leroux-Roels, G. Unmet needs in modern vaccinology adjuvants to improve the immune response. Vaccine, 2010, 28S, C25-C36.
    • (2010) Vaccine , vol.28 S , pp. 25-36
    • Leroux-Roels, G.1
  • 143
    • 4444310289 scopus 로고    scopus 로고
    • Adjuvant effect of Panax notoginseng saponins on the immune responses to ovalbumin in mice
    • Sun, H-X.; Ye, Y-P.; Pan, H-J.; Pan, Y-J. Adjuvant effect of Panax notoginseng saponins on the immune responses to ovalbumin in mice. Vaccine, 2004, 22, 3882-3889.
    • (2004) Vaccine , vol.22 , pp. 3882-3889
    • Sun, H.-X.1    Ye, Y.-P.2    Pan, H.-J.3    Pan, Y.-J.4
  • 144
    • 27744578514 scopus 로고    scopus 로고
    • Relationship between haemolytic and adjuvant activity and structure of protopanaxadiol-type saponins from the roots of Panax notoginseng
    • Sun, H.X.; Qin, F.; Ye, Y.P. Relationship between haemolytic and adjuvant activity and structure of protopanaxadiol-type saponins from the roots of Panax notoginseng. Vaccine, 2005, 23, 5533-5542.
    • (2005) Vaccine , vol.23 , pp. 5533-5542
    • Sun, H.X.1    Qin, F.2    Ye, Y.P.3
  • 145
    • 55049137629 scopus 로고    scopus 로고
    • Immunological adjuvant effect of Japanese ginseng saponins (JGS) on specific antibody and cellular response to ovalbumin and its haemolytic activities
    • Sun, Y.; Tong, H.; Li, M.; Li, Y.; Guan, S.; Liu, J. Immunological adjuvant effect of Japanese ginseng saponins (JGS) on specific antibody and cellular response to ovalbumin and its haemolytic activities. Vaccine, 2008, 26, 5911-5917.
    • (2008) Vaccine , vol.26 , pp. 5911-5917
    • Sun, Y.1    Tong, H.2    Li, M.3    Li, Y.4    Guan, S.5    Liu, J.6
  • 146
    • 33845230376 scopus 로고    scopus 로고
    • Ginsenoside Rd elicits Th1 and Th2 immune responses to ovalbumin in mice
    • Yang, Z.; Chen, A.; Sun, H.; Ye, Y.; Fang, W. Ginsenoside Rd elicits Th1 and Th2 immune responses to ovalbumin in mice. Vaccine, 2007, 25, 161-169.
    • (2007) Vaccine , vol.25 , pp. 161-169
    • Yang, Z.1    Chen, A.2    Sun, H.3    Ye, Y.4    Fang, W.5
  • 147
    • 33845595321 scopus 로고    scopus 로고
    • Adjuvant effects of protopanaxadiol and protopanaxatriol saponins from ginseng roots on the immune responses to ovalbumin in mice
    • Sun, J.; Hu, S.; Song, X. Adjuvant effects of protopanaxadiol and protopanaxatriol saponins from ginseng roots on the immune responses to ovalbumin in mice. Vaccine, 2007, 25, 1114-1120.
    • (2007) Vaccine , vol.25 , pp. 1114-1120
    • Sun, J.1    Hu, S.2    Song, X.3
  • 148
    • 58249097459 scopus 로고    scopus 로고
    • Platycodin D is a potent adjuvant of specific cellular and humoral immune response against recombinant hepatitis B antigen
    • Xie, Y.; Sun, H-X.; Li, D. Platycodin D is a potent adjuvant of specific cellular and humoral immune response against recombinant hepatitis B antigen. Vaccine, 2009, 27, 757-764.
    • (2009) Vaccine , vol.27 , pp. 757-764
    • Xie, Y.1    Sun, H.-X.2    Li, D.3
  • 149
    • 77949711408 scopus 로고    scopus 로고
    • Improves the immunogenicity of Newcastle disease virus-based recombinant avian influenza vaccine in mice
    • Xie, Y.; Sun, H-X.; Li, D. Platycodin D improves the immunogenicity of Newcastle disease virus-based recombinant avian influenza vaccine in mice. Chem. Biodivers., 2010, 7, 677-689.
    • (2010) Chem. Biodivers , vol.7 , pp. 677-689
    • Xie, Y.1    Sun, H.-X.2    Li, D.3    Platycodin, D.4
  • 150
    • 75449115911 scopus 로고    scopus 로고
    • Platycodin D2 improves specific cellular and humoral responses to hepatitis B surface antigen in mice
    • Xie, Y.; He, S.W.; Sun, H.X.; Li, D. Platycodin D2 improves specific cellular and humoral responses to hepatitis B surface antigen in mice. Chem. Biodivers., 2010, 7, 178-185.
