Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy

BMC Structural Biology

Volumn 9, Issue , 2009, Pages

  Roosild, Tarmo P ^a   Castronovo, Samantha ^a   Fabbiani, Michael ^a   Pizzorno, Giuseppe ^a  

^a NEVADA CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 BENZYLACYCLOURIDINE; ACYCLOURIDINE DERIVATIVE; ENZYME INHIBITOR; FLUOROPYRIMIDINE DERIVATIVE; FLUOROURACIL; FLUOROURACIL DERIVATIVE; URIDINE PHOSPHORYLASE; 5-BENZYLACYCLOURIDINE; BACTERIAL PROTEIN; DRUG DERIVATIVE; RECOMBINANT PROTEIN; URACIL;

ARTICLE; DRUG MECHANISM; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME STRUCTURE; HUMAN; CHEMISTRY; COMPARATIVE STUDY; CRYSTALLIZATION; DIMERIZATION; DRUG ANTAGONISM; DRUG DESIGN; ESCHERICHIA COLI; GENETICS; METABOLISM; PROTEIN BINDING; PROTEIN CONFORMATION; STRUCTURAL HOMOLOGY;

BACTERIAL PROTEINS; CATALYTIC DOMAIN; CRYSTALLIZATION; DIMERIZATION; DRUG DESIGN; ENZYME INHIBITORS; ESCHERICHIA COLI; HUMANS; PROTEIN BINDING; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; STRUCTURAL HOMOLOGY, PROTEIN; URACIL; URIDINE PHOSPHORYLASE;

EID: 63849164243     PISSN: None     EISSN: 14726807     Source Type: Journal    
DOI: 10.1186/1472-6807-9-14     Document Type: Article

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