Investigations on biodistribution of technetium-99m-labeled carbohydrate-coated poly(propylene imine) dendrimers

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 3, Issue 2, 2007, Pages 120-127

  Agashe, Hrushikesh B ^a   Babbar, Anil Kumar ^b   Jain, Sanyog ^b   Sharma, Rakesh Kumar ^b   Mishra, Anil Kumar ^b   Asthana, Abhay ^a   Garg, Minakshi ^a   Dutta, Tathagata ^a   Jain, Narendra Kumar ^a  

^a DR H S GOUR UNIVERSITY   (India)

^b INSTITUTE OF NUCLEAR MEDICINE AND ALLIED SCIENCES   (India)

Author keywords

Biodistribution; Glycodendrimers; Poly(propylene imine) dendrimers; Technetium 99m

Indexed keywords

BIOACTIVE AGENTS; BIODISTRIBUTION; DRUG CARRIERS; GLYCODENDRIMERS; TECHNETIUM-99M;

BIOLOGICAL ORGANS; CARBOHYDRATES; CHARACTERIZATION; DRUG PRODUCTS; MOLECULAR WEIGHT; RADIOACTIVE ELEMENTS; TECHNETIUM;

DENDRIMERS;

DENDRIMER; POLY(PROPYLENE IMINE)DENDRIMER; TECHNETIUM 99M; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR WEIGHT; MOUSE; NEW ZEALAND; NONHUMAN; PLASMA CLEARANCE; PROTEIN INTERACTION; RABBIT; RADIOACTIVITY; STATISTICAL SIGNIFICANCE;

ANIMALS; CARBOHYDRATES; COATED MATERIALS, BIOCOMPATIBLE; DENDRIMERS; DRUG CARRIERS; FEMALE; ISOTOPE LABELING; MATERIALS TESTING; METABOLIC CLEARANCE RATE; MICE; MICE, INBRED BALB C; ORGAN SPECIFICITY; POLYPROPYLENES; RABBITS; RADIOPHARMACEUTICALS; TECHNETIUM; TISSUE DISTRIBUTION;

MUS; ORYCTOLAGUS CUNICULUS;

EID: 34250175792     PISSN: 15499634     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nano.2007.02.002     Document Type: Article

References (44)

