Gallic acid, an antioxidant, exhibits antiapoptotic potential in normal human lymphocytes: A Bcl-2 independent mechanism

Journal of Nutritional Science and Vitaminology

Volumn 49, Issue 4, 2003, Pages 221-227

  Sohi, Kiranjit K ^a   Mittal, Nidhi ^a   Hundal, Manjinder K ^b   Khanduja, Krishan L ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

^b TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Antioxidants; Apoptosis; DNA fragmentation; Gallic acid; Reactive oxygen species (ROS)

Indexed keywords

ALPHA TOCOPHEROL DERIVATIVE; ANTIOXIDANT; CAFFEIC ACID; ELLAGIC ACID; FERULIC ACID; FREE RADICAL; GALLIC ACID; HYDROGEN PEROXIDE; PHENOL DERIVATIVE; PHOSPHATIDYLSERINE; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; TROLOX C;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA STRAND BREAKAGE; DRUG MECHANISM; HUMAN; HUMAN CELL; LIPID PEROXIDATION; LYMPHOCYTE; OXIDATIVE STRESS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

EID: 0141814698     PISSN: 03014800     EISSN: 18817742     Source Type: Journal    
DOI: 10.3177/jnsv.49.221     Document Type: Article

References (41)

1. Michael OH. 2000. The biochemistry of apoptosis. Nature 407: 770-776.
2. Nunez G, London L, Hockenberry DM, Alexander M, Mckern JP and Korsmeyer SJ. 1990. Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor deprived cell lines. J Immunol 144: 3602-3610.
3. Hockenberry DM, Oltvai ZN, Yin X-M, Milliman CL and Korsmeyer SJ. 1993. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75: 241-251.
4. Buttke TM and Sandstrom PA. 1994. Oxidative stress as a mediator or apoptosis. Immunol Today 15: 7-10.
5. Rusnak JM, Calmels TPG, Hoyt DG, Kondo DG, Yalowich JC and Lazo JS. 1995. Genesis of higher order DNA fragments in apoptotic human prostate carcinoma cells. Mol Pharmacol 49: 244-252.
6. Sellins KS and Cohen JJ. 1987. Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes. J Immunol 139: 3199-3206.
7. Greenlund LJS, Deckwerth TL and Johnson EM Jr. 1995. Superoxide dismutase delays neuronal apoptosis: A role for reactive oxygen species in programmed neuronal cell death. Neuron 14: 303-315.
8. Sandstrom PA and Buttke TM. 1993. Autocrine production of extracellular catalase prevents apoptosis of human CEM T-cell line in serum free medium. Proc Natl Acad Sci USA 90: 4708-4712.
9. Forrest VJ, Kang YH, McClain DE, Robinson DH and Ramakrishnan N. 1994. Oxidative stress induced apoptosis prevented by Trolox. Free Radical Biol Med 16: 675-684.
10. Kane DJ, Sarafian TA, Anton R, Hahn H, Gralla EB, Valentine JS, Ord T and Bredesen DE. 1993. Bcl-2 inhibition of neuronal death: decreased generation of reactive oxygen species. Science 262: 1274-1277.
11. Kane DJ, Ord T, Anton R and Bredesen DE. 1995. Expression of Bcl-2 inhibits necrotic neuronal cell death. J Neurosci Res 40: 269-275.
12. Sarafian TA and Bredesen DE. 1994. Is apoptosis mediated by reactive oxygen species? Free Radical Res 21: 1-8.
13. Jacobson MD, and Raff MC. 1995. Programmed cell death and Bcl-2 protection in very low oxygen. Nature 374: 814-816.
14. Machalin L and Bendich A. 1987. Free radical tissue damage: Protective role of antioxidant nutrients. FASEB J 1: 441-445.
15. Obeid LM and Hannum YA. 1995. Ceramide: a stress signal and mediator of growth suppression and apoptosis. J Cell Biochem 58: 191-198.
16. Sandstrom PA, Pard D, Tebbey PW, Dudek RW, Terrian, DM, Folk TM and Buttke TM. 1995. Lipid hydroperoxide induced apoptosis: lack of inhibition by Bcl-2 over-expression. FEBS Lett 365: 66-70.
17. Mellors A and Tappel AL. 1966. The inhibition of mitochondria peroxidation by ubiquinone and ubiquinol. J Biol Chem 241: 4353-4356.
18. Ohkawa H, Ohishi N and Yagi K. 1979. Assay for peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95: 351-358.
19. Lowry OH, Rosenbrough NJ, Farr AL and Randall RJ. 1951. Protein measurement with folin phenol reagent. J Biol Chem 193: 265-275.
20. Tanaka T. 1994. Cancer chemoprevention by natural products. Oncol Rep 1: 1139-1155.