    • (2010) Chem. Biodivers , vol.7 , pp. 178-185
    • Xie, Y.1    He, S.W.2    Sun, H.X.3    Li, D.4
  • 151
    • 0033787978 scopus 로고    scopus 로고
    • Medicinal plants and phytomedicines. Linking plant biochemistry and physiology to human health
    • Briskin, D.P. Medicinal plants and phytomedicines. Linking plant biochemistry and physiology to human health. Plant Physiol., 2000, 124, 507-551.
    • (2000) Plant Physiol , vol.124 , pp. 507-551
    • Briskin, D.P.1
  • 153
    • 77955426593 scopus 로고    scopus 로고
    • Large scale culture of ginseng adventitious roots for production of ginsenosides
    • Paek, K-Y.; Murthy, H.N.; Hahn, E-J.; Zhong, J-J. Large scale culture of ginseng adventitious roots for production of ginsenosides. Adv. Biochem. Eng. Biotechnol., 2009, 113, 151-176.
    • (2009) Adv. Biochem. Eng. Biotechnol , vol.113 , pp. 151-176
    • Paek, K.-Y.1    Murthy, H.N.2    Hahn, E.-J.3    Zhong, J.-J.4
  • 156
    • 33947543920 scopus 로고    scopus 로고
    • Production of asiaticoside and madecassoside in Centella asiatica in vitro and in vivo
    • Aziz, Z.A.; Davey, M.R.; Power, J.B.; Anthony, P.; Smith, R.M.; Lowe, K.C. Production of asiaticoside and madecassoside in Centella asiatica in vitro and in vivo. Biol. Plantarum, 2007, 51, 34-42.
    • (2007) Biol. Plantarum , vol.51 , pp. 34-42
    • Aziz, Z.A.1    Davey, M.R.2    Power, J.B.3    Anthony, P.4    Smith, R.M.5    Lowe, K.C.6
  • 157
    • 0035226724 scopus 로고    scopus 로고
    • Biochemical engineering of the production of plantspecific secondary metabolites by cell suspension culture
    • Zhong, J.J. Biochemical engineering of the production of plantspecific secondary metabolites by cell suspension culture. Adv. Biochem. Eng. Biotechnol., 2001, 72, 1-26.
    • (2001) Adv. Biochem. Eng. Biotechnol , vol.72 , pp. 1-26
    • Zhong, J.J.1
  • 158
    • 24644465573 scopus 로고    scopus 로고
    • Production of saponins from Panax ginseng suspension and adventitious root cultures
    • Langhansová, L.; Marsìk, P.; Vanek, T. Production of saponins from Panax ginseng suspension and adventitious root cultures. Biol. Plantarum, 2005; 49, 463-465.
    • (2005) Biol. Plantarum , vol.49 , pp. 463-465
    • Langhansová, L.1    Marsìk, P.2    Vanek, T.3
  • 159
    • 41549107995 scopus 로고    scopus 로고
    • Improved production of ginsenosides in suspension cultures of Ginseng by medium replenishment strategy
    • Jeong, C.S.; Murthy, H.N.; Hahn, E.J.; Paek, K.Y. Improved production of ginsenosides in suspension cultures of Ginseng by medium replenishment strategy. J. Biosci. Bioeng., 2008, 105, 288-291.
    • (2008) J. Biosci. Bioeng , vol.105 , pp. 288-291
    • Jeong, C.S.1    Murthy, H.N.2    Hahn, E.J.3    Paek, K.Y.4
  • 160
    • 77953873722 scopus 로고    scopus 로고
    • Selection and optimization of a high-producing tissue culture of Panax ginseng C.A. Meyer
    • Huang, T.; Gao, W.Y.; Wang, J.; Cao, Y.; Zhao, Y.X.; Huang, L.Q.; Liu, C.X. Selection and optimization of a high-producing tissue culture of Panax ginseng C.A. Meyer. Acta Physiol. Plant., 2010, 32, 765-772.
    • (2010) Acta Physiol. Plant , vol.32 , pp. 765-772
    • Huang, T.1    Gao, W.Y.2    Wang, J.3    Cao, Y.4    Zhao, Y.X.5    Huang, L.Q.6    Liu, C.X.7
  • 162
    • 77649339535 scopus 로고    scopus 로고
    • Growth kinetics and ginsenosides production in transformed hairy roots of American ginseng - Panax quinquefolium L
    • Manthur, A.; Gangwar, A.; Mathur, A.K.; Verma, P.; Uniyal, C.G.; Lal, R.K. Growth kinetics and ginsenosides production in transformed hairy roots of American ginseng - Panax quinquefolium L. Biotechnol. Lett., 2010, 32, 457-461.