1. Tomalia D.A., Baker H., Dewald J., Hall M., Kallos G., Martin S., et al. A new class of polymers: starburst dendrimeric macromolecules. J. Polym 17 (1985) 117-132
2. de Braber-van den Berg E.M.M., and Meijer E.W. Poly(propylene imine) dendrimers: large scale synthesis by heterogeneously catalyzed hydrogenation. Angew Chem Int Ed Engl 32 (1993) 1308-1311
3. Hawker C.J., Wooly K.L., and Frechet J.M.J. Unimolecular micelles and globular amphiphiles: dendrimeric macromolecules as novel recyclable solubilization agents. J Chem Soc Perkin Trans 1 (1993) 1287-1297
4. Liu M., Kono K., and Frechet J.M.J. Water soluble unimolecular micelles: their potential as drug delivery agents. J Control Rel 65 (2000) 121-131
5. Stevelmans S., van Hest J.G.M., Jansen J.F.G.A., van Bixtel D.A.F.G., de Brabander-van den Berg E.M.M., and Meijer E.W. Synthesis, characterization, and guest host properties of inverted unimolecular dendrimeric micelles. J Am Chem Soc 118 (1996) 7398-7399
6. Newkome G.R., He E., and Morefield C.N. Supramolecules with novel properties: metallodendrimers. Chem Rev 99 (1999) 1689-1746
7. Khandare J., Kolhe P., Pillai O., Kannan S., Leih-Lai M., and Kannan R.K. Synthesis, cellular transport, and activity of polyamidoamine dendrimers-methyl prednisolone conjugates. Bioconjugate Chem 16 (2005) 330-337
8. Papagiannaross A., Dimas K., Papaioannal G.T., and Demetzos C. Doxorubicin-PAMAM dendrimers complex attached to liposomes: cytotoxic studies against human cancer cell lines. Int J Pharm 302 (2005) 29-38
9. Kolhe P., Mishra E., Kannan R.M., Kannan S., and Lieh-Lai M. Drug complexation in vitro release and cellular entry of dendrimers and hyperbranched polymers. Int J Pharm 259 (2003) 143-160
10. Kojima C., Kono K., Maruyama K., and Takagishi T. Synthesis of polyamidoamine dendrimers having poly(ethylene) glycol grafts and their ability to encapsulate anticancer drugs. Bioconjugate Chem 11 (2000) 910-917
11. Ambade A.V., Savariar E., and Thayumanavan S. Dendrimeric micelles for controlled drug release and targeted delivery. Mol Pharm 2 (2005) 264-272
12. Kohle P., Khandare J., Pillai O., Kannan S., Lieh-Lai M., and Kannan R.M. Preparation, cellular transport and activity of polyamidoamine-based dendrimeric nanodevices with a high drug payload. Biomaterials 27 (2005) 660-669
13. Khandare J., Kolhe P., Pillai O., Kannan S., Lieh-Lai M., and Kannan R.M. Synthesis, cellular transport and activity of polyamidoamine dendrimer-methylprednisolone conjugates. Bioconjugate Chem 16 (2005) 330-337
14. Aulenta F., Hayes W., and Rannard S. Dendrimers: a new class of nanoscopic containers and delivery devices. Eur Polym J 39 (2003) 1741-1771
15. Kihara F., Arima H., Tsutsumi T., Hirayama F., and Uekama K. In vitro and in vivo gene transfer by optimized (-cyclodextrin conjugate with polyamido amine dendrimer. Bioconjugate Chem 14 (2003) 342-350
16. Zinselmeyer B.H., Mackay S.P., Schatzlein A.G., and Uchegbu I.F. The lower-generation polypropyleneimine dendrimers are effective gene transfer agents. Pharm Res 19 (2002) 960-967 [judy]
17. Jayaraman N., Nepogodier S.A., and Stoddart J.F. Synthetic carbohydrate containing dendrimers. Chem Eur J 38 (1997) 1193-1199
18. Roy R., Zanini D., Meunier S., and Romanowska A. Solid phase synthesis of dendrimeric sialoside inhibitors of influenza A virus hemaglutinin. J Chem Soc Commun 24 (1993) 1869-1872
19. 125I-labeled polyamidoamine dendrimers in vivo. J Control Rel 65 (2000) 133-148
20. Roberts J.C., Balghat M.K., and Zera R.T. Preliminary biological evaluations of polyamidoamine (PAMAM) starburst dendrimers. J Biomed Res 30 (1996) 53-65
21. Wilbur D.S., Pathare P.P., Hamlin D.K., Bhular K.R., and Vessela R.L. Biotin reagents for antibody pretargeting, 3. Synthesis, radioiodination, and evaluation of biotinylated starburst dendrimers. Bioconjugate Chem 9 (1998) 813-825
22. Ashton P.R., Boyd S.E., Brown C.L., Nepogodier S.A., Meijer E.W., Peerlings H.W.I., et al. Synthesis of glycodendrimers by modification of poly(propylene imine) dendrimers. Chem Eur J 3 (1997) 974-984
