메뉴 건너뛰기




Volumn 59, Issue 13, 2011, Pages 7005-7012

Antioxidant and cytotoxic activities of carob tree fruit pulps are strongly influenced by gender and cultivar

Author keywords

apoptosis; cell cycle; cytotoxicity; HeLa cells; polyphenol; ROS

Indexed keywords

ANTIOXIDANT ACTIVITIES; BIOLOGICAL ACTIVITIES; CAROB TREES; CELL CYCLE; CELL VIABILITY; CHEMICAL CONTENT; CYTOTOXIC ACTIVITIES; FRUIT PULPS; GALLIC ACIDS; HELA CELL; HERMAPHRODITE TREES; HUMAN CANCER CELLS; LIPID OXIDATION; PHENOLIC COMPOUNDS; PHENOLICS; POLYPHENOLS; RADICAL SCAVENGING ACTIVITY; ROS; TIME-DEPENDENT; TOTAL CONTENT;

EID: 79960038855     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf200838f     Document Type: Article
Times cited : (61)

References (42)
  • 1
    • 33644620070 scopus 로고    scopus 로고
    • The antioxidant and radical scavenging activities of black pepper (Piper nigrum) seeds
    • Gulcin, I. The antioxidant and radical scavenging activities of black pepper (Piper nigrum) seeds Int. J. Food Sci. Nutr. 2005, 56, 491-499
    • (2005) Int. J. Food Sci. Nutr. , vol.56 , pp. 491-499
    • Gulcin, I.1
  • 3
    • 78651113311 scopus 로고    scopus 로고
    • Dietary fiber as a carrier of dietary antioxidants: An essential physiological function
    • Saura-Calixto, F. Dietary fiber as a carrier of dietary antioxidants: an essential physiological function J. Agric. Food Chem. 2011, 59, 43-49
    • (2011) J. Agric. Food Chem. , vol.59 , pp. 43-49
    • Saura-Calixto, F.1
  • 4
    • 0020960114 scopus 로고
    • Promoting activities of butylated hydroxyanisole and butylated hydroxytoluene on 2-stage urinary bladder carcinogenesis and inhibition of α-glutamyl transpeptidase-positive foci development in the liver of rats
    • Imaida, K.; Fukushima, S.; Shirai, T.; Ohtani, M.; Nakanishi, K.; Ito, N. Promoting activities of butylated hydroxyanisole and butylated hydroxytoluene on 2-stage urinary bladder carcinogenesis and inhibition of gamma-glutamyl transpeptidase-positive foci development in the liver of rats Carcinogenesis 1983, 4, 895-899 (Pubitemid 13010785)
    • (1983) Carcinogenesis , vol.4 , Issue.7 , pp. 895-899
    • Imaida, K.1    Fukushima, S.2    Shirai, T.3
  • 5
    • 0034666458 scopus 로고    scopus 로고
    • Phytochemicals: Nutraceuticals and human health
    • DOI 10.1002/1097-0010(20000915 )80:12<1744::AID-JSFA725>3.0.CO;2-W
    • Dillard, C. J.; German, J. B. Phytochemicals: nutraceuticals and human health J. Sci. Food Agric. 2000, 80, 1744-1756 (Pubitemid 30656654)
    • (2000) Journal of the Science of Food and Agriculture , vol.80 , Issue.12 , pp. 1744-1756
    • Dillard, C.J.1    Bruce German, J.2
  • 6
    • 0033916031 scopus 로고    scopus 로고
    • Antioxidant phytochemicals in fruits and vegetables: Diet and health implications
    • Prior, R. L.; Cao, G. Antioxidant phytochemicals in fruits and vegetables: diet and health implications Hortic. Sci. 2000, 35, 588-592 (Pubitemid 30495804)
    • (2000) HortScience , vol.35 , Issue.4 , pp. 588-592
    • Prior, R.L.1    Cao, G.2
  • 7
    • 0034928799 scopus 로고    scopus 로고
    • Inhibition of carcinogenesis by dietary polyphenolic compounds
    • DOI 10.1146/annurev.nutr.21.1.381
    • Yang, C.; Landau, J.; Huang, M.-T.; Newmark, H. Inhibition of carcinogenesis by dietary polyphenolic compounds Ann. Rev. Nutr. 2001, 21, 381-406 (Pubitemid 32695277)
    • (2001) Annual Review of Nutrition , vol.21 , pp. 381-406
    • Yang, C.S.1    Landau, J.M.2    Huang, M.-T.3    Newmark, H.L.4
  • 8
    • 0000552483 scopus 로고    scopus 로고
    • Determination of chemical composition of carob (Ceratonia siliqua): Protein, fat, carbohydrates, and tannins
