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Volumn 17, Issue 6, 2006, Pages 653-658

Biopharmaceutical drug discovery using novel protein scaffolds

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; DRUG PRODUCTS; MOLECULAR STRUCTURE;

EID: 33751347582     PISSN: 09581669     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.copbio.2006.10.003     Document Type: Review
Times cited : (65)

References (24)
  • 1
    • 33751329140 scopus 로고    scopus 로고
    • Guide to Biotechnology: Biotechnology Industry Organization 2006; p. 3.
  • 2
    • 33644864036 scopus 로고    scopus 로고
    • Crystal gazing: biotech's financial outlook: the biotech analyst's view
    • Schmidt E. Crystal gazing: biotech's financial outlook: the biotech analyst's view. Nat Biotechnol 24 (2006) 261-262
    • (2006) Nat Biotechnol , vol.24 , pp. 261-262
    • Schmidt, E.1
  • 3
    • 33751340235 scopus 로고    scopus 로고
    • Monoclonal Antibody Therapeutics - Current Market Dynamics & Future Outlook. AS Insights Publishers, June 1; 2004.
  • 4
    • 33751335800 scopus 로고    scopus 로고
    • Carreyrou J, Anand G: Wary of backlash, cancer-drug makers weight price limits. Wall Street Journal, May 10, 2006, p. B1.
  • 5
    • 27144432842 scopus 로고    scopus 로고
    • Engineered antibody fragments and the rise of single domains
    • Holliger P., and Hudson P.J. Engineered antibody fragments and the rise of single domains. Nat Biotechnol 23 (2005) 1126-1136
    • (2005) Nat Biotechnol , vol.23 , pp. 1126-1136
    • Holliger, P.1    Hudson, P.J.2
  • 6
    • 0024461313 scopus 로고
    • Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli
    • Ward E.S., Gussow D., Griffiths A.D., Jones P.T., and Winter G. Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli. Nature 341 (1989) 544-546
    • (1989) Nature , vol.341 , pp. 544-546
    • Ward, E.S.1    Gussow, D.2    Griffiths, A.D.3    Jones, P.T.4    Winter, G.5
  • 10
    • 0029746203 scopus 로고    scopus 로고
    • H domains with improved protein stability
    • H domains with improved protein stability. Protein Eng 9 (1996) 531-537
    • (1996) Protein Eng , vol.9 , pp. 531-537
    • Davies, J.1    Riechmann, L.2
  • 11
    • 33751316932 scopus 로고    scopus 로고
    • Haan K, Maggos C: The protein engineers. Biocentury Jan 26, 2004.
  • 14
    • 33646740974 scopus 로고    scopus 로고
    • Antagonists to human and mouse vascular endothelial growth factor receptor 2 generated by directed protein evolution in vitro
    • Describes the use of the 10FN3 scaffold to derive potent inhibitors of VEGFR2, one of which is in early clinical development. The power of directed evolution in isolating hits that are cross-reactive between human and rodent species is described.
    • Getmanova E.V., Chen Y., Bloom L., Gokemeijer J., Shamah S., Warikoo V., Wang J., Ling V., and Sun L. Antagonists to human and mouse vascular endothelial growth factor receptor 2 generated by directed protein evolution in vitro. Chem Biol 13 (2006) 549-556. Describes the use of the 10FN3 scaffold to derive potent inhibitors of VEGFR2, one of which is in early clinical development. The power of directed evolution in isolating hits that are cross-reactive between human and rodent species is described.
    • (2006) Chem Biol , vol.13 , pp. 549-556
    • Getmanova, E.V.1    Chen, Y.2    Bloom, L.3    Gokemeijer, J.4    Shamah, S.5    Warikoo, V.6    Wang, J.7    Ling, V.8    Sun, L.9
  • 15
    • 0033616638 scopus 로고    scopus 로고
    • Structural independence of ligand-binding modules five and six of the LDL receptor
    • North C.L., and Blacklow S.C. Structural independence of ligand-binding modules five and six of the LDL receptor. Biochemistry 38 (1999) 3926-3935
    • (1999) Biochemistry , vol.38 , pp. 3926-3935
    • North, C.L.1    Blacklow, S.C.2
  • 16
    • 28644436100 scopus 로고    scopus 로고
    • Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains
    • Reports a completely novel approach that uses A-domains to built multimers of protein antagonists. These proteins have several properties of classical protein therapeutics, but have the additional advantage of high bacterial expression and good thermal stability. An example of avimers against interleukin-6 is described.
    • Silverman J., Liu Q., Bakker A., To W., Duguay A., Alba B.M., Smith R., Rivas A., Li P., Le H., et al. Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains. Nat Biotechnol 23 (2005) 1556-1561. Reports a completely novel approach that uses A-domains to built multimers of protein antagonists. These proteins have several properties of classical protein therapeutics, but have the additional advantage of high bacterial expression and good thermal stability. An example of avimers against interleukin-6 is described.
    • (2005) Nat Biotechnol , vol.23 , pp. 1556-1561
