Anti-inflammatory glycoterpenoids from Scrophularia auriculata

European Journal of Pharmacology

Volumn 389, Issue 2-3, 2000, Pages 243-252

  Giner, Rosa María ^a   Villalba, María Luisa ^a   Recio, María Carmen ^a   Máñez, Salvador ^a   Cerdá Nicolás, Miguel ^a   Ríos, José Luis ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

Author keywords

(Scrophularia auriculata ssp. pseudoauriculata); Anti inflammatory activity; Scropolioside A; Scrovalentinoside; Verbascosaponin; Verbascosaponin A

Indexed keywords

GLYCOTERPENOID; SAPONIN; SCROPOLIOSIDE A; SCROVALENTINOSIDE; TERPENOID; UNCLASSIFIED DRUG; VERBASCOSAPONIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ANTIINFLAMMATORY ACTIVITY; ARTICLE; B LYMPHOCYTE ACTIVATION; CONTROLLED STUDY; DRUG ISOLATION; DRUG POTENCY; ENZYME ACTIVITY; MEDIATOR RELEASE; MESSENGER RNA SYNTHESIS; MOUSE; NONHUMAN; PAW EDEMA; PHAGOCYTOSIS; PRIORITY JOURNAL;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CAPILLARY PERMEABILITY; EAR; EDEMA; FEMALE; GLUCOSIDES; GLYCOSIDES; HYPERSENSITIVITY, DELAYED; IRIDOIDS; MICE; PLANTS, MEDICINAL; PYRANS; SAPONINS; SEROTONIN; TERPENES; TETRADECANOYLPHORBOL ACETATE; TRITERPENES;

EID: 0034681404     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00846-8     Document Type: Article

References (29)

