The X-ray structure of Salmonella typhimurium uridine nucleoside phosphorylase complexed with 2,2'-anhydrouridine, phosphate and potassium ions at 1.86 Å resolution

Acta Crystallographica Section D: Biological Crystallography

Volumn 66, Issue 1, 2010, Pages 51-60

  Lashkov, Alexander A ^a,b   Zhukhlistova, Nadezhda E ^a   Gabdoulkhakov, Azat H ^a   Shtil, Alexander A ^c   Efremov, Roman G ^b   Betzel, Christian ^d   Mikhailov, Al'Bert M ^a  

^a SHUBNIKOV INSTITUTE OF CRYSTALLOGRAPHY   (Russian Federation)

^b SHEMYAKIN OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY   (Russian Federation)

^c N N BLOKHIN RUSSIAN CANCER RESEARCH CENTER   (Russian Federation)

^d UNIVERSITY OF HAMBURG   (Germany)

Author keywords

2,2' anhydrouridine; Computer assisted molecular design; Enzyme inhibitors; Pyrimidine nucleoside phosphorylases; Salmonella typhimurium; Uridine phosphorylase

Indexed keywords

BACTERIAL PROTEIN; DRUG DERIVATIVE; ION; PHOSPHATE; POTASSIUM; URIDINE; URIDINE PHOSPHORYLASE;

ARTICLE; CHEMISTRY; CRYSTALLIZATION; ENZYMOLOGY; HUMAN; MACROMOLECULE; METABOLISM; PROTEIN CONFORMATION; SALMONELLA TYPHIMURIUM; X RAY CRYSTALLOGRAPHY;

BACTERIAL PROTEINS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; HUMANS; IONS; MACROMOLECULAR SUBSTANCES; PHOSPHATES; POTASSIUM; PROTEIN CONFORMATION; SALMONELLA TYPHIMURIUM; URIDINE; URIDINE PHOSPHORYLASE;

SALMONELLA TYPHIMURIUM;

EID: 74549218848     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444909044175     Document Type: Article

References (41)

