Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 1: Discovery and initial structure-activity relationships for 1-amino-2-phenyl-4-(piperidin-1-yl) butanes

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 2, 2001, Pages 259-264

  Dorn, Conrad P ^a   Finke, Paul E ^a   Oates, Bryan ^a   Budhu, Richard J ^a   Mills, Sander G ^a   MacCoss, Malcolm ^a   Malkowitz, Lorraine ^a   Springer, Martin S ^a   Daugherty, Bruce L ^a   Gould, Sandra L ^a   DeMartino, Julie A ^a   Siciliano, Salvatore J ^a   Carella, Anthony ^a   Carver, Gwen ^a   Holmes, Karen ^a   Danzeisen, Renee ^a   Hazuda, Daria ^a   Kessler, Joseph ^a   Lineberger, Janet ^a   Miller, Michael ^a   Schleif, William A ^a   Emini, Emilio A ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 AMINO 2 PHENYL 4 (PIPERIDIN 1 YL)BUTANE; 2 (3,4 DICHLOROPHENYL) 1 [N (METHYL) N (PHENYLSULFONYL)AMINO] 4 [SPIRO(2,3 DIHYDROBENZTHIOPHENE 3,4' PIPERIDIN 1' YL)]BUTANE OXIDE; ANTIVIRUS AGENT; BENZOTHIOPHENE DERIVATIVE; CHEMOKINE RECEPTOR CCR5; PIPERIDINE DERIVATIVE; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG STRUCTURE; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; NONHUMAN; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; SYNTHESIS; VIRUS INHIBITION;

ANIMALS; ANTI-HIV AGENTS; CHO CELLS; COMBINATORIAL CHEMISTRY TECHNIQUES; CRICETINAE; HUMANS; INHIBITORY CONCENTRATION 50; MACROPHAGE INFLAMMATORY PROTEIN-1; PIPERIDINES; PROTEIN BINDING; RECEPTORS, CCR5; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0035931442     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00637-5     Document Type: Article

References (33)