Phytochemical Profile, Antioxidant and Cytotoxic Activities of the Carob Tree (Ceratonia siliqua L.) Germ Flour Extracts

Plant Foods for Human Nutrition

Volumn 66, Issue 1, 2011, Pages 78-84

  Custódio, Luísa ^a   Escapa, Ana Luísa ^a   Fernandes, Eliana ^a   Fajardo, Alba ^b   Aligué, Rosa ^b   Alberício, Fernando ^b,c   Neng, Nuno ^d   Nogueira, José Manuel Florêncio ^d   Romano, Anabela ^a  

^a UNIVERSITY OF ALGARVE   (Portugal)

^b UNIVERSITY OF BARCELONA   (Spain)

^c INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^d UNIVERSITY OF LISBON   (Portugal)

Author keywords

Alkaloids; Antioxidant; Antiproliferative; Oxidative stress; Phenolic compounds; ROS; Theophylline

Indexed keywords

ALGAROBA; ANTIOXIDANT; GALACTAN; MANNAN; PHENOL DERIVATIVE; PLANT EXTRACT; PLANT GUM; THEOPHYLLINE;

ARTICLE; CHEMISTRY; HELA CELL; HUMAN; LEGUME;

ANTIOXIDANTS; FABACEAE; GALACTANS; HELA CELLS; HUMANS; MANNANS; PHENOLS; PLANT EXTRACTS; PLANT GUMS; THEOPHYLLINE;

CERATONIA SILIQUA;

EID: 79955068294     PISSN: 09219668     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11130-011-0214-8     Document Type: Article

References (27)

1. Dakia P, Wathelet B, Paquot M (2007) Isolation and chemical evaluation of carob (Ceratonia siliqua L.) seed germ. Food Chem 102: 1368-1374.
2. Bengoechea C, Romero A, Villanueva A, Moreno G, Alaiz M, Millán F, Guerrero A, Puppo MC (2008) Composition and structure of carob (Ceratonia siliqua L.) germ proteins. Food Chem 107: 675-683.
3. Wang Y, Belton PS, Bridon H, Garanger E, Wellner N, Parker ML, Grant A, Feillet P, Noel TR (2001) Physicochemical studies of caroubin: A gluten-like protein. J Agric Food Chem 49: 3414-3419.
4. Avallone R, Plessi M, Baraldi M, Monzani A (1997) Determination of chemical composition of carob (Ceratonia siliqua): Protein, fat, carbohydrates, and tannins. J Food Comp Anal 10: 166-172.
5. Luthria D (2006) Significance of sample preparation in developing analytical methodologies for accurate estimation of bioactive compounds in functional foods. J Sci Food Agric 86: 2266-2272.
6. Gülçin I, Mshvildadze V, Gepdiremen A, Elias R (2006) Antioxidant activity of a triterpenoid glycoside isolated from the berries of Hedera colchica: 3-O-(β-d-glucopyranosyl)- hederagenin. Phytother Res 20: 130-134.
7. Custódio L, Fernandes E, Escapa AL, Aligué R, Alberício F, Romano A (2009) Antioxidant activity and in vitro inhibition of tumor cell growth by leaf extracts from the carob tree (Ceratonia siliqua L.). Pharm Biol 47: 721-728.
8. Julkunen-Tiitto R (1985) Phenolic constituents in the leaves of northern willows: Methods for the analysis of certain phenolics. J Agric Food Chem 33: 213-217.
9. Naczk M, Amarowicz R, Pink D, Shahidi F (2000) Insoluble condensed tannins of canola/rapeseed. J Agric Food Chem 48: 1758-1762.
10. Lamaison L, Carnat A (1990) Teneurs en acide rosmarinique, en dérivés hydroxycinnamiques totaux et activités antioxydantes chez les Apiacées, les Borraginacées et les Lamiacées médicinales. Pharm Acta Helv 65: 315-320.
11. Brand-Williams W, Cuvelier ME, Berset C (1995) Use of a free radical method to evaluate antioxidant activity. Lebensm Wiss Technol 28: 25-30.
12. Wang D, Wang L, Zhu F, Zhu J, Chen XD, Zou L, Saito M, Li L (2008) In vitro and in vivo studies on the antioxidant activities of the aqueous extracts of Douchi (a traditional Chinese salt-fermented soybean food). Food Chem 107: 1421-1428.
13. Choi Y, Jeong HS, Lee J (2007) Antioxidant activity of methanolic extracts from some grains consumed in Korea. Food Chem 103: 130-138.
14. Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55-63.
15. Chang M, Ho Y, Lee P, Chan C, Lee J, Hahn L, Wang Y (2001) Areca nut extract and arecoline induced the cell cycle arrest but not apoptosis of cultured oral KB epithelial cells: Association of glutathione, reactive oxygen species and mitochondrial membrane potential. Carcinogenesis 22: 1527-1535.
16. Li W, Gao Y, Zhao J, Wang Q (2007) Phenolic, flavonoid, and lutein ester content and antioxidant activity of 11 cultivars of Chinese marigold. J Agric Food Chem 255: 8478-8484.
17. Barracosa P, Osório J, Cravador A (2007) Evaluation of fruit and seed diversity and characterization of carob (Ceratonia siliqua L.) cultivars in Algarve region. Sci Hortic 114: 250-257.
18. Corsi L, Avallone R, Cosenza F, Farina F, Baraldi C, Baraldi M (2002) Antiproliferative effects of Ceratonia siliqua L. on mouse hepatocellular carcinoma cell line. Fitoterapia 73: 674-684.
19. Ito K, Lim S, Caramori G, Cosi B, Chun KF, Adcock IM, Barnes PJ (2002) A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. PNAS 99: 8921-8926.
20. Pleuvry BJ (2006) CNS stimulants: Basic pharmacology and relevance to anaesthesia. Anesth Int Care Med 7: 60-62.
21. Ordoñez AAL, Gomez JD, Vattuone MA, Isla MI (2006) Antioxidant activities of Sechium edule (Jacq.) Swartz extracts. Food Chem 97: 452-458.
22. Chon S-U, Heo B-U, Park Y-S, Kim D-K, Gorinstein S (2009) Total phenolics level, antioxidant activities and cytotoxicity of young sprouts of some traditional Korean salad plants. Plant Foods Hum Nutr 64: 25-31.
23. Hamad İ, Erol-Dayi Ö, Pekmez M, Önay-Uçar E, Arda N (2010) Antioxidant and cytotoxic activities of Aphanes arvensis extracts. Plant Foods Hum Nutr 65: 44-49.
24. Klenow S, Jahns F, Pool-Zobel BL, Glei M (2009) Does an extract of carob (Ceratonia siliqua L.) have chemopreventive potential related to oxidative stress and drug metabolism in human colon cells? J Agric Food Chem 57: 2999-3004.
25. Klenow S, Glei M (2009) New insight into the influence of carob extract and gallic acid on hemin induced modulation of HT29 cell growth parameters. Toxicol in Vitro 23: 1055-1061.
26. Miller AB (1990) Diet and cancer. Rev Oncol 3: 87-95.
27. Halliwell B (2007) Oxidative stress and cancer: Have we moved forward? Biochem J 401: 1-11.