-
1
-
-
45149090978
-
Fragment-based drug discovery using rational design
-
Jhoti H. Fragment-based drug discovery using rational design. Ernst Schering Found Symp Proc 2007; 3:169-85.
-
(2007)
Ernst Schering Found Symp Proc
, vol.3
, pp. 169-185
-
-
Jhoti, H.1
-
2
-
-
33847381100
-
A decade of fragment-based drug design: strategic advances and lessons learned
-
Hajduk PJ, Greer J. A decade of fragment-based drug design: strategic advances and lessons learned. Nat Rev Drug Discov 2007; 6:211-19.
-
(2007)
Nat Rev Drug Discov
, vol.6
, pp. 211-219
-
-
Hajduk, P.J.1
Greer, J.2
-
3
-
-
4344698577
-
The use of recombinant methods and molecular engineering in protein crystallization
-
Derewenda ZS. The use of recombinant methods and molecular engineering in protein crystallization. Methods 2004; 34:354-63.
-
(2004)
Methods
, vol.34
, pp. 354-363
-
-
Derewenda, Z.S.1
-
4
-
-
0004253967
-
Cocrystals of the DNA-binding domain of phage 434 repressor and a synthetic phage 434 operator
-
Anderson J, Ptashne M, Harrison SC. Cocrystals of the DNA-binding domain of phage 434 repressor and a synthetic phage 434 operator. Proc Natl Acad Sci USA 1984; 81:1307-11.
-
(1984)
Proc Natl Acad Sci USA
, vol.81
, pp. 1307-1311
-
-
Anderson, J.1
Ptashne, M.2
Harrison, S.C.3
-
5
-
-
0036667741
-
Crystallisation of membrane proteins mediated by antibody fragments
-
Hunte C, Michel H. Crystallisation of membrane proteins mediated by antibody fragments. Curr Opin Struct Biol 2002; 12:503-8.
-
(2002)
Curr Opin Struct Biol
, vol.12
, pp. 503-508
-
-
Hunte, C.1
Michel, H.2
-
6
-
-
0024388120
-
Crystallization and characterisation of human chorionic gonadotropin in chemically deglycosylated and enzymatically desialylated states
-
Lustbader JW, Birken S, Pileggi NF etal. Crystallization and characterisation of human chorionic gonadotropin in chemically deglycosylated and enzymatically desialylated states. Biochemistry 1989; 28:9239-43.
-
(1989)
Biochemistry
, vol.28
, pp. 9239-9243
-
-
Lustbader, J.W.1
Birken, S.2
Pileggi, N.F.3
-
7
-
-
0029671464
-
Engineering the lac permease for purification and crystallization
-
Privé GG, Kaback HR. Engineering the lac permease for purification and crystallization. J Bioenerg Biomembr 1996; 28:29-34.
-
(1996)
J Bioenerg Biomembr
, vol.28
, pp. 29-34
-
-
Privé, G.G.1
Kaback, H.R.2
-
8
-
-
36448995359
-
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor
-
Cherezov V, Rosenbaum DM, Hanson MA etal. High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science 2007; 318:1258-65.
-
(2007)
Science
, vol.318
, pp. 1258-1265
-
-
Cherezov, V.1
Rosenbaum, D.M.2
Hanson, M.A.3
-
10
-
-
69249107262
-
Engineering of recombinant crystallization chaperones
-
Koide S. Engineering of recombinant crystallization chaperones. Curr Opin Struct Biol 2009; 19:449-57.
-
(2009)
Curr Opin Struct Biol
, vol.19
, pp. 449-457
-
-
Koide, S.1
-
11
-
-
53049085400
-
Chaperone-assisted crystallography with DARPins
-
Sennhauser G, Grütter MG. Chaperone-assisted crystallography with DARPins. Structure 2008; 16:1443-53.
-
(2008)
Structure
, vol.16
, pp. 1443-1453
-
-
Sennhauser, G.1
Grütter, M.G.2
-
12
-
-
33751347582
-
Biopharmaceutical drug discovery using novel protein scaffolds
-
Gill DS, Damle NK. Biopharmaceutical drug discovery using novel protein scaffolds. Curr Opin Biotechnol 2006; 17:653-8.
