Feature article are neurons lost from the primate cerebral cortex during normal aging?

Cerebral Cortex

Volumn 8, Issue 4, 1998, Pages 295-300

  Peters, Alan ^a,d,e   Morrison, John H ^b   Rosene, Douglas L ^a,d   Hyman, Bradley T ^c  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MOUNT SINAI MEDICAL CENTER   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d EMORY UNIVERSITY   (United States)

^e BOSTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; ANIMAL TISSUE; BRAIN CORTEX; CELL DENSITY; CELL POPULATION; COGNITION; ELECTRON MICROSCOPY; IMAGE ANALYSIS; MONKEY; NERVE CELL DEGENERATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; TEMPORAL CORTEX;

AGING; ANIMALS; CELL COUNT; CEREBRAL CORTEX; HUMANS; NEURONS; PRIMATES; REFERENCE VALUES;

EID: 0031814240     PISSN: 10473211     EISSN: None     Source Type: Journal    
DOI: 10.1093/cercor/8.4.295     Document Type: Review

References (23)

1. Ahmad A, Spear PD (1993) Effects of aging on the size, density and number of rhesus monkey lateral geniculate neurons. J Comp Neurol 334:631-643.
2. Amaral DG (1993) Morphological analysis of the brains of behaviorally characterized aged nonhuman primates. Neurobiol Aging 14:671-672.
3. Anderson JM, Hubbard BM, Coghill GR, Slidders W (1983) Neuropsychological changes in healthy adults across the age range. Neurobiol Aging 14:623-625.
4. Ball MJ (1977) Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia. Acta Neuropathol. 37:111-118.
5. Braak H, Braak E (1991) Neuropathological staging of Alzheimer related changes. Acta Neuropathol (Berl.) 82:239-259.
6. Braendgaard H, Evans, SM, Howard CV, Gundersen HJG (1990) The total number of neurons in the human neocortex unbiasedly estimated using optical disectors. J Microsc 157:285-304.
7. Brizzee KR (1973) Quantitative studies on aging changes in cerebral cortex of rhesus monkey and albino rat with notes on effects of prolonged low-dose radiation in the rat. Progr Brain Res 40:141-160.
8. Brizzee K, Klara P, Johnson J (1975) Changes in microanatomy, neurocytology and fine structure with aging. In: Neurobiology of aging (Ordy JM, Brizzee KR, eds), pp. 574-594. New York: Plenum Press.
9. Brizzee KR, Ordy JM, Bartus RT (1980) Localization of cellular changes within multimodal sensory regions in aged monkey brain. Possible implications of age related cognitive loss. Neurobiol Aging 1:445-52.
10. Brody HD (1955) Organization of the cerebral cortex. III. A study of aging in the human cerebral cortex. J Comp Neurol 1023:511-556.
11. Brody H (1970) Structural changes in the aging nervous system. Interdise Top Gerontol 7:9-21.
12. Coggeshall RE, Lekan, HA (1996) Methods for determining numbers of cells and synapses. J Comp Neurol 364:6-15.
13. Coleman PD, Flood DG (1987) Neuron number and dendritic extent in normal aging and Alzheimer's disease. Neurobiol Aging 8:521-516.
14. Colon EJ (1972) A quantitative analysis of the cerebral cortex in two cases. Psychiatr Neurol Neurochir 75:261-279.
15. Cragg BG (1975) The density of synapses and neurons in normal, mentally defective and aging human brains. Brain 98:81-90.
16. Devaney KO, Johnson HA (1980) Neuron loss in the aging visual cortex of man. J Gerontol 35:836-841.
17. Double KL, Halliday GM, Kril JJ, Harasty JA, Cullen K, Brooks WS, Creasey H, Broes GA (1996) Topography of brain atrophy during normal aging and Alzheimer's disease. Neurobiol Aging 17:513-521.
18. Gazzaley AH, Siegel SJ, Kordower JH, Mufson EJ, Morrison JH (1996) Circuit-specific alterations of N-methyl-D-aspartate receptor subunit 1 in the dentate gyrus of aged monkeys. Proc Natl Acad Sci USA 93:3121-3125.
19. Gazzaley AH, Thakker MM, Hof PR, Morrison JH (1997) Preserved number of entorhinal cortex layer II neurons in aged macaque monkeys. Neurobiol Aging 18:549-554.
20. Gómez-Isla T, Price JL, McKeel DW, Morris JC, Growdon JH, Hyman BT (1996) Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease.J Neurosci 16:4491-4500.
21. Gómez-Isla T, Hollister R, West H, Mui S, Growdon JH, Petersen RC, Parisi JE, Hyman BT (1997) Neuronal loss corrrelates with, but exceeds neurofibrillary tangles in Alzheimer's disease. Ann Neurol 41:17-24.
22. Gundersen HJG, Bendtsen TF, Korbo L, Marcussen N, Møller A, Nielsen K, Nyengaard JR, Pakkenberg B, Serensen FB, Vesterby A, West MJ (1988a) Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS 96:379-394.
23. Gundersen HJG, Bagger B, Bendtsen TF, Evans SM, Korbo L, Marcussen N, Moller A, Nielsen K, Nyengaard JR, Pakkenberg B, Sorensen A, Vesterby A, West MJ (1988b) The new stereological tools: disector, fractionator, nucleator, and point sampled intercepts and their use in pathological research and diagnosis. APMIS 96:857-881.