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Volumn 26, Issue 31, 2008, Pages 3937-3945

A promising balanced Th1 and Th2 directing immunological adjuvant, saponins from the root of Platycodon grandiflorum

Author keywords

Adjuvanticity; Antibody; Campanulaceae; Cellular immunity; Haemolysis; OVA; Platycodon grandiflorum; Saponins

Indexed keywords

ALUMINUM POTASSIUM SULFATE; CONCANAVALIN A; IMMUNOGLOBULIN ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2B ANTIBODY; IMMUNOLOGICAL ADJUVANT; OVALBUMIN; PLATYCODIGENIN; PLATYCODON GRANDIFLORUM EXTRACT; PLATYCOGENIC ACID A; PLATYCONIC ACID A LACTONE; POKEWEED MITOGEN; POLYGALACIC ACID; QUIL A; SAPONIN DERIVATIVE; SODIUM CHLORIDE;

EID: 46149092981     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2008.01.061     Document Type: Article
Times cited : (53)

References (88)
  • 2
    • 0034826521 scopus 로고    scopus 로고
    • Recent developments in adjuvants for vaccines against infectious diseases
    • O'Hagan D.T., Mackichan M.L., and Singh M. Recent developments in adjuvants for vaccines against infectious diseases. Biomol Eng 18 3 (2001) 69-85
    • (2001) Biomol Eng , vol.18 , Issue.3 , pp. 69-85
    • O'Hagan, D.T.1    Mackichan, M.L.2    Singh, M.3
  • 3
    • 0141889064 scopus 로고    scopus 로고
    • Vaccine adjuvants: role and mechanisms of action in vaccine immunogenicity
    • Marciani D.J. Vaccine adjuvants: role and mechanisms of action in vaccine immunogenicity. Drug Discov Today 8 (2003) 934-943
    • (2003) Drug Discov Today , vol.8 , pp. 934-943
    • Marciani, D.J.1
  • 5
    • 0141606205 scopus 로고    scopus 로고
    • New approaches in vaccine development
    • Leclerc C. New approaches in vaccine development. Comp Immunol Microbiol Infect Dis 26 (2003) 329-341
    • (2003) Comp Immunol Microbiol Infect Dis , vol.26 , pp. 329-341
    • Leclerc, C.1
  • 6
    • 9344271546 scopus 로고    scopus 로고
    • Immunity in response to particulate antigen-delivery systems
    • Storni T., Kündig T.M., Senti G., and Johansen P. Immunity in response to particulate antigen-delivery systems. Adv Drug Deliv Rev 57 (2005) 333-355
    • (2005) Adv Drug Deliv Rev , vol.57 , pp. 333-355
    • Storni, T.1    Kündig, T.M.2    Senti, G.3    Johansen, P.4
  • 7
    • 34247169514 scopus 로고    scopus 로고
    • Vaccine adjuvants revisited
    • Aguilar J.C., and Rodríguez E.G. Vaccine adjuvants revisited. Vaccine 25 (2007) 3752-3762
    • (2007) Vaccine , vol.25 , pp. 3752-3762
    • Aguilar, J.C.1    Rodríguez, E.G.2
  • 8
    • 0034845702 scopus 로고    scopus 로고
    • Polysaccharide isolated from the radix of Platycodon grandiflorum selectively activates B cells and macrophages but not T cells
    • Han S.B., Park S.H., Lee K.H., Lee C.W., Lee S.H., Kim H.C., et al. Polysaccharide isolated from the radix of Platycodon grandiflorum selectively activates B cells and macrophages but not T cells. Int Immunopharmacol 1 (2001) 1969-1978
    • (2001) Int Immunopharmacol , vol.1 , pp. 1969-1978
    • Han, S.B.1    Park, S.H.2    Lee, K.H.3    Lee, C.W.4    Lee, S.H.5    Kim, H.C.6
  • 9
    • 0242580047 scopus 로고    scopus 로고
    • Toll-like receptor 4-dependent activation of macrophages by polysaccharide isolated from the radix of Platycodon grandiflorum
    • Yoon Y.D., Han S.B., Kang J.S., Lee C.W., Park S.K., Lee H.S., et al. Toll-like receptor 4-dependent activation of macrophages by polysaccharide isolated from the radix of Platycodon grandiflorum. Int Immunopharmacol 3 (2003) 1873-1882
    • (2003) Int Immunopharmacol , vol.3 , pp. 1873-1882
    • Yoon, Y.D.1    Han, S.B.2    Kang, J.S.3    Lee, C.W.4    Park, S.K.5    Lee, H.S.6
  • 10
    • 4444225420 scopus 로고    scopus 로고
    • Activation of mitogen-activated protein kinases and AP-1 by polysaccharide isolated from the radix of Platycodon grandiflorum in RAW 264 7 cells
    • Yoon Y.D., Kang J.S., Han S.B., Park S.K., Lee H.S., Kang J.S., et al. Activation of mitogen-activated protein kinases and AP-1 by polysaccharide isolated from the radix of Platycodon grandiflorum in RAW 264 7 cells. Int Immunopharmacol 4 (2004) 1477-1487
    • (2004) Int Immunopharmacol , vol.4 , pp. 1477-1487
    • Yoon, Y.D.1    Kang, J.S.2    Han, S.B.3    Park, S.K.4    Lee, H.S.5    Kang, J.S.6
  • 11
    • 0343832081 scopus 로고    scopus 로고
    • Aqueous extract isolated from Platycodon grandiflorum elicits the release of nitric oxide and tumor necrosis factor-α from murine macrophages
    • Choi C.Y., Kim J.Y., Kim Y.S., Chung Y.C., Seo J.K., and Jeong H.G. Aqueous extract isolated from Platycodon grandiflorum elicits the release of nitric oxide and tumor necrosis factor-α from murine macrophages. Int Immunopharmacol 1 (2001) 1141-1151
    • (2001) Int Immunopharmacol , vol.1 , pp. 1141-1151
    • Choi, C.Y.1    Kim, J.Y.2    Kim, Y.S.3    Chung, Y.C.4    Seo, J.K.5    Jeong, H.G.6
  • 12
    • 0035837657 scopus 로고    scopus 로고
    • Augmentation of macrophage functions by an aqueous extract isolated from Platycodon grandiflorum
    • Choi C.Y., Kim J.Y., Kim Y.S., Chung Y.C., Hahm K.S., and Jeong H.G. Augmentation of macrophage functions by an aqueous extract isolated from Platycodon grandiflorum. Cancer Lett 166 (2001) 17-25