-
(2006)
Curr Opin Biotechnol
, vol.17
, pp. 653-658
-
-
Gill, D.S.1
Damle, N.K.2
-
13
-
-
34548522063
-
Alternative non-antibody scaffolds for molecular recognition
-
Skerra A. Alternative non-antibody scaffolds for molecular recognition. Curr Opin Biotechnol 2007; 18:295-304.
-
(2007)
Curr Opin Biotechnol
, vol.18
, pp. 295-304
-
-
Skerra, A.1
-
14
-
-
34047155118
-
Affibody molecules: potential for in vivo imaging of molecular targets for cancer therapy
-
Tolmachev V, Orlova A, Nilsson FY etal. Affibody molecules: potential for in vivo imaging of molecular targets for cancer therapy. Exp Opin Biol Ther 2007; 7:555-68.
-
(2007)
Exp Opin Biol Ther
, vol.7
, pp. 555-568
-
-
Tolmachev, V.1
Orlova, A.2
Nilsson, F.Y.3
-
15
-
-
27144511241
-
Engineering novel binding proteins from nonimmunoglobulin domains
-
Binz HK, Amstutz P, Plückthun A. Engineering novel binding proteins from nonimmunoglobulin domains. Nat Biotechnol 2005; 23:1257-68.
-
(2005)
Nat Biotechnol
, vol.23
, pp. 1257-1268
-
-
Binz, H.K.1
Amstutz, P.2
Plückthun, A.3
-
16
-
-
77956176686
-
Structural basis for high affinity HER2 receptor binding by an engineered protein
-
Eigenbrot C, Ultsch M, Dubnovitsky A, Abrahmsén L, Härd T. Structural basis for high affinity HER2 receptor binding by an engineered protein. Proc Natl Acad Sci USA 2010; 107:15039-44.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 15039-15044
-
-
Eigenbrot, C.1
Ultsch, M.2
Dubnovitsky, A.3
Abrahmsén, L.4
Härd, T.5
-
19
-
-
70450225039
-
DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerisation and ubiquitin binding
-
Grubisha O, Kaminska M, Duquerroy S etal. DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerisation and ubiquitin binding. J Mol Biol 2010; 395:89-104.
-
(2010)
J Mol Biol
, vol.395
, pp. 89-104
-
-
Grubisha, O.1
Kaminska, M.2
Duquerroy, S.3
-
20
-
-
61649103747
-
Structural basis for recognition of diubiquitins by NEMO
-
Lo YC, Lin SC, Rospigliosi CC etal. Structural basis for recognition of diubiquitins by NEMO. Mol Cell 2009; 33:602-15.
-
(2009)
Mol Cell
, vol.33
, pp. 602-615
-
-
Lo, Y.C.1
Lin, S.C.2
Rospigliosi, C.C.3
-
21
-
-
62549155321
-
Specific recognition of linear ubiquitin chains by NEMO is important for NF-κB activation
-
Rahighi S, Ikeda F, Kawasaki M etal. Specific recognition of linear ubiquitin chains by NEMO is important for NF-κB activation. Cell 2009; 136:1098-109.
-
(2009)
Cell
, vol.136
, pp. 1098-1109
-
-
Rahighi, S.1
Ikeda, F.2
Kawasaki, M.3
-
22
-
-
23444448571
-
Allosteric inhibition of aminoglycoside phosphotransferase by a designed ankyrin repeat protein
-
Kohl A, Amstutz P, Parizek P etal. Allosteric inhibition of aminoglycoside phosphotransferase by a designed ankyrin repeat protein. Structure 2005; 13:1131-41.
-
(2005)
Structure
, vol.13
, pp. 1131-1141
-
-
Kohl, A.1
Amstutz, P.2
Parizek, P.3
-
23
-
-
34247853389
-
Inhibition of caspase-2 by a designed ankyrin repeat protein: specificity, structure and inhibition mechanism
-
Schweizer A, Roschitzki-Voser H, Amstutz P etal. Inhibition of caspase-2 by a designed ankyrin repeat protein: specificity, structure and inhibition mechanism. Structure 2007; 15:625-36.
