Neuroprotective effect of guanosine against glutamate-induced cell death in rat hippocampal slices is mediated by the phosphatidylinositol-3 kinase/Akt/ glycogen synthase kinase 3β pathway activation and inducible nitric oxide synthase inhibition

Journal of Neuroscience Research

Volumn 89, Issue 9, 2011, Pages 1400-1408

  Molz, Simone ^a,b   Dal Cim, Tharine ^a   Budni, Josiane ^a   Martin de Saavedra M D ^c   Egea, Javier ^c   Romero, Alejandro ^c   del Barrio, Laura ^c   Rodrigues, Ana L S ^a   López, Manuela G ^c   Tasca, Carla I ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^b UNIVERSIDADE DO CONTESTADO   (Brazil)

^c INSTITUTO TEÓFILO HERNANDO   (Spain)

Author keywords

Akt; Glutamate; Guanosine; INOS; Neuroprotection

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; GLUTAMIC ACID; GLYCOGEN SYNTHASE KINASE 3BETA; GUANOSINE; INDUCIBLE NITRIC OXIDE SYNTHASE; N ACETYL S NITROSOPENICILLAMINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HIPPOCAMPUS; MALE; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANALYSIS OF VARIANCE; ANIMALS; CELL DEATH; GLUTAMIC ACID; GLYCOGEN SYNTHASE KINASES; GUANOSINE; HIPPOCAMPUS; MALE; NEUROPROTECTIVE AGENTS; NEUROTOXINS; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHATIDYLINOSITOL 3-KINASE; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; SECOND MESSENGER SYSTEMS; STATISTICS, NONPARAMETRIC;

EID: 79960049379     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22681     Document Type: Article

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