23. Reddy L.H., Sharma R.K., Chuttani K., Mishra A.K., and Murthy R.S.R. Influence of administration route on tumour uptake and biodistribution of etoposide loaded solid lipid nanoparticles in Dalton's lymphoma tumour bearing mice. J Control Rel 105 (2005) 185-198
24. Reddy L.H., Sharma R.K., and Murthy R.S.R. Enhanced tumour uptake of doxorubicin loaded poly(butyl cynoacrylate) nanoparticles in mice bearing Dalton's lymphoma tumours. J Drug Target 2 (2004) 443-451
25. Thakkar H., Sharma R.K., Mishra A.K., Chuttani K., and Murthy R.S.R. Efficiency of chitosan microspheres for controlled intra-articular delivery of celecoxib in inflamed joints. J Pharm Pharmcol 56 (2004) 1091-1099
26. Reddy L.H., Sharma R.K., Chuttani K., Mishra A.K., and Murthy R.S.R. Etoposide incorporated tripalmitin nanoparticles with different surface charge: formation, characterization, radiolabeling and biodistribution studies. AAPS J 6 (2004) 1-10
27. Banergee T., Singh A.K., Sharma R.K., and Maitra A.N. Labeling efficiency and biodistribution of technetium-99m labeled nanoparticles: influence by colloidal tin particles. Int J Pharm 289 (2005) 189-195
28. Bezouska K. Design, functional evaluation and biomedical application of carbohydrate dendrimers (glycodendrimers). Rev Mol Biotechnol 90 (2000) 269-290
29. Davis B.G., and Robinson M.A. Drug delivery systems based on sugar-macromolecule conjugates. Curr Opin Drug Discovery Dev 5 (2002) 279-288
30. Goyal P., Goyal K., Vijaykumar S.G., Singh A., Katare O.P., and Mishra D.N. Liposomal drug delivery systems-clinical applications. Acta Pharm 55 (2005) 1-25
31. Sinha R., Kim G.J., Nie S., and Shin D.M. Nanotechnology in cancer therapeutics: bioconjugated nanoparticles for drug delivery. Mol Cancer Ther 5 (2006) 1909-1917
32. Vijayrajkumar P., Asthana A., Dutta T., and Jain N.K. Intracellular macrophage uptake of rifampicin loaded mannosylated dendrimers. J Drug Target 14 (2006) 546-556
33. Bhadra D., Yadav A.K., Bhadra S., and Jain N.K. Glycodendrimeric nanoparticulate carriers of primaquine phosphate for liver targeting. Int J Pharm 295 (2005) 221-233
34. Yamaoka T., Tabata Y., and Ikada Y. Distribution and tissue uptake of poly(ethylene) glycol with different molecular weights after intravenous administration to mice. J Pharm Sci 83 (1994) 601-606
35. Drobnik J., and Rypeck F. Soluble synthetic polymers in biological systems. Adv Polym Sci 57 (1984) 23-49
36. Roos P.H., Hartman H.J., Schlepper-Schofer J., Kolb H., and Kolb-Bachofen V. Galactose specific receptors on liver cells II. Characterization of purified receptors from macrophages reveals no structural relationship to hepatocyte receptors. Biochim Biophys Acta 847 (1985) 115-121
37. Jones E.A., and Summerfield J.A. Kupffer cells. In: Arias I.M., Jakavy W.B., Popper H., Schacter D., and Shafritz D.A. (Eds). The liver: biology and pathobiology. 2nd ed. (1988), Raven, New York 683-704
38. Elverold K.H., Nedredal G.I., Revhaug A., and Smedsrd B. Scavenger properties of cultivated pig liver endothelial cell. Comp Hepatol 3 (2004) 1-11
39. Lee Y.C. Biochemistry of carbohydrate-protein interaction. FASEB J 6 (1992) 3193-3200
40. Ponpipom M.M., Bugianesi R.L., Robbins J.C., Doeberry J.C., and Shen J.Y. Cell specific ligands for drug delivery to tissues and organs. J Med Chem 24 (1981) 1388-1395
41. Kichler A., and Schuber R. Versatile synthesis of bi- and tri-antenary galactose ligands: interactions with Gal/GalNac receptors of human hepatoma cells. Glycoconj J 12 (1995) 275-281
42. Grandjen C., Rommens C., Gras-Masse H., and Melnyk O. One-pot synthesis of antigen bearing, leucine base cluster mannoside using two orthogonal chemoselective ligation interactions. Angew Chem Int Ed 39 (2000) 1068-1072
43. Smith J.E., Prison P., and Sinden R.E. Studies on the kinetics of uptake and distribution of free and liposome entrapped primaquine and of sporozoites by isolated perfused rat liver. Ann Trop Med Parasitol 77 (1983) 379-386
44. Rensen D.C.N., van Dijk M.C.M., Havenaar E.C., Bijsterbosch M.K., Kruijt J.K., and van Berkel T.J.C. Selective liver targeting of antiviral by recombinant chylomicrons-a new therapecutic approach to hepatitis B. Nat Med 1 (1995) 221-225