-
(2007)
Structure
, vol.15
, pp. 625-636
-
-
Schweizer, A.1
Roschitzki-Voser, H.2
Amstutz, P.3
-
24
-
-
0142242170
-
Crystal structure of caspase-2 apical initiator of the intrinsic apoptotic pathway
-
Schweizer A, Briand C, Grütter MG. Crystal structure of caspase-2 apical initiator of the intrinsic apoptotic pathway. J Biol Chem 2003; 278:42441-7.
-
(2003)
J Biol Chem
, vol.278
, pp. 42441-42447
-
-
Schweizer, A.1
Briand, C.2
Grütter, M.G.3
-
26
-
-
71049152941
-
Crystal structure and function of a DARPin neutralising inhibitor of lactococcal phage TP901-1
-
Veesler D, Dreier B, Blangy S etal. Crystal structure and function of a DARPin neutralising inhibitor of lactococcal phage TP901-1. J Biol Chem 2009; 284:30718-26.
-
(2009)
J Biol Chem
, vol.284
, pp. 30718-30726
-
-
Veesler, D.1
Dreier, B.2
Blangy, S.3
-
29
-
-
66149127336
-
Crystal structure of full-length KcsA in its closed conformation
-
Uysal S, Vásquez V, Tereshko V etal. Crystal structure of full-length KcsA in its closed conformation. Proc Natl Acad Sci USA 2009; 106:6644-9.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 6644-6649
-
-
Uysal, S.1
Vásquez, V.2
Tereshko, V.3
-
30
-
-
0023432797
-
Distribution of sequence differences in influenza N9 neuraminidase of tern and whale viruses and crystallization of the whale neuraminidase complexed with antibodies
-
Air GM, Webster RG, Colman PM, Laver WG. Distribution of sequence differences in influenza N9 neuraminidase of tern and whale viruses and crystallization of the whale neuraminidase complexed with antibodies. Virology 1987; 160:346-54.
-
(1987)
Virology
, vol.160
, pp. 346-354
-
-
Air, G.M.1
Webster, R.G.2
Colman, P.M.3
Laver, W.G.4
-
31
-
-
0025598904
-
Preparation and crystallization of a human immunodeficiency virus p24-Fab complex
-
Prongay AJ, Smith TJ, Rossmann MG etal. Preparation and crystallization of a human immunodeficiency virus p24-Fab complex. Proc Natl Acad Sci USA 1990; 87:9980-4.
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 9980-9984
-
-
Prongay, A.J.1
Smith, T.J.2
Rossmann, M.G.3
-
32
-
-
0025748148
-
Crystals of a ternary complex of human immunodeficiency virus type 1 reverse transcriptase with a monoclonal antibody Fab fragment and double-stranded DNA diffract X-Rays to 3·5Å resolution
-
Jacobo-Molina A, Clark JAD, Williams RL etal. Crystals of a ternary complex of human immunodeficiency virus type 1 reverse transcriptase with a monoclonal antibody Fab fragment and double-stranded DNA diffract X-Rays to 3·5Å resolution. Proc Natl Acad Sci USA 1991; 88:10895-9.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 10895-10899
-
-
Jacobo-Molina, A.1
Clark, J.A.D.2
Williams, R.L.3
-
33
-
-
0029646090
-
The use of antibody fragments for crystallization and structure determinations
-
Kovari LC, Momany C, Rossmann MG. The use of antibody fragments for crystallization and structure determinations. Structure 1995; 3:1291-3.