    • DOI 10.1006/jfca.1997.0528, PII S0889157597905287
    • Avallone, R.; Plessi, M.; Baraldi, M.; Monzani., A. Determination of chemical composition of carob (Ceratonia siliqua): protein, fat, carbohydrates, and tannins J. Food Compos. Anal. 1997, 10, 166-172 (Pubitemid 127341245)
    • (1997) Journal of Food Composition and Analysis , vol.10 , Issue.2 , pp. 166-172
    • Avallone, R.1    Plessi, M.2    Baraldi, M.3    Monzani, A.4
  • 9
    • 0036906615 scopus 로고    scopus 로고
    • Antiproliferative effects of Ceratonia siliqua L. on mouse hepatocellular carcinoma cell line
    • DOI 10.1016/S0367-326X(02)00227-7, PII S0367326X02002277
    • Corsi, L.; Avallone, R.; Cosenza, F.; Farina, F.; Baraldi, C.; Baraldi, M. Antiproliferative effects of Ceratonia siliqua L. on mouse hepatocellular carcinoma cell line Fitoterapia 2002, 73, 674-684 (Pubitemid 35477765)
    • (2002) Fitoterapia , vol.73 , Issue.7-8 , pp. 674-684
    • Corsi, L.1    Avallone, R.2    Cosenza, F.3    Farina, F.4    Baraldi, C.5    Baraldi, M.6
  • 12
    • 2942528726 scopus 로고    scopus 로고
    • Identification and quantification of polyphenols in carob fruits (Ceratonia siliqua L.) and derived products by HPLC-UV-ESI/MS
    • Papagiannopoulos, M.; Wollseifen, H.; Mellenthin, A.; Haber, B.; Galensa, R. Identification and quantification of polyphenols in carob fruits (Ceratonia siliqua L.) and derived products by HPLC-UV-ESI/MS J. Agric. Food Chem. 2004, 52, 3784-3791
    • (2004) J. Agric. Food Chem. , vol.52 , pp. 3784-3791
    • Papagiannopoulos, M.1    Wollseifen, H.2    Mellenthin, A.3    Haber, B.4    Galensa, R.5
  • 14
    • 0030233673 scopus 로고    scopus 로고
    • Carob bean in food and feed: Current status and future potentials - A critical appraisal
    • Marakis, S. Carob bean in food and feed: current status and future potentials: a critical appraisal J. Food Sci. Technol. 1996, 33, 365-383 (Pubitemid 126535552)
    • (1996) Journal of Food Science and Technology , vol.33 , Issue.5 , pp. 365-383
    • Marakis, S.1
  • 15
    • 33646817108 scopus 로고    scopus 로고
    • Carob pulp preparation rich in insoluble dietary fiber and polyphenols enhances lipid oxidation and lowers postprandial acylated ghrelin in humans
    • Gruendel, S.; Garcia, A. L.; Otto, B.; Mueller, C.; Steiniger, J.; Weickert, M. O.; Speth, M.; Katz, N.; Koebnick, C. Carob pulp preparation rich in insoluble dietary fiber and polyphenols enhances lipid oxidation and lowers postprandial acylated ghrelin in humans J. Nutr. 2006, 136, 1533-1538 (Pubitemid 43765358)
    • (2006) Journal of Nutrition , vol.136 , Issue.6 , pp. 1533-1538
    • Gruendel, S.1    Garcia, A.L.2    Otto, B.3    Mueller, C.4    Steiniger, J.5    Weickert, M.O.6    Speth, M.7    Katz, N.8    Koebnick, C.9
  • 16
    • 39149133188 scopus 로고    scopus 로고
    • Carob fibre compounds modulate parameters of cell growth differently in human HT29 colon adenocarcinoma cells than in LT97 colon adenoma cells
    • DOI 10.1016/j.fct.2007.09.003, PII S0278691507003389
    • Klenow, S.; Glei, M.; Haber, B.; Owen, R.; Pool-Zobel, B. L. Carob fibre compounds modulate parameters of cell growth differently in human HT29 colon adenocarcinoma cells than in LT97 colon adenoma cells Food Chem. Toxicol. 2008, 46, 1389-1397 (Pubitemid 351258202)
    • (2008) Food and Chemical Toxicology , vol.46 , Issue.4 , pp. 1389-1397
    • Klenow, S.1    Glei, M.2    Haber, B.3    Owen, R.4    Pool-Zobel, B.L.5
  • 17
    • 64549131698 scopus 로고    scopus 로고
    • Does an extract of carob (Ceratonia siliqua L.) have chemopreventive potential related to oxidative stress and drug metabolism in human colon cells?