    • (2001) Cancer Lett , vol.166 , pp. 17-25
    • Choi, C.Y.1    Kim, J.Y.2    Kim, Y.S.3    Chung, Y.C.4    Hahm, K.S.5    Jeong, H.G.6
  • 13
    • 3242741237 scopus 로고    scopus 로고
    • Anticancer activities of organic extracts from Platycodon grandiflorum A De Candolle roots
    • Lee J.Y., Hwang W.I., Lim S.T., and Antioxidant. Anticancer activities of organic extracts from Platycodon grandiflorum A De Candolle roots. J Ethnopharmacol 93 (2004) 409-415
    • (2004) J Ethnopharmacol , vol.93 , pp. 409-415
    • Lee, J.Y.1    Hwang, W.I.2    Lim, S.T.3    Antioxidant4
  • 14
    • 14644399849 scopus 로고    scopus 로고
    • Induction of apoptosis and inhibition of telomerase activity by aqueous extract from Platycodon grandiflorum in human lung carcinoma cells
    • Park D.I., Lee J.H., Moon S.K., Kim C.H., Lee Y.T., Cheong J., et al. Induction of apoptosis and inhibition of telomerase activity by aqueous extract from Platycodon grandiflorum in human lung carcinoma cells. Pharmacol Res 51 (2005) 437-443
    • (2005) Pharmacol Res , vol.51 , pp. 437-443
    • Park, D.I.1    Lee, J.H.2    Moon, S.K.3    Kim, C.H.4    Lee, Y.T.5    Cheong, J.6
  • 15
    • 33748351414 scopus 로고    scopus 로고
    • Chemopreventive effect of saponins derived from roots of Platycodon grandiflorum on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice
    • Lee K.J., Shin D.W., Chung Y.C., and Jeong H.G. Chemopreventive effect of saponins derived from roots of Platycodon grandiflorum on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice. Arch Pharm Res 29 (2006) 651-656
    • (2006) Arch Pharm Res , vol.29 , pp. 651-656
    • Lee, K.J.1    Shin, D.W.2    Chung, Y.C.3    Jeong, H.G.4
  • 16
    • 33750688244 scopus 로고    scopus 로고
    • Inhibition of tumor invasion and metastasis by aqueous extract of the radix of Platycodon grandiflorum.
    • Lee K.J., Kim J.Y., Choi J.H., Kim H.G., Chung Y.C., Roh S.H., et al. Inhibition of tumor invasion and metastasis by aqueous extract of the radix of Platycodon grandiflorum. Food Chem Toxicol 44 (2006) 1890-1896
    • (2006) Food Chem Toxicol , vol.44 , pp. 1890-1896
    • Lee, K.J.1    Kim, J.Y.2    Choi, J.H.3    Kim, H.G.4    Chung, Y.C.5    Roh, S.H.6
  • 17
    • 7944237939 scopus 로고    scopus 로고
    • An aqueous extract of Platycodi radix inhibits LPS-induced NF-kappaB nuclear translocation in human cultured airway epithelial cells
    • Lee J.H., Choi Y.H., Kang H.S., and Choi B.T. An aqueous extract of Platycodi radix inhibits LPS-induced NF-kappaB nuclear translocation in human cultured airway epithelial cells. Int J Mol Med 13 (2004) 843-847
    • (2004) Int J Mol Med , vol.13 , pp. 843-847
    • Lee, J.H.1    Choi, Y.H.2    Kang, H.S.3    Choi, B.T.4
  • 18
    • 33745848859 scopus 로고    scopus 로고
    • Effects of Platycodon grandiflorum on lipopolysaccharide-stimulated production of prostaglandin E2, nitric oxide, and interleukin-8 in mouse microglial BV2 cells
    • Jang M.H., Kim C.J., Kim E.H., Kim M.G., Leem K.H., and Kim J. Effects of Platycodon grandiflorum on lipopolysaccharide-stimulated production of prostaglandin E2, nitric oxide, and interleukin-8 in mouse microglial BV2 cells. J Med Food 9 (2006) 169-174
    • (2006) J Med Food , vol.9 , pp. 169-174
    • Jang, M.H.1    Kim, C.J.2    Kim, E.H.3    Kim, M.G.4    Leem, K.H.5    Kim, J.6
  • 19
    • 0035841944 scopus 로고    scopus 로고
    • Hepatoprotective effects of Platycodon grandiflorum on acetaminophen-induced liver damage in mice
    • Lee K.J., You H.J., Park S.J., Kim Y.S., Chung Y.C., Jeong T.C., et al. Hepatoprotective effects of Platycodon grandiflorum on acetaminophen-induced liver damage in mice. Cancer Lett 174 (2001) 73-81
    • (2001) Cancer Lett , vol.174 , pp. 73-81
    • Lee, K.J.1    You, H.J.2    Park, S.J.3    Kim, Y.S.4    Chung, Y.C.5    Jeong, T.C.6
  • 20
    • 0036125615 scopus 로고    scopus 로고
    • Protective effect of Platycodi radix on carbon tetrachloride-induced hepatotoxicity
    • Lee K.J., and Jeong H.G. Protective effect of Platycodi radix on carbon tetrachloride-induced hepatotoxicity. Food Chem Toxicol 40 (2002) 517-525
    • (2002) Food Chem Toxicol , vol.40 , pp. 517-525
    • Lee, K.J.1    Jeong, H.G.2
  • 21
    • 13744249740 scopus 로고    scopus 로고
    • Suppressive effects of Platycodon grandiflorum on the progress of carbon tetrachloride-induced hepatic fibrosis
    • Lee K.J., Kim J.Y., Jung K.S., Choi C.Y., Chung Y.C., Kim D.H., et al. Suppressive effects of Platycodon grandiflorum on the progress of carbon tetrachloride-induced hepatic fibrosis. Arch Pharm Res 27 (2004) 1238-1244
    • (2004) Arch Pharm Res , vol.27 , pp. 1238-1244
    • Lee, K.J.1    Kim, J.Y.2    Jung, K.S.3    Choi, C.Y.4    Chung, Y.C.5    Kim, D.H.6
  • 22
    • 34347366351 scopus 로고    scopus 로고
    • Protective effects of Platycodi radix on alcohol-induced fatty liver
    • Kim H.K., Kim D.S., and Cho H.Y. Protective effects of Platycodi radix on alcohol-induced fatty liver. Biosci Biotechnol Biochem 71 (2007) 1550-1552
    • (2007) Biosci Biotechnol Biochem , vol.71 , pp. 1550-1552
    • Kim, H.K.1    Kim, D.S.2    Cho, H.Y.3
  • 23
    • 0029349124 scopus 로고