1. Adams, P. D., Grosse-Kunstleve, R. W., Hung, L.-W., Ioerger, T. R., McCoy, A. J., Moriarty, N. W., Read, R. J., Sacchettini, J. C., Sauter, N. K. & Terwilliger, T. C. (2002). Acta Cryst. D58, 1948-1954.
2. Balestri, F., Barsotti, C., Lutzemberger, L., Camici, M. & Ipata, P. L. (2007). Neurochem. Int. 51, 517-523.
3. Beck, D. A. & O'Donovan, G. A. (2008). Curr. Microbiol. 56, 162-167.
4. Berman, H. M., Henrick, K. & Nakamura, H. (2003). Nature Struct. Biol. 10, 980.
5. Bernstein, F. C., Koetzle, T. F.,Wiliams, G. J. B., Meyer, E. F. Jr, Brice, M. D., Rogers, J. R., Kennard, O., Shimanouchi, T. & Tasumi, M. (1977). J. Mol. Biol. 112, 535-542.
6. Bu, W., Settembre, E. C., el Kouni, M. H. & Ealick, S. E. (2005). Acta Cryst. D61, 863-872.
7. Burling, F. T., Kniewel, R., Buglino, J. A., Chadha, T., Beckwith, A. & Lima, C. D. (2003). Acta Cryst. D59, 73-76.
8. Caradoc-Davies, T. T., Cutfield, S. M., Lamont, I. L. & Cutfield, J. F. (2004). J. Mol. Biol. 337, 337-354.
9. Chandana, S. R. & Conley, B. A. (2009). Curr. Opin. Oncol. 21, 218-223.
10. Choi, J. W., Shin, C. Y., Choi, M. S., Yoon, S. Y., Ryu, J. H., Lee, J. C., Kim,W. K., el Kouni, M. H. & Ko, K. H. (2008). J. Neurotrauma, 25, 695-707.
11. Dontsova, M. V., Savochkina, Y. A., Gabdoulkhakov, A. G., Baidakov, S. N., Lyashenko, A. V., Zolotukhina, M., Errais Lopes, L., Garber, M. B., Morgunova, E. Y., Nikonov, S. V., Mironov, A. S., Ealick, S. E. & Mikhailov, A. M. (2004). Acta Cryst. D60, 709-711.
12. el Kouni, M. H., Naguib, F. N., Chu, S. H., Cha, S. M., Ueda, T., Gosselin, G., Imbach, J. L., Shealy, Y. F. & Otter, B. A. (1988). Mol. Pharmacol. 34, 104-110.
13. el Kouni, M. H., Naguib, F. N., Niedzwicki, J. G., Iltzsch, M. H. & Cha, S. (1988). J. Biol. Chem. 263, 6081-6086.
14. Emsley, P. & Cowtan, K. (2004). Acta Cryst. D60, 2126-2132.
15. Friesner, R. A., Murphy, R. B., Repasky, M. P., Frye, L. L., Greenwood, J. R., Halgren, T. A., Sanschagrin, P. C. & Mainz, D. T. (2006). J. Med. Chem. 49, 6177-6196.
16. Gieringer, J. H., Wenz, A. F., Just, H. M. & Daschner, F. D. (1986). Chemotherapy, 32, 418-424.
17. Iigo, M., Nishikata, K., Nakajima, Y., Szinai, I., Veres, Z., Szabolcs, A. & De Clercq, E. (1990). Biochem. Pharmacol. 39, 1247-1253.
18. Jimenez, B. M., Kranz, P., Lee, C. S., Gero, A. M. & O'Sullivan, W. J. (1989). Biochem. Pharmacol. 38, 3785-3789.
19. Kabsch, W. (2001). International Tables for Crystallography, Vol.F, edited by M. G. Rossmann & E. Arnold, pp. 218-225. Dordrecht: Kluwer Academic Publishers.
20. Kemeny, N. (1987). Semin. Surg. Oncol. 3, 190-214.
21. Kohne, C. H. & Lenz, H. J. (2009). Oncologist, 14, 478-488.
22. Larkin, M. A., Blackshields, G., Brown, N. P., Chenna, R., McGettigan, P. A., McWilliam, H., Valentin, F., Wallace, I. M., Wilm, A., Lopez, R., Thompson, J. D., Gibson, T. J. & Higgins, D. G. (2007). Bioinformatics, 23, 2947-2948.
23. Lashkov, A. A., Zhukhlistova, N. E., Gabdulkhakov, A. G. & Mikhailov, A. M. (2009). Crystallogr. Rep. 54, 267-278.
24. Laskowski, R. A., MacArthur, M. W., Moss, D. S. & Thornton, J. M. (1993). J. Appl. Cryst. 26, 283-291.
25. Lee, C. S., Jimenez, B. M. & O'Sullivan, W. J. (1988). Mol. Biochem. Parasitol. 30, 271-277.
26. Matsusaka, S., Yamasaki, H., Fukushima, M. & Wakabayashi, I. (2007). Chemotherapy, 53, 36-41.
27. McCoy, A. J. (2007). Acta Cryst. D63, 32-41.
28. Mikhailov, A. M., Smirnova, E. A., Tsuprun, V. L., Tagunova, I. V., Vainshtein, B. K., Linkova, E. V., Komissarov, A. A., Siprashvili, Z. Z. & Mironov, A. S. (1992). Biochem. Int. 26, 607-615.
29. Molchan, O. K., Dmitrieva, N. A., Romanova, D. V., Lopes, L. E., Debabov, V. G. & Mironov, A. S. (1998). Biochemistry (Mosc.), 63, 195-199.
30. Morgunova, E., Mikhailov, A. M., Popov, A. N., Blagova, E. V., Smirnova, E. A., Vainshtein, B. K., Mao, C., Armstrong, S. R., Ealick, S. E., Komissarov, A. A., Linkova, E. V., Burlakova, A. A., Mironov, A. S. & Debabov, V. G. (1995). FEBS Lett. 367, 183-187.
31. Murshudov, G. N., Vagin, A. A. & Dodson, E. J. (1997). Acta Cryst. D53, 240-255.
32. Niedzwicki, J. G., el Kouni, M. H., Chu, S. H. & Cha, S. (1983). Biochem. Pharmacol. 32, 399-415.
33. Paege, L.M. & Schlenk, F. (1952). Arch. Biochem. Biophys. 40, 42-49.
34. Ramachandran, G. N., Ramakrishnan, C. & Sasisekharan, V. (1963). J. Mol. Biol. 7, 95-99.
35. Roosild, T. P., Castronovo, S., Fabbiani, M. & Pizzorno, G. (2009). BMC Struct. Biol. 9, 14.
36. Schüttelkopf, A. W. & van Aalten, D. M. F. (2004). Acta Cryst. D60, 1355-1363.
37. Temmink, O. H., de Bruin, M., Laan, A. C., Turksma, A.W., Cricca, S., Masterson, A. J., Noordhuis, P. & Peters, G. J. (2006). Int. J. Biochem. Cell Biol. 38, 1759-1765.
38. Timofeev, V. I., Lashkov, A. A., Gabdoulkhakov, A. G., Pavlyuk, B. P., Kachalova, G. S., Betzel, C., Morgunova, E. Y., Zhukhlistova, N. E. & Mikhailov, A. M. (2007). Acta Cryst. F63, 852-854.
39. Xie, X. Q. & Chen, J. Z. (2008). J. Chem. Inf. Model. 48, 465-475.
40. Yamashiro, Y., Fukuoka, Y., Yotsuji, A., Yasuda, T., Saikawa, I. & Ueda, Y. (1986). J. Antimicrob. Chemother. 18, 703-708.
41. Zolotukhina, M., Ovcharova, I., Eremina, S., Errais Lopes, L. & Mironov, A. S. (2003). Res. Microbiol. 154, 510-520.