    • (2010) Biotechnol. Lett , vol.32 , pp. 457-461
    • Manthur, A.1    Gangwar, A.2    Mathur, A.K.3    Verma, P.4    Uniyal, C.G.5    Lal, R.K.6
  • 163
    • 9944221512 scopus 로고    scopus 로고
    • Enhancement of saponin production in Panax ginseng cell culture by osmotic stress and nutrient feeding
    • Wu, J. Y.; Wong, K.; Ho, K.P.; Zhou, L.G. Enhancement of saponin production in Panax ginseng cell culture by osmotic stress and nutrient feeding. Enzyme Microb. Technol., 2005, 36, 133-138.
    • (2005) Enzyme Microb. Technol , vol.36 , pp. 133-138
    • Wu, J.Y.1    Wong, K.2    Ho, K.P.3    Zhou, L.G.4
  • 164
    • 17644391449 scopus 로고    scopus 로고
    • Elicitor signal transduction leading to production of plant secondary metabolites
    • Zhao, J.; Davis, L.C.; Verpoorte, R. Elicitor signal transduction leading to production of plant secondary metabolites. Biotechnol. Adv., 2005, 23, 283-333.
    • (2005) Biotechnol. Adv , vol.23 , pp. 283-333
    • Zhao, J.1    Davis, L.C.2    Verpoorte, R.3
  • 165
    • 0345359203 scopus 로고    scopus 로고
    • Elicitation of different Panax ginseng transformated root phenotypes for an improved ginsenoside production
    • Palazón, J.; Cusidó, R.M.; Bonfill, M.; Mallol, A.; Moyano, E.; Morales, C.; Piñol, M.T. Elicitation of different Panax ginseng transformated root phenotypes for an improved ginsenoside production. Plant Physiol. Biochem., 2003, 41, 1019-1025.
    • (2003) Plant Physiol. Biochem , vol.41 , pp. 1019-1025
    • Palazón, J.1    Cusidó, R.M.2    Bonfill, M.3    Mallol, A.4    Moyano, E.5    Morales, C.6    Piñol, M.T.7
  • 166
    • 33749060647 scopus 로고    scopus 로고
    • Copper-induced changes in the growth, oxidative metabolism, and saponin production in suspension culture roots of Panax ginseng in bioreactors
    • Ali, M.B.; Hahn, E.J.; Paek, K.Y. Copper-induced changes in the growth, oxidative metabolism, and saponin production in suspension culture roots of Panax ginseng in bioreactors. Plant Cell Rep., 2006, 25, 1122-1132.
    • (2006) Plant Cell Rep , vol.25 , pp. 1122-1132
    • Ali, M.B.1    Hahn, E.J.2    Paek, K.Y.3
  • 167
    • 11844298448 scopus 로고    scopus 로고
    • Ginsenoside production by hairy root cultures of Panax ginseng: Influence of temperature and light quality
    • Yu, K.; Murthy, H.N.; Hahn, E.J.; Paek, K.Y. Ginsenoside production by hairy root cultures of Panax ginseng: influence of temperature and light quality. Biochem. Eng. J., 2005, 23, 53-56.
    • (2005) Biochem. Eng. J , vol.23 , pp. 53-56
    • Yu, K.1    Murthy, H.N.2    Hahn, E.J.3    Paek, K.Y.4
  • 168
    • 33751176445 scopus 로고    scopus 로고
    • Effect of oxygen supply on cell growth and saponin production in bioreactor cultures of Panax ginseng
    • Thahn, N.T.; Murthy, H.N.; Yu, K.W.; Jeong, C.S.; Hahn, E.J. Paek, K.Y. Effect of oxygen supply on cell growth and saponin production in bioreactor cultures of Panax ginseng. J. Plant Physiol., 2006, 163, 1337-1341.
    • (2006) J. Plant Physiol , vol.163 , pp. 1337-1341
    • Thahn, N.T.1    Murthy, H.N.2    Yu, K.W.3    Jeong, C.S.4    Hahn, E.J.5    Paek, K.Y.6
  • 169
    • 33646868795 scopus 로고    scopus 로고
    • Methyl jasmonate and salicylic acid elicitation induces ginsenosides accumulation, enzymatic and non-enzymatic antioxidant in suspension culture Panax ginseng roots in bioreactors
    • Ali, M.B.; Yu, K.W.; Hahn, E.J.; Paek, K.Y. Methyl jasmonate and salicylic acid elicitation induces ginsenosides accumulation, enzymatic and non-enzymatic antioxidant in suspension culture Panax ginseng roots in bioreactors. Plant Cell Rep., 2006, 25, 613-620.