    • Effects of Platycodon grandiflorum feeding on serum and liver lipid concentrations in rats with diet-induced hyperlipidemia
    • Kim K.S., Ezaki O., Ikemoto S., and Itakura H. Effects of Platycodon grandiflorum feeding on serum and liver lipid concentrations in rats with diet-induced hyperlipidemia. J Nutr Sci Vitaminol 41 (1995) 485-491
    • (1995) J Nutr Sci Vitaminol , vol.41 , pp. 485-491
    • Kim, K.S.1    Ezaki, O.2    Ikemoto, S.3    Itakura, H.4
  • 24
    • 34547401085 scopus 로고    scopus 로고
    • Platycodon grandiflorum extract represses up-regulated adipocyte fatty acid binding protein triggered by a high fat feeding in obese rats
    • Park Y.S., Yoon Y., and Ahn H.S. Platycodon grandiflorum extract represses up-regulated adipocyte fatty acid binding protein triggered by a high fat feeding in obese rats. World J Gastroenterol 13 (2007) 3493-3499
    • (2007) World J Gastroenterol , vol.13 , pp. 3493-3499
    • Park, Y.S.1    Yoon, Y.2    Ahn, H.S.3
  • 25
    • 33847294294 scopus 로고    scopus 로고
    • Antihyperglycemic effects of Platycodon grandiflorum (Jacq ) A. DC. extract on streptozotocin-induced diabetic mice
    • Zheng J., He J., Ji B., Li Y., and Zhang X. Antihyperglycemic effects of Platycodon grandiflorum (Jacq ) A. DC. extract on streptozotocin-induced diabetic mice. Plant Foods Hum Nutr 62 (2007) 7-11
    • (2007) Plant Foods Hum Nutr , vol.62 , pp. 7-11
    • Zheng, J.1    He, J.2    Ji, B.3    Li, Y.4    Zhang, X.5
  • 27
    • 34249878782 scopus 로고    scopus 로고
    • Neuroprotective activity of triterpenoid saponins from Platycodi radix against glutamate-induced toxicity in primary cultured rat cortical cells
    • Son I.H., Park Y.H., Lee S.I., Yang H.D., and Moon H.I. Neuroprotective activity of triterpenoid saponins from Platycodi radix against glutamate-induced toxicity in primary cultured rat cortical cells. Molecules 12 (2007) 1147-1152
    • (2007) Molecules , vol.12 , pp. 1147-1152
    • Son, I.H.1    Park, Y.H.2    Lee, S.I.3    Yang, H.D.4    Moon, H.I.5
  • 28
    • 13444302476 scopus 로고    scopus 로고
    • New triterpenoid saponins from the roots of Platycodon grandiflorum
    • He Z.D., Qiao C.F., Han Q.B., Wang Y., Ye W.C., and Xu H.X. New triterpenoid saponins from the roots of Platycodon grandiflorum. Tetrahedron 61 (2005) 2211-2215
    • (2005) Tetrahedron , vol.61 , pp. 2211-2215
    • He, Z.D.1    Qiao, C.F.2    Han, Q.B.3    Wang, Y.4    Ye, W.C.5    Xu, H.X.6
  • 29
    • 46149089502 scopus 로고    scopus 로고
    • Isolation and identification of triterpenoid saponins from Platycodon grandiflorum (Jacq ) A. DC.
    • Fu W.W., Dou D.Q., Hou W.B., Cheng B.H., Liu F., Chen Y.J., et al. Isolation and identification of triterpenoid saponins from Platycodon grandiflorum (Jacq ) A. DC. Chin J Med Chem 15 (2005) 296-301
    • (2005) Chin J Med Chem , vol.15 , pp. 296-301
    • Fu, W.W.1    Dou, D.Q.2    Hou, W.B.3    Cheng, B.H.4    Liu, F.5    Chen, Y.J.6
  • 30
    • 21344449760 scopus 로고    scopus 로고
    • Isolation of a new saponin and cytotoxic effect of saponins from the root of Platycodon grandiflorum on human tumor cell lines
    • Kim Y.S., Kim J.S., Choi S.U., Kim J.S., Lee H.S., Roh S.H., et al. Isolation of a new saponin and cytotoxic effect of saponins from the root of Platycodon grandiflorum on human tumor cell lines. Planta Med 71 (2005) 566-568
    • (2005) Planta Med , vol.71 , pp. 566-568
    • Kim, Y.S.1    Kim, J.S.2    Choi, S.U.3    Kim, J.S.4    Lee, H.S.5    Roh, S.H.6
  • 31
    • 33846245166 scopus 로고    scopus 로고
    • Chemical constituents from roots of Platycodon grandiflorum
    • Li L.J., Liu Z.H., Chen Y., and Tian J.K. Chemical constituents from roots of Platycodon grandiflorum. China J Chin Mat Med 31 (2006) 1506-1509
    • (2006) China J Chin Mat Med , vol.31 , pp. 1506-1509
    • Li, L.J.1    Liu, Z.H.2    Chen, Y.3    Tian, J.K.4
  • 32
    • 33645539655 scopus 로고    scopus 로고
    • Studies on the chemical constituents from the roots of Platycodon grandiflorum
    • Fu W.W., Dou D.Q., Shimizu N., Takeda T., Pei Y.H., and Chen Y.J. Studies on the chemical constituents from the roots of Platycodon grandiflorum. J Nat Med 60 (2006) 68-72
    • (2006) J Nat Med , vol.60 , pp. 68-72
    • Fu, W.W.1    Dou, D.Q.2    Shimizu, N.3    Takeda, T.4    Pei, Y.H.5    Chen, Y.J.6
  • 33
    • 33744946561 scopus 로고    scopus 로고
    • Saponins of polygalacic acid type from Platycodon grandiflorum
    • Fu W.W., Hou W.B., Dou D.Q., Hua H.M., Gui M.H., Fu R., et al. Saponins of polygalacic acid type from Platycodon grandiflorum. Acta Pharm Sin 41 (2006) 358-360
    • (2006) Acta Pharm Sin , vol.41 , pp. 358-360
    • Fu, W.W.1    Hou, W.B.2    Dou, D.Q.3    Hua, H.M.4    Gui, M.H.5    Fu, R.6
  • 34
    • 33645536919 scopus 로고    scopus 로고
    • Five new triterpenoid saponins from the roots of Platycodon grandiflorum
    • Fu W.W., Shimizu N., Dou D.Q., Takeda T., Fu R., Pei Y.H., et al. Five new triterpenoid saponins from the roots of Platycodon grandiflorum. Chem Pharm Bull 54 (2006) 557-560
    • (2006) Chem Pharm Bull , vol.54 , pp. 557-560
    • Fu, W.W.1    Shimizu, N.2    Dou, D.Q.3    Takeda, T.4    Fu, R.5    Pei, Y.H.6
