Transcytosis of nanoparticle and dendrimer delivery systems: Evolving vistas

Advanced Drug Delivery Reviews

Volumn 50, Issue SUPPL. 1, 2001, Pages

  Florence, Alexander T ^a   Hussain, Nasir ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Absorption; Dendrimer; Drug delivery; Gene therapy; Intestine; Nanoparticle; Peyer's patch; Transfection; Translocation; Uptake

Indexed keywords

ADHESION; BIODEGRADATION; DRUG DOSAGE; PLASTICITY; TISSUE;

TRANSCYTOSIS;

NANOSTRUCTURED MATERIALS;

ARCHAEAL DNA; BILE ACID; CHITOSAN; CYANOACRYLATE DERIVATIVE; DENDRIMER; DEOXYCHOLIC ACID; DIAMINE DERIVATIVE; DOXORUBICIN; DRUG VEHICLE; FUMARIC ACID DERIVATIVE; IMINE; LIPOFECTAMINE; LIPOSOME; MACROGOL; METHOTREXATE; MONTELUKAST; NANOPARTICLE; NIOSOME; PLASMID DNA; POLYAMINE; POLYLACTIC ACID; POLYPROPYLENE; SILANE DERIVATIVE; TITANIUM DIOXIDE; VACCINE; ZAFIRLUKAST; ZILEUTON;

ADHESION; CELL ACTIVATION; COLLOID; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED DRUG RELEASE; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG STABILITY; DRUG STRUCTURE; DRUG UPTAKE; ENCAPSULATION; GENE THERAPY; HUMAN; INTESTINE; INTESTINE EPITHELIUM; LYMPHOID TISSUE; MOLECULAR INTERACTION; MUCUS; PARTICLE SIZE; PLASTICITY; PRIORITY JOURNAL; SALIVA; SURFACE PROPERTY; TRANSCYTOSIS;

ADMINISTRATION, ORAL; ANIMALS; DRUG DELIVERY SYSTEMS; EXOCYTOSIS; HUMANS; INTESTINAL ABSORPTION; INTESTINAL DISEASES; MICROSPHERES;

EID: 0035478442     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(01)00184-3     Document Type: Conference Paper

References (87)

1. Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics
2. Plasticity of the gastrointestinal epithelium: The M cell paradigm and opportunism of pathogenic microorganisms
3. The oral absorption of micro- and nanoparticulates: Neither exceptional nor unusual
4. Binding and uptake of biodegradable poly-DL-lactide micro- and nanoparticles in intestinal epithelia
5. Influence of colloid stabilizing agents on interactions between nanoparticles and mucus
6. Migration of adhesive and nonadhesive particles in the rat intestine under altered mucus secretion conditions
7. Novel formulation approaches to oral mucoadhesive drug delivery systems
8. Mechanistic studies in the simultaneous flow and adsorption of polymer-coated latex particles on intestinal mucus I: Methods and physical model development
9. Pinocytosis and phagocytosis: The effect of size of a particulate substrate on its mode of capture by rat peritoneal macrophages cultured in vitro
10. Bioadhesion of lectin-latex conjugates to rat intestinal mucosa
11. Mucoadhesion of latexes. II. Adsorption isotherms and desorption studies
12. Mucoadhesion of latexes. I. Analytical methods and kinetic studies
13. Bioadhesion by means of specific binding of tomato lectin
14. Cystic fibrosis sputum: A barrier to the transport of nanospheres
15. The transport of microspheres from the gastrointestinal tract to inflammatory air pouches in the rat
16. A commentary on morphological and quantitative aspects of microparticle translocation across the gastrointestinal mucosa
17. Role of chemotaxis in the association of motile bacteria with intestinal mucosa: In vivo studies
18. Bacterial translocation from the gastrointestinal tract
19. Particle diameter influences adhesion under flow
20. Weakly adhering vesicles in shear flow: Tanktreading and anomalous flow
21. Specific adhesion of glycophorin liposomes to a lectin surface in shear flow
22. Identification of invasin: A protein that allows enteric bacteria to penetrate cultured mammalian cells
23. Utilizing bacterial mechanisms of epithelial cell entry: Invasin-induced oral uptake of latex nanoparticles
24. Bacterial invasion factors and lectins as second generation bioadhesives
25. The in vitro cell association of invasin coated polylactide-co-glycolide nanoparticles
26. A mechanistic analysis of carrier-mediated oral delivery of protein therapeutics
27. Enhancement of transfection by physical concentration of DNA at the cell surface
28. Coating the surface: A model for expression of capsular polysialic acid in Escherichia coli K1
29. Translocation of polysialic acid across model membranes: Kinetic analysis and dynamic studies
30. Nanoparticle uptake by the rat gastrointestinal mucosa: Quantitation and particle size dependency
31. The uptake and translocation of latex nanospheres and microspheres after oral administration to rats
32. 99mTc-sulphur colloid gastroesophageal scintigraphy with late lung imaging to evaluate patients with posterior laryngitis
33. Surface and colloid chemical aspects of saliva particle interactions
34. Reflectometry: A new method for quantitative determinations of intraoral film formation
35. Binding of salivary proteins and oral bacteria to hydrophobic and hydrophilic surfaces in vivo and in vitro
36. Retention of streptococci to defined solid surfaces in the presence of saliva secretions
37. A unique dosage form to evaluate the mechanical destructive force in the gastrointestinal tract
38. Gliding motility in cyanobacterial: Observations and possible explanations
39. Gastrointestinal uptake of biodegradable microparticles: Effect of particle size
40. Vaccine-containing biodegradable microspheres specifically enter the gut-associated lymphoid tissue following oral administration and induce a disseminated mucosal immune response
41. Oral uptake and translocation of a polylysine dendrimer with a lipid surface
42. The measured level of prion infectivity varies in a predictable way according to the aggregation state of the infectious agent
43. Oral delivery of poly(lactide-co-glycolide) microspheres containing ovalbumin as vaccine formulation: Particle size study
44. Impairment of alveolar macrophage phagocytosis by ultrafine particles
45. Protein instability in poly(lactic-co-glycolic acid) microparticles
46. Mathematical modeling of bioerodible, polymeric drug delivery systems
47. Self-assembling dendrimers
48. In vitro dissolution and in vivo absorption of nitrofurantoin from deoxycholic acid co precipitates
49. Synthetic methods of glycopeptide assembly, and biological analysis of glycopeptide products
50. The role of PEG on the stability in digestive fluids and in vivo fate of PEG-PLA nanoparticles following oral administration
51. Factors affecting the oral uptake and translocation of polystyrene nanoparticles: Histological and analytical evidence
52. Limited adhesion of biodegradable microspheres to E and P-selectin under flow
53. Cellular uptake of PEO surface-modified nanoparticles: Evaluation of nanoparticles made of PLA:PEO diblock and triblock copolymers
54. Degradation of poly(D,L-lactic acid) nanoparticles coated with albumin in model digestive fluids (USP XXII)
55. Peroral administration of 14C-poly(D,L-lactic acid) nanoparticles coated with human serum albumin or polyvinyl alcohol to guinea pigs
56. Evaluation of biological and physical protection against nuclease degradation of clay-bound plasmid DNA
57. The transport of microspheres from the gastrointestinal tract to inflammatory air pouches in the rat
58. Synthesis of polyamidoamine dendrimers having poly(ethylene glycol) grafts and their ability to encapsulate anticancer drugs
59. Oral immunization with peptide and protein antigens by formulation in lipid vesicles incorporating bile salts (bilosomes)
60. A direct method for the formation of peptide and carbohydrate dendrimers
61. Synthesis and physicochemical properties of lipophilic polyamide dendrimers
62. Uptake by enterocytes and subsequent translocation to internal organs, e.g., the thymus, of Percoll microspheres administered per os to suckling mice
63. Internalin of Listeria monocytogenes with an intact leucine-rich repeat region is sufficient to promote internalization
64. Trojan peptides: The penetratin system for intracellular delivery
65. PAMAM dendrimers as delivery agents for antisense oligonucleotides
66. Activated polyamidoamine dendrimers, a non-viral vector for gene transfer to the corneal endothelium
67. In vitro uptake of polystyrene microspheres: Effect of particle size, cell line and cell density
68. Dendrimer-platinate: A novel approach to cancer chemotherapy
69. Enhanced delivery of antisense oligonucleotides with fluorophore-conjugated PAMAM dendrimers
70. Immune potentiation of ultrafine dietary particles in normal subjects and patients with inflammatory bowel disease
71. Size dependency of nanoparticles deposition in the inflamed colon in inflammatory bowel disease: In vivo results from the rat
72. Positively charged gelatin microspheres as gastric mucoadhesive drug delivery system for eradication of H. pylori
73. Conversion by Peyer's patch lymphocytes of human enterocytes into M cells that transport bacteria
74. Expression of specific markers and particle transport in a new human intestinal M-cell model
75. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell
76. Comparison of two methods of encapsulation of an oligonucleotide into poly(D,L-lactic acid) particles
77. Chitosan and depolymerized chitosan oligomers as condensing carriers for in vivo plasmid delivery
78. Chitosan microparticles for oral vaccination: Preparation, characterization and preliminary in vivo uptake studies in murine Peyer's patches
79. Oral gene delivery with chitosan-DNA nanoparticles generates immunological protection in a murine model of peanut allergy
80. Biologically erodable microspheres as potential oral drug delivery systems
81. Oral DNA vaccination promotes mucosal and systemic immune responses to HIV envelope glycoprotein
82. Innovations in oral gene delivery: Challenges and potentials
83. Plasmid DNA adsorbed onto cationic microparticles mediates target gene expression and antigen presentation by dendritic cells
84. Liposome mediated gene delivery into murine gastrointestinal tract
85. Oral drug delivery