-
(1995)
Structure
, vol.3
, pp. 1291-1293
-
-
Kovari, L.C.1
Momany, C.2
Rossmann, M.G.3
-
34
-
-
0028294931
-
Recombinant anti-sialidase single-chain variable fragment antibody. Characterisation, formation of dimer and higher-molecular-mass multimers and the solution of the crystal structure of the single-chain variable fragment/sialidase complex
-
Kortt AA, Malby RL, Caldwell JB etal. Recombinant anti-sialidase single-chain variable fragment antibody. Characterisation, formation of dimer and higher-molecular-mass multimers and the solution of the crystal structure of the single-chain variable fragment/sialidase complex. Eur J Biochem 1994; 221:151-7.
-
(1994)
Eur J Biochem
, vol.221
, pp. 151-157
-
-
Kortt, A.A.1
Malby, R.L.2
Caldwell, J.B.3
-
35
-
-
0034660152
-
1 complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment
-
1 complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment. Structure 2000; 8:669-84.
-
(2000)
Structure
, vol.8
, pp. 669-684
-
-
Hunte, C.1
Koepke, J.2
Lange, C.3
Roßmanith, T.4
Michel, H.5
-
36
-
-
0028991525
-
Fv fragment-mediated crystallization of the membrane protein bacterial cytochrome c oxidase
-
Ostermeier C, Iwata S, Ludwig B, Michel H. Fv fragment-mediated crystallization of the membrane protein bacterial cytochrome c oxidase. Nat Struct Biol 1995; 2:842-46.
-
(1995)
Nat Struct Biol
, vol.2
, pp. 842-846
-
-
Ostermeier, C.1
Iwata, S.2
Ludwig, B.3
Michel, H.4
-
37
-
-
0030886203
-
Structure at 2·7Å resolution of the Paracoccus denitrificans two-subunit cytochrome c oxidase complexed with an antibody Fv fragment
-
Ostermeier C, Harrenga A, Ermler U, Michel H. Structure at 2·7Å resolution of the Paracoccus denitrificans two-subunit cytochrome c oxidase complexed with an antibody Fv fragment. Proc Natl Acad Sci USA 1997; 94:10547-53.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 10547-10553
-
-
Ostermeier, C.1
Harrenga, A.2
Ermler, U.3
Michel, H.4
-
39
-
-
0033603623
-
Crystal structure of a ternary complex between human chorionic gonadotropin (hCG) and two Fv fragments specific for the α and β-subunits
-
Tegoni M, Spinelli S, Verhoeyen M, Davis P, Cambillau C. Crystal structure of a ternary complex between human chorionic gonadotropin (hCG) and two Fv fragments specific for the α and β-subunits. J Mol Biol 1999; 289:1375-85.
-
(1999)
J Mol Biol
, vol.289
, pp. 1375-1385
-
-
Tegoni, M.1
Spinelli, S.2
Verhoeyen, M.3
Davis, P.4
Cambillau, C.5
-
40
-
-
0001470914
-
The isolation and crystallization of the enzyme urease
-
Sumner JB. The isolation and crystallization of the enzyme urease. J Biol Chem 1926; 69:435-41.
-
(1926)
J Biol Chem
, vol.69
, pp. 435-441
-
-
Sumner, J.B.1
-
41
-
-
0036008537
-
Crystallization and preliminary X-ray structure determination of jack bean urease with a bound antibody fragment
-
Sheridan L, Wilmot CM, Cromie KD, van der Logt P, Phillips SEV. Crystallization and preliminary X-ray structure determination of jack bean urease with a bound antibody fragment. Acta Crystallogr Sect D Biol Crystallogr 2002; 58:374-6.
-
(2002)
Acta Crystallogr Sect D Biol Crystallogr
, vol.58
, pp. 374-376
-
-
Sheridan, L.1
Wilmot, C.M.2
Cromie, K.D.3
van der Logt, P.4
Phillips, S.E.V.5
-
42
-
-
0030932886
-
Crystal structure of Lyme disease antigen outer surface protein A complexed with an Fab
-
Li H, Dunn JJ, Luft BJ, Lawson CL. Crystal structure of Lyme disease antigen outer surface protein A complexed with an Fab. Proc Natl Acad Sci USA 1997; 94:3584-9.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 3584-3589
-
-
Li, H.1
Dunn, J.J.2
Luft, B.J.3
Lawson, C.L.4
-
43
-
-
0038076054
-
X-Ray structure of a voltage-dependent K+ channel
-
Jiang Y, Lee A, Chen J etal. X-Ray structure of a voltage-dependent K+ channel. Nature 2003; 423:33-41.