    • (2006) Plant Cell Rep , vol.25 , pp. 613-620
    • Ali, M.B.1    Yu, K.W.2    Hahn, E.J.3    Paek, K.Y.4
  • 170
    • 77950862771 scopus 로고    scopus 로고
    • Influences of polyunsaturated fatty acids (PUFAs) on growth and secondary metabolite accumulation in Panax ginseng C.A. Meyer adventitious roots cultured in air-lift bioreactors
    • Dewir, Y.H.; Chakrabarty, D.; Wu, C.H.; Hahn, E.J.; Jeon, W.K.; Paek, K.Y. Influences of polyunsaturated fatty acids (PUFAs) on growth and secondary metabolite accumulation in Panax ginseng C.A. Meyer adventitious roots cultured in air-lift bioreactors. S. Afr. J. Bot., 2010, 76(2), 354-358.
    • (2010) S. Afr. J. Bot , vol.76 , Issue.2 , pp. 354-358
    • Dewir, Y.H.1    Chakrabarty, D.2    Wu, C.H.3    Hahn, E.J.4    Jeon, W.K.5    Paek, K.Y.6
  • 171
    • 70350128769 scopus 로고    scopus 로고
    • Significant enhancement of oleanolic acid accumulation by biotic elicitors in cell suspension cultures of Calendula officinalis L
    • Wiktorowska, E.; Dlugosz, M. Janiszowska, W. Significant enhancement of oleanolic acid accumulation by biotic elicitors in cell suspension cultures of Calendula officinalis L. Enzyme Microb. Technol., 2010, 46, 14-20.
    • (2010) Enzyme Microb. Technol , vol.46 , pp. 14-20
    • Wiktorowska, E.1    Dlugosz, M.2    Janiszowska, W.3
  • 172
    • 20844445188 scopus 로고    scopus 로고
    • Effect of growth regulators on asiaticoside production in whole plant cultures of Centella asiatica (L.) Urban
    • Kim, O.K.; Kim, M.Y.; Huh, S.M.; Ahn, J.C.; Seong, N.S.; Hwang, B. Effect of growth regulators on asiaticoside production in whole plant cultures of Centella asiatica (L.) Urban. J. Plant Biol., 2004, 47, 361-365.
    • (2004) J. Plant Biol , vol.47 , pp. 361-365
    • Kim, O.K.1    Kim, M.Y.2    Huh, S.M.3    Ahn, J.C.4    Seong, N.S.5    Hwang, B.6
  • 173
    • 33748040067 scopus 로고    scopus 로고
    • The effect of methyl jasmonate on triterpene and sterol metabolisms of Centella asiatica, Ruscus aculeatus and Galphimia glauca cultured plants
    • Mangas, S.; Bonfill, M.; Osuna, L.; Moyano, E.; Tortoriello, J.; Cusido, R.M.; Piñol, M.T.; Palazón, J. The effect of methyl jasmonate on triterpene and sterol metabolisms of Centella asiatica, Ruscus aculeatus and Galphimia glauca cultured plants. Phytochemistry, 2006, 67, 2041-2049.
    • (2006) Phytochemistry , vol.67 , pp. 2041-2049
    • Mangas, S.1    Bonfill, M.2    Osuna, L.3    Moyano, E.4    Tortoriello, J.5    Cusido, R.M.6    Piñol, M.T.7    Palazón, J.8
  • 174
    • 14844304997 scopus 로고    scopus 로고
    • Stimulation of asiaticoside accumulation in the whole plant cultures of Centella asiatica (L.) Urban by elicitors
    • Kim, O.K.; Kim, M.Y.; Hong, M.H.; Ahn, J.C.; Hwang, B. Stimulation of asiaticoside accumulation in the whole plant cultures of Centella asiatica (L.) Urban by elicitors. Plant Cell Rep., 2004, 23, 339-344.
    • (2004) Plant Cell Rep , vol.23 , pp. 339-344
    • Kim, O.K.1    Kim, M.Y.2    Hong, M.H.3    Ahn, J.C.4    Hwang, B.5
  • 176
    • 66749155933 scopus 로고    scopus 로고
    • Cloning and functional analysis of a ��-amyrin synthase gene associated with oleanolic acid biosynthesis in Gentiana straminea MAXIM
    • Liu, Y.L.; Cai, Y.F.; Zhao, Z.J.; Wang, J.F.; Li, J.; Xin, W. Cloning and functional analysis of a ��-amyrin synthase gene associated with oleanolic acid biosynthesis in Gentiana straminea MAXIM. Biological Biol. Pharm. Bull., 2009, 32, 818-824.
    • (2009) Biological Biol. Pharm. Bull , vol.32 , pp. 818-824
    • Liu, Y.L.1    Cai, Y.F.2    Zhao, Z.J.3    Wang, J.F.4    Li, J.5    Xin, W.6
  • 177
    • 16644392005 scopus 로고    scopus 로고
    • Differential expression of three oxidosqualene cyclase mRNAs in Glycyrrhiza glabra
    • Hayashi, H.; Huang, P.; Takada, S.; Obinata, M.; Inoue, K.; Shibuya, M. Differential expression of three oxidosqualene cyclase mRNAs in Glycyrrhiza glabra. Biol. Pharm. Bull., 2004, 27, 1086-1092.
