Preliminary biological evaluation of polyamidoamine (PAMAM) Starburst™ dendrimers

Journal of Biomedical Materials Research

Volumn 30, Issue 1, 1996, Pages 53-65

  Roberts, Jeanette C ^a   Bhalgat, Mahesh K ^a   Zera, Richard T ^b  

^a UNIVERSITY OF UTAH   (United States)

^b HENNEPIN COUNTY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; BIOMATERIALS; IMMUNOLOGY; PHYSIOLOGICAL MODELS; TOXICITY;

BIODISTRIBUTION; BIOLOGICAL EVALUATION; POLYAMIDOAMINE DENDRIMERS;

POLYAMIDES;

BIOMATERIAL; DENDRIMER; POLYAMINE;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOENGINEERING; CAPILLARY ELECTROPHORESIS; HAMSTER; IMMUNOGENICITY; MACROMOLECULE; MOUSE; NONHUMAN;

ANIMALS; BIOCOMPATIBLE MATERIALS; CELLS, CULTURED; CRICETINAE; CRICETULUS; MALE; MATERIALS TESTING; MICE; POLYAMINES; TISSUE DISTRIBUTION;

EID: 0030042315     PISSN: 00219304     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4636(199601)30:1<53::AID-JBM8>3.0.CO;2-Q     Document Type: Article

References (40)

