Troglitazone treatment of aging Brown Norway rats improves food intake and weight gain after fasting without increasing hypothalamic NPY gene expression

Experimental Gerontology

Volumn 37, Issue 5, 2002, Pages 679-691

  Wolden Hanson, Tami ^a   Marck, Brett T ^a   Matsumoto, Alvin M ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Anorexia; Brown Norway rat; Energy regulation; Feeding; Neuropeptide Y; Thiazolidinedione

Indexed keywords

INSULIN; LEPTIN; MESSENGER RNA; NEUROPEPTIDE Y; TROGLITAZONE;

AGING; ANIMAL MODEL; ARCUATE NUCLEUS; ARTICLE; BODY FAT; CONTROLLED STUDY; DIET RESTRICTION; ENERGY BALANCE; FOOD INTAKE; GENE EXPRESSION; GROUPS BY AGE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPERINSULINEMIA; HYPOTHALAMUS; IN SITU HYBRIDIZATION; INSULIN BLOOD LEVEL; MALE; NONHUMAN; PRIORITY JOURNAL; WEIGHT GAIN;

AGING; ANIMALS; BODY COMPOSITION; CHROMANS; EATING; FASTING; GENE EXPRESSION; HYPOGLYCEMIC AGENTS; HYPOTHALAMUS; IN SITU HYBRIDIZATION; INSULIN; LEPTIN; MALE; NEUROPEPTIDE Y; PROTEIN PRECURSORS; RATS; RATS, INBRED BN; RNA, MESSENGER; THIAZOLES; THIAZOLIDINEDIONES; WEIGHT GAIN;

ANIMALIA; RATTUS NORVEGICUS;

EID: 0036119806     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(01)00233-9     Document Type: Article

References (65)

1. Unexpected regulation of hypothalamic neuropeptide Y by food deprivation and refeeding in the Zucker rat
2. Hyperphagia in cold-exposed rats is accompanied by decreased plasma leptin but unchanged hypothalamic NPY
3. Independent and additive effects of central POMC and leptin pathways on murine obesity
4. The MONA LISA hypothesis in the time of leptin
5. Evidence for the anorexia of aging: gastrointestinal transit and hunger in healthy elderly vs. young adults
6. Effects of small intestinal nutrient infusion on appetite and pyloric motility are modified by age
7. Effect of sustained physiological hyperinsulinemia on hypothalamic neuropeptide Y and NPY mRNA levels in the rat
8. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
9. Hyperphagia induced by hypoglycemia in rats is independent of leptin and hypothalamic neuropeptide Y (NPY)
10. Leptin activates hypothalamic CART neurons projecting to the spinal cord
11. Low body weight and weight loss in the aged
12. Obesity and the hypothalamus; novel peptides for new pathways
13. Excessive testicular progesterone secretion in aged male Fischer 344 rats: a potential cause of age-related gonadotropin suppression and a confounding variable in aging studies
14. The Brown Norway rat as a model of male reproductive aging: evidence for both primary and secondary testicular failure
15. Age-related decrease in neuropeptide Y gene expression in the hypothalamic arcuate nucleus of the male rat brain is independent of testicular feedback
16. Fasting-induced increases in food intake and neuropeptide Y gene expression are attenuated in aging male brown Norway rats
17. Rat neuropeptide Y precursor gene expression mRNA structure, tissue distribution and regulation by glucocorticoids, cyclic AMP and phorbol ester
18. Functional antagonism between CCAAT/enhancer binding protein-alpha and peroxisome proliferator-activated receptor-gamma on the leptin promoter
19. Effects of age and drugs on food and fluid intake
20. Dual-energy X-ray absorptiometry for the measurement of gross body composition in rats
21. Critical effects of aging and nutritional state on hypothalamic neuropeptide Y and galanin gene expression in lean and genetically obese Zucker rats
22. Troglitazone: review and assessment of its role in the treatment of patients with impaired glucose tolerance and diabetes mellitus
23. Troglitazone (CS-045): a new antidiabetic agent
24. Hypothalamic CART is a new anorectic peptide regulated by leptin
25. Effect of food deprivation and streptozotocin-induced diabetes on hypothalamic neuropeptide Y release as measured by a radioimmunoassay-linked microdialysis procedure
26. CART peptides in the central control of feeding and interactions with neuropeptide Y
27. Aging and fasting regulation of leptin and hypothalamic neuropeptide Y gene expression
28. Pathologic characterization of Brown Norway, Brown Norway×Fischer 344, and Fischer 344×Brown Norway rats with relation to age
29. Peripheral insulin administration attenuates the increase in neuropeptide Y concentrations in the hypothalamic arcuate nucleus of fasted rats
30. Refusal to eat in the elderly
31. Neuropeptide regulation of appetite and weight
32. Anorexia of aging: physiologic and pathologic
33. Effect of troglitazone on leptin production. Studies in vitro and in human subjects
34. Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats
35. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
36. Feeding and drinking responses to neuropeptide Y injections in the paraventricular hypothalamic nucleus of aged rats
37. Physiological predictors of increasing total and central adiposity in aging men and women
38. Evaluation by dual-energy X-ray absorptiometry of age-related changes in body composition of male rats
39. Control of food intake in older men
40. Effects of age on energy expenditure and substrate oxidation during experimental overfeeding in healthy men
41. Effects of age on energy expenditure and substrate oxidation during experimental underfeeding in healthy men
42. Age-related impairments in the regulation of food intake
43. A C-terminal fragment of agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo
44. Absence of increased neuropeptide Y neuronal activity before and during the luteinizing hormone (LH) surge may underlie the attenuated preovulatory LH surge in middle-aged rats
45. Evidence that hypothalamic neuropeptide Y secretion decreases in aged male rats: implications for reproductive aging
46. Aging in male rats modifies castration and testosterone-induced neuropeptide Y response in various microdissected brain nuclei
47. Impaired leptin responsiveness in aged rats
48. Orexins and appetite: the big picture of energy homeostasis gets a little bigger
49. Central insulin administration reduces neuropeptide Y mRNA expression in the arcuate nucleus of food-deprived lean (Fa/Fa) but not obese (fa/fa) Zucker rats
50. Inhibition of hypothalamic neuropeptide Y gene expression by insulin
51. Insulin, neuropeptide Y, and food intake
52. Differential effect of fasting on hypothalamic expression of genes encoding neuropeptide Y, galanin, and glutamic acid decarboxylase
53. Resistance to the anorexic and thermogenic effects of centrally administrated leptin in obese aged rats
54. Troglitazone reduces plasma leptin concentration but increases hunger in NIDDM patients
55. Angiotensin II and fluid ingestion in old rats
56. Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression
57. Troglitazone
58. Growth curves and survival characteristics of the animals used in the Biomarkers of Aging Program
59. Effect of age on the activity of phosphoenolpyrovate carboxykinase in the kidney following fasting and refeeding
60. Failure to thrive in old age: follow-up on a workshop
61. Increased feeding in fatty Zucker rats by the thiazolidinedione BRL 49653 (rosiglitazone) and the possible involvement of leptin and hypothalamic neuropeptide Y
62. Cross-sectional and longitudinal analysis of age-associated changes in body composition of male Brown Norway rats: association of serum leptin levels with peripheral adiposity
63. Signals that regulate food intake and energy homeostasis
64. Calorie and nutrient intakes of elderly and young subjects measured under identical conditions
65. Down-regulation of the expression of the obese gene by an antidiabetic thiazolidinedione in Zucker diabetic fatty rats and db/db mice