Resistance to the CCR5 inhibitor 5P12-RANTES requires a difficult evolution from CCR5 to CXCR4 Coreceptor use

PLoS ONE

Volumn 6, Issue 7, 2011, Pages

  Nedellec, Rebecca ^a   Coetzer, Mia ^a   Lederman, Michael M ^b   Offord, Robin E ^c   Hartley, Oliver ^d   Mosier, Donald E ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Foundation for Medical Research   (Switzerland)

^d UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; CHEMOKINE RECEPTOR CXCR4; MARAVIROC; RANTES; 5P12 RANTES; 5P12-RANTES; BETA CHEMOKINE; CYCLOHEXANE DERIVATIVE; GLYCOPROTEIN GP 160; TRIAZOLE DERIVATIVE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENE DELETION; GENE SWITCHING; HUMAN IMMUNODEFICIENCY VIRUS; IN VITRO STUDY; MOLECULAR EVOLUTION; NONHUMAN; VIRUS ENTRY; VIRUS ENVELOPE; VIRUS MUTATION; VIRUS REPLICATION; VIRUS RESISTANCE; VIRUS STRAIN; ANTIVIRAL RESISTANCE; CHEMISTRY; DIRECTED MOLECULAR EVOLUTION; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

AMINO ACID SEQUENCE; CHEMOKINES, CC; CYCLOHEXANES; DIRECTED MOLECULAR EVOLUTION; DRUG RESISTANCE, VIRAL; HIV ENVELOPE PROTEIN GP160; HIV-1; HUMANS; MOLECULAR SEQUENCE DATA; RECEPTORS, CCR5; RECEPTORS, CXCR4; TRIAZOLES; VIRUS REPLICATION;

EID: 79960078119     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0022020     Document Type: Article

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