-
(2003)
Nature
, vol.423
, pp. 33-41
-
-
Jiang, Y.1
Lee, A.2
Chen, J.3
-
44
-
-
64149097998
-
Crystallization of the receptor-binding domain of parathyroid hormone-related protein in complex with a neutralising monoclonal antibody Fab fragment
-
McKinstry WJ, Polekhina G, Diefenbach-Jagger H etal. Crystallization of the receptor-binding domain of parathyroid hormone-related protein in complex with a neutralising monoclonal antibody Fab fragment. Acta Crystallogr Sect F Struct Biol Cryst Commun 2009; 65:336-8.
-
(2009)
Acta Crystallogr Sect F Struct Biol Cryst Commun
, vol.65
, pp. 336-338
-
-
McKinstry, W.J.1
Polekhina, G.2
Diefenbach-Jagger, H.3
-
45
-
-
36248970132
-
Crystal structure of the human beta2 adrenergic G protein-coupled receptor
-
Rasmussen SG, Choi H-J, Rosenbaum DM etal. Crystal structure of the human beta2 adrenergic G protein-coupled receptor. Nature 2007; 450:383-7.
-
(2007)
Nature
, vol.450
, pp. 383-387
-
-
Rasmussen, S.G.1
Choi, H.-J.2
Rosenbaum, D.M.3
-
46
-
-
23844441276
-
Comparison of the crystallization and crystal packing of two Fab single-site mutant protein L complexes
-
Granata V, Housden NG, Harrison S etal. Comparison of the crystallization and crystal packing of two Fab single-site mutant protein L complexes. Acta Crystallogr D Biol Crystallogr 2005; 61:750-4.
-
(2005)
Acta Crystallogr D Biol Crystallogr
, vol.61
, pp. 750-754
-
-
Granata, V.1
Housden, N.G.2
Harrison, S.3
-
47
-
-
33748486747
-
Structure of anti-FLAG M2 Fab domain and its use in the stabilization of engineered membrane proteins
-
Roosild TP, Castronovo S, Choe S. Structure of anti-FLAG M2 Fab domain and its use in the stabilization of engineered membrane proteins. Acta Crystallogr Sect F Struct Biol Cryst Commun 2006; 62:835-9.
-
(2006)
Acta Crystallogr Sect F Struct Biol Cryst Commun
, vol.62
, pp. 835-839
-
-
Roosild, T.P.1
Castronovo, S.2
Choe, S.3
-
48
-
-
79955374721
-
Conversion of scFv peptide-binding specificity for crystal chaperone development
-
Pai JC, Culver JA, Drury JE etal. Conversion of scFv peptide-binding specificity for crystal chaperone development. Protein Eng Des Sel 2011; 24:419-28.
-
(2011)
Protein Eng Des Sel
, vol.24
, pp. 419-428
-
-
Pai, J.C.1
Culver, J.A.2
Drury, J.E.3
-
49
-
-
0027310612
-
Naturally occurring antibodies devoid of light chains
-
Hamers-Casterman C, Atarhouch T, Muyldermans S etal. Naturally occurring antibodies devoid of light chains. Nature 1993; 363:446-8.
-
(1993)
Nature
, vol.363
, pp. 446-448
-
-
Hamers-Casterman, C.1
Atarhouch, T.2
Muyldermans, S.3
-
50
-
-
0029764444
-
Crystal structure of a camel single-domain VH antibody fragment in complex with lysozyme
-
Desmyter A, Transue TR, Ghahroudi MA etal. Crystal structure of a camel single-domain VH antibody fragment in complex with lysozyme. Nat Struct Biol 1996; 3:803-11.
