Improved production of ginsenosides in suspension cultures of ginseng by medium replenishment strategy

Journal of Bioscience and Bioengineering

Volumn 105, Issue 3, 2008, Pages 288-291

  Jeong, Cheol Seung ^a   Murthy, Hosakatte Niranjana ^a,b   Hahn, Eun Joo ^a   Paek, Kee Yoeup ^a  

^a Chungbuk National University   (South Korea)

^b KARNATAK UNIVERSITY   (India)

Author keywords

bioreactors; biosynthesis; fed batch cultures; ginseng; large scale cultivation; medium exchange

Indexed keywords

ACETIC ACID; BIOREACTORS; BIOSYNTHESIS; CELL CULTURE; DRUG PRODUCTS; NUTRIENTS;

FED-BATCH CULTURES; GINSENG; LARGE-SCALE CULTIVATION; MEDIUM EXCHANGE;

METABOLITES;

GINSENOSIDE; INDOLEACETIC ACID; SUCROSE;

ARTICLE; BIOREACTOR; BIOSYNTHESIS; CHEMICAL COMPOSITION; GINSENG; KINETICS; MURASHIGE AND SKOOG MEDIUM; NUTRITIONAL REQUIREMENT; PLANT ROOT; ROOT GROWTH;

BIOREACTORS; CELL CULTURE TECHNIQUES; GINSENOSIDES; INDOLEACETIC ACIDS; PANAX; PLANT ROOTS; SUCROSE;

PANAX GINSENG;

EID: 41549107995     PISSN: 13891723     EISSN: None     Source Type: Journal    
DOI: 10.1263/jbb.105.288     Document Type: Article

References (15)

1. Attele A.S., Wu J.A., and Yuan C.S. Ginseng pharmacology: multiple constituents and multiple actions. Biochem. Pharmacol. 54 (1999) 1-8
2. Wu J., and Zhong J.J. Production of ginseng and its bioactive components in plant cell culture: current technological and applied aspects. J. Biotechnol. 68 (1999) 89-99
3. Choi S.M., Son S.H., Yun S.R., Kwaon O.W., Seon J.H., and Paek K.Y. Pilot scale culture of adventitious roots of ginseng in a bioreactor system. Plant Cell Tissue Org. Cult. 62 (2000) 187-193
4. Yu K.W., Murthy H.N., Jeong C.S., Hahn E.J., and Paek K.Y. Organic germanium stimulates the growth of ginseng adventitious roots and ginsenoside production. Process Biochem. 40 (2005) 2959-2961
5. Zhong J.J. Biochemical engineering of the production of plant-specific secondary metabolites by cell suspension cultures. In: Scheper Th. (Ed). Advances in biochemical engineering/biotechnology vol. 72 (2001), Springer-Verlag, Berlin 1-26
6. Jeong C.S., Chakrabarty D., Hahn E.J., Lee H.L., and Paek K.Y. Effect of oxygen, carbon dioxide and ethylene on growth and bioactive compound production in bioreactor culture of ginseng adventitious roots. Biochem. Eng. J. 27 (2006) 252-263
7. Murashige T., and Skoog F. A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol. Plant. 15 (1962) 473-497
8. Yu K.W., Gao W., Hahn E.J., and Paek K.Y. Jasmonic acid improves ginsenoside accumulation in adventitious root culture of Panax ginseng C.A. Meyer. Biochem. Eng. J. 11 (2002) 211-215
9. Zhong J.J., Chen F., and Hu W.W. High density cultivation of Panax notoginseng cells in stirred bioreactors for the production of ginseng biomass and ginseng saponin. Process Biochem. 35 (1999) 491-496
10. Wu J.Y., Wong K., Ho K.P., and Zhou L.G. Enhancement of saponin production in Panax ginseng cell culture by osmotic stress and nutrient feeding. Enzyme Microb. Technol. 36 (2005) 133-138
11. Zhang Y.H., and Zhong J.J. Hyperproduction of ginseng saponin and polysaccharide by high density cultivation of Panax ginseng cells. Enzyme Microb. Technol. 21 (1997) 59-63
12. Wang H.Q., Yu J.T., and Zhong J.J. Significant improvement of taxane production in suspension cultures of Taxus chinensis by sucrose feeding strategy. Process Biochem. 35 (1999) 479-483
13. Panda A.K., Mishra S., and Bisaria V.S. Alkaloid production by plant suspension of Holarrhena antidysenterica: effect of major nutrients. Biotechnol. Bioeng. 59 (1992) 1043-1051
14. Srinivsan V., and Ryu D.D. Improvement of shikonin productivity in Lithospermum erythrorhizon cell cultures by altering carbon and nitrogen feeding strategy. Biotechnol. Bioeng. 42 (1993) 793-799
15. Wu C.H., Murthy H.N., Hahn E.J., and Paek K.Y. Improved production of caffeic acid derivatives in suspension cultures of Echinacea purpurea by medium replenishment strategy. Arch. Pharm. Res. 30 (2007) 945-949