The novel selective toll-like receptor 4 signal transduction inhibitor tak-242 prevents endotoxaemia in conscious guinea-pigs

Clinical and Experimental Pharmacology and Physiology

Volumn 36, Issue 5-6, 2009, Pages 589-593

  Kuno, Masamune ^a,b   Nemoto, Kayo ^b   Ninomiya, Norifumi ^b,d   Inagaki, Eiji ^b   Kubota, Minoru ^a   Matsumoto, Tatsumi ^c   Yokota, Hiroyuki ^b  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b Department of Emergency and Critical Care Medicine ^*  (Japan)

^c TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^d GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

Guinea pig; High morbidity group box 1; Intestinal paralysis; Lipopolysaccharide; TAK 242

Indexed keywords

6 [N (2 CHLORO 4 FLUOROPHENYL)SULFAMOYL] 1 CYCLOHEXENE 1 CARBOXYLIC ACID ETHYL ESTER; HIGH MOBILITY GROUP B1 PROTEIN; LIPOPOLYSACCHARIDE; TOLL LIKE RECEPTOR 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTERY CATHETER; ARTICLE; CAROTID ARTERY; COLON; CONTROLLED STUDY; DRUG EFFICACY; ENDOTOXEMIA; GUINEA PIG; HYPOTENSION; INTESTINE CONTRACTION; INTESTINE MUSCLE; INTRAVENOUS CATHETER; MALE; MUSCLE TONE; NONHUMAN; PARALYSIS; SEPSIS; SURVIVAL RATE; TELEMETRY;

ANIMALS; ANTI-INFECTIVE AGENTS; BLOOD PRESSURE; CONSCIOUSNESS; DRUG EVALUATION, PRECLINICAL; ENDOTOXEMIA; GUINEA PIGS; LIPOPOLYSACCHARIDES; MALE; MODELS, BIOLOGICAL; MUSCLE TONUS; MUSCLE, SMOOTH; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY; SULFONAMIDES; SURVIVAL ANALYSIS; TOLL-LIKE RECEPTOR 4;

EID: 65349148160     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2008.05121.x     Document Type: Article

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