Haemolytic activities and adjuvant effect of Gynostemma pentaphyllum saponins on the immune responses to ovalbumin in mice

Phytotherapy Research

Volumn 19, Issue 10, 2005, Pages 895-900

  Sun, Hongxiang ^a   Zheng, Quanfang ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Adjuvants; Antibody; Cucurbitaceae; Gynostemma pentaphyllum; Haemolysis; Proliferation; Saponins

Indexed keywords

ALUMINUM HYDROXIDE; CONCANAVALIN A; GYNOSTEMMA PENTAPHYLLUM EXTRACT; LIPOPOLYSACCHARIDE; PLANT EXTRACT; SAPONIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; HEMOLYSIS; IMMUNE RESPONSE; IMMUNIZATION; MALE; MOUSE; NONHUMAN; SPLEEN CELL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; GYNOSTEMMA; IMMUNIZATION; IMMUNOGLOBULIN G; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED ICR; OVALBUMIN; PHYTOTHERAPY; PLANT EXTRACTS; RABBITS; SAPONINS; SPLEEN;

ANIMALIA; CUCURBITACEAE; GYNOSTEMMA PENTAPHYLLUM;

EID: 27944495709     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ptr.1754     Document Type: Article

References (35)

1. Attawish A, Chivapat S, Phadungpat S et al. 2004. Chronic toxicity of Gynostemma pentaphyllum. Fitoterapia 75: 539-551.
2. Aucouturier J, Dupuis L, Ganne V. 2001. Adjuvants designed for veterinary and human vaccines. Vaccine 19: 2666-2672.
3. Chen JC, Chung JG, Chen LD. 1999. Gypenoside induces apoptosis in human Hep3B and HA22T tumour cells. Cytobios 100: 37-48.
4. Chen W, Hau D, Chen K, Wang M, Lin I. 1996. Protective effects of Gynostemma pentaphyllum in gamma irradiated mice. Am J Chin Med 24: 83-92.
5. Cui JF, Eneroth P, Bruhn JG. 1999. Gynostemma pentaphyllum: identification of major sapogenins and differentiation from Panax species. Eur J Pharm Sci 8: 187-191.
6. Espinet EG. 1951. Nuevo tipo de vacuna antiaftosa a complejo glucovirico. Gac Vet 74: 1-13.
7. Evans TG, McElrath MJ, Matthews T, et al. 2001. QS-21 promotes an adjuvant effect allowing for reduced antigen dose during HIV-1 envelope subunit immunization in humans. Vaccine 19: 2080-2091.
8. Gupta RK. 1998. Aluminum compounds as vaccine adjuvants. Adv Drug Deliv Rev 32: 155-172.
9. Hau D, Feng Y, Chen W et al. 1996. Effects of gypenosides on cellular immunity of gamma-ray-irradiated mice. Chin Med J 109: 143-146.
10. Hou J, Liu S, Ma Z, Lang X, Wang J, Liang Z. 1991. Effects of Gynostemma pentaphyllum Makino on the immunological function of cancer patients. J Tradit Chin Med 11: 47-52.
11. Kensil CR, Patel U, Lennick M, Marciani DJ. 1991. Separation and characterization of saponins with adjuvant activity from Quillaja saponaria Molina cortex. J Immunol 146: 431-437.
12. Kensil CR, Wu JY, Anderson CA, Wheeler DA, Bcsden J. 1998. QS-21 and QS-7: purified saponin adjuvants. Dev Biol Stand 92: 41-47.
13. + T-cell frequencies by the elispot assay in health individuals and in patients with metastatic melanoma immunized with tyrosinase peptide. Int J Cancer 87: 391-398.
14. Lin CC, Huang PC, Lin JM. 2000. Antioxidant and hepatoprotective effects of Anoectochilus formosanus and Gynostemma pentaphyllum. Am J Chin Med 28: 87-96.
15. Lin JM, Lin CC, Chiu HF, Yang JJ, Lee SG. 1993. Evaluation of the anti-inflammatory and liver-protective effects of Anoectochilus formosanus, Ganoderma lucidum, and Gynostemma pentaphyllum in rats. Am J Chin Med 21: 59-69.
16. Lin X, Yu RM, Hsiao WL, Zhao SX, Ye WC. 2004. Three new dammarane glycosides from Gynostemma pentaphyllum. Chin Chem Lett 15: 46-48.