1. Baghdikian B., Lanhers M.C., Fleurentin J., Ollivier E., Maillard C., Balansard G., Mortier F. An analytical study, anti-inflammatory and analgesic effects of Harpagophytum procumbens and Harpagophytum zeyheri. Planta Med. 63:1997;171-176.
2. Bermejo P., Abad M.J., Silván A.M., Sanz A., Fernández L., Sánchez S., Díaz A.M. In vivo and in vitro anti-inflammatory activity of saikosaponins. Life Sci. 63:1998;1147-1156.
3. Bougelet C., Roland I.H., Ninane N., Arnould T., Remacle J., Michiels C. Effect of aescine on hypoxia-induced neutrophil adherence to umbilical vein endothelium. Eur. J. Pharmacol. 345:1998;89-95.
4. Bratssand R., Thalén A., Roempke K., Källström L., Gruvstad E. Influence of 16α,17α-acetal substitution and steroid nucleus fluorination on the topical to systemic activity ratio of glucocorticoids. J. Steroid Biochem. 16:1982;779-786.
5. 2 saponins from an anti-inflammatory extract of Zanha africana root bark. J. Nat. Prod. 60:1997;1158-1160.
6. Cuéllar M.J., Giner R.M., Recio M.C., Just M.J., Máñez S., Cerdá M., Ríos J.L. Screening of anti-inflammatory medicinal plants used in traditional medicine against skin diseases. Phytother. Res. 12:1998;18-23.
7. De Young L.M., Kheifets J.B., Ballaron S.J., Young J.M. Edema and cell infiltration in the phorbol ester-treated mouse ear are temporally separate and can be differentially modulated by pharmacologic agents. Agents Actions. 26:1989;335-341.
8. Edwards C.R., Benediktsson R., Lindsay R.S., Seckl J.R. 11β-Hydroxysteroid dehydrogenases: key enzymes in determining tissue-specific glucocorticoid effects. Steroids. 61:1996;263-269.
9. Garg H.S., Bhandari S.P.S., Tripathi S.C., Patnaik G.K., Puri A., Saxena R., Saxena R.P. Antihepatotoxic and immunomodulatory properties of iridoid glycosides of Scrophularia koelzii. Phytother. Res. 8:1994;224-228.
10. Ghisalberti E.L. Biological and pharmacological activity of naturally occurring iridoids and secoiridoids. Phytomedicine. 5:1998;147-163.
11. Giner R.M., Sanz M.J., Ferrándiz M.L., Recio M.C., Terencio M.C., Ríos J.L. Topical anti-inflammatory activity of some iridoids and phenylpropanoids. Planta Med. 57(Suppl. 2):1991;A57.
12. Giner R.M., Villalba M.L., Recio M.C., Máñez S., Gray A.I., Ríos J.L. A new iridoid from Scrophularia auriculata ssp. pseudoauriculata. J. Nat. Prod. 61:1998;1162-1163.
13. Gupta P.P., Srimal R.C., Srivastava M., Singh K.L., Tandon J.S. Antiallergic activity of arbortristosides from Nyctanthus arbor-tristis. Int. J. Pharmacogn. 33:1995;70-72.
14. Ivanovskova N., Iossifova T., Kostova I. Complement-mediated anti-inflammatory action of extracts and pure secoiridoid isolated from Fraxinus species. Phytother. Res. 10:1996;555-558.
15. Ju D.W., Zheng Q.Y., Cao X., Fang J., Wang H.B. Esculentoside A inhibits tumor necrosis factor, interleukin-1, and interleukin-6 production induced by lipopolysaccharide in mice. Pharmacology. 56:1998;187-195.
16. Ju D.W., Zheng Q.Y., Wang H.B., Guan X.J., Fang J., Yi Y.H. Inhibitory effects of esculentoside A on mouse macrophages and antibody production. Yao Hsueh Hsueh Pao. 29:1994;252-255.
17. Just M.J., Recio M.C., Giner R.M., Cuéllar M.J., Máñez S., Bilia A.R., Ríos J.L. Anti-inflammatory activity of unusual lupane saponins from Bupleurum fruticescens. Planta Med. 64:1998;404-407.
18. Lanhers M.C., Fleurentin J., Mortier F., Vinche A., Younos C. Anti-inflammatory and analgesic effects of an aqueous extract of Harpagophytum procumbens. Planta Med. 58:1992;117-123.
19. Lee S.J., Shin E.J., Son K.H., Chang H.W., Kang S.S., Kim H.P. Anti-inflammatory activity of the major constituents of Lonicera japonica. Arch. Pharmacol. Res. 18:1995;133-135.
20. Recio M.C., Giner R.M., Máñez S., Ríos J.L. Structural considerations on the iridoids as anti-inflammatory agents. Planta Med. 60:1994;232-234.
21. Recio M.C., Giner R.M., Máñez S., Ríos J.L. Investigations on the steroidal anti-inflammatory activity of triterpenoids from Diospyros leucomelas. Planta Med. 61:1995;9-12.
22. Recio M.C., Just M.J., Giner R.M., Máñez S., Ríos J.L. Anti-inflammatory activity on saikosaponins from Heteromorpha trifoliata. J. Nat. Prod. 58:1995b;140-144.
23. Ríos J.L., Recio M.C., Giner R.M., Sanz M.J., Terencio M.C., Máñez S. Two new catalpol derivatives from Scrophularia auriculata. Planta Med. 57(Suppl.):1991;A88.
24. Shimizu K., Amagaya S., Ogihara Y. Structural transformation of saikosaponins by gastric juice and intestinal flora. J. Pharm. Dyn. 8:1985;718-725.
25. Stanley P.L., Steiner S., Havens M., Tramposch K.M. Mouse skin inflammation induced by multiple topical applications of 12-O-tetradecanoylphorbol-13-acetate. Skin Pharmacol. 4:1991;262-271.
26. Sugishita E., Amagaya S., Ogihara Y. Anti-inflammatory testing methods: comparative evaluation of mice and rats. J. Pharm. Dyn. 4:1981;565-575.
27. Sugishita E., Amagaya S., Ogihara Y. Studies on the mechanism of anti-inflammatory activities of papyriogenin A and C. J. Pharm. Dyn. 6:1983;287-294.
28. Yosikawa M., Ueda T., Matsuda H., Yamahara J., Murami N. Absolute stereostructures of hydramacrosides A and B, new bioactive secoiridoid glucoside complexes from the leaves of Hydrangea macrophylla Seringe var. thunbergii Makino. Chem. Pharm. Bull. 42:1994;1691-1693.
29. Young J.M., De Young L.M. Spector J., Back N. Pharmacological Methods in the Control of Inflammation. 1989;215-231 Alan R. Liss, New York.