21. Liu Z, Ma LP, Zhou B, Yang L and Liu ZL. 2000. Antioxidant effects of green tea polyphenols on free radical initiated and photosensitised peroxidation of human low density lipoprotein. Chem Phys Lipids 106: 53-63.
22. Sciuto AM and Moran TS. 2001. Effect of dietary treatment with n-propylgallate or vitamin E on the survival of mice exposed in phosgene. J Appl Toxicol 21: 33-39.
23. Wright JS, Johnson ER and DiLabio GA. 2001. Predicting the activity of Phenolic Antioxidants: Theoretical method, Analysis of Substituent Effects, and Application to Major Families of Antioxidants. J Am Chem Soc 123: 1173-1183.
24. Pedulli GF, Lucarini M and Pedrielli P. 1997. Free Radicals in Biology and Environment (Minisci F. ed.), p169. Kluwer Academic Publishers, Dordrecht, The Netherlands
25. Slater AFG, Nobel CSI and Orrenius S. 1995. The role of intracellular oxidants in apoptosis. Biochem Biophys Acta 1271: 59-62.
26. Jacobson MD. 1996. Reactive oxygen species and programmed cell death. Trends Biochem Sci 21: 83-86.
27. Sandstrom PA, Tebbey PW, VanCleave S and Buttke TM. 1994. Lipid hydroperoxides induce apoptosis in T-cells displaying a HIV associated glutathione peroxidase deficiency. J Biol Chem 269: 798-801.
28. Oberhammer F, Wilson JW, Dive C, Morris ID, Hickman JA, Walkerling AE, Walker PR and Sikorska M. 1993. Apoptotic death in epithelial cells: Cleavage of DNA to SOD and/or 50 kb fragments prior or in the absence of internucleosomal fragmentation. EMBO J 12: 3679-3684.
29. 2+ in the formation of high molecular weight DNA fragments in thymocyte apoptosis. Biochem Biophys Res Commun 202: 120-127.
30. Higuchi Y and Matsukawa S. 1998. Active oxygen-mediated chromosomal 1-2 Mbp giant DNA fragmentation into internucleosomal DNA fragmentation in apoptosis of glioma cells induced by glutamate. Free Radic Biol Med 24: 418-426.
31. Higuchi Y and Matsukawa S. 1997. Appearance of 1-2 mbp giant DNA fragments as an early common response leading to cell death induced by various substances that cause oxidative stress. Free Radical Biol Med 23: 90-99.
32. Higuchi Y and Matsukawa S. 1999. Glutathione depletion induces giant DNA and high-molecular weight DNA fragmentation associated with apoptotic through lipid peroxidation and protein kinase C activation in C6 Glioma cells. Arch Biochem Biophys 363: 33-42.
33. Verhoven B, Schlegal RA and Williamson PAC. 1990. Rapid loss and restoration of lipid asymmetry by different pathways in resealed erythrocyte ghosts. Biochem Biophys Acta 1026: 153-160.
34. Martin SJ, Reutelingsperger CPM, McGahon AJ, Radar JA, VanSchie RCAA, La face DM and Green DR. 1995. Early redistribution of plasma membrane phosphatidyl serine is a general feature of apoptosis regardless of initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J Exp Med 182: 1545-1556.
35. + thymocytes. Int Immunol 10: 1807-1817.
36. Serrano A, Palacios C, Roy G, Cespon C, Villar ML, Nocito M and Gonzalez-Porque P. 1998. Derivatives of gallic acid induce apoptosis in tumoral cell lines and inhibit lymphocyte proliferation. Arch Biochem Biophys 350: 49-54.
37. Inoue M, Sakaguchi N, Isuzugawa K, Tani H and Ogihara Y. 2000. Role of reactive oxygen species in gallic acid induced apoptosis. Biol Pharm Bull 23: 1153-1157.
38. Saeki K, Yuo A, Isemura M, Abe II, Seki T and Noguchi H. 2000. Apoptosis inducing activity of lipid derivatives of gallic acid. Biol Pharm Bull 23: 1391-1394.
39. Yoshioka K, Kataoka T, Hayashi T, Hasegawa M, Ishi Y and Hibasami H. 2000. Induction of apoptosis by gallic acid in human stomach cancer KATO III and colon adenocarcinoma COLO 205 cell lines. Oncol Rep 7: 1221-1223.
40. Sakaguchi N, Inoue M, Isuzugawa K, Ogihara Y and Osaka K. 1999. Cell death inducing activity by gallic acid derivatives. Biol Pharm Bull 22: 471-475.
41. Isuzugawa K, Ogihara Y and Inoue M. 2001. Different generation of inhibitors against gallic acid induced apoptosis produces different sensitivity to gallic acid. Biol Pharm Bull 24: 249-253.