    • (2004) Biol. Pharm. Bull , vol.27 , pp. 1086-1092
    • Hayashi, H.1    Huang, P.2    Takada, S.3    Obinata, M.4    Inoue, K.5    Shibuya, M.6
  • 178
    • 77952090886 scopus 로고    scopus 로고
    • Glycyrrhizin production by in vitro cultured Glycyrrhiza glabra elicited by methyl jasmonate and salicylic acid
    • Shabani, L.; Ehsanpour, A.A.; Asghari, G.; Emami, J. Glycyrrhizin production by in vitro cultured Glycyrrhiza glabra elicited by methyl jasmonate and salicylic acid. Russ. J. Plant Physiol., 2009, 56, 621-626.
    • (2009) Russ. J. Plant Physiol , vol.56 , pp. 621-626
    • Shabani, L.1    Ehsanpour, A.A.2    Asghari, G.3    Emami, J.4
  • 179
    • 13244292589 scopus 로고    scopus 로고
    • Metabolic profiling of Medicago truncatula cell cultures reveals the effects of biotic and abiotic elicitors on metabolism
    • Broeckling, C.D.; Huhman, D.V.; Farag, M.A.; Smith, G.D.M.; Mendes, P.; Dixon, R.A. Metabolic profiling of Medicago truncatula cell cultures reveals the effects of biotic and abiotic elicitors on metabolism. J. Exp. Bot., 2005, 56, 323-336.
    • (2005) J. Exp. Bot , vol.56 , pp. 323-336
    • Broeckling, C.D.1    Huhman, D.V.2    Farag, M.A.3    Smith, G.D.M.4    Mendes, P.5    Dixon, R.A.6
  • 180
    • 20144376484 scopus 로고    scopus 로고
    • Methyl jasmonate and yeast elicitor induce differential transcriptional and metabolic re-programming in cell suspension cultures of the model legume Medicago truncatula
    • Suzuki, H.; Reddy, M.S.S.; Naoumkina, M.; Aziz, N.; May, G.D.; Huhman, D.V. Methyl jasmonate and yeast elicitor induce differential transcriptional and metabolic re-programming in cell suspension cultures of the model legume Medicago truncatula. Planta, 2005, 220, 696-707.
    • (2005) Planta , vol.220 , pp. 696-707
    • Suzuki, H.1    Reddy, M.S.S.2    Naoumkina, M.3    Aziz, N.4    May, G.D.5    Huhman, D.V.6
  • 181
    • 62549137403 scopus 로고    scopus 로고
    • Methyl jasmonate induced accumulation of kalopanaxsaponin I in Nigella sativa
    • Scholz, M.; Lipinski, M.; Leupold, M.; Luftmann, H.; Harig, L.; Ofirc, R. Methyl jasmonate induced accumulation of kalopanaxsaponin I in Nigella sativa. Phytochemistry, 2009, 70, 517-522.
    • (2009) Phytochemistry , vol.70 , pp. 517-522
    • Scholz, M.1    Lipinski, M.2    Leupold, M.3    Luftmann, H.4    Harig, L.5    Ofirc, R.6
  • 182
    • 67349119465 scopus 로고    scopus 로고
    • A squalene epoxidase from Nigella sativa participates in saponin biosynthesis and mediates terbinafine resistance in yeast
    • Lipinski, M.; Scholz, M.; Pieper, K.; Fischer, R.; Pruefer, D.; Muller, K.J. A squalene epoxidase from Nigella sativa participates in saponin biosynthesis and mediates terbinafine resistance in yeast. Cent. Eur. J. Biol. 2009, 4, 163-169.
    • (2009) Cent. Eur. J. Biol , vol.4 , pp. 163-169
    • Lipinski, M.1    Scholz, M.2    Pieper, K.3    Fischer, R.4    Pruefer, D.5    Muller, K.J.6
  • 183
    • 4644290998 scopus 로고    scopus 로고
    • Enhanced triterpene and phytosterol biosynthesis in Panax ginseng overexpressing squalene synthase gene
    • Lee, M.H.; Jeong, J.H.; Seo, J.W.; Shin, C.G.; Kim, Y.S.; In, J.G. Enhanced triterpene and phytosterol biosynthesis in Panax ginseng overexpressing squalene synthase gene. Plant Cell Physiol., 2004, 45, 976-984.
