Molecular mechanism of endothelial nitric-oxide synthase activation by Platycodon grandiflorum root-derived saponins

Toxicology Letters

Volumn 195, Issue 2-3, 2010, Pages 106-113

  Kim, Hyung Gyun ^a   Hien, Tran Thi ^b   Han, Eun Hee ^a   Chung, Young Chul ^c   Jeong, Hye Gwang ^a  

^a Chungnam National University   (South Korea)

^b Chosun University   (South Korea)

^c Korea International University   (South Korea)

Author keywords

Akt; AMPK; ENOS; P38 MAPK; Platycodon grandiflorum

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; COMPOUND C; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENZYME INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MUTANT PROTEIN; N (6 AMINOHEXYL) 5 CHLORO 1 NAPHTHALENESULFONAMIDE; NITRIC OXIDE; PLATYCODON GRANDIFLORUM EXTRACT; PROTEIN KINASE B; SAPONIN; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PLANT ROOT; PLATYCODON; PLATYCODON GRANDIFLORUM; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

AMP-ACTIVATED PROTEIN KINASES; ENDOTHELIAL CELLS; ENZYME ACTIVATION; HUMANS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PLANT EXTRACTS; PLANT ROOTS; PLATYCODON; PROTO-ONCOGENE PROTEINS C-AKT; SAPONINS;

PLATYCODON GRANDIFLORUM;

EID: 77952547186     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2010.03.006     Document Type: Article

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