    • Klenow, S.; Jahns, F.; Pool-Zobel, B. L.; Glei, M. Does an extract of carob (Ceratonia siliqua L.) have chemopreventive potential related to oxidative stress and drug metabolism in human colon cells? J. Agric. Food Chem. 2009, 57, 2999-3004
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 2999-3004
    • Klenow, S.1    Jahns, F.2    Pool-Zobel, B.L.3    Glei, M.4
  • 18
    • 68049126128 scopus 로고    scopus 로고
    • New insight into the influence of carob extract and gallic acid on hemin induced modulation of HT29 cell growth parameters
    • Klenow, S.; Glei, M. New insight into the influence of carob extract and gallic acid on hemin induced modulation of HT29 cell growth parameters Toxicol. in Vitro 2009, 23, 1055-1061
    • (2009) Toxicol. in Vitro , vol.23 , pp. 1055-1061
    • Klenow, S.1    Glei, M.2
  • 20
    • 35648929290 scopus 로고    scopus 로고
    • Evaluation of fruit and seed diversity and characterization of carob (Ceratonia siliqua L.) cultivars in Algarve region
    • DOI 10.1016/j.scienta.2007.06.024, PII S0304423807002415
    • Barracosa, P.; Osório, J.; Cravador, A. Evaluation of fruit and seed diversity and characterization of carob (Ceratonia siliqua L.) cultivars in Algarve region Sci. Hortic. 2007, 114, 250-257 (Pubitemid 350027759)
    • (2007) Scientia Horticulturae , vol.114 , Issue.4 , pp. 250-257
    • Barracosa, P.1    Osorio, J.2    Cravador, A.3
  • 21
    • 77149140167 scopus 로고    scopus 로고
    • Antioxidant activity and in vitro inhibition of tumor cell growth by leaf extracts from the carob tree (Ceratonia siliqua L.)
    • Custódio, L.; Fernandes, E.; Escapa, A. L.; Aligué, R.; Alberício, F.; Romano, A. Antioxidant activity and in vitro inhibition of tumor cell growth by leaf extracts from the carob tree (Ceratonia siliqua L.) Pharm. Biol. 2009, 8, 721-728
    • (2009) Pharm. Biol. , vol.8 , pp. 721-728
    • Custódio, L.1    Fernandes, E.2    Escapa, A.L.3    Aligué, R.4    Alberício, F.5    Romano, A.6
  • 22
    • 33646095419 scopus 로고
    • Phenolic constituents in the leaves of northern willows: Methods for the analysis of certain phenolics
    • Julkunen-Tiitto, R. Phenolic constituents in the leaves of northern willows: methods for the analysis of certain phenolics J. Agric. Food Chem. 1985, 33, 213-217
    • (1985) J. Agric. Food Chem. , vol.33 , pp. 213-217
    • Julkunen-Tiitto, R.1
  • 23
    • 0035543008 scopus 로고    scopus 로고
    • Effect of principal polyphenolic components in relation to antioxidant characteristics of aged red wines
    • DOI 10.1021/jf010827s
    • Arnous, A.; Makris, D.; Kefalas, P. Effect of principal polyphenolic components in relation to antioxidant characteristics of aged red wines J. Agric. Food Chem. 2001, 49, 5736-5742 (Pubitemid 34062528)
    • (2001) Journal of Agricultural and Food Chemistry , vol.49 , Issue.12 , pp. 5736-5742
    • Arnous, A.1    Makris, D.P.2    Kefalas, P.3
  • 24
    • 0025151620 scopus 로고
    • Teneurs en acide rosmarinique, en dérivés hydroxycinnamiques totaux et activités antioxydantes chez les Apiacées, les Borraginacées et les Lamiacées médicinales
    • Lamaison, L.; Carnat, A. Teneurs en acide rosmarinique, en dérivés hydroxycinnamiques totaux et activités antioxydantes chez les Apiacées, les Borraginacées et les Lamiacées médicinales Pharm. Acta Helv. 1990, 65, 315-320
    • (1990) Pharm. Acta Helv. , vol.65 , pp. 315-320
    • Lamaison, L.1    Carnat, A.2
  • 26
  • 27
    • 31844448140 scopus 로고    scopus 로고
    • Screening of the antioxidative and antimicrobial properties of the essential oils of Pimpinella anisetum and Pimpinella flabellifolia from Turkey
    • DOI 10.1016/j.foodchem.2005.05.045, PII S0308814605004450
    • Tepe, B.; Akpulat, A.; Sokmen, M.; Daferera, D.; Yumrutas, O.; Aydinm, E.; Polissiou, M.; Sokmen, A. Screening of the antioxidative and antimicrobial properties of the essential oils of Pimpinella anisetum and Pimpinella flabellifolia from Turkey Food Chem. 2006, 97, 719-724 (Pubitemid 43181670)
    • (2006) Food Chemistry , vol.97 , Issue.4 , pp. 719-724
    • Tepe, B.1    Akpulat, H.A.2    Sokmen, M.3    Daferera, D.4    Yumrutas, O.5    Aydin, E.6    Polissiou, M.7    Sokmen, A.8
  • 28
    • 84860392558 scopus 로고    scopus 로고
    • In vitro cytotoxic effects and apoptosis induction by a methanol leaf extract of carob tree (Ceratonia siliqua)
    • in press
    • Custódio, L.; Fernandes, E.; Escapa, A. L.; Aligué, R.; Alberício, F.; Romano, A. In vitro cytotoxic effects and apoptosis induction by a methanol leaf extract of carob tree (Ceratonia siliqua). J. Med. Plants Res. 2011, in press.