    • (2004) Plant Cell Physiol , vol.45 , pp. 976-984
    • Lee, M.H.1    Jeong, J.H.2    Seo, J.W.3    Shin, C.G.4    Kim, Y.S.5    In, J.G.6
  • 184
    • 17844403288 scopus 로고    scopus 로고
    • Methyl jasmonate elicitation enhanced synthesis of ginsenoside by cell suspension cultures of Panax ginseng in 5-l balloon type bubble bioreactors
    • Thanh, N. T.; Murthy, H. N.; Yu, K. W.; Hahn, E. J.; Paek, K.Y. Methyl jasmonate elicitation enhanced synthesis of ginsenoside by cell suspension cultures of Panax ginseng in 5-l balloon type bubble bioreactors. Appl. Microbiol. Biotechnol., 2005, 67, 197-201.
    • (2005) Appl. Microbiol. Biotechnol , vol.67 , pp. 197-201
    • Thanh, N.T.1    Murthy, H.N.2    Yu, K.W.3    Hahn, E.J.4    Paek, K.Y.5
  • 185
    • 67349125738 scopus 로고    scopus 로고
    • Upregulation of ginsenoside and gene expression related to triterpene biosynthesis in ginseng hairy root cultures elicited by methyl jasmonate
    • Kim, O.T.; Bang, K.H.; Kim, Y.C.; Hyun, D.Y.; Kim, M. Y.; Cha, S.W. Upregulation of ginsenoside and gene expression related to triterpene biosynthesis in ginseng hairy root cultures elicited by methyl jasmonate. Plant Cell Tiss. Org., 2009, 98, 25-33.
    • (2009) Plant Cell Tiss. Org , vol.98 , pp. 25-33
    • Kim, O.T.1    Bang, K.H.2    Kim, Y.C.3    Hyun, D.Y.4    Kim, M.Y.5    Cha, S.W.6
  • 186
    • 33746042541 scopus 로고    scopus 로고
    • Enhanced ginsenoside productivity by combination of ethephon and methyl jasmonate in ginseng (Panax ginseng C.A. Meyer) adventitious root cultures
    • Bae, K.H.; Choi, Y.E.; Shin, C.G.; Kim, Y.Y.; Kim, Y.S. Enhanced ginsenoside productivity by combination of ethephon and methyl jasmonate in ginseng (Panax ginseng C.A. Meyer) adventitious root cultures. Biotechnol. Lett. 2006, 28, 1163-1166.
    • (2006) Biotechnol. Lett , vol.28 , pp. 1163-1166
    • Bae, K.H.1    Choi, Y.E.2    Shin, C.G.3    Kim, Y.Y.4    Kim, Y.S.5
  • 187
    • 33847709064 scopus 로고    scopus 로고
    • Stimulation of saponin production in Panax ginseng hairy roots by two oligosaccharides from Paris polyphylla var yunnanensis
    • Zhou, L.; Cao, X.; Zhang, R.; Peng, Y.; Zhao, S.; Wu, J. Stimulation of saponin production in Panax ginseng hairy roots by two oligosaccharides from Paris polyphylla var yunnanensis. Biotechnol. Lett., 2007, 29, 631-634.
    • (2007) Biotechnol. Lett , vol.29 , pp. 631-634
    • Zhou, L.1    Cao, X.2    Zhang, R.3    Peng, Y.4    Zhao, S.5    Wu, J.6
  • 188
    • 37149000762 scopus 로고    scopus 로고
    • Jasmonic acid mediates gene transcription of ginsenoside biosynthesis in cell cultures of Panax notoginseng treated with chemically synthesized 2-hydroxyethyl jasmonate
    • Hu, F. X.; Zhong, J. J. Jasmonic acid mediates gene transcription of ginsenoside biosynthesis in cell cultures of Panax notoginseng treated with chemically synthesized 2-hydroxyethyl jasmonate. Process Biochem., 2008, 43, 113-118.
    • (2008) Process Biochem , vol.43 , pp. 113-118
    • Hu, F.X.1    Zhong, J.J.2
  • 189
    • 18144431988 scopus 로고    scopus 로고
    • Enhancement of ginsenoside biosynthesis in high-density cultivation of Panax notoginseng cells by various strategies of methyl jasmonate elicitation
    • Wang, W.; Zhang, Z. Y.; Zhong, J. J. Enhancement of ginsenoside biosynthesis in high-density cultivation of Panax notoginseng cells by various strategies of methyl jasmonate elicitation. Appl. Microbiol. Biotechnol., 2005, 67, 752-758.
    • (2005) Appl. Microbiol. Biotechnol , vol.67 , pp. 752-758
    • Wang, W.1    Zhang, Z.Y.2    Zhong, J.J.3
  • 190
    • 33644768323 scopus 로고    scopus 로고
    • Efficient induction of ginsenoside biosynthesis and alteration of ginsenoside heterogeneity in cell cultures of Panax notoginseng by using chemically synthesized 2-hydroxyethyl jasmonate
    • Wang, W.; Zhao, Z. J.; Xu, Y.; Qian, X.; Zhong, J. J. Efficient induction of ginsenoside biosynthesis and alteration of ginsenoside heterogeneity in cell cultures of Panax notoginseng by using chemically synthesized 2-hydroxyethyl jasmonate. Appl. Microbiol. Biotechnol., 2006, 70, 298-307.