  • 35
    • 33748460082 scopus 로고    scopus 로고
    • New A-ring lactone triterpenoid saponins from the roots of Platycodon grandiflorum
    • Fu W.W., Shimizu N., Takeda T., Dou D.Q., Chen B., Pei Y.H., et al. New A-ring lactone triterpenoid saponins from the roots of Platycodon grandiflorum. Chem Pharm Bull 54 (2006) 1285-1287
    • (2006) Chem Pharm Bull , vol.54 , pp. 1285-1287
    • Fu, W.W.1    Shimizu, N.2    Takeda, T.3    Dou, D.Q.4    Chen, B.5    Pei, Y.H.6
  • 36
    • 34247876145 scopus 로고    scopus 로고
    • Cytotoxic triterpenoid saponins from the roots of Platycodon grandiflorum
    • Zhang L., Liu Z.H., and Tian J.K. Cytotoxic triterpenoid saponins from the roots of Platycodon grandiflorum. Molecules 12 (2007) 832-841
    • (2007) Molecules , vol.12 , pp. 832-841
    • Zhang, L.1    Liu, Z.H.2    Tian, J.K.3
  • 37
    • 34247251926 scopus 로고    scopus 로고
    • A new triterpenoid saponin from the roots of Platycodon grandiflorum
    • Li W., Xiang L., Zhang J., Zheng Y.N., Han L.K., and Saito M. A new triterpenoid saponin from the roots of Platycodon grandiflorum. Chin Chem Lett 18 (2007) 306-308
    • (2007) Chin Chem Lett , vol.18 , pp. 306-308
    • Li, W.1    Xiang, L.2    Zhang, J.3    Zheng, Y.N.4    Han, L.K.5    Saito, M.6
  • 38
    • 0027087023 scopus 로고
    • Phytoehemical studies of seeds of medicinal plants II A new dihydroflavonol glycoside and a new 3-methyl-1-butanol glycoside from seeds of Platycodon grandiflorum A.D.
    • Inada A., Murata H., Somekawa M., and Nakanish T. Phytoehemical studies of seeds of medicinal plants II A new dihydroflavonol glycoside and a new 3-methyl-1-butanol glycoside from seeds of Platycodon grandiflorum A.D. Chem Pharm Bull 40 (1992) 3081-3083
    • (1992) Chem Pharm Bull , vol.40 , pp. 3081-3083
    • Inada, A.1    Murata, H.2    Somekawa, M.3    Nakanish, T.4
  • 39
    • 17144391837 scopus 로고    scopus 로고
    • Polyphenolic compounds from Platycodon grandiflorum A DC.
    • Mazol I., Glensk M., and Cisowski W. Polyphenolic compounds from Platycodon grandiflorum A DC. Acta Pol Pharm 61 (2004) 203-208
    • (2004) Acta Pol Pharm , vol.61 , pp. 203-208
    • Mazol, I.1    Glensk, M.2    Cisowski, W.3
  • 40
    • 7044226084 scopus 로고    scopus 로고
    • Antioxidant activity of phenylpropanoid esters isolated and identified from Platycodon grandiflorum A DC.
    • Lee J.Y., Yoon J.W., Kim C.T., and Lim S.T. Antioxidant activity of phenylpropanoid esters isolated and identified from Platycodon grandiflorum A DC. Phytochem 65 (2004) 3033-3039
    • (2004) Phytochem , vol.65 , pp. 3033-3039
    • Lee, J.Y.1    Yoon, J.W.2    Kim, C.T.3    Lim, S.T.4
  • 41
    • 0029108218 scopus 로고
    • Polyacetylenes in Platycodon grandiflorum hairy root and campanulaceous plants
    • Tada H., Shimomura K., and Ishimaru K. Polyacetylenes in Platycodon grandiflorum hairy root and campanulaceous plants. J Plant Physiol 145 (1995) 7-10
    • (1995) J Plant Physiol , vol.145 , pp. 7-10
    • Tada, H.1    Shimomura, K.2    Ishimaru, K.3
  • 42
    • 33750375026 scopus 로고    scopus 로고
    • Qualitative and quantitative determination of ten major saponins in Platycodi Radix by high performance liquid chromatography with evaporative light scattering detection and mass spectrometry
    • Ha Y.W., Na Y.C., Seo J.J., Kim S.N., Linhardt R.J., and Kim Y.S. Qualitative and quantitative determination of ten major saponins in Platycodi Radix by high performance liquid chromatography with evaporative light scattering detection and mass spectrometry. J Chromatogr A 1135 (2006) 27-35
    • (2006) J Chromatogr A , vol.1135 , pp. 27-35
    • Ha, Y.W.1    Na, Y.C.2    Seo, J.J.3    Kim, S.N.4    Linhardt, R.J.5    Kim, Y.S.6
  • 43
    • 3042511600 scopus 로고    scopus 로고
    • Platycodin D and D3 isolated from the root of Platycodon grandiflorum modulate the production of nitric oxide and secretion of TNF-α in activated RAW 264 7 cells
    • Wang C.H., Schuller Levis G.B., Lee E.B., Levis W.R., Lee D.W., Kim B.S., et al. Platycodin D and D3 isolated from the root of Platycodon grandiflorum modulate the production of nitric oxide and secretion of TNF-α in activated RAW 264 7 cells. Int Immunopharmacol 4 (2004) 1039-1049
    • (2004) Int Immunopharmacol , vol.4 , pp. 1039-1049
    • Wang, C.H.1    Schuller Levis, G.B.2    Lee, E.B.3    Levis, W.R.4    Lee, D.W.5    Kim, B.S.6
  • 44
    • 14644424029 scopus 로고    scopus 로고
    • Inhibition of inducible nitric oxide synthase and cyclooxygenase II by Platycodon grandiflorum saponins via suppression of nuclear factor-κB activation in RAW 264 7 cells
    • Ahn K.S., Noh E.J., Zhao H.L., Jung S.H., Kang S.S., and Kim Y.S. Inhibition of inducible nitric oxide synthase and cyclooxygenase II by Platycodon grandiflorum saponins via suppression of nuclear factor-κB activation in RAW 264 7 cells. Life Sci 76 (2005) 2315-2328
    • (2005) Life Sci , vol.76 , pp. 2315-2328
    • Ahn, K.S.1    Noh, E.J.2    Zhao, H.L.3    Jung, S.H.4    Kang, S.S.5    Kim, Y.S.6
  • 45
    • 33646153996 scopus 로고    scopus 로고
    • Platycodin D-induced apoptosis through nuclear factor-κB activation in immortalized keratinocytes