    • Silverman, J.1    Liu, Q.2    Bakker, A.3    To, W.4    Duguay, A.5    Alba, B.M.6    Smith, R.7    Rivas, A.8    Li, P.9    Le, H.10
  • 17
    • 12844276589 scopus 로고    scopus 로고
    • Lipocalins in drug discovery: from natural ligand-binding proteins to 'anticalins'
    • Schlehuber S., and Skerra A. Lipocalins in drug discovery: from natural ligand-binding proteins to 'anticalins'. Drug Discov Today 10 (2005) 23-33
    • (2005) Drug Discov Today , vol.10 , pp. 23-33
    • Schlehuber, S.1    Skerra, A.2
  • 18
    • 3142734131 scopus 로고    scopus 로고
    • Construction of an artificial receptor protein ('anticalin') based on the human apolipoprotein D
    • Vogt M., and Skerra A. Construction of an artificial receptor protein ('anticalin') based on the human apolipoprotein D. ChemBioChem 5 (2004) 191-199
    • (2004) ChemBioChem , vol.5 , pp. 191-199
    • Vogt, M.1    Skerra, A.2
  • 19
    • 0032792551 scopus 로고    scopus 로고
    • The ankyrin repeat: a diversity of interactions on a common structural framework
    • Sedgwick S.G., and Smerdon S.J. The ankyrin repeat: a diversity of interactions on a common structural framework. Trends Biochem Sci 24 (1999) 311-316
    • (1999) Trends Biochem Sci , vol.24 , pp. 311-316
    • Sedgwick, S.G.1    Smerdon, S.J.2
  • 20
    • 2342624119 scopus 로고    scopus 로고
    • High-affinity binders selected from designed ankyrin repeat protein libraries
    • This paper demonstrated another novel approach of using ankyrin repeat proteins as scaffolds. Because these proteins contain no cysteines, they can be efficiently expressed in the cytoplasm of bacteria. Thus, intracellular targets such as kinases can be targeted with high specificity.
    • Binz H.K., Amstutz P., Kohl A., Stumpp M.T., Briand C., Forrer P., Grutter M.G., and Pluckthun A. High-affinity binders selected from designed ankyrin repeat protein libraries. Nat Biotechnol 22 (2004) 575-582. This paper demonstrated another novel approach of using ankyrin repeat proteins as scaffolds. Because these proteins contain no cysteines, they can be efficiently expressed in the cytoplasm of bacteria. Thus, intracellular targets such as kinases can be targeted with high specificity.
    • (2004) Nat Biotechnol , vol.22 , pp. 575-582
    • Binz, H.K.1    Amstutz, P.2    Kohl, A.3    Stumpp, M.T.4    Briand, C.5    Forrer, P.6    Grutter, M.G.7    Pluckthun, A.8
  • 21
    • 21244441508 scopus 로고    scopus 로고
    • A fully human recombinant IgG-like bispecific antibody to both the epidermal growth factor receptor and the insulin-like growth factor receptor for enhanced antitumor activity
    • Lu D., Zhang H., Koo H., Tonra J., Balderes P., Prewett M., Corcoran E., Mangalampalli V., Bassi R., Anselma D., et al. A fully human recombinant IgG-like bispecific antibody to both the epidermal growth factor receptor and the insulin-like growth factor receptor for enhanced antitumor activity. J Biol Chem 280 (2005) 19665-19672
    • (2005) J Biol Chem , vol.280 , pp. 19665-19672
    • Lu, D.1    Zhang, H.2    Koo, H.3    Tonra, J.4    Balderes, P.5    Prewett, M.6    Corcoran, E.7    Mangalampalli, V.8    Bassi, R.9    Anselma, D.10
  • 22
    • 9144256621 scopus 로고    scopus 로고
    • Simultaneous blockade of both the epidermal growth factor receptor and the insulin-like growth factor receptor signaling pathways in cancer cells with a fully human recombinant bispecific antibody
    • Lu D., Zhang H., Ludwig D., Persaud A., Jimenez X., Burtrum D., Balderes P., Liu M., Bohlen P., Witte L., and Zhu Z. Simultaneous blockade of both the epidermal growth factor receptor and the insulin-like growth factor receptor signaling pathways in cancer cells with a fully human recombinant bispecific antibody. J Biol Chem 279 (2004) 2856-2865
    • (2004) J Biol Chem , vol.279 , pp. 2856-2865
    • Lu, D.1    Zhang, H.2    Ludwig, D.3    Persaud, A.4    Jimenez, X.5    Burtrum, D.6    Balderes, P.7    Liu, M.8    Bohlen, P.9    Witte, L.10    Zhu, Z.11
  • 23
    • 33751341721 scopus 로고    scopus 로고
    • Burge DJ, Bookbinder SA, Kivitz A J, Fleischmann RM, Shu C, Bannink J, Barone D: Phase 1 study of TRU-015, a CD-20 directed small modular immunopharmaceutical protein therapeutic, in subjects with rheumatoid arthritis. European League Against Rheumatism 2006 Amsterdam, June 24-26. Annals of the Rheumatic Diseases 2006, 65(Suppl 2):180. Early clinical success with the anti-CD20 SMIP is demonstrated. This novel protein scaffold is safe and well-tolerated in man. The pharmacokinetic profile looks good, which could allow weekly or bimonthly dosing in rheumatoid arthritis patients.
  • 24
    • 31844440732 scopus 로고    scopus 로고
    • Ticking the right boxes
    • Macilwain C. Ticking the right boxes. Nature 439 (2006) 553
    • (2006) Nature , vol.439 , pp. 553
    • Macilwain, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.