    • (2006) Appl. Microbiol. Biotechnol , vol.70 , pp. 298-307
    • Wang, W.1    Zhao, Z.J.2    Xu, Y.3    Qian, X.4    Zhong, J.J.5
  • 191
    • 80051668049 scopus 로고    scopus 로고
    • Elicitation of diosgenin production in Trigonella foenum-graecum L. seedlings by heavy metals and signaling molecules
    • Available from: 10.1007/s11738-010-0691-7
    • Debjani, D.; Batrati, D. Elicitation of diosgenin production in Trigonella foenum-graecum L. seedlings by heavy metals and signaling molecules. Acta Physiol. Plant. Available from: 10.1007/s11738-010-0691-7.
    • Acta Physiol. Plant
    • Debjani, D.1    Batrati, D.2
  • 192
    • 34147146097 scopus 로고    scopus 로고
    • Opposite effects of synthetic auxins, 2,4-dichlorophenoxyacetic acid and 1- naphthalene acetic acid on growth of true ginseng cell culture and synthesis of ginsenosides
    • Smolenskaya, I.N.; Res hetnyak, O.V.; Smirnova, Y.N.; Chernyak, N.D.; Globa, E.B.; Nosov, A.M.; Nosov, A.V. Opposite effects of synthetic auxins, 2,4-dichlorophenoxyacetic acid and 1- naphthalene acetic acid on growth of true ginseng cell culture and synthesis of ginsenosides. Russ. J. Plant Physiol., 2007, 54, 215-223.
    • (2007) Russ. J. Plant Physiol , vol.54 , pp. 215-223
    • Smolenskaya, I.N.1    Res, H.O.V.2    Smirnova, Y.N.3    Chernyak, N.D.4    Globa, E.B.5    Nosov, A.M.6    Nosov, A.V.7
  • 193
    • 33745673788 scopus 로고    scopus 로고
    • Effect of carbon dioxide on cell growth and saponin production in suspension cultures of Panax ginseng
    • Thanh, N.T., Murthy, H.N.; Pandey, D.M.; Yu, K.W.; Hahn, E.J.; Paek, K.Y. Effect of carbon dioxide on cell growth and saponin production in suspension cultures of Panax ginseng. Biol. Plantarum, 2006, 50(4), 752-754.
    • (2006) Biol. Plantarum , vol.50 , Issue.4 , pp. 752-754
    • Thanh, N.T.1    Murthy, H.N.2    Pandey, D.M.3    Yu, K.W.4    Hahn, E.J.5    Paek, K.Y.6
  • 194
    • 17444400413 scopus 로고    scopus 로고
    • Overexpression of squalene synthase in Eleutherococcus senticosus increases phytosterol and triterpene aaccumulation
    • Seo, J.W.; Jeong, J.H.; Shin, C.G.; Lo, S.C.; Han, S.S.; Yu, K.W. Overexpression of squalene synthase in Eleutherococcus senticosus increases phytosterol and triterpene aaccumulation. Phytochemistry, 2005, 66, 869-877.
    • (2005) Phytochemistry , vol.66 , pp. 869-877
    • Seo, J.W.1    Jeong, J.H.2    Shin, C.G.3    Lo, S.C.4    Han, S.S.5    Yu, K.W.6
  • 195
    • 72149121133 scopus 로고    scopus 로고
    • Regulation of ginsenoside and phytosterol biosynthesis by RNA interferences of squalene epoxidase gene in Panax ginseng
    • Han, J.Y.; In, J.G.; Kwon, Y.S.; Choi, Y.E. Regulation of ginsenoside and phytosterol biosynthesis by RNA interferences of squalene epoxidase gene in Panax ginseng. Phytochemistry. 2010, 71, 36-46.
    • (2010) Phytochemistry , vol.71 , pp. 36-46
    • Han, J.Y.1    In, J.G.2    Kwon, Y.S.3    Choi, Y.E.4
  • 196
    • 70350005063 scopus 로고    scopus 로고
    • Antisense suppression of cycloartenol synthase results in elevated ginsenoside levels in Panax ginseng hairy roots
    • Liang, Y.; Zhao, S.; Zhanh, X. Antisense suppression of cycloartenol synthase results in elevated ginsenoside levels in Panax ginseng hairy roots. Plant Mol. Biol. Rep., 2009, 27(3), 298-304.