1. D. A. Tomalia, H. Baker, J. Dewald, M. Hall, G. Kailos, S. Martin, J. Roeck, J. Ryder, and P. Smith, "A new class of polymers: Starburst-dendritic macromolecules," Polymer J., 17, 117-132 (1985).
2. D. A. Tomalia, H. Baker, J. Dewald, M. Hall, G. Kallos, S. Martin, J. Roeck, J. Ryder, and P. Smith, "Dendritic macromolecules: Synthesis of Starburst dendrimers," Macromolecules, 19, 2466-2468 (1986).
3. D. A. Tomalia, A. M. Naylor, and W. A. Goddard III, "Starburst dendrimers: Molecular-level control of size, shape, surface chemistry, topology, and flexibility from atoms to macroscopic matter," Agnew. Chem. Int. Ed. Engl., 29, 138-175 (1990).
4. D. Tomalia, "Meet the molecular superstars," New Scientist, 23 November, 30-34 (1991).
5. J. Alper, "Rising chemical 'stars' could play many roles," Science, 251, 1562-1564 (1991).
6. J. C. Roberts, Y. E. Adams, D. Tomalia, J. A. MercerSmith, and D. K. Lavallee, "Using Starburst dendrimers as linker molecules to radiolabel antibodies," Bioconjugate Chem., 1, 305-308 (1990).
7. F. C. M. Chen and N. L. Benoiton, "A new method for quaternizing amines and its use in amino acid and peptide chemistry," Can. J. Chem., 54, 3310-3311 (1976).
8. Tables of Spectral Data for Structure Determination of Organic Compounds, Second Edition, E. Pretsch, J. Seibl, W. Simon, and T. Clerc (eds.), Springer-Verlag, New York, 1989, p. C174.
9. D. A. Tomalia, M. Hall, and D. M. Hedstrand, "Starburst dendrimers. 3. The importance of branch junction symmetry in the development of topological shell molecules," J. Am. Chem. Soc., 109, 1601-1603 (1987).
10. A. B. Padias, H. K. Hall, Jr., D. A. Tomalia, and J. R. McConnell, "Starburst polyether dendrimers," J. Org. Chem., 52, 5305-5312 (1987).
11. D. A. Tomalia, V. Berry, M. Hall, and D. M. Hedstrand, "Starburst dendrimers. 4. Covalently fixed unimolecular assemblages reminiscent of spheroidal micelles," Macromolecules, 20, 1164-1167 (1987).
12. A. M. Naylor, W. A. Goddard III, G. E. Kiefer, and D. A. Tomalia, "Starburst dendrimers. 5. Molecular shape control," J. Am. Chem. Soc., 111, 2339-2341 (1989).
13. D. A. Tomalia, "Starburst™/cascade dendrimers: Fundamental building blocks for a new nanoscopic chemistry set," Aldrichimica Acta, 26, 91-101 (1993).
14. G. R. Newkome, G. R. Baker, S. Arai, M. J. Saunders, P. S. Russo, K. J. Theriot, C. N. Moorefield, L. E. Rogers, J. E. Miller, T. R. Lieux, M. E. Murray, B. Phillips, and L. Pascal, "Synthesis and characterization of two-directional cascade molecules and formation of aqueous gels," J. Am. Chem. Soc., 112, 8458-8465 (1990).
15. S. Serroni, G. Denti, S. Campagna, A. Juris, M. Ciano, and V. Balzani, "Arborols based on luminescent and redox-active transition metal complexes," Angew. Chem. Int. Ed. Engl., 31, 1493-1496 (1992).
16. P. L. Dubin, S. L. Edwards, J. I. Kaplan, M. S. Mehta, D. Tomalia, and J. Xia, "Carbcixylated Starburst dendrimers as calibration standards for aqueous size exclusion chromatography," Anal. Chem., 64, 2344-2347 (1992).
17. Y. H. Kim, "Lyotropic liquid crystalline hyperbranched aromatic polyamides," J. Am. Chem. Soc., 114, 4947-4948 (1992).
18. J. M. Frechet, "Functional polymers and dendrimers: Reactivity, molecular architecture, and interfacial energy," Science, 263, 1710-1715 (1994).
19. R.-N, Jin, T. Aida, and S. Inoue, "'Caged' porphyrin: The first dendritic molecule having a core photochemical functionality," J. Chem. Soc., Chem. Commun., 1260-1262 (1993).
20. R. H. E. Hudson and M. J. Damha, "Nucleic acid dendrimers: Novel biopolymer structures," J. Am. Chem. Soc., 115, 2119-2124 (1993).
21. E. C. Wiener, M. W. Brechbiel, H. Brothers, R. L. Magin, O. A. Gansow, D. A. Tomalia, and P. C. Lauterbur, "Dendrimer-based metal chelates: A new class of magnetic resonance imaging contrast agents," Magn. Reson. Med., 31, 1-8 (1994).
22. J. Haensler and F. C. Szoka, Jr., "Polyamidoamine cascade polymers mediate efficient transfection of cells in culture," Bioconjugate Chem., 4, 372-379 (1993).
23. R. F. Earth, D. M. Adams, A. H. Soloway, F. Alam, and M. V. Darby, "Boronated Starburst dendrimermonoclonal antibody immunoconjugates: Evaluation as a potential delivery system for neutron capture therapy," Bioconjugate Chem., 5, 58-66 (1994).
24. O. A. Gansow, C. Wu, and M. Brechbiel, "Dendrimer-based metal chelates; Linkage to monoclonal antibodies as isotope carriers in radioimmunotherapy," Abstract 24, Division of Nuclear Chemistry and Technology, 208th ACS National Meeting, Washington, D. C., August 21-25, 1994.
25. P. Singh, F. Moll III, S. H. Lin, C. Ferzli, K. S. Yu, R. K. Koski, R. G. Saul, and P. Cronin, "Starburst™ dendrimers: Enhanced performance and flexibility for immunoassays," Clin. Chem., 40, 1845-1849 (1994).
26. J. F. G. A. Jansen, E. M. M. de Brabander-van den Berg, and E. W. Meijer, "Encapsulation of guest molecules into a dendritic box," Science, 266, 1226-1229 (1994).
27. K. Masuda, M. Ohta, M. Ito, S. Ohsuka, T. Kaneda, and N. Kato, "Bactericidal action of tachyplesin I against oral streptococci," Oral Microbiol. Immunol., 9, 77-80 (1994).
28. M. Ruzzene, P. James, A. M. Brunati, A. Donella-Deana, and L. A. Pinna, "Regulation of c-Fgr protein kinase by c-Src kinase (CSK) and by polycationic effectors," J. Biol. Chem., 269, 15885-15891 (1994).
29. 2+ -ATPase by spermine and other polycationic compounds," Biochem., 33, 4745-4754 (1994).
30. M. Hammes and A. Singh, "Effect of polycations on permeability of glomerular epithelial cell monolayers to albumin," J. Lab. Clin. Med., 123, 437-446 (1994).
31. M. L. de Barros e Silva, W. A. Varanda, J. J. Lachat, C. G. Alves da Silva, and T. M. Coimbra, "Glomerular permeability to macromolecules in gentamicintreated rats," Braz. J. Med. Biol. Res., 25, 409-417 (1992).
32. A. Santana, S. Hyslop, E. Antunes, M. Mariano, Y. S. Bakhle, and G. de Nucci, "Inflammatory responses induced by poly-L-arginine in rat lungs in vivo," Agents Actions, 39, 104-110 (1993).
33. A. J. Coyle, S. J. Ackerman, and C. G. Irvin, "Cationic proteins induce airway hyperresponsiveness dependent on charge interactions," Am. Rev. Respir. Dis., 147, 896-900 (1993).
34. I. Westergren and B. B. Johansson, "Altering the blood-brain barrier in the rat by intracarotid infusion of polycations: A comparison between protamine, poly-L-lysine and poly-L-arginine," Acta Physiol. Scand., 149, 99-104 (1993).
35. A. DeLucia III, T. W. Wakefield, P. C. Andrews, B. J. Nichol, A. M. Kadell, W. K. Wrobleski, L. J. Downing, and J. C. Stanely, "Efficacy and toxicity of differently charged polycationic protamine-like peptides for heparin anticoagulation reversal," J. Vasc. Surg., 18, 49-58 (1993).
36. 125I labeled T-actemodulin (TAM)," Acta Physiol. Pharmacol. Bulg., 19, 61-65 (1993).
37. R. Goto and Y. Ibuki, "Tissue distribution of liposomes prepared from synthetic amphiphiles after in-traperitoneal injection into mice," Appl. Radiat. Isot., 45, 57-62 (1994).
38. F. Hudecz, J. A. Clegg, J. Kajtar, M. J. Embleton, M. V. Pimm, M. Szekerke, and R. W. Baldwin, "Influence of carrier on biodistribution and in vitro cytotoxicity of methotrexate-branched polypeptide conjugates," Bioconjugate Chem., 4, 25-33 (1993).
39. J. A. Clegg, F. Hudecz, G. Mezo, M. V. Pimm, M. Szekerke, and R. W. Baldwin, "Carrier design: Biodistribution of branched polypeptides with a poly (L-lysine) backbone," Bioconjugaie Chem., 1, 425-430 (1990).
40. J. B. Tarloff and R. S. Goldstein, "Biochemical mechanisms of renal toxicity," in Introduction to Biochemical Toxicology, Second Edition, E. Hodgson and P. E. Levi (eds.), Appleton & Lange, Norwalk, Connecticut, 1994, p. 522.