Positive effects of polyethylene glycol conjugation to generation-4 polyamidoamine dendrimers as macromolecular MR contrast agents

Magnetic Resonance in Medicine

Volumn 46, Issue 4, 2001, Pages 781-788

  Kobayashi, Hisataka ^a,c   Kawamoto, Satomi ^b   Saga, Tsuneo ^c   Sato, Noriko ^d   Hiraga, Akira ^e   Ishimori, Takayoshi ^a   Konishi, Junji ^a   Togashi, Kaori ^a   Brechbiel, Martin W ^a  

^a HITACHI LTD   (Japan)

^b Department of Nuclear Medicine and Diagnostic Imaging ^*  (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d Otsu Municipal Hospital   (Japan)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Contrast agent; Macromolecular; MRI; Polyamidoamine dendrimer; Polyethylene glycol

Indexed keywords

ALIPHATIC COMPOUNDS; BLOOD; DENDRIMERS; MAGNETIC RESONANCE IMAGING; POLYETHYLENE GLYCOLS; POLYETHYLENES; SYNTHESIS (CHEMICAL);

CONTRAST AGENT; DIETHYLENETRIAMINE PENTA-ACETIC ACIDS; HALF LIVES; IMMUNOGENICITY; MACROMOLECULAR; MR CONTRAST AGENTS; MRI CONTRAST AGENTS; POLYAMIDOAMINE DENDRIMERS;

MACROMOLECULES;

2 (4 ISOTHIOCYANATOBENZYL) 6 METHYLDIETHYLENETRIAMINEPENTAACETIC ACID; DENDRIMER; GADOLINIUM PENTETATE ALBUMIN; MACROGOL; MACROGOL 2 (4 ISOTHIOCYANATOBENZYL) 6 METHYLDIETHYLENETRIAMINEPENTAACETIC ACID GADOLINIUM GD 153; NUCLEAR MAGNETIC RESONANCE IMAGING AGENT; POLYAMIDOAMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG CONJUGATION; DRUG EXCRETION; DRUG FORMULATION; DRUG HALF LIFE; DRUG LIVER LEVEL; DRUG RETENTION; DRUG SYNTHESIS; DRUG TISSUE LEVEL; HYDROPHILICITY; IMMUNOGENICITY; KIDNEY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING;

EID: 0034789562     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrm.1257     Document Type: Article

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