Induction of an immediate early gene egr-1 by zinc through extracellular signal-regulated kinase activation in cortical culture: Its role in zinc- induced neuronal death

Journal of Neurochemistry

Volumn 73, Issue 2, 1999, Pages 450-456

  Park, Jeong Ae ^a   Jae Young, Koh ^a  

^a University of Ulsan College of Medicine   (South Korea)

Author keywords

Antisense oligonucleotide; Calcium; Ionomycin; Neurotoxicity; NMDA

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CALCIUM; IONOMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; N METHYL DEXTRO ASPARTIC ACID; TRANSCRIPTION FACTOR; ZINC;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN ISCHEMIA; CONTROLLED STUDY; ENZYME ACTIVATION; FETUS; IMMEDIATE EARLY GENE; MOUSE; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; ORGAN CULTURE; PRIORITY JOURNAL;

ANIMALS; ANTISENSE ELEMENTS (GENETICS); CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL DEATH; CELLS, CULTURED; CEREBRAL CORTEX; DIZOCILPINE MALEATE; DNA-BINDING PROTEINS; EARLY GROWTH RESPONSE PROTEIN 1; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; EXTRACELLULAR SPACE; GENE EXPRESSION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, IMMEDIATE-EARLY; IMMEDIATE-EARLY PROTEINS; IONOMYCIN; IONOPHORES; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; N-METHYLASPARTATE; NEURONS; NEUROTOXINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; ZINC;

ANIMALIA;

EID: 0001482329     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1999.0730450.x     Document Type: Article

References (34)