    • (2011) J. Med. Plants Res.
    • Custódio, L.1    Fernandes, E.2    Escapa, A.L.3    Aligué, R.4    Alberício, F.5    Romano, A.6
  • 29
    • 33845361180 scopus 로고    scopus 로고
    • The nature-versus-nurture debate on bioactive phytochemicals: The genome versus terroir
    • DOI 10.1002/jsfa.2677
    • Lila, M. The nature-versus-nurture debate on bioactive phytochemicals: The genome versus terroir J. Sci. Food Agr. 2006, 86, 2510-2515 (Pubitemid 44884991)
    • (2006) Journal of the Science of Food and Agriculture , vol.86 , Issue.15 , pp. 2510-2515
    • Lila, M.A.1
  • 30
    • 37349064440 scopus 로고    scopus 로고
    • Distribution of flavonoids and furocoumarins in juices from cultivars of Citrus bergamia risso
    • DOI 10.1021/jf072065s
    • Gattuso, G.; Barreca, D.; Caristi, C.; Gargiulli, C.; Leuzzi, U. Distribution of flavonoids and furocoumarins in juices from cultivars of Citrus bergamia Risso J. Agric. Food Chem. 2007, 55, 9921-9927 (Pubitemid 350305177)
    • (2007) Journal of Agricultural and Food Chemistry , vol.55 , Issue.24 , pp. 9921-9927
    • Gattuso, G.1    Barreca, D.2    Caristi, C.3    Gargiulli, C.4    Leuzzi, U.5
  • 31
    • 35548941825 scopus 로고    scopus 로고
    • Phenolic, flavonoid, and lutein ester content and antioxidant activity of 11 cultivars of Chinese marigold
    • DOI 10.1021/jf071696j
    • Li, W.; Gao, Y.; Zhao, J.; Wang, Q. Phenolic, flavonoid, and lutein ester content and antioxidant activity of 11 cultivars of Chinese marigold J. Agric. Food Chem. 2007, 255, 8478-8484 (Pubitemid 350013091)
    • (2007) Journal of Agricultural and Food Chemistry , vol.55 , Issue.21 , pp. 8478-8484
    • Li, W.1    Gao, Y.2    Zhao, J.3    Qi, W.4
  • 33
    • 0036164041 scopus 로고    scopus 로고
    • Screening of plant extracts for antioxidant activity: A comparative study on three testing methods
    • DOI 10.1002/pca.611
    • Koleva, I. I.; Van Beek, T. A.; Linssen, J. P. H.; de Groot, A.; Evstatieva, L. N. Screening of plant extracts for antioxidant activity: a comparative study on three testing methods Phytochem. Anal. 2002, 13, 8-17 (Pubitemid 34126609)
    • (2002) Phytochemical Analysis , vol.13 , Issue.1 , pp. 8-17
    • Koleva, I.I.1    Van Beek, T.A.2    Linssen, J.P.H.3    De Groot, A.4    Evstatieva, L.N.5
  • 34
    • 0037332959 scopus 로고    scopus 로고
    • Phenolic compounds and antioxidant activity from red grape marc extracts
    • DOI 10.1016/S0960-8524(02)00202-X, PII S096085240200202X
    • Negro, C.; Tommasi, L.; Miceli, A. Phenolic compounds and antioxidant activity from red grape marc extracts Bioresour. Technol. 2003, 87, 41-44 (Pubitemid 35441029)
    • (2003) Bioresource Technology , vol.87 , Issue.1 , pp. 41-44
    • Negro, C.1    Tommasi, L.2    Miceli, A.3
  • 35
    • 62949103543 scopus 로고    scopus 로고
    • A comparative study of phenolic compounds and antioxidant and antiproliferative activities in frequently consumed raw vegetables
    • Gorinstein, S.; Park., Y.; Heo, B.; Namiesnik, J.; Leontowicz, H.; Leontowicz, M.; Ham, K.; Cho, J.; Kang, S. A comparative study of phenolic compounds and antioxidant and antiproliferative activities in frequently consumed raw vegetables Eur. Food Res. Technol. 2009, 228, 903-911
