Zinc irreversibly damages major enzymes of energy production and antioxidant defense prior to mitochondrial permeability transition

Journal of Biological Chemistry

Volumn 282, Issue 33, 2007, Pages 24373-24380

  Gazaryan, Irina G ^a,b   Krasinskaya, Inna P ^a   Kristal, Bruce S ^a,b   Brown, Abraham M ^a,b  

^a BURKE MEDICAL RESEARCH INSTITUTE   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; ENZYMES; METABOLISM; ZINC;

CHELATORS; ENERGY PRODUCTION; ENZYME INACTIVATION; MITOCHONDRIAL PERMEABILITY TRANSITION (MPT); MITOCHONDRIAL RESPIRATION;

CELL DEATH;

DIHYDROLIPOAMIDE DEHYDROGENASE; GLUTATHIONE REDUCTASE; OXOGLUTARATE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RUTHENIUM RED; THIOREDOXIN REDUCTASE; ZINC;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; CARBOHYDRATE METABOLISM; CONTROLLED STUDY; ENERGY YIELD; ENZYME INHIBITION; ISCHEMIA; MITOCHONDRIAL PERMEABILITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIOXIDANTS; CALCIUM; ENERGY METABOLISM; ENZYME ACTIVATION; ENZYMES; INTRACELLULAR MEMBRANES; MITOCHONDRIA; NAD; OXIDATION-REDUCTION; PERMEABILITY; RATS; ZINC;

EID: 34548226964     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M611376200     Document Type: Article

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