    • Ahn K.S., Hahn B.S., Kwack K.B., Lee E.B., and Kim Y.S. Platycodin D-induced apoptosis through nuclear factor-κB activation in immortalized keratinocytes. Eur J Pharmacol 537 (2006) 1-11
    • (2006) Eur J Pharmacol , vol.537 , pp. 1-11
    • Ahn, K.S.1    Hahn, B.S.2    Kwack, K.B.3    Lee, E.B.4    Kim, Y.S.5
  • 46
    • 33646153527 scopus 로고    scopus 로고
    • Inhibitory effect of the saponins derived from roots of Platycodon grandiflorum on carrageenan-induced inflammation
    • Kim J.Y., Hwang Y.P., Kim D.H., Han E.H., Chung Y.C., Roh S.H., et al. Inhibitory effect of the saponins derived from roots of Platycodon grandiflorum on carrageenan-induced inflammation. Biosci Biotechnol Biochem 70 (2006) 858-864
    • (2006) Biosci Biotechnol Biochem , vol.70 , pp. 858-864
    • Kim, J.Y.1    Hwang, Y.P.2    Kim, D.H.3    Han, E.H.4    Chung, Y.C.5    Roh, S.H.6
  • 47
    • 0842346030 scopus 로고    scopus 로고
    • Protective effect of saponins derived from roots of Platycodon grandiflorum on tertbutyl hydroperoxide-induced oxidative hepatotoxicity
    • Lee K.J., Choi C.Y., Chung Y.C., Kim Y.S., Ryu S.Y., Roh S.H., et al. Protective effect of saponins derived from roots of Platycodon grandiflorum on tertbutyl hydroperoxide-induced oxidative hepatotoxicity. Toxicol Lett 147 (2004) 271-282
    • (2004) Toxicol Lett , vol.147 , pp. 271-282
    • Lee, K.J.1    Choi, C.Y.2    Chung, Y.C.3    Kim, Y.S.4    Ryu, S.Y.5    Roh, S.H.6
  • 48
    • 29044450102 scopus 로고    scopus 로고
    • Inhibition of tumor necrosis factor-α-induced expression of adhesion molecules in human endothelial cells by the saponins derived from roots of Platycodon grandiflorum
    • Kim J.Y., Kim D.H., Kim H.G., Song G.Y., Chung Y.C., Roh S.H., et al. Inhibition of tumor necrosis factor-α-induced expression of adhesion molecules in human endothelial cells by the saponins derived from roots of Platycodon grandiflorum. Toxicol Appl Pharmacol 210 (2006) 150-156
    • (2006) Toxicol Appl Pharmacol , vol.210 , pp. 150-156
    • Kim, J.Y.1    Kim, D.H.2    Kim, H.G.3    Song, G.Y.4    Chung, Y.C.5    Roh, S.H.6
  • 49
    • 33646127601 scopus 로고    scopus 로고
    • Cholesterol-lowering effect of platycodin D in hypercholesterolemic ICR mice
    • Zhao H.L., Cho K.H., Ha Y.W., Jeong T.S., Lee W.S., and Kim Y.S. Cholesterol-lowering effect of platycodin D in hypercholesterolemic ICR mice. Eur J Pharmacol 537 (2006) 166-173
    • (2006) Eur J Pharmacol , vol.537 , pp. 166-173
    • Zhao, H.L.1    Cho, K.H.2    Ha, Y.W.3    Jeong, T.S.4    Lee, W.S.5    Kim, Y.S.6
  • 50
    • 16644384077 scopus 로고    scopus 로고
    • Determination of the kineticproperties of platycodin D for the inhibition of pancreatic lipase using a 1 2-diglyceride-based colorimetric assay
    • Zhao H.L., and Kim Y.S. Determination of the kineticproperties of platycodin D for the inhibition of pancreatic lipase using a 1 2-diglyceride-based colorimetric assay. Arch Pharm Res 27 (2004) 968-972
    • (2004) Arch Pharm Res , vol.27 , pp. 968-972
    • Zhao, H.L.1    Kim, Y.S.2
  • 51
    • 21844471043 scopus 로고    scopus 로고
    • In vitro inhibitory effect of triterpenoidal saponins from Platycodi Radix on pancreatic lipase
    • Xu B.J., Han L.K., Zheng Y.N., Lee J.H., and Sung C.K. In vitro inhibitory effect of triterpenoidal saponins from Platycodi Radix on pancreatic lipase. Arch Pharm Res 28 (2005) 180-185
    • (2005) Arch Pharm Res , vol.28 , pp. 180-185
    • Xu, B.J.1    Han, L.K.2    Zheng, Y.N.3    Lee, J.H.4    Sung, C.K.5
  • 52
    • 0036748248 scopus 로고    scopus 로고
    • Antinociceptive mechanisms of platycodin D administered intracere-broventricularly in the mouse
    • Choi S.S., Han E.J., Lee T.H., Han K.J., Lee H.K., and Suh H.W. Antinociceptive mechanisms of platycodin D administered intracere-broventricularly in the mouse. Planta Med 68 (2002) 794-798
    • (2002) Planta Med , vol.68 , pp. 794-798
    • Choi, S.S.1    Han, E.J.2    Lee, T.H.3    Han, K.J.4    Lee, H.K.5    Suh, H.W.6
  • 53
    • 33645242521 scopus 로고    scopus 로고
    • Adjuvant effect of Achyranthes bidentata saponins on specific antibody and cellular response to ovalbumin in mice
    • Sun H.X. Adjuvant effect of Achyranthes bidentata saponins on specific antibody and cellular response to ovalbumin in mice. Vaccine 24 (2006) 3432-3439
    • (2006) Vaccine , vol.24 , pp. 3432-3439
    • Sun, H.X.1
  • 54
    • 25144454868 scopus 로고    scopus 로고
    • Haemolytic activities and adjuvant effect of Astragalus membranaceus saponins on the immune responses to ovalbumin in mice
    • Yang Z.G., Sun H.X., and Fang W.H. Haemolytic activities and adjuvant effect of Astragalus membranaceus saponins on the immune responses to ovalbumin in mice. Vaccine 23 (2005) 5196-5203
    • (2005) Vaccine , vol.23 , pp. 5196-5203
    • Yang, Z.G.1    Sun, H.X.2    Fang, W.H.3
  • 55
    • 32344449646 scopus 로고    scopus 로고
    • Haemolytic activities and adjuvant effect of Bupleurum chinense saponins on the immune responses to ovalbumin in mice
    • Sun H.X. Haemolytic activities and adjuvant effect of Bupleurum chinense saponins on the immune responses to ovalbumin in mice. Vaccine 24 (2006) 1324-1331