17. Liu G, Anderson C, Scaltreto H, Barbon J, Kensil C. 2002. QS-21 structure/function studies: effect of acylation on adjuvant activity. Vaccine 20: 2808-2815.
18. Meng Q, Sun P, Wang LL, Ma XY and Zhao JY. 1998. Haemolytic activities of the saponins from Panax ginseng and Panax quinquefolium. J N Bethune Univ Med Sci 24: 135-136.
19. Oda K, Matsuda H, Murakami T, Katajama S, Oghitani T, Yoshikawa M. 2000. Adjuvant and hemolytic activities of 47 saponins derived from medicinal and food plants. Biol Chem 381: 67-74.
20. Purmova J, Opletal L. 1995. Phytotherapeutic aspects of diseases of the cardiovascular system: Saponins and possibilities of their use in prevention and therapy. Ceska Slov Farm 44: 246-251.
21. Rivera E, Daggfeldt A, Hu S. 2003. Ginseng extract in aluminium hydroxide adjuvanted vaccines improves the antibody response of pigs to porcine parvovirus and Erysipelothrix rhusiopathiae. Vet Immunol Immunopathol 91: 19-27.
22. Rujjanawate C, Kanjanapothi D, Amornlerdpison D. 2004. The anti-gastric ulcer effect of Gynostemma pentaphyllum Makino. Phytomedicine 11: 431-435.
23. Santos WR, de Lima VMF, de Souza EP, Bernardo RR, Palatnik M, de Sousa CBP. 2002. Saponins, IL12 and BCG adjuvant in the FML-vaccine formulation against murine visceral leishmaniasis. Vaccine 21: 30-43.
24. Soltysik S, Wu JY, Recchia J et al. 1995. Structure/function studies of QS-21 adjuvant: assessment of triterpene aldehyde and glucuronic acid roles in adjuvant function. Vaccine 13: 1403-1410.
25. Stoute JA, Slaoui M, Heppnerm DG et al. 1997. A preliminary evaluation of a recombinant circumsporozoite vaccine against Plasmodium falciparum malaria. N Engl J Med 9: 86-91.
26. Sun HX, Ye YP, Pan HJ, Pan YJ. 2004. Adjuvant effect of Panax notoginseng saponins on the immune responses to ovalbumin in mice. Vaccine 22: 3882-3889.
27. Takechi M, Tanaka Y. 1995. Haemolytic time course differences between steroid and triterpenoid saponins. Planta Med 61: 76-77.
28. Tanner MA, Bu X, Steimle JA, Myers PR. 1999. The direct release of nitric oxide by gypenosides derived from the herb Gynostemma pentaphyllum. Nitric Oxide 3: 359-365.
29. Wagner U, Burkhardt E, Failing K. 1999. Evaluation of canine lyphocyte proliferation: comparison of three different colorimetric methods with the H-thymidine incorporation assay. Vet Immunol Immunopathol 70: 151-159.
30. Waite DC, Jacobson EW, Ennis FA et al. 2001. Three double-blind, randomized trials evaluating the safety and tolerance of different formulations of the saponin adjuvant QS-21. Vaccine 19: 3957-3967.
31. Wang B, Ge ZD, Zhou AW, Chen MZ. 1999. Effects of gypenosides on immune function of rats in vitro. Tradit Chin Drug Res Clin Pharmacol 10: 36-37.
32. Yin F, Hu L, Lou F, Pan R. 2004. Dammarane-type glycosides from Gynostemma pentaphyllum. J Nat Prod 67: 942-952.
33. Zeng XW, Sun HX, Wang ZF. 1990. Influence of different collection time on constituents of saponins of medicinal plants from Gynostemma. J Mod Appl Pharm 7: 41-42.
34. Zhang C, Yang X, Xu L. 1990. Immunomodulatory action of the total saponin of Gynostemma pentaphylla. J Mod Dev Tradit Med 10: 69-70.
35. Zhou Z, Wang Y, Zhou Y. 1996. The effect of Gynostemma pentaphyllum Makino (GP) on carcinogenesis of the golden hamster cheek pouch induced by DMBA. Chin J Stomatol 31: 267-270.