The crystal structure of streptococcus pyogenes uridine phosphorylase reveals a distinct subfamily of nucleoside phosphorylases

Biochemistry

Volumn 50, Issue 30, 2011, Pages 6549-6558

  Tran, Timothy H ^a   Christoffersen, S ^b   Allan, Paula W ^c   Parker, William B ^c   Piškur, Jure ^b   Serra, I ^d   Terreni, M ^d   Ealick, Steven E ^a  

^a Department of Obstetrics Gynecology   (United States)

^b LUND UNIVERSITY   (Sweden)

^c SOUTHERN RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF PAVIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ACTIVE SITE RESIDUES; BIOCHEMICAL STUDIES; BIOLOGICAL UNITS; DEOXYURIDINE; HEXAMERS; KEY ENZYMES; NEGATIVE CHARGE; NUCLEOSIDE PHOSPHORYLASE; PHOSPHOROLYSIS; PHYLOGENETIC ANALYSIS; SALVAGE PATHWAY; STREPTOCOCCUS PYOGENES; SUBSTRATE SPECIFICITY; TRANSITION STATE; TRANSITION STATE STABILIZATION; WILD TYPES;

AROMATIC COMPOUNDS; BIOMOLECULES; ENZYMES; ESCHERICHIA COLI; PHOSPHORYLATION; SUBSTRATES;

CRYSTAL STRUCTURE;

NUCLEOSIDE PHOSPHORYLASE; OXYGEN; RIBOSE 1 PHOSPHATE; URACIL; URIDINE PHOSPHORYLASE;

ARTICLE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SPECIFICITY; ESCHERICHIA COLI; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN QUATERNARY STRUCTURE; STREPTOCOCCUS PYOGENES; WILD TYPE;

BACTERIAL PROTEINS; CATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; MULTIGENE FAMILY; MUTAGENESIS, SITE-DIRECTED; PROTEIN FOLDING; RIBOSEMONOPHOSPHATES; STATIC ELECTRICITY; STREPTOCOCCUS PYOGENES; SUBSTRATE SPECIFICITY; URACIL; URIDINE PHOSPHORYLASE;

ESCHERICHIA COLI; STREPTOCOCCUS PYOGENES;

EID: 79960756791     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200707z     Document Type: Article

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