Characterization of sparstolonin B, a chinese herb-derived compound, as a selective toll-like receptor antagonist with potent anti-inflammatory properties

Journal of Biological Chemistry

Volumn 286, Issue 30, 2011, Pages 26470-26479

  Liang, Qiaoli ^a,b   Wu, Qinan ^b   Jiang, Jihong ^c   Duan, Jin'ao ^b   Wang, Chao ^d   Smith, Mark D ^d   Lu, Hong ^a   Wang, Qian ^d   Nagarkatti, Prakash ^a   Fan, Daping ^a  

^a UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^c JIANGSU NORMAL UNIVERSITY   (China)

^d UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-INFLAMMATORIES; CHIMERIC RECEPTORS; CHINESE HERBS; CO-IMMUNOPRECIPITATIONS; CYTOKINE EXPRESSION; CYTOKINE SECRETIONS; INFLAMMATORY DISEASE; INFLAMMATORY SIGNALING; LIPOPOLYSACCHARIDES; TOLL-LIKE RECEPTORS;

DISEASES; MACROPHAGES; MAMMALS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHORYLATION; SIGNALING; X RAY CRYSTALLOGRAPHY;

LIGANDS;

CD4 ANTIGEN; CYTOKINE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 14; MYELOID DIFFERENTIATION FACTOR 88; RECEPTOR BLOCKING AGENT; SPARSTOLONIN B; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL STRAIN; CELL STRAIN HEK293; CELL STRAIN THP 1; CHINESE HERB; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG ISOLATION; DRUG STRUCTURE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MACROPHAGE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; SEPSIS; SIGNAL TRANSDUCTION; SPAGANIUM STOLONIFERUM; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

ANGIOSPERMS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CRYSTALLOGRAPHY, X-RAY; CYTOKINES; DRUGS, CHINESE HERBAL; HEK293 CELLS; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MOLECULAR STRUCTURE; MYELOID DIFFERENTIATION FACTOR 88; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

MUS;

EID: 79960675607     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.227934     Document Type: Article

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