    • (2006) Vaccine , vol.24 , pp. 1324-1331
    • Sun, H.X.1
  • 56
    • 32544439349 scopus 로고    scopus 로고
    • Immunological adjuvant effect of Glycyrrhiza uralensis saponins on the immune responses to ovalbumin in mice
    • Sun H.X., and Pan H.J. Immunological adjuvant effect of Glycyrrhiza uralensis saponins on the immune responses to ovalbumin in mice. Vaccine 24 (2006) 1914-1920
    • (2006) Vaccine , vol.24 , pp. 1914-1920
    • Sun, H.X.1    Pan, H.J.2
  • 57
    • 27944495709 scopus 로고    scopus 로고
    • Haemolytic activities and adjuvant effect of Gynostemma pentaphyllum saponins on the immune responses to ovalbumin in mice
    • Sun H.X., and Zheng Q.F. Haemolytic activities and adjuvant effect of Gynostemma pentaphyllum saponins on the immune responses to ovalbumin in mice. Phytother Res 19 (2005) 895-900
    • (2005) Phytother Res , vol.19 , pp. 895-900
    • Sun, H.X.1    Zheng, Q.F.2
  • 58
    • 4444310289 scopus 로고    scopus 로고
    • Adjuvant effect of Panax notoginseng saponins on the immune responses to ovalbumin in mice
    • Sun H.X., Ye Y.P., Pan H.J., and Pan Y.J. Adjuvant effect of Panax notoginseng saponins on the immune responses to ovalbumin in mice. Vaccine 22 (2004) 3882-3889
    • (2004) Vaccine , vol.22 , pp. 3882-3889
    • Sun, H.X.1    Ye, Y.P.2    Pan, H.J.3    Pan, Y.J.4
  • 59
    • 0031171173 scopus 로고    scopus 로고
    • Haemolytic activities of plant saponins and adjuvants Effect of Periandra mediterranea saponin on the humoral response to the FML antigen of Leishmania donovani
    • Santos W.R., Bernardo R.R., Pecanha L.M., Palatnik M., Parente J.P., and de-Sousa C.B. Haemolytic activities of plant saponins and adjuvants Effect of Periandra mediterranea saponin on the humoral response to the FML antigen of Leishmania donovani. Vaccine 15 (1997) 1024-1029
    • (1997) Vaccine , vol.15 , pp. 1024-1029
    • Santos, W.R.1    Bernardo, R.R.2    Pecanha, L.M.3    Palatnik, M.4    Parente, J.P.5    de-Sousa, C.B.6
  • 60
    • 0034995057 scopus 로고    scopus 로고
    • Development of immunoadjuvants for immunotherapy of cancer
    • Azuma I., and Seya T. Development of immunoadjuvants for immunotherapy of cancer. Int Immunopharmacol 1 (2006) 1249-1259
    • (2006) Int Immunopharmacol , vol.1 , pp. 1249-1259
    • Azuma, I.1    Seya, T.2
  • 61
    • 0026443146 scopus 로고
    • The control of the antibody isotype response to recombinant immunodeficiency virus gp120 antigen by adjuvants
    • Bomford R., Stapleton M., Winsor S., Mc Night A., and Andronova T. The control of the antibody isotype response to recombinant immunodeficiency virus gp120 antigen by adjuvants. AIDS Res Hum Retrovir 8 (1992) 1765-1771
    • (1992) AIDS Res Hum Retrovir , vol.8 , pp. 1765-1771
    • Bomford, R.1    Stapleton, M.2    Winsor, S.3    Mc Night, A.4    Andronova, T.5
  • 62
    • 0029919141 scopus 로고    scopus 로고
    • Induction of homologous virus neutralizing antibodies in guinea-pigs immunized with two human immunodeficiency virus type 1 glycoprotein gp120-iscom preparations: a comparison with other adjuvant systems
    • Sjolander S., Hansen J.E., Lovgren-Bengtsson K., Akerblom L., and Morein B. Induction of homologous virus neutralizing antibodies in guinea-pigs immunized with two human immunodeficiency virus type 1 glycoprotein gp120-iscom preparations: a comparison with other adjuvant systems. Vaccine 14 (1996) 344-352
    • (1996) Vaccine , vol.14 , pp. 344-352
    • Sjolander, S.1    Hansen, J.E.2    Lovgren-Bengtsson, K.3    Akerblom, L.4    Morein, B.5
  • 63
    • 0035961455 scopus 로고    scopus 로고
    • QS-21 promotes an adjuvant effect allowing for reduced antigen dose during HIV-1 envelope subunit immunization in humans
    • Evans T.G., McElrath M.J., Matthews T., Maontefiori D., Weinhold K., WolffM, et al. QS-21 promotes an adjuvant effect allowing for reduced antigen dose during HIV-1 envelope subunit immunization in humans. Vaccine 19 (2001) 2080-2091
    • (2001) Vaccine , vol.19 , pp. 2080-2091
    • Evans, T.G.1    McElrath, M.J.2    Matthews, T.3    Maontefiori, D.4    Weinhold, K.5    WolffM6
  • 64
    • 0028171987 scopus 로고
    • Phase I trial of immunological adjuvant QS-21 with a GM2 ganglioside-keyhole limpet haemocyanin conjugate vaccine in patients with malignant melanoma
    • Livingston P.O., Adluri S., Helling F., Yao T.J., Kensil C.R., Newman M.J., et al. Phase I trial of immunological adjuvant QS-21 with a GM2 ganglioside-keyhole limpet haemocyanin conjugate vaccine in patients with malignant melanoma. Vaccine 12 (1994) 1275-1280
    • (1994) Vaccine , vol.12 , pp. 1275-1280
    • Livingston, P.O.1    Adluri, S.2    Helling, F.3    Yao, T.J.4    Kensil, C.R.5    Newman, M.J.6
  • 65
    • 0034017617 scopus 로고    scopus 로고
    • Induction of antibodies against GM2 ganglioside by immunizing melanoma patients using GM2-keyhole limpet hemocyanin + QS-21 vaccine: a dose-response study
    • Chapman P.B., Morrissey D.M., Panageas K.S., Hamilton W.B., Zhan C., Destro A.N., et al. Induction of antibodies against GM2 ganglioside by immunizing melanoma patients using GM2-keyhole limpet hemocyanin + QS-21 vaccine: a dose-response study. Clin Cancer Res 6 (2000) 874-879