1. Akins P. T., Liu P. K., and Hsu C. Y. (1996) Immediate early gene expression in response to cerebral ischemia. Stroke 27, 1682-1687.
2. Bading H., Segal M. M., Sucher N. J., Dudek H., Lipton S. A., and Greenberg M. E. (1995) N-Methyl-D-aspartate receptors are critical for mediating the effects of glutamate on intracellular calcium concentration and immediate early gene expression in cultured hippocampal neurons. Neuroscience 64, 653-664.
3. Beckmann A. M. and Wilce P. A. (1997) Egr transcription factors in the nervous system. Neurochem. Int. 31, 477-510.
4. Budde T., Minta A., White J. A., and Kay A. R. (1997) Imaging free zinc in synaptic terminals in live hippocampal slices. Neuroscience 79, 347-358.
5. Choi D. W. (1992) Excitotoxic cell death. J. Neurobiol. 23, 1261-1276.
6. Choi D. W. (1994) Calcium and excitotoxic neuronal injury. Ann. NY Acad. Sci. 747, 162-171.
7. Choi D. W. and Koh J. Y. (1998) Zinc and brain injury. Annu. Rev. Neurosci. 21, 347-375.
8. Cole A. J., Saffen D. W., Baraban J. M., and Worley P. F. (1989) Rapid increase of an immediate early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation. Nature 340, 474-476.
9. Frederickson C. J., Hernandez M. D., and McGinty J. F. (1989) Translocation of zinc may contribute to seizure-induced death of neurons. Brain Res. 480, 317-321.
10. Fukunaga K. and Miyamoto E. (1998) Role of MAP kinase in neurons. Mol. Neurobiol. 16, 79-95.
11. Gwag B. J., Canzoniero L. M. T., Sensi S. L., DeMaro J. A., Koh J. Y., Goldberg M. P., Jacquin M., and Choi D. W. (1999) Calcium ionophores can induce either apoptosis or necrosis in cultured cortical neurons. Neuroscience 90, 1339-1348.
12. Herdegen T., Skene P., and Bahr M. (1997) The c-Jun transcription factor - bipotential mediator of neuronal death, survival and regeneration. Trends Neurosci. 20, 227-231.
13. Hodge C., Liao J., Stofega M., Guan K., Carter-Su C., and Schwartz J. (1998) Growth hormone stimulates phosphorylation and activation of elk-1 and expression of c-fos, egr-1, and junB through activation of extracellular signal-regulated kinase 1 and 2. J. Biol. Chem. 273, 31327-31336.
14. Hu B. R. and Wieloch T. (1994) Tyrosine phosphorylation and activation of mitogen-activated protein kinase in the rat brain following transient cerebral ischemia. J. Neurochem. 62, 1357-1367.
15. Kanterewicz B. I., Knapp L. T., and Klann E. (1998) Stimulation of p42 and p44 mitogen-activated protein kinases by reactive oxygen species and nitric oxide in hippocampus. J. Neurochem. 70, 1009-1016.
16. Karin M. (1998) Mitogen-activated protein kinase cascades as regulators of stress responses. Ann. NY Acad. Sci. 851, 139-146.
17. Karin M., Liu Z., and Zandi E. (1997) AP-1 function and regulation. Curr. Opin. Cell Biol. 9, 240-246.
18. Kim Y.-H., Kim E. Y., Gwag B. J., Sohn S., and Koh J.-Y. (1999) Zinc-induced cortical neuronal death with features of apoptosis and necrosis: mediation by free radicals. Neuroscience 89, 175-182.
19. Koh J. Y. and Choi D. W. (1994) Zinc toxicity on cultured cortical neurons: involvement of N-methyl-D-aspartate receptors. Neuroscience 60, 1049-1057.
20. Koh J.-Y., Suh S. W., Gwag B. J., He Y. Y., Hsu C. Y., and Choi D. W. (1996) The role of zinc in selective neuronal death after transient global cerebral ischemia. Science 272, 1013-1016.
21. Milbrandt J. (1987) A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. Science 238, 797-799.
22. Murphy T. H., Worley P. F., and Baraban J. M. (1991) L-type voltage-sensitive calcium channels mediate synaptic activation of immediate early genes. Neuron 7, 625-635.
23. Nguyen H. Q., Hoffman-Liebermann B., and Liebermann D. A. (1993) The zinc finger transcription factor Egr-1 is essential for and restricts differentiation along the macrophage lineage. Cell 72, 197-209.
24. Ozaki N. and Chuang D.-M. (1997) Lithium increases transcription factor binding to AP-1 and cyclic AMP-responsive element in cultured neurons and rat brain. J. Neurochem. 69, 2336-2344.
25. Reiser C. O. A., Lanz T., Hofmann F., Hofer G., Rupprecht H. D., and Goppelt-Struebe M. (1998) Lysophosphatidic acid-mediated signal-transduction pathways involved in the induction of the early-response genes prostaglandin G/H synthase-2 and egr-1: a critical role for the mitogen-activated protein kinase p38 and for rho proteins. Biochem. J. 330, 1107-1114.
26. Samet J. M., Graves L. M., Quay J., Dailey L. A., Devlin R. B., Ghio A. J., Wu W., Bromberg P. A., and Reed W. (1998) Activation of MAPKs in human bronchial epithelial cells exposed to metals. Am. J. Physiol. 275, L551-L558.
27. Schwachtgen J.-L., Houston P., Campbell C., Sukhatme V., and Braddock M. (1998) Fluid shear stress activation of egr-1 transcription in cultured human endothelial and epithelial cells is mediated via the extracellular signal-related kinase 1/2 mitogen-activated protein kinase pathway. J. Clin. Invest. 101, 2540-2549.
28. Sensi S. L., Canzoniero L. M., Yu S. P., Ying H. S., Koh J. Y., Kerchner G. A., and Choi D. W. (1997) Measurement of intracellular free zinc in living cortical neurons: routes of entry. J. Neurosci. 17, 9554-9564.
29. Sgambato V., Pages C., Rogard M., Besson M. J., and Caboche J. (1998) Extracellular signal-regulated kinase (ERK) controls immediate early gene induction on corticostriatal stimulation. J. Neurosci. 18, 8814-8825.
30. Struhl K. (1989) Helix-turn-helix, zinc-finger, and leucine-zipper motifs for eukaryotic transcriptional regulatory proteins. Trends Biochem. Sci. 14, 137-140.
31. Tong L., Toliver-Kinsky T., Taglialatela G., Werrbach-Perez K., Wood T., and Perez-Polo J. R. (1998) Signal transduction in neuronal death. J. Neurochem. 71, 447-459.
32. Vaccarino F. M., Hayward M. D., Nestler E. J., Duman R. S., and Tallman J. F. (1992) Differential induction of immediate early genes by excitatory amino acid receptor types in primary cultures of cortical and striatal neurons. Brain Res. Mol. Brain Res. 12, 233-241.
33. Weiss J. H., Hartley D. M., Koh J. Y., and Choi D. W. (1993) AMPA receptor activation potentiates zinc neurotoxicity. Neuron 10, 43-49.
34. Worley P. F., Christy B. A., Nakabeppu Y., Bhat R. V., Cole A. J., and Baraban J. M. (1991) Constitutive expression of zif/268 in neocortex is regulated by synaptic activity. Proc. Natl. Acad. Sci. USA 88, 5106-5110.