    • (2009) Eur. Food Res. Technol. , vol.228 , pp. 903-911
    • Gorinstein, S.1    Park, Y.2    Heo, B.3    Namiesnik, J.4    Leontowicz, H.5    Leontowicz, M.6    Ham, K.7    Cho, J.8    Kang, S.9
  • 36
    • 33645318137 scopus 로고    scopus 로고
    • Methanolic extract of Pterocarpus santalinus induces apoptosis in HeLa cells
    • Kwon, H.; Hong, Y.; Kim, K.; Han, C.; Cho, S.; Choi, J.; Ki, B.-W. Methanolic extract of Pterocarpus santalinus induces apoptosis in HeLa cells J. Ethnopharmacol. 2006, 105, 229-234
    • (2006) J. Ethnopharmacol. , vol.105 , pp. 229-234
    • Kwon, H.1    Hong, Y.2    Kim, K.3    Han, C.4    Cho, S.5    Choi, J.6    Ki, B.-W.7
  • 37
    • 0141814698 scopus 로고    scopus 로고
    • Gallic acid, an antioxidant, exhibits antiapoptotic potential in normal human lymphocytes: A Bcl-2 independent mechanism
    • Sohi, K. K.; Mittal, N.; Hundal, M. K.; Khanduja, K. L. Gallic acid, an antioxidant, exhibits antiapoptotic potential in normal human lymphocytes: A Bcl-2 independent mechanism J. Nutr. Sci. Vitaminol. 2003, 49, 221-227 (Pubitemid 37129111)
    • (2003) Journal of Nutritional Science and Vitaminology , vol.49 , Issue.4 , pp. 221-227
    • Sohi, K.K.1    Mittal, N.2    Hundal, M.K.3    Khanduja, K.L.4
  • 38
    • 33947726393 scopus 로고    scopus 로고
    • Anticancer effects of gallic acid isolated from Indonesian herbal medicine, Phaleria macrocarpa (Scheff.) Boerl, on human cancer cell lines
    • Faried, A.; Kurnia, D.; Faried, L. S.; Usman, N.; Miyazaki, T.; Kato, H.; Kuwano, H. Anticancer effects of gallic acid isolated from Indonesian herbal medicine, Phaleria macrocarpa (Scheff.) Boerl, on human cancer cell lines Int. J. Oncol. 2007, 30, 605-613
    • (2007) Int. J. Oncol. , vol.30 , pp. 605-613
    • Faried, A.1    Kurnia, D.2    Faried, L.S.3    Usman, N.4    Miyazaki, T.5    Kato, H.6    Kuwano, H.7
  • 39
    • 0037141470 scopus 로고    scopus 로고
    • Flavonoids uptake and their effect on cell cycle of human colon adenocarcinoma cells (Caco2)
    • DOI 10.1038/sj.bjc.6600295
    • Salucci, M.; Stivala, L. A.; Maiani, G.; Bugianesi, R.; Vannini, V. Flavonoids uptake and their effect on cell cycle of human colon adenocarcinoma cells (Caco2) Br. J. Cancer 2002, 8, 1645-1651 (Pubitemid 34628121)
    • (2002) British Journal of Cancer , vol.86 , Issue.10 , pp. 1645-1651
    • Salucci, M.1    Stivala, L.A.2    Maiani, G.3    Bugianesi, R.4    Vannini, V.5
  • 42
    • 34248994200 scopus 로고    scopus 로고
    • Floral analysis and seasonal dynamics of mineral levels in carob tree leaves
    • DOI 10.1080/01904160701289750, PII 778919148
    • Custódio, L.; Correia, P. J.; Martins-Loução, M. A.; Romano, A. Floral analysis and seasonal dynamics of mineral levels in carob tree leaves J. Plant Nutr. 2007, 30, 739-753 (Pubitemid 46791615)
    • (2007) Journal of Plant Nutrition , vol.30 , Issue.5 , pp. 739-753
    • Custodio, L.1    Correia, P.J.2    Martins-Loucao, M.A.3    Romano, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.