    • (2000) Clin Cancer Res , vol.6 , pp. 874-879
    • Chapman, P.B.1    Morrissey, D.M.2    Panageas, K.S.3    Hamilton, W.B.4    Zhan, C.5    Destro, A.N.6
  • 66
    • 0033588527 scopus 로고    scopus 로고
    • Preclinical evaluation of a synthetic Plasmodium falciparum MAP malaria vaccine in Aotus monkeys and mice
    • Moreno C.A., Rodriguez R., Oliveira G.A., Ferreira V., Nussenzweig R.S., Castro Z.R.M., et al. Preclinical evaluation of a synthetic Plasmodium falciparum MAP malaria vaccine in Aotus monkeys and mice. Vaccine 18 (2000) 89-99
    • (2000) Vaccine , vol.18 , pp. 89-99
    • Moreno, C.A.1    Rodriguez, R.2    Oliveira, G.A.3    Ferreira, V.4    Nussenzweig, R.S.5    Castro, Z.R.M.6
  • 67
    • 0028902386 scopus 로고
    • Formulation of the purified fusion protein of respiratory syncytial virus with the saponin QS-21 induces protective immune response in Balb/c mice that are similar to those generated by experimental infection
    • Hancock G.E., Speeelman D.J., Frenchick P.J., Mineo-Kuhn M.M., Baggs R.B., and Hahn D.J. Formulation of the purified fusion protein of respiratory syncytial virus with the saponin QS-21 induces protective immune response in Balb/c mice that are similar to those generated by experimental infection. Vaccine 13 (1995) 391-400
    • (1995) Vaccine , vol.13 , pp. 391-400
    • Hancock, G.E.1    Speeelman, D.J.2    Frenchick, P.J.3    Mineo-Kuhn, M.M.4    Baggs, R.B.5    Hahn, D.J.6
  • 68
    • 0028858810 scopus 로고
    • Formulation of an immunogenic human cytomegalovirus vaccine: response in mice
    • Britt W., Fay J., Seals J., and Kensil C. Formulation of an immunogenic human cytomegalovirus vaccine: response in mice. J Infect Dis 171 (1995) 18-25
    • (1995) J Infect Dis , vol.171 , pp. 18-25
    • Britt, W.1    Fay, J.2    Seals, J.3    Kensil, C.4
  • 69
    • 0025883977 scopus 로고
    • + T cell immunity against fatal Toxoplasm gondii infection in mice
    • + T cell immunity against fatal Toxoplasm gondii infection in mice. J Immunol 147 (1991) 3501-3506
    • (1991) J Immunol , vol.147 , pp. 3501-3506
    • Khan, I.A.1    Ely, K.H.2    Kasper, L.H.3
  • 71
    • 11144258881 scopus 로고    scopus 로고
    • Pulcherrimasaponin, from the leaves of Calliandra pulcherrima, as adjuvant for immunization in the murine model of visceral leishmaniasis
    • da Silva B.P., Correa Soares J.B.R., Paraguai de Souza E., Palatnik M., Palatnik de Sousa C.B., and Parente J.P. Pulcherrimasaponin, from the leaves of Calliandra pulcherrima, as adjuvant for immunization in the murine model of visceral leishmaniasis. Vaccine 23 (2005) 1061-1071
    • (2005) Vaccine , vol.23 , pp. 1061-1071
    • da Silva, B.P.1    Correa Soares, J.B.R.2    Paraguai de Souza, E.3    Palatnik, M.4    Palatnik de Sousa, C.B.5    Parente, J.P.6
  • 72
    • 33646135059 scopus 로고    scopus 로고
    • Acylated and deacylated saponins of Quillaja saponaria mixture as adjuvants for the FML-vaccine against visceral leishmaniasis
    • Oliveira-Freitas E., Casas C.P., Borja-Cabrera G.P., Santos F.N., Nico D., Souza L.O.P., et al. Acylated and deacylated saponins of Quillaja saponaria mixture as adjuvants for the FML-vaccine against visceral leishmaniasis. Vaccine 24 (2006) 3909-3920
    • (2006) Vaccine , vol.24 , pp. 3909-3920
    • Oliveira-Freitas, E.1    Casas, C.P.2    Borja-Cabrera, G.P.3    Santos, F.N.4    Nico, D.5    Souza, L.O.P.6
  • 74
    • 0028800377 scopus 로고
    • Structure/function studies of QS-21 adjuvant: assessment of triterpene aldehyde and glucuronic acid roles in adjuvant function
    • Soltysik S., Wu J.Y., Recchia J., Wheeler D.A., Newman M.J., Coughlin R.T., et al. Structure/function studies of QS-21 adjuvant: assessment of triterpene aldehyde and glucuronic acid roles in adjuvant function. Vaccine 13 (1995) 1403-1410
    • (1995) Vaccine , vol.13 , pp. 1403-1410
    • Soltysik, S.1    Wu, J.Y.2    Recchia, J.3    Wheeler, D.A.4    Newman, M.J.5    Coughlin, R.T.6
  • 75
    • 0026655265 scopus 로고
    • Vaccination of dogs against Babesia canis infection using parasite antigens from in vitro culture
    • Schetters T.P., Kleuskens J., Scholtes N.C., and Bos H.J. Vaccination of dogs against Babesia canis infection using parasite antigens from in vitro culture. Parasite Immunol 14 (1992) 295-305
    • (1992) Parasite Immunol , vol.14 , pp. 295-305
    • Schetters, T.P.1    Kleuskens, J.2    Scholtes, N.C.3    Bos, H.J.4
  • 76
    • 0033538068 scopus 로고    scopus 로고
    • Emergency vaccination of sheep against foot-and-mouth disease: protection against disease and reduction in contact transmission
    • Cox S.J., Barnett P.V., Dani P., and Salt J.S. Emergency vaccination of sheep against foot-and-mouth disease: protection against disease and reduction in contact transmission. Vaccine 17 (1999) 1858-1868
    • (1999) Vaccine , vol.17 , pp. 1858-1868
    • Cox, S.J.1    Barnett, P.V.2    Dani, P.3    Salt, J.S.4
  • 77
    • 0035898945 scopus 로고    scopus 로고
    • Three double-blind, randomized trials evaluating the safety and tolerance of different formulations of the saponin adjuvant QS-21