    • (2009) Plant Mol. Biol. Rep , vol.27 , Issue.3 , pp. 298-304
    • Liang, Y.1    Zhao, S.2    Zhanh, X.3
  • 197
    • 33748809553 scopus 로고    scopus 로고
    • Dammarenediol- II synthase, the first dedicated enzyme for ginsenoside biosynthesis, in Panax ginseng
    • Tansakul, P.; Shibuya, M.; Kushiro, T.; Ebizuka, Y. Dammarenediol- II synthase, the first dedicated enzyme for ginsenoside biosynthesis, in Panax ginseng. FEBS Lett., 2006, 580(22), 5143-5149.
    • (2006) FEBS Lett , vol.580 , Issue.22 , pp. 5143-5149
    • Tansakul, P.1    Shibuya, M.2    Kushiro, T.3    Ebizuka, Y.4
  • 198
    • 58149391298 scopus 로고    scopus 로고
    • Enhanced triterpene saponin biosynthesis and root nodulation in transgenic barrel medic (Medicago truncatula Gaertn.) expressing a novel beta-amyrin synthase (AsOXA1) gene
    • Confalonieri, M.; Cammareri, M.; Biazzi, E.; Pecchia, P.; Fevereiro, M.P.S.; Balestrazzi, A. Enhanced triterpene saponin biosynthesis and root nodulation in transgenic barrel medic (Medicago truncatula Gaertn.) expressing a novel beta-amyrin synthase (AsOXA1) gene. Plant Biotechnol. J., 2009, 7, 172-182.
    • (2009) Plant Biotechnol. J , vol.7 , pp. 172-182
    • Confalonieri, M.1    Cammareri, M.2    Biazzi, E.3    Pecchia, P.4    Fevereiro, M.P.S.5    Balestrazzi, A.6
  • 201
    • 42949125371 scopus 로고    scopus 로고
    • Synthesis and structure verification of the vaccine adjuvant QS-7-Api. Synthetic access to homogeneous Quillaja saponaria immunostimulants
    • Deng, K.; Adams, M. M.; Gin, D. Y. Synthesis and structure verification of the vaccine adjuvant QS-7-Api. Synthetic access to homogeneous Quillaja saponaria immunostimulants. J. Am. Chem. Soc. 2008, 130, 5860-5861.
    • (2008) J. Am. Chem. Soc , vol.130 , pp. 5860-5861
    • Deng, K.1    Adams, M.M.2    Gin D., Y.3
  • 203
    • 39649125143 scopus 로고    scopus 로고
    • Facile synthesis and cytotoxicity of triterpenoid saponins bearing a unique disaccharide moiety: Hederacolchiside A1 and its analogues
    • Yan, MC.; Liu, Y.; Lu, WX.; Wang, H.; Sha, Y.; Cheng, MS. Facile synthesis and cytotoxicity of triterpenoid saponins bearing a unique disaccharide moiety: hederacolchiside A1 and its analogues Carbohydrate Research, 2008, 343, 780-784.
    • (2008) Carbohydrate Research , vol.343 , pp. 780-784
    • Yan, M.C.1    Liu, Y.2    Lu, W.X.3    Wang, H.4    Sha, Y.5    Cheng, M.S.6
  • 204
    • 66249144699 scopus 로고    scopus 로고
    • Synthesis of oleanolic acid saponins mimicking components of Chinese folk medicine Di Wu
    • Huang, X.; Cheng, S.; Du, Y.; Bing, F. Synthesis of oleanolic acid saponins mimicking components of Chinese folk medicine Di Wu. Carbohyd. Res., 2009, 344, 1153-1158.
    • (2009) Carbohyd. Res , vol.344 , pp. 1153-1158
    • Huang, X.1    Cheng, S.2    Du, Y.3    Bing, F.4
  • 205
    • 65449136347 scopus 로고    scopus 로고
    • Synthesis and cytotoxicities of icogenin analogues with disaccharide residues
    • Wang, H.; Su, F.; Zhou, L.; Chen, X.; Pingsheng Lei, P. Synthesis and cytotoxicities of icogenin analogues with disaccharide residues. Bioorg. Med. Chem. Lett., 2009, 19, 2796-800.
    • (2009) Bioorg. Med. Chem. Lett , vol.19 , pp. 2796-800
    • Wang, H.1    Su, F.2    Zhou, L.3    Chen, X.4    Pingsheng, L.P.5
  • 207
    • 78650516089 scopus 로고    scopus 로고
    • The synthesis of cholestane and furostan saponin analogues and the determination of sapogenin's absolute configuration at C-22
    • Wang, H.; Guo, Y.; Guan, Y.; Zhou, L.; Pingsheng Lei, P. The synthesis of cholestane and furostan saponin analogues and the determination of sapogenin's absolute configuration at C-22. Steroid, 2011, 76(1-2):18-27.
    • (2011) Steroid , vol.76 , Issue.1-2 , pp. 18-27
    • Wang, H.1    Guo, Y.2    Guan, Y.3    Zhou, L.4    Pingsheng, L.P.5


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