-
(1996)
Nat Struct Biol
, vol.3
, pp. 803-811
-
-
Desmyter, A.1
Transue, T.R.2
Ghahroudi, M.A.3
-
51
-
-
0344447084
-
Potent enzyme inhibitors derived from dromedary heavy-chain antibodies
-
Lauwereys M, Ghahroudi MA, Desmyter A etal. Potent enzyme inhibitors derived from dromedary heavy-chain antibodies. EMBO J 1998; 17:3512-20.
-
(1998)
EMBO J
, vol.17
, pp. 3512-3520
-
-
Lauwereys, M.1
Ghahroudi, M.A.2
Desmyter, A.3
-
52
-
-
0042346293
-
Crystal structure of the intrinsically flexible addiction antidote MazE
-
Loris R, Marianovsky I, Lah J etal. Crystal structure of the intrinsically flexible addiction antidote MazE. J Biol Chem 2003; 278:28252-7.
-
(2003)
J Biol Chem
, vol.278
, pp. 28252-28257
-
-
Loris, R.1
Marianovsky, I.2
Lah, J.3
-
53
-
-
0037738520
-
Crystal structure of the MazE/MazF complex: molecular bases of antidote-toxin recognition
-
Kamada K, Hanaoka F, Burley SK. Crystal structure of the MazE/MazF complex: molecular bases of antidote-toxin recognition. Mol Cell 2003; 11:875-84.
-
(2003)
Mol Cell
, vol.11
, pp. 875-884
-
-
Kamada, K.1
Hanaoka, F.2
Burley, S.K.3
-
54
-
-
36549083700
-
The crystal structure of a binary complex of two pseudopilins: EpsI and EpsJ from the type 2 secretion system of Vibrio vulnificus
-
Yanez ME, Korotkov KV, Abendroth J, Hol WG. The crystal structure of a binary complex of two pseudopilins: EpsI and EpsJ from the type 2 secretion system of Vibrio vulnificus. J Mol Biol 2008; 375:471-86.
-
(2008)
J Mol Biol
, vol.375
, pp. 471-486
-
-
Yanez, M.E.1
Korotkov, K.V.2
Abendroth, J.3
Hol, W.G.4
-
55
-
-
60949108827
-
Nanobody-aided structure determination of the EpsI:EpsJ pseudopilin heterodimer from Vibrio vulnificus
-
Lam AY, Pardon E, Korotkov KV, Hol WGJ, Steyaert J. Nanobody-aided structure determination of the EpsI:EpsJ pseudopilin heterodimer from Vibrio vulnificus. J Struct Biol 2009; 166:8-15.
-
(2009)
J Struct Biol
, vol.166
, pp. 8-15
-
-
Lam, A.Y.1
Pardon, E.2
Korotkov, K.V.3
Hol, W.G.J.4
Steyaert, J.5
-
56
-
-
59649092183
-
Crystal structure of the N-terminal domain of the secretin GspD from ETEC determined with the assistance of a nanobody
-
Korotkov KV, Pardon E, Steyaert J, Hol WGJ. Crystal structure of the N-terminal domain of the secretin GspD from ETEC determined with the assistance of a nanobody. Structure 2009; 17:255-65.
-
(2009)
Structure
, vol.17
, pp. 255-265
-
-
Korotkov, K.V.1
Pardon, E.2
Steyaert, J.3
Hol, W.G.J.4
-
57
-
-
77956885443
-
Structure and properties of a complex of α-synuclein and a single-domain camelid antibody
-
De Genst E, Guilliams T, Wellens J etal. Structure and properties of a complex of α-synuclein and a single-domain camelid antibody. J Mol Biol 2010; 402:326-43.
-
(2010)
J Mol Biol
, vol.402
, pp. 326-343
-
-
De Genst, E.1
Guilliams, T.2
Wellens, J.3
-
58
-
-
79952152956
-
Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic beta2-microglobulin variant
-
Domanska K, Vanderhaegen S, Srinivasan V etal. Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic beta2-microglobulin variant. Proc Natl Acad Sci USA 2011; 108:1314-19.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 1314-1319
-
-
Domanska, K.1
Vanderhaegen, S.2
Srinivasan, V.3
|