    • Waite D.C., Jacobson E.W., Ennis F.A., Edelman R., White B., Kammer R., et al. Three double-blind, randomized trials evaluating the safety and tolerance of different formulations of the saponin adjuvant QS-21. Vaccine 19 (2001) 3957-3967
    • (2001) Vaccine , vol.19 , pp. 3957-3967
    • Waite, D.C.1    Jacobson, E.W.2    Ennis, F.A.3    Edelman, R.4    White, B.5    Kammer, R.6
  • 78
    • 0034662482 scopus 로고    scopus 로고
    • Development of semisynthetic triterpenoid saponin derivatives with immune stimulating activity
    • Marciani D.J., Press J.B., Reynolds R.C., Pathak A.K., Pathak V., Gundy L.E., et al. Development of semisynthetic triterpenoid saponin derivatives with immune stimulating activity. Vaccine 18 (2000) 3141-3151
    • (2000) Vaccine , vol.18 , pp. 3141-3151
    • Marciani, D.J.1    Press, J.B.2    Reynolds, R.C.3    Pathak, A.K.4    Pathak, V.5    Gundy, L.E.6
  • 79
    • 0141882443 scopus 로고    scopus 로고
    • Fractionation, structural studies, and immunological characterization of the semi-synthetic Quillaja saponins derivative GPI-0100
    • Marciani D.J., Reynolds R.C., Pathak A.K., Finley-Woodman K., and May R.D. Fractionation, structural studies, and immunological characterization of the semi-synthetic Quillaja saponins derivative GPI-0100. Vaccine 21 (2003) 3961-3971
    • (2003) Vaccine , vol.21 , pp. 3961-3971
    • Marciani, D.J.1    Reynolds, R.C.2    Pathak, A.K.3    Finley-Woodman, K.4    May, R.D.5
  • 81
    • 0031819540 scopus 로고    scopus 로고
    • Adjuvant action of Chenopodium quinoa saponins on the induction of antibody responses to intragastric and intranasal administered antigens in mice
    • Estrada A., Li B., and Laarveld B. Adjuvant action of Chenopodium quinoa saponins on the induction of antibody responses to intragastric and intranasal administered antigens in mice. Comp Immunol Microbiol Infect Dis 21 (1998) 225-236
    • (1998) Comp Immunol Microbiol Infect Dis , vol.21 , pp. 225-236
    • Estrada, A.1    Li, B.2    Laarveld, B.3
  • 82
    • 0030981761 scopus 로고    scopus 로고
    • Study of the adjuvant activity of new MDP derivatives and purified saponins and their influence on HIV-1 replication in vitro
    • Krivorutchenko Y.L., Andronovskaja I.B., Hinkula J., Krivoshein Y.S., Ljungdahl-Stahle E., Pertel S.S., et al. Study of the adjuvant activity of new MDP derivatives and purified saponins and their influence on HIV-1 replication in vitro. Vaccine 15 (1997) 1479-1486
    • (1997) Vaccine , vol.15 , pp. 1479-1486
    • Krivorutchenko, Y.L.1    Andronovskaja, I.B.2    Hinkula, J.3    Krivoshein, Y.S.4    Ljungdahl-Stahle, E.5    Pertel, S.S.6
  • 83
    • 0037428002 scopus 로고    scopus 로고
    • Adjuvant effect of ginseng extracts on the immune responses to immunisation against Staphylococcus aureus in dairy cattle
    • Hu S., Concha C., Lin F., and Waller K.P. Adjuvant effect of ginseng extracts on the immune responses to immunisation against Staphylococcus aureus in dairy cattle. Vet Immunol Immunopathol 91 (2003) 29-37
    • (2003) Vet Immunol Immunopathol , vol.91 , pp. 29-37
    • Hu, S.1    Concha, C.2    Lin, F.3    Waller, K.P.4
  • 84
    • 0033979115 scopus 로고    scopus 로고
    • Isolation and evaluation of immunological adjuvant activities of saponins from Polygala senega L.
    • Estrada A., Katselis G.S., Laarveld B., and Barl B. Isolation and evaluation of immunological adjuvant activities of saponins from Polygala senega L. Comp Immunol Microbiol Infect Dis 23 (2000) 27-43
    • (2000) Comp Immunol Microbiol Infect Dis , vol.23 , pp. 27-43
    • Estrada, A.1    Katselis, G.S.2    Laarveld, B.3    Barl, B.4
  • 85
    • 33846208386 scopus 로고    scopus 로고
    • Adjuvant activity of Quillaja brasiliensis saponins on the immune responses to bovine herpesvirus type 1 in mice
    • Fleck J.D., Kauffmann C., Spilki F., Lencina C.L., Roehe P.M., and Gosmann G. Adjuvant activity of Quillaja brasiliensis saponins on the immune responses to bovine herpesvirus type 1 in mice. Vaccine 24 (2006) 7129-7134
    • (2006) Vaccine , vol.24 , pp. 7129-7134
    • Fleck, J.D.1    Kauffmann, C.2    Spilki, F.3    Lencina, C.L.4    Roehe, P.M.5    Gosmann, G.6
  • 87
    • 0028926776 scopus 로고
    • Interleukin-12 profoundly up-regulates the synthesis of antigen-specific complement-fixing IgG2a IgG2b and IgG3 antibody subclasses in vivo
    • Germann T., Bongartz M., Dlugonska H., Hess H., Schmitt E., Kolbe L., et al. Interleukin-12 profoundly up-regulates the synthesis of antigen-specific complement-fixing IgG2a IgG2b and IgG3 antibody subclasses in vivo. Eur J Immunol 25 (1995) 823-829
    • (1995) Eur J Immunol , vol.25 , pp. 823-829
    • Germann, T.1    Bongartz, M.2    Dlugonska, H.3    Hess, H.4    Schmitt, E.5    Kolbe, L.6
  • 88
    • 46149118724 scopus 로고    scopus 로고
    • Comparison of lysis of red blood cells induce by platycodins and prosapogenins
    • Liu M.X., Yu H.Y., Huang Y., and Qiu Z.M. Comparison of lysis of red blood cells induce by platycodins and prosapogenins. J Yangzhou Univ (Agric Life Sci) 27 4 (2006) 26-28
    • (2006) J Yangzhou Univ (Agric Life Sci) , vol.27 , Issue.4 , pp. 26-28
    • Liu, M.X.1    Yu, H.Y.2    Huang, Y.3    Qiu, Z.M.4


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